Quality Control Process
Resume:
Uma Kotipalli
Brantford, ON N*T 0H1
Phone : 519 - 304 - 1624, Cell: 519 - 771
- 1425
Email: **********@*****.***
OBJECTIVE
To utilize my education, knowledge and experience in the chemical industry
and contribute as a " Chemist-II"
EDUCATION
M.Sc. (Industrial Chemistry) 1997
Andhra University, India
B.Sc. (Chemistry, Physics, Mathematics)
1995
Andhra University, India
SUMMARY OF SKILLS
> Highly motivated process R&D chemist, with more than 17 years
experience in industry at reputed organizations.
> Proven skills in synthesis and process development of APIs.
> Strong analytical interpretation capability, in NMR, LC-MS, HR-MS, GC-
MS, UV-VIS and IR
> Collected extensive literature of new molecules from websites and
scientific databases and search engines.
> Quality control analysis related to research and development
experiments including TLC, Preparative HPLC, moisture content, melting
range and determined product specification
> In-depth experience of safe handling all toxic and corrosive chemicals
> Successfully conducted laboratory experiments to manufacture API, and
delivered the compounds to support further studies / technology
transfer
> Familiar with cGMPs, ICH guidelines and ensured compliance with all
applicable regulation and SOPs
> Evaluated impurity profile of approved pharmaceutical ingredients,
chemical process technology and equipment
> Maintained lab documentation as per GLP and FDA Guidelines
> Hands on experience for the Active Pharmaceutical Ingredients of
ROSUVASTATIN CALCIUM, ATROVASTATIV CALCIUM PG SOLVATE, LUBIPROSTONE,
NILOTINIB HCl, VILAZODONE HCl BEZOATE SOLAVTE, RUFINAMIDE, PAROXETINE
MESYLATE, MONTELUKAST SODIUM, PANTAPRAZOLE, LAMIVUDINE, LORATADINE,
MIRTAZAPINE, PIOGLITAZONE, ALFUZOSIN, VENLAFAXINE HCl, CELECOXIB and
multiple steps of Cancer therapeutic drugs and intermediates.
> Hands on experience the Synthetic Reactions of Grignard, Aldol, Swern
Oxidation, Wittig, Suzuki Coupling, Buchwald Coupling, Silylation,
Chlorination, Bromination, Mesylation, Selective Reductions,
Oxidation, Protection, Deprotection, Benzylation, Esterification,
Hydrolysis, Acetylation, Methylation, and Cyanation etc
> Knowledge of purification techniques by using different solvents and
chromatography separation of compounds by using ordinary and pressure
columns
> Prepared and reviewed product labeling, batch records, specification
sheets, and test methods for compliance with applicable regulations
and policies for both in-house and vendor samples
> Maintained documents, lab note books, analytical results and SOPs
> Prepared documents related to process development like, reference
standard reports, process development reports, process flow diagrams
etc
> Prepared presentation for meetings. Posses good written and oral
communication skills
> Evaluated impurity profile of approved pharmaceutical ingredients,
chemical process technology and equipment
> Developed and modified laboratory exercised to satisfy safety and
pollution inspections
> Knowledge of MS Office, higher speed typing certification, Chem draw,
ACD Chem sketch, ISIS MDL draw
EMPLOYMENT HISTORY
Chemist-I R&D: APOTEX Pharmachem Inc, Brantford, ON, Canada 2006 -
Present
(8 years)
Research Technician: LORUS Therapeutics Inc, Toronto, ON, Canada 2005 -
2006
(8 months)
Scientist: BIOCON Limited, Banagalore, India
2002 - 2005
(2 years 10 months)
Research Executive: CIPLA Limited, Banagalore, India
2001 - 2002
(1 year 3 months)
Assistant Officer R&D: MATRIX Laboratory Limited, India
1997 - 2001
(3 years 9 months)
PATENTS AND PUBLICATIONS
1) ATORVASTATIN Calcium Propylene Glycol Solvate prepared from Racemic
Propylene Glycol:
United States Patent US 7,834,195,B2 Issued: Nov16, 2010
2) Methods of Making LUBIPROSTONE and Intermediates thereof:
USPTO Application #201******** Issued: 03/15/12
3) More efficient Palladium Catalyst for Hydrogenolysis of Benzyl Groups:
Synthetic Communications, 36: 925-928, 2006 (Prasad Subramaniam)
REFERENCES AVAILABLE UPON REQUEST
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