curriculum vitae

Taposh Kumar Gorrela

mobile: 963-***-****

E-MAIL: accm14@r.postjobfree.com . accm14@r.postjobfree.com

EXPERIENCE SUMMARY

. 10+ years of Apllication experience in

. Metabolamics (Targetted and Non Targetted screening of Transgenic

Plant and animal cell lines)

. Bioanalysis

. Food safety

. Peptide Bioanalysis

. Impurity profiling

. Clinical Diagnostics (quantification of Aminoacids and Vitamins for

Metabolamic disorder investigation)

. Experience in sample preparation using SPE, LLE and other preparation

techniques.

. Experience in working with people from different cultures (Belgium,

Tanzania, China,Bulgeria Germany,US, Srilanka,Bangaldesh and Egypt).

Current Job Summary

. Responsible for providing Analytical solutions to various research

organizations (etc. Pharmaindustires, Non Pharamaindustries, Food

safety organizations. Research instiutions and Universities) during

their drug development phase using advanced TOF and Tandem quadrupoles

like Xevo TQ-S, Xevo TQ MS, Synapt G2S and Xevo TQD, and to publish

their application notes for global appliance.

. Responsible to provide Trainings on Mass spec applications at various

research environments and interact with external customers during

seminars, conferences and workshops.

Analytical Tools

Separation Liquid chromatography (LC,UPLC and 2DUPLC), Capillary

techniques electrophoresis (CE), Flash chromatography

Sampling tool Direct injection (DBS), solid phase extraction (SPE),

liquid - Liquid extraction (LLE), Protein

precipitation and Quechers.

Hyphenations LC-MS/MS, FT-MS, UPLC-MS/MS, HTLC-MS/MS

Mass analyzers Single quadrupole, triple quadrupole and TOF

WATERS ( Xevo TQ-S, Xevo TQD, TQD and Synapt G2S)

SCIEX (LC-MS/MS 2000, 3000, 4000)

THERMO (TSQ, Ion trap,Thermo LCQ and Fourior

transformer

MS Ionization Electro spray ionization (ESI), Atmospheric chemical

tools ionization (APCI), Atmospheric photo ionization (APPI)

and Electron ionization (EI)

Detection Ultraviolet visible spectrophotometer (UV), Flame

techniques ionization detection (FID), Photodiode array (PDA),

Electrolight scattering detector (ELSD)

Statistical Principle component analysis (PCA), Experimental design

applications

MS software Masslynx (Waters), UNIFY(Waters), Analyst (Applied Bio

systems) and Xcaliber (Thermo)

LC and GC software Empower, Chromeleon (Dionex), EZChrom Elite (Merck)

Data handling SIMPCA P+, XCMS-R, MARKERLYNX, MODDE (Unimetrics),

Excel

Others Microsoft office

Employment History

Sr.Applicatio WATERS(I) Pvt. Ltd,

n Specialist Bangalore, India

(May 2012 -

Performs Challenging Bioanalytical method development and

Till now) validation for the quantification of drugs and metabolites.

To develope analytical methodologies for Peptide quantification

form different matrix and giving training to industry people.

To develope analytical methodologies for Food safety regulated

compounds quantification.

To develope quantification methodologies for Impurity

profiling and support to industry customers.

To aply Omics methodologies to targetted and non-targetted

screening of metabolites.

Developed methods for Pesticides residues, Antibiotic residues,

Illegal Dyes, REACH samples and Aflatoxins as per SANCO as well

as other EU LCMSMS validation guidelines

Conducting LC/MS Schools and Application trainings for

customers at waters and customer place.

Write Application Notes and Scientific articles in peer

reviewed journals.

Maintain and continuously improve the technical capabilities of

the analytical Application programs. Investigates and corrects

analytical, instrumental and procedural problems, if necessary

.

Received two trainings on pharma and food safety every year

from Waters Corporation US and UK.

Scientific Department of pharmaceutical analysis, University of Antwerp,

Researcher Belgium

(Oct 2008 -

Nov 2011) 3.0 experience in metabolite profiling of different cell lines

using LC-MS/MS, FT-MS, UPLC-MS.

2 years of experience in guiding undergraduate & master

students theses.

Experience in validation of analytical methods using

Chemometrics.

Involved in development and validation of analytical method for

5-hydroxy tryptophan and its metabolites from human brain

fluid by using UPLC in combination with UV and MS.

Application of Principle Component Analysis to compare

metabolite profile of different cell lines.

Experience in isolating pure compounds from different sources

using Flash chromatography.

3 years of experience in validating and maintaining SOPs for

analytical instruments LC-MS, FT-MS, UPLC-MS, HPLC-UV Karl

Fischer titrator, Potentiometers, UV, IR and general tools

related to monograph analysis.

Experience in training undergraduate students for monograph

analysis according to European pharmacopoeia and United states

pharmacopoeia (2007-2008)

Group leader, CRBio(I) Pvt. Ltd,

Hyderabad, India

Bioanalytical

Actively involved and guided bioanalytical method development

(Oct 2006 - for various drugs in biological matrices using HTLC-MS/MS,

LC/MS/MS and HPLC.

Sep 2007) Planning and execution of experiments & providing training in

technical and scienctific aspects.

Actively involved and guided different extraction procedures

(SPE, LLE and protein precipitation) for extraction of drugs

from biological matrices.

Documentation, checking the data according to GLP and other

regulatory standards.

Actively Involved in :

Preparation and review of SOPs.

Preparation of method reports as per regulatory standards.

Preparation of SOPs for various drugs.

Preparation and review of SOPs for instrument handling.

Research GVK Bio Sciences Pvt.Ltd,

associate, Hyderabad, India

Bioanlalytica

l Actively involved in bioanalytical method development,

(Nov 2003 - validation of various drugs using LC/MS/MS.

Sep 2006) Actively involved and guided method validations and submission

studies (ANVISA, FDA) as per regulatory requirements.

Maintenance of Deep Freezers for monitoring the required

temperatures of various biological matrix samples and drugs.

Calibration of (as per SOPs) analytical instruments used in

analytical lab.

Education

2007-2008 Masters in Pharmaceutical Sciences, Katholieke Universiteit

of Leuven, Leuven, Belgium

Thesis: Method development and validation of the water

solouble vitamins using LC-UV by using Chemometrix.

1999-2003 Bachelor of Pharmacy, Andhra University, Vishakhapatnam,

A.P, India.

International Postersand Certifications

. Method development for analysis of 5-hydroxytryptophan and its

metabolites by using UPLC-MS/MS, Drug analysis, Antwerp, Belgium, 2010

. Metabolomic analysis of Measa Lanceolata transgenic hairy roots, Drug

analysis, Antwerp, Belgium, 2010.

AcademicResearch Projects and Workshops

. Developing analytical methods and validating for assay and related

substances present in pharmaceutical drugs using LC-UV.

. LC-MS analysis, metabolite profiling and structural conformation of

new components of Maesa transgenic cell lines produced by

combinatorial biosynthesis.

Method development and validation of the water solouble vitamins using

Liquid chromatography.

Method development for the dye Tripan Blue by Capillary Electrophoresis.

Qualitative Evaluation of Marketed Products of Ciprofloxacin.

Industrial training in formulation, quality control area in Indu drugs

Pvt. Ltd.

. Participated in Educational programme workshop on Basic principles,

Applications and Regulatory requirements of HPLC & LC/MS/MS in

Analytical and Bioanalytical analysis conducted by Biosphere

Technology Pvt. Ltd., Goa, India.

Awards and Achievements

. Awarded as a best employee of the year 2005 and 2006 from Clinical

pharmacology Division of GVK Bio Sciences Pvt. Ltd.

. Achieved a 'BOF NOI Scholorship for foreigner researcher' from

University of Antwerp, Belgium.

Personnel Details

Strengths: Self confidant, Self motivated, Strong team leader/team player

depending on the situation, Analytical thinking, Not disturbed/stressed by

deadlines.

Name: Taposh kumar

Family Name: Gorrela

Date of birth: 10th Feb 1980

Sex: Male

Marital status: Married

Languages: English, Telugu, Hindi

Present address

Gorrela Taposh kumar

H.No-008, Shrigurumohanam appartment,

LG Enclave,

Nanjappacircle,Vidyaranyapura

Babgalore -, Karnataka-India

Contact this candidate