Medical Manager

Ivana Knezevic, M.D.

**** *. ******* ***.

Chicago, IL 60630

Cell Phone: 773-***-****

E-mails: *****@***.***, ***************@*****.***

Summary of Qualifications

. MD with extensive clinical and translational research experience

. Two years of clinical research experience (all phases and steps of

clinical trials)

. Extensive knowledge of GCPs, ICH and FDA regulatory requirements

. Nine years scientific research experience (designing experiments and

conducting research)

. Ten years teaching experience (MD, PhD students and Postdoctoral Fellows)

. Skillful in writing proposals, protocols and research articles

. Great organizing, interpersonal and leadership skills

Education

10/96-03/03 M.D.

Medical School University of Belgrade, Serbia

Professional Experience

04/12-present Clinical Research Coordinator/Manager

Department of Anesthesiology and Pain Management,

Advocate Illinois Masonic Medical Center, Chicago, IL

. Involved in all steps of clinical trials, writing protocols, case

report forms, coordinating and monitoring clinical trials

. Interviewing and recruiting patients for studies

. Maintaining extensive patient contact, via telephone and written

correspondence, tracking patients' follow-up visits

. Preparing source documents and maintain patients medical records and

files

. Responsible for drug accountability

. Record any adverse effects

. Maintains calendars, scheduling and preparing monitors visits and

timely submissions of query responses

. Follows protocols and following guidelines of the NIH, FDA, IRB and

industry

. Prepares documents for central IRBs and maintain database files for

IRB protocols

. Communicates with IRB staff in writing and by phone for clarification

and questions about applications

. Making poster and Power Point presentations, writing manuscripts and

abstracts for local and international meetings

. Involved in collecting clinical research data, provides graphic and

statistical analysis of data

. Connecting multiple cooperative clinical trial groups and

investigational drug companies

05/09-10/12 Senior Research Specialist in Health Sciences

Department of Physiology and Biophysics,

University of Illinois at Chicago, IL

. Processed patient's blood samples

. Measured concentration of different preservatives in injectable

solutions

. Gave lectures and seminars on graduated courses to MD, PhD students

and postdoctoral fellows

. Co-investigator in departmental NIH and AHA grants

. Involved in Pre-Clinical research including in vivo and ex vivo

animal models, Molecular and Cell Biology techniques

. Explored molecular mechanism of cardiovascular diseases in terms of

basic and translational medical research

04/08-05/09 Postdoctoral Research Associate

Department of Pharmacology, RUSH University

Medical Center, IL

. Involved in basic and translational medical research of lung

vascular permeability and restoration of endothelial function

05/09-04/08 Postdoctoral Research Associate

Department of Pharmacology, University of Illinois

at Chicago, IL

. Advise medical students and post doctoral fellows in basic and

translational methods and protocols

. Gave lectures and seminars on graduated courses

. Co-investigator in Departmental NIH grants

Honors and Awards

05/09-04/12 National Institute of Health - Training Grant Department

of Physiology and Biophysics, University of

Illinois at Chicago, IL

10/99-09/02 Scholarship for Graduate Students granted by the Ministry

of Education, Republic of Serbia

1996-2003 The best student in generation "Vuk Karadzic Award"

Belgrade, Serbia

Memberships

AHA- American Heart Association

ISHR- International Society of Heart Research

AAAS - American Association for the Advancement of Science

BOS - Belgrade Open School Alumni Organization

Selected publications

1. Predescu S, Knezevic I, Bardita C, Neamu RF, Brovcovych V, Predescu

D. Platelet Activating Factor-Induced Ceramide Micro-Domains Drive

Endothelial NOS Activation and Contribute to Barrier Dysfunction.PLoS One.

2013 Sep 27;8(9):e75846

2. Knezevic I, Patel A, Sundaresan N.R,Gupta P.M, Solaro RJ, Gupta M.

A novel cardiomyocyte enriched micro RNA, miR378, targets IGF1R:

implications in postnatal cardiac remodeling and cell survival. J Biol

Chem. 2012 Apr 13;287(16):12913-26.

3. Tagileri MD, Monasky MM, Knezevic I, Sheehan AK, Lei M, Wang X,

Chernoff J, Wolska MB, Ke Y, Solaro RJ. Ablation of P21-activated kinase-1

in mice promotes Isoproterenol-induced Cardiac Hypertrophy in association

with activation of Erk1/2 and inhibition of Protein Phosphatase 2A. J Mol

Cell Cardiol 2011;51(6):988-96.

4. Candido KD, Knezevic I, Mukalel J, Knezevic NN. Enhancing the

Relative Safety of Intentional or Unintentional Intrathecal

Methylprednisolone Administration by Removing Polyethylene Glycol. Anesth

Analg 2011;113(6):1487-9.

5. Knezevic I, Predescu D, Bardita C,Wang M. P Sharma T, Keith B,

Neamu R, Malik A, Predescu S. Regulation of Dynamin-2 Assembly-Disassembly

and Function Through the SH3A Domain of Intersectin-1s J Cell Mol Med.

2011;15(11):2364-76.

6. Klein IK, Predescu DN, Sharma T, Knezevic I, Malik AB, Predescu S.

Intersectin-2L regulates caveola endocytosis secondary to Cdc42-mediated

actin polymerization. J Biol Chem. 2009;284(38):25953-61

7. Knezevic I, Predescu S, Neamu R, Gorovoy M, Knezevic N, Easington

C, Malik AB, Predescu D. Tiam1 and Rac1 required For PAF-induced

endothelial junctional disassembly and increase In vascular permeability. J

Biol Chem 2009;284(8):5381-94.

8. Predescu S, Predescu D, Knezevic I, Klein I, Malik AB. Intersectin-

1s Regulates the Mitochondrial Apoptotic Pathway in Endothelial Cells J.

Biol. Chem 2007; 282: 171**-*****.

9. Dragovic G, Knezevic N, Nesic D, Knezevic I, Lukic R, Jovanovic I.

Neuroprotective activity of magnesium. General Medicine 2006; 12(1-2):27-9.

10. Dragovic G, Knezevic N, Nesic D, Knezevic I, Lukic R, Jovanovic I.

Antiviral drugs in the treatment of respiratory tract infections. General

Medicine 2005; 11(3-4):202-5.

11. Dragovic G, Knezevic N, Nesic D, Knezevic I, Lukic R, Jovanovic I.

Drug choice in the treatment for non-complicated urinary infections in

eldery patinets. Gerontology 2005; 33(1):116-21.

12. Knezevic N, Dragovic G, Knezevic I, Lukic R, Jovanovic I, Nesic D.

Neuroprotective effect of magnesium in elderly patients. Gerontology 2002;

30(1):137-42.

13. Dragovic G, Knezevic N, Lukic R, Knezevic I, Jovanovic I, Nesic D.

Sildenafil in the treatmnet of erectile dysfunction. Gerontology 2002;

30(1):148-52.

14. Koso S, Knezevic N, Dragovic G, Nesic D, Knezevic I, Lukic R,

Alekis S. The use of mineral waters of Gornja Trepca Spa in the treatment

of diseases of central and peripheral nervous system. General Medicine

2002;8(1-2):39-42.

15. Sainovic M, Dragovic G, Knezevic N, Lukic R, Paunovic I, Nesic D.

Important characteristics of mineral water "Banja Rusanda -Melenci" for the

therapeutical uses. General Medicine 2001;7(3-4):253-6.

Selected Abstracts

1.Knezevic N, Candido KD Berth SL, Krbanjevic A, Knezevic I.

Cytotoxic Effects of Methylprednisolone Acetate With and Without

Preservatives on Dorsal Root Ganglion Sensory Neurons in Rats. ASRA, 12th

Annual Pain Medicine Meeting, Phoenix, AZ

2. Knezevic I, Patel P.A., Solaro R.J, Gupta M. Micro RNA378 targets

IGF 1 receptor and regulates cardiomyocytes survival. American Heart

Association Meeting, November 2011

3. Knezevic I, Patel P.A., Solaro R.J, Gupta M. Micro RNA 208a is

involved in post-natal cardiac remodeling by targeting slow skeletal

Troponin I isoform in mouse heart. International Society of Heart Research,

May 2011

4. Knezevic I, Solaro R.J, Gupta M. Micro RNA 208a down regulates

ssTnI expression during heart development. American Heart Association

Meeting, March 2011

5. Candido KD, Knezevic N, Mukalel J, Knezevic I. Removing

polyethylene glycol from methylprednisolone makes suspension safer for

intrathecal use. ASRA 2010 Meeting; Phoenix, AZ November 17-21.

6. Knezevic I, Predescu S, Neamu R, Easington C, Knezevic N, Brokowich

V, Predescu D. Platelet Activating Factor Receptor-Mediated Activation of

Endothelial Nitric Oxide Synthase. The American Society for Cell Biology

48th Meeting 2008;B588.

7. Knezevic I, Predescu D, Malik AB, Predescu S. Intersectin -1s a

regulator of dynamin function at the neck region of caveolae. The American

Society for Cell Biology 48th Meeting 2008;B187.

8. Predescu S, Neamu F, Predescu D, Knezevic I, Malik A. Intersectin-

1s regulates endothelial permeability by coordinating the cross-talk

between transcellular and paracellular pathways. The American Society for

Cell Biology 47th Meeting 2007; B255.

9. Predescu D, Predescu S, Knezevic I, Neamu R, Knezevic N, Malik AB.

Non-clathrin non-caveolin vesicular carriers involved in transcytosis. The

American Society for Cell Biology 46th Meeting 2006; B582.

10. Predescu D, Knezevic I, Predescu S, Neamu F, Gorovoy M, Knezevic

N, Malik AB. Activation of PAF receptor leads to endothelial actin

rearrangement and increased vascular permeability. The American Society

for Cell Biology 46th Meeting 2006; B339.

11. Predescu S, Predescu D, Knezevic I, Malik AB. Scaffold protein

intersectin 1s (ITNS1s) regulates mitochondrial-dependent apoptosis. The

American Society for Cell Biology 46th Meeting 2006; B36.

12. Knezevic N, Beljic T, Dragovic G, Knezevic I. The risk of breast

cancer and hormone replacement therapy. Maturitas 2003;44(Suppl.2):S93-4.

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