RESUME

MAOZHEN TIAN

303-***-****

acbx89@r.postjobfree.com

EDUCATION

**/**-**/** **.D Department of Molecular Biology, University of Wyoming, Laramie, Wyoming.

**/**-**/** *.S. Department of Molecular Biology, University of Wyoming, Laramie, Wyoming.

09/93-07/96 M.S. Department of Horticulture, Agricultural University of HeBei, Baoding, HeBei, China.

09/89-07/93 B.S. Department of Horticulture, Agricultural University of HeBei, Baoding, HeBei, China.

PROFESSIONAL EXPERIENCES

11/12-present Clinical SAS programmer, VDA Consulting Inc., Fort Lee, NJ.

Participation in two phase II clinical studies;

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Data mapping based on eCRF, annotated eCRF, SDTM/ADaM IGs or other specifications;

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construction of SDTM/ADaM datasets;

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Generation of AE, VS, LB, etc. tables, listings, and figures according to SAP;

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Performing safety analysis for FDA submission.

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03/12-10/12 Instructor, Division of Endocrinology, Motabolism & Diabetes, University of Colorado, Denver, CO.

06/10-02/12 Sr. Research Assoc., Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH.

08/06-05/10 Postdoc, Department of Pharmacology, University of Colorado Denver, Denver, CO.

08/05-08/06 Postdoc, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO.

07/96-07/99 Assistant professor, Biotech. Center, Agricultural University of Hebei, Baoding, Hebei, China.

PROFESSIONAL SKILLS

Extensive research experiences in Clinical Cancer Biology, Immunology and Clinical Oncology.

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Specialized in human/mouse model on breast cancer progression and metastasis, and pharmaceutical

intervention of breast cancer initiation and metastasis. Extensive experience in NIH, VA grant

preparation and submission.

Knowledge on C++, Fortune language (in college).

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SAS Techniques in Clinical Trials:

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Proficient in SAS/BASE, SAS/STAT, SAS MACRO and PROC SQL;

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Familiar with CDISC, MeDRA, ICH/GCP, ISS/ISE;

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Proficient in data mapping, construction of SDTM/ADaM datasets for FDA submission;

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Proficient in production of Tables, Listings, Figures/Graphs using different SAS tools;

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Familiar with both Windows and Unix operating systems.

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Computer Techniques: Microsoft Excel/Advanced Excel, Crystal Report, Microsoft Word, Power Point,

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Photoshop, Freehand.

LANGUAGE SKILLS

Fluently speak and write in both English and Chinese. Proficient in scientific and technical writing.

PUBLICATIONS

1. Xiumin Wang, Xueyou Wei, Yunhui Liu, Maozhen Tian. (1999) The research of the effect of Co in the growth of

maze plant and Co contents in them. Journal of Agricultural University of HeBei (in Chinese ). 22(2): 45-48.

2. Maozhen Tian, Congzhou Liu, Randy Lewis (2004) Analysis of major ampullate silk cDNAs from two non-orb-

weaving spiders. Biomacromolecules 5(3): 657-660.

3. Maozhen Tian and Randy Lewis (2005) Molecular characterization and evolutionary study of spider tubuliform

(eggcase) silk protein. Biochemistry 44(22):8006-12.

4. Maozhen Tian and Randy Lewis (2006) Extreme sequence conservation in spider tubuliform (eggcase) silk orthologs

compared with the great divergence with its silk paralogs. Applied Physics A 82, 265-273.

5. Maozhen Tian, William P. Schiemann (2009) The TGF-β Paradox in Human Cancer: An Update. Future Oncology

5(2):259-71.

6. Maozhen Tian and William P. Schiemann (2009) Preclinical efficacy of cystatin C to target the oncogenic activity of

transforming growth factor Beta in breast cancer. Transl Oncol. 2(3):174-83.

7. Neil JR, Maozhen Tian, Schiemann WP (2009) X-linked inhibitor of apoptosis protein and its E3 ligase activity

promote transforming growth factor-β-mediated nuclear factor-{kappa}B activation during breast cancer progression. J

Biol Chem 284(32):21209-17.

8. Maozhen Tian and William P. Schiemann (2010) PGE2 receptor EP2 mediates the antagonistic effect of COX-2 on

TGF-β signaling during mammary tumorigenesis. FASEB J. 2010 Apr; 24(4): 1105-16.

9. Maozhen Tian, Jason Neil, William P. Schiemann (2010) TGF-β and the Hallmarks of Cancer. Cellular Signaling.

23(6): 951-62.

10. Michael Wendt*, Maozhen Tian*, William P. Schiemann (2011) Deconstructing the mechanisms and consequences

of TGF-β-induced EMT during cancer progression. Cell & Tissue Research. June 2011 (E-pub)

* Co-first author

11. Raju R, Nanjappa V, Balakrishnan L, Radhakrishnan A, Thomas JK, Sharma J, Tian M, Palapetta SM, Subbannayya

T, Sekhar NR, Muthusamy B, Goel R, Subbannayya Y, Telikicherla D, Bhattacharjee M, Pinto SM, Syed N, Srikanth

MS, Sathe GJ, Ahmad S, Chavan SN, Sameer Kumar GS, Marimuthu A, Prasad TS, Harsha HC, Rahiman BA, Ohara O,

Bader GD, Sujatha Mohan S, Schiemann WP, Pandey A. (2011) NetSlim: high-confidence curated signaling maps.

Database (Oxford). Sep 29; 2011(0):bar032. Print 2011.

12. Maozhen Tian, William P. Schiemann (2014) TGF-β stimulation of epithelial to mesenchymal transition elicits non-

genomic ERα activity and anti-estrogen resistance in breast cancer cells. Breast Cancer Research. In preparation for

submission.

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13. Maozhen Tian, William P. Schiemann (2014) Insulin-Like growth factor I receptor promotes oncogenic

TGF-β signaling during mammary tumor progression and metastasis. In preparation for submission.

CO-REVIEWED ARTICLES

1. The roles of FER in epidermal growth factor-induced activation of NF-κB and resistance to quinacrine.

Canhui Guo and George R. Stark. Proceedings of the National Academy of Sciences

2. PGE2 contributes to TGF-β induced T regulatory cell function in human non-small cell lung cancer. Felicia

Baratelli, Jay M. Lee, Saswati Hazra, Ying Lin, Tonya C. Walser, Dorthe Schaue, Peter S. Pak, David

Elashoff, Karen Reckamp, Ling Zhang, Michael C. Fishbein, Sherven Sharma, and Steven M. Dubinett.

Human Cancer biology

3. Epithelial to mesenchymal transition in development and cancer. Douglas S. Micalizzi, and Heide L Ford.

Future Oncology

4. TGF-beta 1 induces epithelial-mesenchymal transition in HaCat derivatives, but leads to expression of Cox2

only in benign, not in malignant keratinocytes. Kati Rasanen and Antti Vaheri. International Journal of

Cancer.

5. Targeting the transforming growth factor-β signaling pathway in human cancer. Andrew Murdock. Expert

opinion on investigational drugs

6. Emergence of the PI3 kinase-Akt-mTor axis in TGF-β induced epithelial-mesenchymal transition Samy

Lamouille and Rik Derynck. Cells Tissues Organs

7. TGF-β suppresses Cox-2 expression by tristetraprolin-mediated destabilization of COX-2 mRNA in A549

human lung cancer cells. Yung-jue Bang, Seock-Ah Im. Cancer letters

8. Inhibition of Cystatin C Expression Enhances Invasion of Prostate Cancer Cells via TGFβRII and AR

Pathways. Barbara Wegiel, Thomas Jiborn, Magnus Abrahamson 3, Leszek Helczynski2, Jenny Liao Persson,

and Anders Bjartell.

9. Internalization of Cystatin C in Human Cancer Cells.

PROFESSIONAL MEMBERSHIP Associate member of American Association for Cancer Research since

2007

PRESENTATIONS AND POSTERS

07/11 Poster: Insulin-like Growth Factor 1 Receptor Facilitates Epithelial to Mesenchymal Transition Induced

by TGF-β in Mammary Tumor Cells.

02/10 Poster: 17-β-estrodiol antagonizes TGF-β induced EMT through ERα in Mammary Epithelial

Cells. 2010 American Association for Cancer Research, EMT meeting, Arlington, VI.

04/09 Poster: Prostaglandin E 2 receptor EP2 mediates the antagonistic effect of Cox2 in TGF-β

signaling during mammary tumorigenesis. 2009 American Association for Cancer Research

Annual Conference, Denver, CO.

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04/08 Poster: CystC inhibits the oncogenic TGF-β signaling during mouse mammary tumor

progression. 2008 American Association for Cancer Research Annual Conference, San Diego,

California.

07/07 Poster: Cystatin C antagonizes TGF-β stimulated angiogenesis in endothelial cells. AACR

Cancer Pathology workshop, Aspen, Colorado

05/05 Presentation: Molecular Characterization and Evolutionary study of Spider Tubuliform silk

The 29th American Arachnological Society 2005 annual conference, Akron, OH

04/05 Presentation: Tubuliform silk (eggcase): a unique silk with extreme sequence conservation

among its orthologs. 2005 Graduate Student Symposium, University of Wyoming,

Laramie, WY

06/04 Presentation: Genetic analysis of a non-orb weaving spider silk cDNA.

The 28th American Arachnological Society 2004 annual conference, Norman, Oklahoma.

03/04 Presentation: Phylogenetic Analysis of Major ampullate silk cDNA from A. aperta.

Research Seminar, Department of Molecular Biology, University of Wyoming, Laramie, WY

02/04 Presentation: Genetic analysis of spider major ampullate silk genes.

2004 Graduate Student Symposium, University of Wyoming, Laramie, WY

06/01 Presentation: Expression and Purification of a Synthetic Spider Silk Protein in Plants.

Research Seminar, Department of Molecular Biology, University of Wyoming, Laramie, WY.

AWARDS

09/03-present University of Wyoming EPSCoR Stipend supplement

09/93-07/96 Agricultural University of HeBei Scholarship

09/89-07/93 Agricultural University of HeBei Scholarship

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