Assistant Development

Vidhi M. Shah

**** ** ******** **. #****

E-mail: acce8e@r.postjobfree.com. Ph:-201-***-****

Hillsboro, OR 97124

Profile: http://www.linkedin.com/pub/vidhi-

shah/22/565/888

PROFESSIONAL SUMMARY:

4+ years of experience working as a Research Assistant for Dr. David Taft.

Currently working on Physicochemical, preformulation, pharmaceutical

formulation strategies for poorly aqueous soluble small molecules.Design,

conduct and analyze in vivo DMPK studies to support drug discovery and

development. Utilizes state of the art Pharmacokinetic (PK) Software

packages to analyze and interpret PK results from in vitro and/or in vivo

experiments.

2 years work experience as a Research Assistant for Dr. Almas Babar doing

extensive research in development of passive transdermal/transmucosal drug

delivery formulations: optimization for simultaneous achievement of

membrane flux and permeability

6+ months as a Research Intern for AstraZeneca which involved Compaction

compression, Inclusion Complex formation projects.

Gold medalist in Bachelor of Pharmacy at Sardar Patel University batch of

2007 for outstanding academic performance.

ACADAMIC QUALIFICATION:

. PhD.Candidate in Pharmaceutical Science

*Graduating: Feb-2014

Long Island University, Brooklyn, NY

GPA: 3.7/4.0

. Master of Industrial Pharmacy:

Graduated: Nov-2009

Long Island University, Brooklyn, NY

GPA: 3.7/4.0

. Bachelor of Pharmacy(Gold Medalist):

Graduated: Jun-2007

Sardar Patel University, Gujarat, India

GPA: 4.0/4.0

RESEARCH AND PUBLICATIONS:

PhD Dissertation: Investigation of permeability of different chemical form

of an anticancer drug and optimization of transmucosal delivery. The

research involves developing an oral formulation including the following:

. Preformulation- pKa determination, pH Partition studies, pH solubility

studies, kinetics studies at pH 7.4. Equilibrium hydrolysis at

different pH.

. Formulation- In vitro diffusion and transport studies of Drug X through

cellulose, silicone, porcine skin and buccal epithelium. Effect of pH,

concentration and efflux transporters on mode of transport of drug.

Studying effects of paracellular and transcellular enhancers on the

permeability of Drug X through different membranes. Effect of current

on the transport of drug .Films casting using various polymers.

. PK studies- Studying the effect of drug X in rats and rabbits through

IV, IP, sublingual,buccal and oral dosing. Evaluating Pharmacokinetic

profile using WinNonlin, Phoenix. Development of bio analytic method

for plasma quantification LC-MS/MS based bioanalysis, in-vitro ADME

methodologies, metabolite identification and/or PK interpretation.

Comparing Bioavailability through different routes.Extensive hands on

LC-MS method development.

. Instuments : UV-Vis,HPLC, LC-MS,IR,XRD,MDSC,Franz Diffusion

cell.

. Software : WinNonlin, Phoenix, R.

In Vitro Permeation of ON 01210.Na (Ex-RADTM) Through Porcine Skin: This

research was a part of ongoing efforts to develop a readily deployable

formulation for ON01210.Na to be used in a radiation emergency.

Developed /Validated HPLC method for ON 01210.Na.

Conducted solubility and partition coefficient studies for preformulation

characterization .

Investigation of dominant transdermal pathway of drug. Study effect of

various penetration enhancers on permeation of ON01210.Na. Steady state

flux as a function of concentration at physiogical pH.

Correlate the invitro Flux parameters to plasma concentrations.

Master's Dissertation: "Improving drug release of Lidocaine with less

amount of drug in it for lesser toxic effect & economical"

Formulated various ointment bases with or without additives.

Evaluated effect of different additives on Chemical systems.

Performed Franz diffusion studies on the prepared batches. UV analysis of

the batches prepared.

Study of release pattern of different formulation using cadaver

skin.Optimization of the formulation.

"Enhancement of rate of dissolution of Aceclofenac by using skimmed milk

powder as a carrier"

Developed a scalable technique to prepare solid dispersion

Evaluated effect of different surfactants on Physical and Chemical

systems.

. Analytical Instruments :UV-Vis,HPLC, LC-MS,IR,XRD,MDSC,Franz

Diffusion cell,tablet machine, Disintegration tester, Dissolution

Apparatus I/II,

. Softwar : WinNonlin, Phoenix, R.

Presenting a poster at AAPS 2013, "Determination of physiochemical

properties of Irinotecan (CPT-11),an anticancer drug".

Presented a poster at AAPS 2012, "In vitro permeation of ON01210.Na (Ex

Rad TM) through porcine skin.

Presented a poster at AAPS 2009 "Evaluation of Low Strengths Topical

Dosage Forms of Lidocaine with Enhanced Drug Release Profiles".

Participated in state level pharmacy paper presentation competition

conducted by "Gujarat council on science and technology 2005-07" and

presented the following papers:

Won the FIRST prize In Presenting the paper titled "HIV/AIDS Mandatory

Testing: Next Frontier in Pandemic Control" 2006-07.Published in Asian

Journal of Pharmaceutical Science 2009.

Co-authored the paper titled " Enhancement of rate of dissolution by using

skimmed milk powder as carrier" 2006-07"

Presented paper titled "Inclination of pharmacist towards patient

counseling" 2005-06

Prepared a research paper titled "Enhancing solubility of Aceclofenac

using solid dispersion" which is in process of publication.Presented an

abstract titled "Preparation and Evaluation of solid dispersion of

Meloxicam with skimmed milk" at Final year of BS Pharmacy.

PROFESSIONAL EXPERIENCE:

Astra Zeneca Pharmaceuticals, DE: Six Month CO-Opt Intern

Feb -2010/ Sept-2010

Compaction and compression project:

Understanding of Hiestand Indices using different excipients.

Study of effect of moisture and temperature on compaction properties.

. Instruments : Triaaxial press, Texture analyser, Dynamic and Static

Indentation Hardness,DMA,Nanovea Laser analyzer.

Inclusion complex formulation:

Understanding solvent effect on API using phase diagrams.

Evaluation of flow properties and moisture effect on final blens through

thermal studies.Stability studies.

Related course work:

Basics of Pharmacokinetics, Mathematical Modeling, Industrial Pharmacy I &

II, Advanced Physical Pharmacy, Instrumental Analysis, Core Pharmaceutical

Seminar, Cosmetics Formulation, Calculus, Master thesis and research,

Advanced Organic Chemistry, Solubility, Differential Equation I & II. Drug

Delivery & Transport Processes, Kinetics & Mechanisms of Drug Degradation,

Drug Stabilization, Interfacial Phenomena, Thermal Physic and Application

to chemistry of Pharmaceutical Systems

Achievements:.

Inducted in the Rho Chi Society for excellence in Academics (2011).

Awarded "Who's who Award" for all round development and leadership

qualities.

Long Island University- Teaching Fellowship.

Extra curricular achievements:

. Secretary/Event Organizer: Sangam "Indian Assosciation"for years 2009-

10.

. President: : Sangam "Indian Assosciation"for years 2010-11.

REFERENCE : Available on Request.

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