University Engineering
Resume:
Chunyan Wang, PhD
Polymer scientist using a variety of different polymerization methods to
develop multifunctional polymer composites with desired chemical and
physical properties for medical applications.
Seeking a challenging position with an active, forward-looking research
team to create, test and evaluate new polymers for marketable applications.
ADDRESS
University of South Florida
Morsani College of Medicine
Dept. of Molecular Medicine
12908 USF Health Drive
Tampa, FL 33612
******@****.***.***
813-***-**** (cell)
A. RESEARCH EXPERIENCE & QUALIFICATIONS
1. Analytical Techniques
I have more than five years experience in the practical use of advanced
analytical techniques including differential scanning calorimetry (DSC),
dynamic mechanical analysis (DMA), TGA, FTIR, Raman spectroscopy, HPLC,
GC/MS, GPC, NMR, scanning and transmission electron microscopy (SEM-EDXA),
confocal microscopy, live animal fluorescence imaging (Xenogen), spin
coating, spray drying, rheometry, potentiometry, and cyclic voltammetry.
2. Materials Chemistry
In my research projects over the past five years, I have designed, produced
and characterized a variety of natural and synthetic polymers including:
. Chitosan-functionalized mPEG-PLA (ring-opening polymerized) polymeric
nanoparticles for targeted in vivo co-delivery of nucleic acids, drugs
and MRI contrast agents using mouse model of human cancer
. Molecular imprinted polymeric nanoparticles for pH-activated drug
release
. Thermoactive polymeric nanoparticles for controlled, temperature-
inducible drug release
. Photocrosslinkable hydrogel coatings for implantable glucose sensors
. Injectable ROS (reactive oxygen species)-activated chitosan-PEG
hydrogel as stem cell carrier for regenerative medicine
. Small molecular weight polyacrylamide by precipitation polymerization
. Poly(acrylamide-co-styrene) by emulsion polymerization
. Cationic polyacrylamides using Hoffmann degradation of polyacrylamide
or poly(acrylamide-co-styrene)
3. In vitro / in vivo safety testing, pharmacokinetics and evaluation
. determine drug loading and release kinetics, cytotoxicity, cell uptake
and subcellular release of the formulation's payload in vitro
. measure the biodistribution, toxicity, and delivery efficiency of the
drugs and nucleic acids in various formulations in vivo (rodent
models)
. synthesize and characterize biocompatible polymer composites for
implantable biosensors and tissue engineering in vitro and in vivo.
B. EDUCATION & TRAINING
. 2013 - present. Research Associate, joint appointment in Dept. of
Internal Medicine and Nanomedicine Research Center, Morsani College of
Medicine, University of South Florida, Tampa, FL
. 2012 - present. Research Associate, Dept. of Molecular Medicine,
Morsani College of Medicine, University of South Florida, Tampa, FL
. 2010 - 2012. Postdoctoral Scholar, Dept. of Molecular Medicine,
Morsani College of Medicine, University of South Florida, Tampa, FL
. 2009 - 2010. Postdoctoral Scholar, Dept. of Mechanical Engineering,
University of Wisconsin-Milwaukee, Milwaukee, WI
. 2005 - 2008. Received Ph.D. in Polymer Chemistry and Physics,
Chemistry Department, University of South Florida, Tampa, FL
. 2000 - 2003. Received MSc in Polymer Chemistry and Physics, Fujian
Normal University, Fuzhou, Fujian, China.
. 1996 - 2000. BSc in Chemistry Education, Shandong Normal University,
Jinan, Shandong, China
C. TEACHING EXPERIENCE
. 2010 - present. Graduate student mentor in the Department of Molecular
Medicine, Morsani College of Medicine University of South Florida
. 2006 - 2008. Teaching assistant and tutor in Chemistry Department,
University of South Florida (Course: General Chemistry I & II Labs)
. 2006 - 2007. Undergraduate student mentor in the Department of
Chemistry, University of South Florida
D. HONORS
. Award of Excellence for best oral presentation at the 5th annual
Nanoscience Technology Symposium (September 2012), University of South
Florida
. Second place prize for oral presentation at the 6th annual Castle
Conference, University of South Florida (April 2008)
. First place prize for oral presentation at the 3rd annual Meeting in
Miniature of the Tampa Bay Section of the American Chemical Society
(March 2007)
. Fred L & Helen M Tharp Endowed Scholarship (summer 2007 and 2008)
E. PROFESSIONAL AFFILIATIONS
. American Chemical Society (ACS), member since 2008
. American Association for Cancer Research (AACR), member since 2011
. American Heart Association, since 2012
. Co-chair of the 6th Castle Conference, 2008
F. PUBLICATIONS
1. Chunyan Wang, Sowndharya Ravi, Jaya Mallela, Ryan Green, Micheal
Cheung, Shyam S. Mohapatra, Subhra Mohapatra, Enhancing the Mulitilineage
Differentiation of Bone Marrow Derived Mesenchymal Stem Cells in Three
Dimentional PEG-Chitosan-Graphene Based Hydrogel Matrix, prepared for
Tissue Engineering A
2. Mahasweta Das, Chunyan Wang, Raminder Bedi, Subhra Mohapatra and Shyam
Mohapatra, Chitosan-PEI-coated magnetic micelle nanoparticles deliver DNA
to rat brains after mild traumatic brain injury, Nanomedicine,
nanotechnology, biology and medicine, accepted, (IF=6.930)
3. Chunyan Wang, Sowndharya Ravi, Ujjwala Sree Garapati, Mahasweta Das,
Mark Howell, Jaya Mallela, Subbiah Alwarappan, Shyam S. Mohapatra and
Subhra Mohapatra, Multifunctional chitosan magnetic-graphene (CMG)
nanoparticles: a theranostic platform for tumor-targeted co-delivery of
drugs, genes and MRI contrast agents, Journal of Material Chemistry B,
2013, 1, 4396-4405 (IF=6.101)
4. Chunyan Wang, Vignesh Chinnasamy, Ujjwala Sree Garapati, Sowndharya
Ravi, Jaya Mallela, Yvonne Davis, Subhra Mohapatra, A Chitosan-Modified
Graphene Nanogel (CGN) for Noninvasive Controlled Drug Release,
Nanomedicine, nanotechnology, biology and medicine, 2013, 9 (7), 903-11
(IF=6.930)
5. Chunyan Wang, Jaya Mallela, Subhra Mohapatra, Pharmacokinetics of
polymeric micelles for cancer treatment, Current Drug Metabolism, 2013, 14
(8), 900-909 (IF=4.9)
6. Yvonne K. Girard, Chunyan Wang, Sowndharya Ravi, Mark C. Howell, Jaya
Mallela, Mahmoud Alibrahim, Ryan Green, Gary Hellermann, Shyam Mohapatra,
Subhra Mohapatra, A 3D fibrous scaffold inducing tumoroids: a platform for
anticancer drug development, PLOS ONE, in press, (IF=3.73)
7. Howell M, Wang C, Mahmoud A, Hellermann G, Mohapatra SS and Mohapatra S,
Dual-function theranostic nanoparticles for drug delivery and medical
imaging contrast: perspectives and challenges for use in lung diseases,
Drug Delivery and Translational Research, 2013, 3(4), 352-363
8. J. Devkota, C. Wang, A. Ruiz, S. Mohapatra, P. Mukherjee, H. Srikanth,
M.H. Phan, Detection of low-concentration superparamagnetic nanoparticles
using an integrated RF magnetic biosensor, Journal of Applied Physics,
vol.113, 2013, 104***-****** (IF=2.21)
9. Jaya Mallela, Frantz Jean Louis, Shyam S. Mohapatra, Sowndharya Ravi,
Bianca Mulaney, Michael Cheung, Ujjwala Sree Garapati, Vignesh Chinnasamy,
Srinivas Nagaraj, Chunyan Wang, Subhra Mohapatra, Natriuretic Peptide
Receptor-A Signaling Regulates Stem Cell Recruitment during Angiogenesis,
Stem Cells, 2013, 31(7), 1321-1329 (IF= 7.701)
10. Chunyan Wang, Sowndharya Ravi, Gary V. Martinez, Vignesh Chinnasamy,
Payal Raulji, Mark Howell, Yvonne Davis, Mohindar S. Seehra, Subhra
Mohapatra, Dual-purpose Magnetic Micelle Nanoparticles for MRI and Gene
Delivery, Journal of Controlled Release, 2012, 163 (1), 82-92 (IF=7.633)
11. Mark Howell, Jaya Mallela, Chunyan Wang, Sowndharya Ravi, Ujjwala Sree
Garapati,
Subhra Mohapatra, Manganese-loaded Lipid-Micellar Theranostics for
Simultaneous Drug and Gene Delivery to Lungs, Journal of Controlled
Release, 2012, 167(2), 210-218 (IF=7.633)
12. Chunyan Wang, Mark Howell, Payal Raulji, Yvonne Davis, Subhra
Mohapatra, Preparation and Characterization of Molecularly Imprinted
Polymeric Nanoparticles for Modulating NPRA (natriuretic peptide receptor
A), Advanced functional materials, 2011, 21(23):4423-4429, (IF=9.765)
13. Chunyan Wang, Javadi, Alireza; Ghaffari, Mehdi; Gong, Shaoqin, A pH-
Sensitive Molecularly Imprinted Nanospheres/Hydrogel Composite as a
Potential Coating Material for Implantable Biosensors, Biomaterials, 2010,
31(18):4944-51 (IF=7.604)
14. Chunyan Wang, Bazhang Yu, Bernard Knudsen, Julie Harmon, Francis
Moussy, Yvonne Moussy, Synthesis and Performance of Novel Hydrogel Coatings
for Implantable Glucose Sensors,Biomacromolecules, 2008, Vol.9, No.2, P561-
567 (IF= 5.371)
15. Bazhang Yu, Chunyan Wang, Young Min Ju, Leigh West, Julie Harmon,
Yvonne Moussy, Francis Moussy, Use of Hydrogel Coating to Improve the
Performance of Implanted Glucose Sensors, Biosensors and Bioelectronics,
2008, Vol. 23, No. 8, P1278-1284 (IF=5.437)
16. Zonghua Wu, Shaoping Chen, Chunyan Wang, Preparation of Cationic
Polyacrylamide Emulsion, Transactions of China Pulp and Paper, 2005, 20(2),
130-133
17. Chunyan Wang, Zonghua Wu, Effect of Molecular Weights of
Polyacrylamides on Its Hofmann Reaction, Chinese Journal of Applied
Chemistry, 2003, 20(8), 803-805
18. Chunyan Wang, Zonghua Wu, The Synthesis of the Low-molecular-weight
Polyacrylamide by Precipitation Polymerization, Journal of Fujian Normal
University (Natural Science Edition), 2002, 18(4), 61-63
19. Zonghua Wu, Chunyan Wang, Stability of Neutral Rosin Sizing Agents,
Paper Chemicals, 2002, 14(1), 12-13
20. Chunyan Wang, Yangyang Zhang. Preparation of glucosamine sulfate
method. Oceanic Industry of China, 2005
G. BOOK CHAPTERS
1. Chunyan Wang, Minghui Yang, Zhiyong Qian, Li He,Biocompatible
Nanocomposites for Bone Tissue Engineering, Recent Developments in Bio-
Nanocomposites for Biomedical Applications, Nova Science Publisher, 2011
2. Chunyan Wang, Bernard Knudsen, Xueji Zhang, Semiconductor Quantum Dots
for Electrochemical Biosensor, Biosensor Nanomaterials, Wiley-VCH
Publisher, 2011
3. Chunyan Wang, Bernard Knudsen, Xueji Zhang, Nanostructure for Nitric
Oxide Electrochemical Sensing, NanoBiosensing--Principles, Development and
Application, Springer Publisher, 2011
H. Patents
1. Subhra Mohapatra, Chunyan Wang, Multilayer magnetic micelle compositions
and methods for their use, WO2013049531 A2
2. Subhra Mohapatra, Chunyan Wang, Molecularly Imprinted Polymers Having
Affinity for Natriuretic Peptides, WO 201-***-**** A1
3. Subhra Mohapatra, Shyam S. Mohapatra, Yvonne Kathleen Davis, and Chunyan
Wang, Construction of the Multilayered Nanofiber (MN) and Chitosan
Multilayered Nanofiber (CMN) Scaffolds, Application No. 61/723,922
4. Subhra Mohapatra, Shyam S. Mohapatra, Mahasweta Das, Chunyan Wang,
Multilayered multifunctional magnetic micelle nanoparticles for delivery of
DNA to brains of rats with mild traumatic brain injury, No. 13/773,718
5. Subhra Mohapatra, Shyam S. Mohapatra, Mark Christian Howell, Suraj
Kishore Dixit, and Chunyan Wang, Micelle Compositions and Methods for Their
Use; No. 61/602,384
6. Subhra Mohapatra and Chunyan Wang, Noninvasive Remote-Controlled Release
of Drugs from a Nanogel Triggered by Near IR, No. 61/602,378
7. Subhra Mohapatra and Chunyan Wang, Graphene Hydrogels and Methods for
Using the Same, No. 13/775,560
8. Subhra Mohapatra and Chunyan Wang, Graphene-Based Theranostics for Tumor
Targeted Drug/Gene Delivery and Imaging, No. 61/767,572
I. CONFERENCE PRESENTATIONS
Invited Oral Presentations
1. Chunyan Wang, Bazhang Yu, Bernard Knudsen, Francis Moussy, Julie Harmon,
Design and Testing of Implanted Glucose Sensors with Novel Hydrogel
Coatings, The 84th Annual Florida Meeting and Exposition, ACS, Orlando, May
2008
2. Chunyan Wang, Development of Novel Biocompatible Hydrogel Coatings for
Implantable Glucose Sensors, C3B Consortium Lecture Series, Center for
Bioelectronics, Biosensors and Biochips, Advanced Materials Center, 100
Technology Drive, Anderson, SC, Department of Bioengineering and Department
of Chemical and Biomolecular Engineering, Clemson University, SC, March
2009
3. Chunyan Wang, pH Sensitive Biomimetic Nanospheres for Drug Delivery &
Biocompatible Hydrogel Coating for Implantable Biosensor, Department of
Molecular Medicine, Nanomedicine Center, University of South Florida, FL,
April, 2010
Oral Presentations
1. Chunyan Wang, Bazhang Yu, Bernard Knudsen, Francis Moussy, Julie Harmon,
Preparation of novel hydrogels coatings for implantable glucose sensors,
The 3rd annual Meeting in Miniature, Tampa, Florida, March 2007
2. Chunyan Wang, Bazhang Yu, Francis Moussy, Julie Harmon,The Effect of 2,3-
dihydroxypropyl methacrylate (DHPMA) on the Release Rate of Dexamethasone
21- phosphate disodium from Hydrogels, 3nd Annual Interdisciplinary
Graduate Student Symposium, University of South Florida, Tampa, FL, April
13, 2007
3. Chunyan Wang, Bazhang Yu, Julie Harmon, Francis Moussy, Yvonne
Moussy,Preparation of Novel Drug Delivery Vehicles for Implantable Glucose
Sensors, The 83rd Annual Florida Meeting and Exposition, ACS, Orlando, May
2007
4. Chunyan Wang, Bazhang Yu, Shisi Liu, Bernard Knudsen, Yvonne Moussy,
Julie Harmon, Francis Moussy,The in vitro and in vivo Evaluation of
Implanted Glucose Sensors with Hydrogel Coatings, 6th Castle conference,
University of South Florida, April 2008
5. Chunyan Wang, Sowndharya Ravi, Gary V. Martinez, Vignesh Chinnasamy,
Payal Raulji, Mark Howell, Yvonne Davis, Mohindar S. Seehra, Subhra
Mohapatra, Multilayered Multifunctional Magnetic Micelles Nanoparticles (4M-
NPs) for MRI and Gene Delivery, NanoBio Collaborative International
Conference, Mar. 28, 2012, Tampa, FL
6. Chunyan Wang, Vignesh Chinnasamy, Sowndharya Ravi, Jaya Mallela, Yvonne
Girard, Mark Howell, Subhra Mohapatra, A Thermosensitive Graphene Nanogel
(TGN) for Noninvasive Controlled Drug Release, NanoFlorida, Sept. 29, 2012,
Tampa, FL
Poster Presentations
1. Chunyan Wang, Bazhang Yu, Shisi Liu, Bernard Knudsen, Julie Harmon,
Francis Moussy, Yvonne Moussy,The Effect of N-vinyl-2-pyrrolidinone (NVP)
on the Release Rate of Dexamethasone 21-phosphate disodium (DX-21) from
Hydrogels, FCoE-BITT, University of South Florida, October 24, 2007
2. Chunyan Wang, Bazhang Yu, Julie Harmon, Francis Moussy, Effect of
Hydrogels Composition on the Drug Release, FCoE-BITT, University of South
Florida, October 15, 2008
3. Chunyan Wang, Mark Howell, Payal Raulji, Yvonne Davis, Subhra Mohapatra,
Molecularly Imprinted Polymeric Nanoparticles for Atrial Natriuretic
Peptide (ANP) to Modulate Cancer, Research Day, Feb., 2011, University of
South Florida, Tampa, FL,
4. Chunyan Wang, Mark Howell, Payal Raulji, Yvonne Davis, Subhra Mohapatra,
Molecularly Imprinted Polymeric Nanoparticles for Atrial Natriuretic
Peptide (ANP), NanoDDS '11, October 15-16, 2011, Salt Lake City, Utah, USA
5. Chunyan Wang, Sowndharya Ravi, Gary V. Martinez, Vignesh Chinnasamy,
Payal Raulji, Mark Howell, Yvonne Davis, Mohindar S. Seehra, Subhra
Mohapatra, Multilayered Multifunctional Magnetic Micelle Nanoparticles (4M-
NPs) for MRI and Gene Delivery, Research Day, Feb., 2012, University of
South Florida, Tampa, FL
6. Chunyan Wang, Vignesh Chinnasamy, Subhra Mohapatra, Noninvasive Remote-
Controlled Release of Drugs from a Nanogel Triggered by Near IR, Research
Day, Feb., 2012, University of South Florida, Tampa, FL
7. Chunyan Wang, Vignesh Chinnasamy, Subhra Mohapatra, Noninvasive Remote-
Controlled Release of Drugs from a Nanogel Triggered by Near IR, NanoBio
Collaborative International Conference, Mar. 28, 2012, Tampa, FL
8. Chunyan Wang, Sowndharya Ravi, Ujjwala Sree Garapati, Mahasweta Das,
Jaya Mallela and Subhra Mohapatra, Multifunctional Chitosan Magnetic-
Graphene Nanoparticles (CMGs): a Theranostic Platform for Tumor-targeted Co-
delivery of Drug, Gene and MRI Contrast Agent, University of South Florida
Research Day, Feb.22, 2013, Tampa, FL
Contact this candidate