Project System

BILLY T. GEORGE

**** ******* ***** . ********, ** 19703

SUMMARY OF QUALIFICATIONS

Experienced in microsomal metabolic stability studies using both human and

monkey liver microsomes

Skilled in analyzing plasma, urine, bile and whole blood supporting DMPK

projects

Performed protein precipitation, solid phase extraction (SPE) and liquid

liquid extraction (LLE) assays supporting both preclinical and clinical

studies

Skilled in LC-MS based assays

Experienced in the use of laboratory automation for sample preparation

Skilled in the use of Watson laboratory information management system

(LIMS)

Experienced in writing bio-analytical reports, methods, and validation

protocols

Experienced in performing tissue homogenization for the bio-analysis of

small molecules and peptides

Experienced with metabolite identification on small molecules.

Skilled in problem solving and finding efficient and timely solutions

PROFESSIONAL EXPERIENCE

FRONTAGE LABORATORIES (Exton, PA) April 2013 - November

2013

Scientist

Successfully contributed to method development and validation projects for

LC-MS based

assays, including separation of parent and 9 metabolites in both dog

and rat plasma

Performed sample assays and generated bio-analytical data packages to meet

project timelines

Used laboratory automation to process samples

Performed metabolic stability studies using both human and monkey liver

microsomes

ADECCO (Nutley, NJ) July 2011 - December

2012

Bio-analytical Scientist contracted in Hoffmann La-Roche

Developed difficult bio-analytical methods for pre-clinical PK, efficacy

and TK samples, including support of a global Central Nervous System (CNS)

project

Developed a LC-MS based assay to analyze both extracted and hydrolyzed

plasma samples for polymer drug conjugate project

Successfully performed LC-MS based assay on peptide for oncology project,

including separation of parent and metabolites

Used laboratory automation for preclinical sample processing

Troubleshot and resolved problems in assays

BILLY T. GEORGE

2305 Society Drive . Claymont, DE 19703

ASTRAZENECA (Wilmington, DE) December 2001 - August

2004

Associate Scientist

Developed and validated a bio-analytical method for pre-clinical study

samples

Performed LC-MS based assays for CNS project

Programmed Liquid Handling Robotic System for sample processing from

various containers into 96 well format

HL YOH (Wilmington, DE) June 1999 -

December 2001

Associate Scientist/AstraZeneca Contractor

Used LC/MS and LC/MS-MS to identify metabolites

Performed the solubility and logD assays using HPLC/UV

Successfully maintained the group's assay scheduling and request system,

compound ordering and solubilization with high efficiency

SL PHARMA LABS (Wilmington, DE) March 1998 - June 1999

Associate Scientist

Performed content uniformity and composite assays of bulk drug, in-process

blends and finished product in compliance with USP, FDA and client

specifications using HPLC

Worked with IR, Optical rotation and melting point for identification of

the active pharmaceutical ingredient (API) for a novel cancer drug

Developed and validated methods of analysis of bulk drug and finished

product to meet the needs of the client in accordance with the FDA and ICH

EDUCATION

ROSS UNIVERSITY SCHOOL OF MEDICINE Jan 2007 - May 2010

Roseau, Dominica

ST CHRISTOPHER'S IBA MAR DIOP COLLEGE OF MEDICINE Sep 2004 - May 2006

Luton, UK

UNIVERSITY OF DELAWARE

May 1997

Newark, DE

Bachelor of Science in Biochemistry

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