PhD, Molecular Cytogenetics
Resume:
Dr. Marine Manvelyan
HACKENSACK NJ 07601
***********@*****.***
http://www.linkedin.com/pub/marine-manvelyan/b/a34/679/
OBJECTIVES
Position in the field of molecular cytogenetics
SUMMARY OF QUALIFICATIONS
> Application of the methods of conventional cytogenetics for diagnosis
of chromosomal disorders
> Investigation of chromosomal disorders by FISH
> Analysis of complex chromosomal disorders by different methods of
multicolor-FISH (M-FISH)
> 3-Dimensional investigation of position and orientation of chromosomes
in interphase nucleus
> G-Banding, R-Banding, C-Banding
> DNA extraction and DNA probes preparation
> Karyotyping
EDUCATION
2004 PhD. Molecular-cytogenetic investigation of complex
chromosomal anomalies
Yerevan State University (Armenia). Department of Genetics
and Cytology, Faculty of Biology
2001-2003 Postgraduate
Yerevan State University (Armenia). Department of Genetics
and Cytology, Faculty of Biology
1999-2001 Master Degree
Yerevan State University (Armenia). Department of Genetics
and Cytology, Faculty of Biology
1995-1999 Bachelor's Degree
Yerevan State University (Armenia). Department of Genetics
and Cytology, Faculty of Biology
WORK EXPERIENCE
2011-2012 Research Scientist at University Hospital of Jena,
Institute of Human Genetic (Germany)
2009-2010 Research Associate at University Hospital of Jena,
Institute of Human Genetic (Germany)
2000-2012 Senior Research Scientist at Department of Genetics and
Cytology, Faculty of Biology of Yerevan State University,
Armenia
2005-2012 Research Scientist at Research Center of Maternal and
Child Health Protection, Laboratory of Cytogenetics.
Yerevan, Armenia
STUDIES AND RESEARCH PROJECTS
2010 DFG-fellow "Vergleichende Studien zur Interphasekernarchitektur
in myeloischen Leuk mien mit und ohne Trisomie 8" (Institut f r
Humangenetik und Anthropologie, Jena, Germany)
2009 BMBF/DLR project "Molecularcytogenetic characterization of
heteromorphic inversion variants of the chromosomes 2 and 9"
(Institut f r Humangenetik und Anthropologie, Jena, Germany)
2008 Clinical Cytogenetics Advanced Course (Goldrain, South Tyrol,
Italy)
2008 DFG-fellow for the "Vergleichende Studien zur
Interphasekernarchitektur in myeloischen Leuk mien mit und ohne
Trisomie 8" (Institut f r Humangenetik und Anthropologie, Jena,
Germany)
2007 DFG-fellow for the "Verifizierung neuer
Subspeziesunterschiedenen der Gattungen Pan und Pongo mittels
molekularer Zytogenetik" (Institut f r Humangenetik und
Anthropologie, Jena, Germany)
2007 DAAD-fellow for the "Orientation and position of chromsomes 18,
19, 21 and 22 in 3D-preserved interphase nuclei of primates"
(Institut f r Humangenetik und Anthropologie, Jena, Germany)
2006 DFG-fellow for the 'Bestimmung von Lage und Orientierung der
menschlichen Chromosomen in den Spermien normaler M nner
(Institut f r Humangenetik und Anthropologie, Jena, Germany)
2005 Training in Prenatal Cytogenetics in Yerevan performed by the
Institut f r Pathologie (Cottbus, Germany)
2004 SCOPES visiting scholar am Institute of Medical Genetics,
University of Z rich (Switzerland)
2004 NATO Advanced Study AM Institute on genetic toxicology, Macomb
(USA)
2002 SCOPES visiting scholar at Institute of Medical Genetics,
University of Z rich (Switzerland)
HONORS AND AWARDS
Special Prize of the Genetics Society of America at International
Conference on Modern Problems of Genetics, Radiobiology, Radioecology
and Evolution. Yerevan, 2005
Successful participation confirmation at the Course on Clinical
Cytogenetics. Goldrain, Italy, 2008
PUBLICATIONS
> Liehr T., Mkrtchyan H., Manvelyan M., Karamysheva T., Klein E., Bhatt
S. Chromosome architecture studied by high-resolution FISH banding in
three dimensionally preserved human interphase nuclei. Human
Interphase Chromosomes: Biomedical Aspects 2013, Chapter 10.
> Kosyakova N., Grigorian A., Liehr T., Manvelyan M., Simonyan I.,
Mkrtchyan H., Aroutiounian4 R., D Polityko A., I Kulpanovich A.,
Egorova T., Jaroshevich E., Frolova A., Shorokh N., Naumchik V.I.,
Volleth M., Schreyer I., Nelle H., Stumm M., Wegner R., Reising-
Ackermann G., Merkas M., Brecevic L., Martin T., Rodr guez L., Bhatt
S., Ziegler M., Kreskowski K., Weise A., Sazci A., Vorsanova S.,
Cioffi M. and Ergul E. Heteromorphic variants of chromosome 9.
Molecular Cytogenetics 2013, 6:14.
> Klein E., Manvelyan M., Simonyan I., Hamid B.A., Guilherme S. R.,
Liehr T., Karamysheva T. Centromeric association of small
supernumerary marker chromosomes with their sister-chromosomes
detected by three dimensional molecular cytogenetics. Molecular
Cytogenetics 2012, 5:15.
> Othman A.K.M., Lier A., Junker S., Kempf P., Dorka F., Gebhart E.,
Sheth J.F., Grygalewicz B., Bhatt S., Weise A., Mrasek K.,Liehr T.,
Manvelyan M. Does positioning of chromosomes 8 and 21 in interphase
drive t(8;21) in acute myelogenous leukemia? BioDiscovery 2012, 42.
> Braulke F., Schanz J., Steffens R., Liehr T., Manvelyan M., Chudoba
I., Haase D. Two Different del(5q) Clones in a Patient with
Myelodysplastic Syndrome: A Case Report. Leukemia and Lymphoma, in
press.
> Garcia D. RN., Bhatt S., Manvelyan M., de Souza M. T., Binato R.,
Aguiar T. F., Abdelhay E., and M Silva M. L. An unusual T-cell
childhood acute lymphoblastic leukemia harboring a yet unreported near-
tetraploid karyotype. Molecular Cytogenetics 2011, 4:20.
> Manvelyan M, Cremer FW, Lanc J, Kl s R, Kelbova C, Ramel C,
Reichenbach H, Schmidt C, Ewers E, Kreskowski K, Ziegler M, Kosyakova
N, Liehr T. New cytogenetically visible copy number variant in region
8q21.2. Mol Cytogenet 2011, 4:1.
> Al-Achkar W, Wafa A, Manvelyan M, Ikhtiar A, Liehr T. De novo
translocation involving two chromosomes in adult prolymphocytic
leukemia-A rare case. Leuk Res 2010, 34:e345-347.
> Ewers E., Hamid B. A., Kosyakova N., Manvelyan M., Thomas L. Small
supernumerary marker chromosomes and uniparental disomy have a story
to tell. Journal of Medical Genetics, in press.
> Al Achkar W., Wafa A., Ali Yousef Ali B., Manvelyan M., Liehr T. A
rare chronic myeloid leukemia case with Philadelphia chromosome, BCR-
ABL e13a3 transcript and complex translocation involving four
different chromosomes. Oncology Letters1: 797-800, 2010.
> Mkrtchyan H, Gross M, Hinreiner S, Polytiko A, Manvelyan M, Mrasek K,
Kosyakova N, Ewers E, Nelle H, Liehr T, Bhatt S, Thoma K, Gebhart E,
Wilhelm S, Fahsold R, Volleth M, Weise A. The human genome puzzle -
the role of copy number variation in somatic mosaicism. Curr Genomics
2010, 11:426-431.
> Mkrtchyan H, Gross M, Hinreiner S, Polytiko A, Manvelyan M, Mrasek K,
Kosyakova N, Ewers E, Nelle H, Liehr T, Volleth M, Weise A. Mkrtchyan
H, Gross M, Hinreiner S, Polytiko A, Manvelyan M, Mrasek K, Kosyakova
N, Ewers E, Nelle H, Liehr T, Volleth M, Weise A. Early Embryonic
Chromosome Instability Results in Stable Mosaic Pattern in Human
Tissues. PLoS ONE. 5, P. 1-7, 2010.
> Ewers E., Yoda K, Hamid B. A., Weise A., Manvelyan M., Liehr T.
Centromere activity in dicentric small supernumerary marker
chromosomes. Chromosome Res, 18:555-562, 2010.
> Manvelyan M., Aroutiounian R., Simonyan I., Liehr T. Chromosome
distribution in human sperm - a 3D multicolor banding-study. Actual
problems of obstetrics and gynecology. Proceeding of international
conference. Yerevan, 2009. P. 88-95.
> Manvelyan M., Okoev G. Preimplantation genetic diagnosis. Obstetrics,
gynaecology and neonatology, 3:17-20, 2009.
> Manvelyan M., Kempf P., Weise A., Mrasek K., Heller A., Lier A.,
H fffken K., Fricke H.J., Sayer H.G., Liehr T., Mkrtchyan H. Preferred
co-localization of chromosome 8 and 21 in myeloid bone marrow cells
detected by three dimensional molecular cytogenetics. Int J Mol Med.
24, P. 335-341, 2009.
> Bhatt S., Moradkhani K., Mrasek K., Puechberty J., Manvelyan M.,
Hunstig F., Lefort G., Weise A., Lespinasse J., Sarda P., Liehr T,
Hamamah S., Pellestor F. Breakpoint mapping and complete analysis of
meiotic segregation patterns in three men heterozygous for paracentric
inversions. European Journal of Human Genetics. 17, P. 44-50, 2009.
> Hinstig F., Manvelyan M., Bhatt S., Steinhaeuser U., Liehr T. Three-
dimensional interphase analysis enabled by suspension FISH.
Fluorescence in situ hybridization (FISH) - application guide.
Springer-Verlag Berlin Heidelberg, 2008, chapter 28, P. 313-320.
> Liehr T., Mrasek K., Kosyakova N., Nelle H., Trifonov V., Manvelyan
M., Weise A. FISH Banding techniques. Fluorescence in situ
hybridization (FISH) - application guide. Springer-Verlag Berlin
Heidelberg, 2008, chapter 22, P. 243-250.
> Manvelyan M., Liehr T. Characterization of archived formalin-
fixed/parafin embedded or cryofixed tissue, including nucleus
extraction. Fluorescence in situ hybridization (FISH) - application
guide. Springer-Verlag Berlin Heidelberg, 2008, chapter 15, P. 147-
156.
> Okoev G., Zurabyan N., Simonyan I., Manvelyan M., Ter-Hakobova K.,
Kazaryan G. The results of the medical genetic consultation and
prenatal diagnostics of congenital malformations. Actual problems
of obstetrics and gynecology. Proc. of international conference.
Yerevan, 2008, P. 103-106.
> Manvelyan M., Simonyan I., Arustamyan K., Zurabyan N., Sarkisyan
N., Mrasek K., Weise A., Liehr T. Molecular cytogenetic
characterization of marker chromosomes at patients with fertility
problems. Actual problems of obstetrics and gynecology. Proc. of
international conference. Yerevan, 2008, P. 72-74.
> Manvelyan M., Hunstig F., Bhatt S., Mrasek K., Pellestor F., Weise
A., Simonyan I., Aroutiounian R., Liehr T. Chromosome distribution
in human sperm - a 3D multicolor banding-study. Molecular
Cytogenetics, 1:25, 2008.
> Manvelyan M., Riegel M., Santos M., Fuster C., Pellestor F.,
Mazaurik M-L, Schulze B., Polityko A., Tittelbach H., Reising-
Ackermann G., Belitz B., Hehr U., Kelbova C., Volleth M., G dde E.,
Anderson J., K pferling P., K hler S., Duba H-C., Dufke A., Aktas
D., Martin T., Schreyer I., Ewers E., Reich D., Mrasek K., Weise
A., Liehr T. 32 new cases with small supernumerary marker
chromosomes (sSMC) detected in connection with fertility problems -
detailed molecular cytogenetic characterization and review of the
literature. Int J Mol Med. 21, P. 705-714, 2008.
> Manvelyan M., Hunstig F., Mrasek K., Bhatt S., Pellestor F., Weise
A., Liehr T. Position of chromosomes 18, 19, 21 and 22 in 3D-
preserved interphase nuclei of human and gorilla and white hand
gibbon. Mol Cytogenet, 1:9, 2008.
> Manvelyan M., Abrahamyan A., Simonyan I., Zurabyan N., Aroutiounian
R. Creation of DNA-probes for molecular-cytogenetic analysis in
clinical genetics. Actual problems of obstetrics and gynecology.
Proc. of international conference. Yerevan, 2007, P. 140-146.
> Okoev G., Zurabyan N., Simonyan I., Manvelyan M., Kazaryan G.,
Nirzoyan A., Ter-Hakobova K. Modern approaches ? the prenatal
diagnosis of chromosomal diseases. Actual problems of obstetrics
and gynecology. Proc. of international conference. Yerevan, 2007,
P. 191-197.
> Kuleshev N., Manvelyan M., Simonyan I., Aroutiounian R., Barceva O.
The methodical approaches for the diagnosis of mosaicism in
interphase cells by FISH-analysis. 'Prenatal Diagnosis, Russia',
2007, v.6, N3, P.198-201.
> Liehr T., Trifonov V., Polityko A., Brecevic L., Mrasek K., Weise
A., Ewers E, Reich D, Iourov I., Mkrtchyan H., Manvelyan M.,
Kosyakova N. Characterization of small supernumerary marker
chromosomes by a simple molecular and molecular cytogenetics
approach. Balkan Journal of Medical Genetics, 10(1), 2007, P.33-37.
> Manvelyan M., Schreyer I., H ls-Herpertz I., K hler S., Niemann R.,
Hehr U., Belitz B., Bartels I., G tz J., Huhle D., Kossakiewicz M.,
Tittelbach H., Neubauer S., Polityko A., Mazauric M-L., Wegner R.,
Stumm M., K pferling P., S ss F., Kunze H., Weise A., Liehr T.,
Mrasek K. 48 new cases with infertility due to balanced chromosomal
rearrangements - detailed molecular cytogenetic analysis of the 90
involved breakpoints. International Journal of Molecular Medicine,
19, 2007, P. 855-864.
> Manvelyan M., Okoev G., Simonyan I., Aroutiounian R. Molecular-
cytogenetic prenatal diagnosis of trisomy 21. Medical Laborator
Diagnosis, Yerevan, 2006, P. 81-83.
> Manvelyan M., Okoev G., Simonyan I., Zurabyan N., Zakeyan A.G.,
Aroutiounian R. Investigation of chromosomal anomalies by FISH in
Armenia. Georgian Medical News, N9(138), Georgia - New York, 2006,
P.53-56
> Manvelyan M., Simonyan I., Okoev G., Aroutiounian R. Molecular-
cytogenetic prenatal diagnosis of trisomy 21: four case reports.
'Prenatal Diagnosis, Russia', 2006, v.5, N2, P. 126-129.
> Manvelyan M. Molecular-cytogenetic investigation of complex
chromosomal anomalies in the medical-genetic service of Armenia.
Modern Problems of Genetics, Radiobiology, Radioecology and
Evolution: Second Intern. Conf., Papers by Young Scientists, Dubna,
2005. P. 230-232.
> Manvelyan M., Simonyan I., Zurabyan N., Aroutiounian R. Molecular-
cytogenetic diagnosis of chromosomal anomalies. Diagnostic
medicine. Materials of Symp. on . 20th anniversary of the
"Diagnostica" Medical Corporation. Yerevan, 2004. P. 95.
> Manvelyan M. Application of method FISH (fluorescence in situ
hybridization) in prenatal and postnatal diagnosis of chromosomal
anomalies. Proceeding of Yerevan State University, Yerevan, 2004.
P. 103-108.
> Arutyunyan R., Kasakyan S., Mkrtchyan H., Hovhannisyan A.,
Manvelyan M., Muradyan A. Application of human DNA probes library
in molecular cytogenetic analysis. Experimental Oncology, v. 25,
N4, 2003, P. 307-309.
> Simonyan I., Zurabyan N., Manvelyan M., Aroutiounian R., Zakeyan
A., Atabekyan M. Clinical-cytogenetic characteristics of Down
syndrome. The methodical recommendations. Yerevan, 2002. P. 1 - 22.
ABSTRACTS
> Liehr T., Grigorian A., Manvelyan M., Simonyan I., Mkrtchyan H,
Aroutiounian R., Polityko A.D., Kulpanovich A.I., Volleth M.,
Ziegler M., Kreskowski K., Weise A., Kosyakova N. Heteromorphic
variants ofchromosome. Medizinische Genetik1, 2013, P-CytoG-167.
> J Gebhardt, H Mkrtchyan, M Manvelyan, P Kempf, T Liehr, S Bhatt.
Cryptic aberrations in acute lymphocytic leukemia with apparently
normal karyotype. Dornburg, 30. April 2011; p 16.
> F Dorka, M Manvelyan, S Bhatt, T Liehr. Interphase architecture in
myeloid bone marrow cells possibly promotes t(8;21) in AML.
Dornburg, 30. April 2011; p 15.
> M Manvelyan, FW Cremer, J Lanc, R Kl s, C Kelbova, C Ramel, H
Reichenbach, C Schmidt, E Ewers, K Kreskowski, M Ziegler, N
Kosyakova, T Liehr. New cytogenetically visible copy number variant
in region 8q21.2. X Russian Federation Congress "Modern
technologies in pediatrics and pediatric surgery" 2011, p 64.
> T Liehr, E Ewers, AB Hamid, N Kosyakova, M Voigt, A Weise, M
Manvelyan. Small supernumerary marker chromosomes and uniparental
disomy have a story to tell. X Russian Federation Congress "Modern
technologies in pediatrics and pediatric surgery" 2011, pp 63-64.
> J Gebhardt, H Mkrtchyan, M Manvelyan, P Kempf, T Liehr, S Bhatt.
Cryptic aberrations in acute lymphocytic leukemia with apparently
normal karyotype. X Russian Federation Congress "Modern
technologies in pediatrics and pediatric surgery" 2011, p 61.
> F Dorka, M Manvelyan, S Bhatt, T Liehr. Do position effects drive
t(8;21) in acute myelogenous leukemia?. X Russian Federation
Congress "Modern technologies in pediatrics and pediatric surgery"
2011, p 60.
> F Braulke, R Steffens, T Liehr, M Manvelyan, I Chudoba, D Haase.
Two different del(5q) clones in a patient with myelodysplastic
syndrome. X Russian Federation Congress "Modern technologies in
pediatrics and pediatric surgery" 2011, p 60.
> Liehr T, Manvelyan M, Lier A, Junker S, Kempf P, Dorka F, Gebhardt
J, Bhatt S,Weise A, Mrasek K. Do position effects drive t(8;21) in acute
myelogenous leukemia? Abstracts of 22nd Wilhelm Bernhard Workshop,
Riga,
Lettland, 25.-29.08.2011, p 26.
> Weise A, Mkrtchyan H, Gross M, S Hinreiner, A Polityko, M
Manvelyan, K
Mrasek, N Kosyakova, E Ewers, H Nelle, S Bhatt, K Thoma, E Gebhart,
S
Wilhelm, R Fahsold, M Volleth, T Liehr. The human genome puzzle -
the
role of copy number variation in somatic mosaicism. Medizinische
Genetik 2011, Vol 23,
p169.
> Manvelyan M., Aroutiounin R., Mkrtchyan H., Kempf P., Weise A.,
Mrasek K., Heller A., Liehr T. Preferred co-localization of
chromosome 8 and 21 in myeloid bone marrow cells detected by three
dimensional molecular cytogenetics. FEBS advanced lecture course,
Yerevan, 2011, P. 85.
> Manvelyan M., de Jesus Marques-Salles T., Pereira Leite E., Maria
Soares-Ventura E., Cartaxo-Muniz M.T., Ferreira E., Liehr T.,
Macedo Silva M.L., Santos N., Junker S., Mkrtchyan H. Complex
karyotype defined by FISH and M-FISH studies in an infant with
acute megakarioblastic leukemia and neurofibromatosis. Medizinische
Genetik, 1, Springer Berlin / Heidelberg 2008, P.137, 2010.
> T Liehr, F Hunstig, S Bhatt, F Pellestor, K Mrasek, A Weise, I
Simonyan, R Aroutiounian, M Manvelyan. The 3-dimensional
distribution of human chromosomes in sperm. Abstracts des 59th
annual meeting of the American Society of Human Genetics, Honolulu,
Hawaii, USA, 20-24, Abstractnummer 1661T.
> Kempf P., Mkrtchyan H., Manvelyan M., Lier A., Heller A., Mrasek
K., Hunstig F., Weise A., Liehr T. 3D-interphase FISH studies of
chromosomes 8 and 21 in AML patients with trisomy 8. Abstracts zum
8. Russischen Kongress Moderne Methoden in der Pediatrie und
Kinderchirurgie. Moskau,
20-22- Oktober, 2009, P.105.
> Liehr T., Hunstig F., Bhatt S., Pellestor F., Mrasek K., Weise A.,
Simonyan I., Aroutiounian R., Manvelyan M. 3-dimensional
multicolor banding (3D-MCB) reveals the distribution of chromosomes
in human sperm. Medizinische Genetik, 1, Springer Berlin /
Heidelberg 2009, P.76.
> Mkrtchyan H., Manvelyan M., Kempf P., Lier A., Hunstig F., Heller
A., Mrasek K., Weise A., Liehr T. 3-D interphase studies of
chromsomes 8 and 21 in AML patients with trisomy 8. Medizinische
Genetik, 1, Springer Berlin / Heidelberg 2009, P.110.
> Kempf P., Mkrtchyan H., Manvelyan M., Lier A., Heller A., Mrasek
K., Hunstig F., Weise A., Liehr T. Molecular cytogenetic
characterization of AML patients with trisomy 8. Postgraduate
symposium on cancer research, Dornburg 2009.
> Kosyakova N., Manvelyan M., Hunstig F., Mrasek K., Bhatt S.,
Pellestor F., Weise A., Liehr T. Position of chromosomes 18, 19, 21
and 22 in 3D-preserved B-lymphocytes interphase nuclei of human and
gorilla and white hand gibbon compared to human sperm. Medizinische
Genetik, 20, Springer Berlin / Heidelberg 2008, P.156.
> Schoder C., T nnies H., Mrasek K., Behr K., Manvelyan M., Liehr T.,
Weise A. Analysis of fragile sites and breakpoints in Fanconi
anemia patients. Medizinische Genetik, 20, Springer Berlin /
Heidelberg 2008, P.102.
> Mrasek K., Manvelyan M., Liehr T., Behr K., Schoder C., Weise A.
Prove of molecular co-localization of fragile sites and
evolutionary conserved breakpoints. Medizinische Genetik, 20,
Springer Berlin / Heidelberg 2008, P.102.
> Manvelyan M., Hunstig F., Pellestor F., Bhatt S., Aroutiounian R.,
Liehr T. 3-D multicolor banding reveals the orientation of
chromosomes in human sperm - a pilot study. Second international
medical congress of Armenia, 2007, P. 22.
> Manvelyan M., Schreyer I., Weise A., Liehr T., Mrasek K., Simonyan
I., Aroutiounian R. 48 new cases with infertility due to balanced
chromosomal rearrangements - detailed molecular cytogenetic
analysis of the 90 involved breakpoints. Second international
medical congress of Armenia, 2007, P. 22.
> Kosyakova N., Trifonov V., Polityko A., Brecevic L., Mrasek K.,
Weise A., Iourov I., Manvelyan M., von Eggeling F., Liehr T. Scheme
for straightforward characterization for small supernumerary marker
chromosomes (sSMC) by simple molecular and molecular cytogenetics
approaches. Medizinische Genetik, 1, 2007, P.85.
> Hunstig F., Manvelyan M., Pellestor F., Bhatt S., Aroutiounian R.,
Liehr T. 3-D multicolor banding reveals the orientation of
chromosomes in human sperm - a pilot study. Medizinische Genetik,
1, 2007, P.57.
> Manvelyan M., Simonyan I., Aroutiounian R. Molecular-cytogenetic
diagnosis of patients with Turner syndrome. European Human Genetics
Conference, The Netherlands, 2006, P. 178.
> Simonyan I., Manvelyan M. Development of clinical cytogenetics in
the Research Center of Maternal and Child Health Protection of
Republic of Armenia. "Current Problems of IVF", International
Congress, Armenia, 2005. P. 70-71.
> Manvelyan M., Okoev G., Simonyan I., Aroutiounian R. Application of
molecular-cytogenetic method FISH in the prenatal cytogenetics.
"Current Problems of IVF", International Congress, Armenia, 2005.
P. 48-49.
> Manvelyan M., Okoev G. Introduction of preimplantation genetic
diagnosis to the reproductive medicine of Armenia. "Current
Problems of IVF", International Congress, Armenia, 2005. P. 47-48.
> Manvelyan M., Simonyan I., Aroutiounian R. Application of molecular-
cytogenetic method FISH (fluorescence in situ hybridization) in pre-
and postnatal diagnostics. Modern Problems of Genetics,
Radiobiology, Radioecology and Evolution: Second Intern. Conf.,
Dubna, 2005. P. 76.
> Okoev G., Zurabyan N., Mirozyan A., Simonyan I., Manvelyan M.,
Kazaryan G. New directions and methods of prenatal diagnosis of
chromosomal anomalies. Diagnostic medicine. Materials of Symposium
on the 20th anniversary of the "Diagnostica" Medical Corporation.
Yerevan, 2004. P. 119.
> Simonyan I., Sulakyan M., Mkrtchyan H., Manvelyan M., Mazmanyan P.,
Aroutiounian R. The case of Down syndrome in combination with Ph/
positive form of myeloleukosis. Actual problems of obstetrics and
gynecology. Proceeding of international conference. Yerevan, 2003.
P. 105.
> Manvelyan M., Simonyan I., Okoev G., Zurabyan N., Aroutiounian R.
Application of FISH in postnatal diagnosis of chromosomal
anomalies. Actual problems of obstetrics and gynecology. Proc. of
international conference. Yerevan, 2003. P. 74.
> Manvelyan M., Okoev G., Simonyan I., Aroutiounian R. Introduction
of molecular cytogenetic method FISH (fluorescence in situ
hybridization) in prenatal diagnosis of Armenia. Actual problems of
obstetrics and gynecology. Proceeding of international conference.
Yerevan, 2003. P. 72.
> Sargsyan N., Abrahamyan G., Manvelyan M. Correction of physical and
hormonal indices in young girls with Turner syndrome. Hormone
Research. European Society for Paediatric Endocrinology (ESPE).
Ljubljana, Slovenia, 2003. P. 164.
> Okoev G., Schinzel A., Riegel M., Simonyan I., Manvelyan M.,
Aroutiounian R. Application of FISH technique in pre- and postnatal
diagnostics of chromosomal anomalies. Proc. of First Internat.
Medical Congress of Armenia. Yerevan, 2003. P. 142.
> Aroutiounian R., Kasakyan S., Mkrtchyan H., Simonyan I., Manvelyan
M., Hovannisyan A., Muradyan A. Creation of the human DNA probes
library for molecular cytogenetic monitoring in Armenia. Proceeding
of the First International Medical Congress of Armenia. Yerevan,
2003. P.138.
> Simonyan I., Zurabyan N., Manvelyan M. Cytogenetic diagnosis of
chromosomal anomalies. Proceeding of the First International
Medical Congress of Armenia. Yerevan, 2003. P. 138.
> Manvelyan M., Simonyan I., Mkrtchyan H., Kasakyan S., Muradyan A.,
Zurabyan N. Molecular-cytogenetic investigation of critical region
at the Down syndrome. Actual problems of obstetrics and gynecology.
Proceeding of international conference. Yerevan, 2002. P. 73.
> Simonyan I., Manvelyan M., Zurabyan N. Burdened obstetrical
anamnesis and complication of pregnancy at the Down syndrome.
Actual problems of obstetrics and gynecology. Proceeding of
international conference. Yerevan, 2001. P. 167.
> Manvelyan M., Simonyan I., Zurabyan N. Importance of karyotyping
for diagnostics and prognosis of Down syndrome. Actual problems of
obstetrics and gynecology. Proceeding of international conference.
Yerevan, 2001. P. 119.
> Manvelyan M., Simonyan I., Zakeyan A., Atabekyan M. Physical
parameters of newborns with Down syndrome. Actual problems of
obstetrics and gynecology. Proceeding of international conference.
Yerevan, 2001. P. 118.
> Manvelyan M., Simonyan I., Zurabyan N. Frequency of Down syndrome
among newborns according to data of cytogenetic investigations in
the period 1989 - 2000. Actual problems of obstetrics and
gynecology. Proceeding of international conference. Yerevan, 2001.
P. 117.
> Simonyan I., Zurabyan N., Zakeyan A., Atabekyan M., Manvelyan M.
Results of karyotyping of patients with Down syndrome. Actual
problems of obstetrics and gynecology. Proceeding of international
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