University C

Rajith Bhaskaran

Research Associate

Current Position

Bioinformatics division

SBST, VIT University, Tamil Nadu - 632014

Email: ******.**@*****.***, ***************@*****.***

.

Ph: +91-904*******.

Education PhD in Bioinformatics 2010-2014

Title “Computational Analysis of Disease Associated Point mutations in

Human Kinase Gene”

VIT University, India

Master of Science in Biotechnology (Integrated) 2003-2008

Annamalai University, India

Research Associate, VIT University (March 2011- present)

Experiences

Maters project on “Production of Single Cell protein by Yeast using

various low cost substrates”, Global institute of Biotechnology,

Hyderabad (December 2007- May 2008).

Skills Computational Biology

Programming Skills: Fortran, Perl and Python

Operating systems: Windows, Unix

Molecular Docking: Autodock, Glide

Computational Biophysics: Molecular simulation techniques

Biochemistry and Molecular Biology

Amplification of DNA/RNA/proteins using PCR, RT-PCR, in vitro

transcription, cloning and expression in vivo (E.coli) and in vitro.

Purification and analysis of DNA/RNA/Proteins using electrophoresis, size

exclusion and ion-exchange column chromatography.

Spectroscopic analysis and physicochemical characterization of molecules-

UV-Vis, FTIR, XRD

Best researcher achievers award from VIT University, 2012.

Best poster presentation award in National workshop on “Recent advances

Achievement

in Proteomics” form NIOT, Chennai, 2012.

Cumulative Impact – 27.75

Research Publications

1. Sripriyalakshmi. S, Anjali. C. H, George Priya Doss. C, Rajith B, Aswathy Ravindran.

(2014) Atorvastatin loaded with albumin nanoparticle: A new facet for an old drug.

PlosOne. 01/2014; 9(1): e86317

2. George Priya Doss C, Rajith B, et al. (2013) In silico profiling and structural insights of

Missense mutations in RET protein kinase domain by molecular dynamics and docking

approach. Molecular Biosystem. 10.1039/C3MB70427K

3. George Priya Doss C, Rajith B (2013) Predicting the Impact of Deleterious Mutations in

the Protein Kinase Domain of FGFR2 in the Context of Function, Structure, and

Pathogenesis-a Bioinformatics Approach. Applied Biochemistry and Biotechnology.

170: 1853-70

4. George Priya Doss C, Rajith B, et al. (2013) In Silico Analysis of Prion Protein

Mutants- A Comparative Study by Molecular Dynamics approach. Cell Biochemistry

and Biophysics. 10.1007/s12013-013-9663-z.

5. George Priya Doss C, Chakraborty C, Rajith B, et al. (2013) In silico discrimination of

nsSNPs in hTERT gene by means of local DNA sequence context and regularity.

Journal of molecular modeling. 19: 3517-27.

6. Rajith B, George Priya Doss (2013) Disease causing mutation in Extracellular domain

and Intracellular domain of FGFR1 protein: Computational approach. Applied

Biochemistry and Biotechnology. 169: 1659-71.

7. George Priya Doss C, Rajith B et al. (2012) Screening of mutations affecting protein

stability and dynamics of FGFR1- A simulation analysis. Applied and Translational

genomics 10.1016/j.atg.2012.06.002.

8. George Priya Doss C, Rajith B et al. (2013) In silico profiling of miRNAs and their target

polymorphisms in leukemia associated genes. Egypt J Med Hum Genet.

10.1016/j.ejmhg.2013.01.004

9. George Priya Doss, Rajith B (2012) A new insight in to structural and functional impact of

Single Nucleotide Polymorphisms in PTEN gene. Cell Biochemistry and Biophysics. 66:

249-63.

10. George Priya Doss C, Rajith B (2012) Computational refinement of functional single

nucleotide polymorphisms associated with ATM gene. PLoS One. 7(4):e34573.

11. Rajith B, George Priya Doss (2011) Path to facilitate the prediction of functional amino

acid substitutions in red blood cell disorders--a computational approach. PLoS One.

6(9):e24607.

Conferences

Participated in International conference on “Structural and functional Genomics” (ICSAFG

2013) organized by SASTRA University.

Participated in National workshop on “Network Pathways & Systems Biology” held at DBT-

BIF centre, Holy Cross College, Trichy, 2012.

Participated in National Conference On “Recent Trends In Biochemistry and Biotechnology”

with special reference to Natural Products In Health, 2006 at Annamalai University,

Annamalainagar.

Participated in UGC-SAP Sponsored National Workshop on “Bioinformatics & Conference

on Free radicals & antioxidants in health” 2007, Annamalai University.

Chaired the Symposium presented on History Of Biology, 2007 at Annamalai University.

Academic Projects

“Exploration of the impact of Point mutations on the structural and functional

stability of various protein kinase genes”

“Identifying the underlying mechanisms conferring drug resistance mutation in

various protein kinase genes”

“In silico profiling of miRNAs and their target polymorphisms in leukemia

associated genes”

“Sequencing of the DNA binding (DBD) and the ligand binding (LBD) domains of

the ecdysteroid receptor gene (EcR) of an estuarine grapsid crab”

“Targeted drug delivery”

References

1. Dr. Aswathy Ravindran, Assistant Professor Research, School of Chemical and

Biotechnology, SASTRA University, Tirumalaisamudram, Thanjavur – 613401,

*******@****.******.***, +91-801*******

2. Dr. C Sudandiradoss, Asssociate Professor, SBST, VIT University, Vellore – 632014,

**************@***.**.**, +91-944*******

3. Dr. R Rajasakeran, Asssociate Professor, SBST, VIT University, Vellore – 632014,

************@***.**.**, +91-944*******

Rajith Bhaskaran

2014

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