Jared R. Helm

The University of Montana

Division of Biological Sciences

** ****** *****, *****

Missoula, MT 59812

406-***-**** (accis7@r.postjobfree.com)

Objective: to apply my scientific and technical research skills in the biotechnology or

biopharmaceutical industries

Education:

2000-2007 The University of Iowa, PhD in Biochemistry, May 2007.

1997-2000 Brigham Young University, BS Degree, Biochemistry, May 2000.

1992-1997 Ricks College, Associate Degree, April 1997

Research Experience:

2008-current Postdoctoral Researcher, University of Montana, Division of Biological

Sciences, mentor: Jesse C. Hay, PhD. Elucidated a mechanism of

neurotoxicity of alpha-synuclein, a protein that when overexpressed or

mutated causes familial Parkinson’s disease. In a second project, I

discovered a role for luminal calcium and elucidated its signaling effector

pathway in the early stages of the biosynthetic secretory pathway.

2007-2008 Postdoctoral Fellow, University of Iowa, Department of Biochemistry,

mentor: John E. Donelson, PhD. Analyzed a large cDNA library set from

different lifecycle stages of Trypanosomes.

2001-2007 PhD thesis research, University of Iowa, Department of Biochemistry,

mentor: John E. Donelson, PhD. Title: “Differential Regulation of the

MSP (GP63) Genes in African Trypanosomes.” Understand RNA

regulation and stabilization in the lifecycle of Trypanosomes.

1998-2000 Brigham Young University, Department of Integrative Biology, mentor:

Michael F. Whiting, PhD. Processed mitochondrial and nuclear DNA

sequences to establish relationships among 69 species of Hawaiian

Platynini, a monophyletic beetle.

1998 Brigham Young University, Department of Chemistry and Biochemistry, mentor:

Terry S. Elton, PhD. Cloned and sequenced alternatively spliced mRNA

products of the human angiotensin II type 1 (AT1) receptor gene, involved

in the pathogenesis of cardiovascular disease, toward understanding the

importance of alternative splicing as a mechanism of regulating number

and function of the AT1 receptor.

Publications:

Jared R. Helm and University of Iowa Central Microscopy Research Facility (2007).

PLoS Pathogens Vol. 3(10). Featured Image.

Helm JR, Wilson ME, Donelson JE. (2008). Different trans RNA splicing events in

bloodstream and procyclic Trypanosoma brucei. Mol. Biochem. Parasitol. 159(2):134-7.

Helm JR, Wilson ME, Donelson JE. (2009). Differential expression of a protease gene

family in African trypanosomes. Mol. Biochem. Parasitol. 163(1):8-18.

Helm JR, Hertz-Fowler C, Aslett M, Berriman M, Sanders M, Soares B, Bonaldo MF,

Inoue N, Donelson JE (2009). Analyses of expressed sequence tags from the four main

developmental stages of Trypanosoma congolense. Mol. Biochem. Parasitol. 168(1):34-

42.

Thayanidhi N, Helm JR, Bentley M, Liang Y, Hay JC. (2010) α-Synuclein delays ER-to-

Golgi transport in mammalian cells by antagonizing ER/Golgi SNAREs. Mol. Biol. Cell.

21(11):1850-63.

Bhandari D, Zhang J, Menon S, Lord C, Chen S, Helm JR, Thorsen K, Corbett KD, Hay

JC, Ferro-Novick S. (2013) Sit4p/PP6 regulates ER to Golgi traffic by controlling the

dephosphorylation of COPII coat subunits. Mol. Biol. Cell. 24(17):2727-38.

Helm JR, Bentley N, Thorsen K, Wang T, Oorschot V, Klumperman J, Hay JC. (2014)

Luminal Calcium Regulates ER-to-Golgi Transport Efficiency Through ALG-2/sec31

Interactions. Revised and re-submitted Mol. Biol. Cell. *Abstract chosen for

minisymposium talk, ASCB 2013 (see below).

Helm JR and Hay JC. (2014) Neuronal SNARE Ykt6 Over-Expression Protects the

Secretory Pathway from Alpha-Synuclein Intoxication. Manuscript in Preparation.

Teaching Experience:

2010 University of Montana, Adjunct Professor for “Advanced Cellular Biology

(BIO 464)”, co-taught course including undergraduate and some graduate

students.

2002 University of Iowa, Teaching Assistant and Discussion Section Leader in

“Biochemistry and Molecular Biology I (099:120)”. ~100 undergraduate

students.

2002 University of Iowa, Teaching Assistant in “Biochemistry for Pharmacy

(099:162) and Dental (099:162)”. ~175 1st year pharmacy and dental

students.

Awards:

2011-2013 Individual National Research Service Award (NRSA) Post-Doctoral

Fellowship, Mechanisms of alpha-Synulclein Inhibition of the Secretory

Pathway (F32 NS067834), awarded by National Institute of Neurological

Disorders and Stroke (NINDS), sponsored by Jesse Hay

2009-2011 ARRA Post-Doctoral Fellowship, Protein Interactions Controlling

ER/Golgi Transport (3R01GM059378-08S1), awarded by National

Institute of General Medical Sciences (NIGMS), sponsored by Jesse Hay

2003-2005 Pre-doctoral Research Fellowship, NIH Training Grant on “Mechanisms

of Parasitism” - Acted as organizer of the Parasitism Journal Club held

once a week in which recently published papers relating to some aspect of

parasitology are presented.

Abstract and Conference Presentations:

2003, Differential Regulation of Trypanosoma brucei MSP Genes

(Poster Session)

Jared R. Helm and John E. Donelson

University of Iowa, Department of Biochemistry

Parasitism/Infectious Diseases Retreat, Iowa City, IA, Sept, 2003

2004, Differential Regulation of the MSP (GP63) Genes in African Trypanosomes

(Poster 229A)

Jared R. Helm, Paul M. Grandgenett, Mary E. Wilson, John E. Donelson

Departments of Biochemistry, Internal Medicine and Microbiology, and

Interdepartmental Genetics Program, University of Iowa, Iowa City, IA 52242

15th Annual Molecular Parasitology Meeting, Woods Hole, MA 2004

2004, Differential Regulation of the MSP (GP63) Genes in African Trypanosomes

(Presentation)

Jared R. Helm, Paul M. Grandgenett, Mary E. Wilson, John E. Donelson

Departments of Biochemistry, Internal Medicine and Microbiology, and

Interdepartmental Genetics Program, University of Iowa, Iowa City, IA 52242

Parasitism/Infectious Diseases Retreat, Iowa City, IA, Oct 2004

2005, Differential Regulation of the MSP B Genes in African Trypanosomes (Poster

218B)

Jared R. Helm, Paul M. Grandgenett, Mary E. Wilson, John E. Donelson

Departments of Biochemistry, Internal Medicine and Microbiology, and

Interdepartmental Genetics Program, University of Iowa, Iowa City, IA 52242

16th Annual Molecular Parasitology Meeting, Woods Hole, MA 2005

2009, Alpha-Synuclein Delays ER-To-Golgi Transport in Mammalian Cells by

Antagonizing ER/Golgi SNARES. (Abstract 2226 Poster B603)

N. Thayanidhi1, J. R. Helm2, M. Bentley1, J. C. Hay1,2,

1

Division of Biological sciences, University of Montana, Missoula, MT,

2

Center for Structural and Functional Neuroscience, University of Montana, Missoula,

MT

Annual Meeting, The American Society for Cell Biology, San Diego, CA 2009

2011, Luminal calcium regulates ER/ Golgi anterograde transport efficiency

(Abstract 1040)

M. Bentley1, J. R. Helm1, J. Klumperman2, J. C. Hay1;

1

Division of Biological Sciences, The University of Montana, Missoula, MT,

2

Department of Cell Biology, University of Utrecht, Utrecht, Netherlands

Annual Meeting, The American Society for Cell Biology, Denver, CO 2011

2012, Luminal Calcium Regulates ER-to-Golgi Transport Efficiency Through ALG-

2/Sec31 Interactions (Abstract 2250)

J. R. Helm1, M. Bentley1, K. Thorsen1, J. Klumperman2, J. C. Hay1;

1

Division of Biological Sciences, The University of Montana, Missoula, MT,

2

Department of Cell Biology, University of Utrecht, Utrecht, Netherlands

Annual Meeting, The American Society for Cell Biology, San Francisco, CA 2012

2013, Luminal Calcium Regulates ER-to-Golgi Transport Efficiency Through ALG-

2/sec31 Interactions **(Selected for Oral Presentation)**

Regulation of Vesicle Trafficking Minisymposium, Jared Helm, Presenter

Annual Meeting, The American Society for Cell Biology, New Orleans, LA 2013

Academic referee / reviewer:

Molecular & Biochemical Parasitology (Journal) 2006

Multiple evaluations of peer reviewed articles for Faculty of 1000 Biology in conjunction

with Dr. Jesse Hay – 2009 to present.

Professional Membership:

American Chemical Society – 1998-2000

Cell Biology Associate Faculty Member, Faculty of 1000 Biology – 2005 to present

American Society for Cell Biology – 2011 to present

Service:

Boy Scouts of America – Scoutmaster and Assistant Scoutmaster – 2002 to present.

Mission in France for my church – 1992-1994

Languages:

French language competency: read, listen, and speak at a basic level

References:

Jesse C. Hay, PhD. Professor of Cell Physiology

Division of Biological Sciences

32 Campus Drive, HS104

Missoula, MT 59812

Email: accis7@r.postjobfree.com

Phone: 406-***-****

Richard Bridges, PhD. Regents Professor and Chair

Department of Biomedical and Pharmaceutical Sciences

32 Campus Drive, Skaggs 395

Missoula, MT 59812

Email: accis7@r.postjobfree.com

Phone: 406-***-****

Mark L. Grimes, PhD. Associate Professor

Division of Biological Sciences

32 Campus Drive, HS104

Missoula, MT 59812

Email: accis7@r.postjobfree.com

Phone: 406-***-****

Sarah Certel, PhD. Assistant Professor

Division of Biological Sciences

32 Campus Drive, HS104

Missoula, MT 59812

Email: accis7@r.postjobfree.com

Phone: 406-***-****

John E. Donelson, PhD. Professor Emeritus of Biochemistry

Carver College of Medicine

The University of Iowa

4-403 Bowen Science Building

51 Newton Rd.

Iowa City, IA 52242

Email: accis7@r.postjobfree.com

Phone: 319-***-****

Fax: 319-***-****

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