Health Assistant

Yi-Ling Huang, PhD

Human Nutrition Research Center on Aging

*** ********** ******, ******, **

Personal address: 114 Fenway APT 1, Boston, MA 02115

Phone: 617-***-****

Email: ***.******@*****.***

Education

2003-2009 Doctor of Philosophy Institute of Environmental Health, College of Public

Health, National Taiwan University, Taiwan

Dissertation: Thioredoxin Modulates Cigarette Smoke-Induced Expression of

Remodeling Factors in Human Airway Epithelial Cells

2002-2003 Master Program Institute of Environmental Health, College of Public

Health, National Taiwan University, Taiwan

1997-2001 Bachelor of Science Department of Public Health, Chung-Shan Medical

University, Taiwan

Bachelor’s Thesis: Exposure assessment of polycyclic aromatic hydrocarbons

(PAHs) in Taichung city, Taiwan

Award

American Association for Cancer Research (AACR) 101st Scholar-in-training

2010

award, (2010 AACR-Sanofi-aventis Scholar-in training award)

Health policy research fellowship award 2011, National Health Research

2011 Institutes, Taiwan

Research skills

Statistics SAS, STATA, SPSS, Microsoft Office Package

program

Study design Case-control design, cohort studies, linear and logistic regression, Meta-analysis

SNP genotyping, haplotype analysis, cell culture, RNA extraction, DNA

Laboratory

extraction, PCR, real-time PCR, ELISA, flow cytometer,

skills

Western blotting, HPLC, GC, airborne sampling (SKC, hi-volume air sampler,

dichotomous sampler)

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Teaching related experiences

Biochip course

Graduate

o Introduction of single nucleotide polymorphisms (SNPs)

program

Environment-gene interaction course

o Introduction of Environment and gene interaction

o Multifactor Dimensionality Reduction (MDR) software

Seminar of environmental Health

o Oxidative stress to lung diseases

Environmental and Occupational Epidemiology

Introduction of serve acute respiratory syndrome (SARS) to community

Undergraduate

Environmental Health

program

Biomedical engineering sciences course

o Lecture and experiment of PCR and qPCR

Work experiences

2012~present Postdoctoral associate, Tufts nutrition center, Boston, MA

Establish the mechanism between glucose related genes to diseases

Review literatures of AMD, and establish the hypotheses of high glucose

effect on AMD

Design in vitro experiments for glucose effect on age-related macular

degeneration (AMD), which are included cell culture, dose-dependent of

protein expression, and protein-protein interaction

Review literatures of high glucose of AMD

2011~2012 Postdoctoral fellow, Graduate Institute of Environmental Health, College of

Public Health, China Medical University, Taiwan

Focus on environmental factors to GI tract diseases

Establish relationship between different kinds databases: National Health

insurance database, diseases report from Center for Disease Control

(CDC), database of Center Weather Bureau (CWB)

Deal with statistical analysis, paper writing

Researcher, Taiwan Food and Drug Administration

Responsible for international food policies in Taiwan

Communicate and negotiate food policies to different countries

2009 ~ 2010 Postdoctoral fellow, Preventive Medicine, College of Public Health, National

Taiwan University

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Projects:

(1) Copy number variations, expression of inflammatory cytokines and the

Risk of dementia – A two-stage genome-wide association study (GWAS)

Literature review of dementia and genetic effects

Identify and standardized the recruited criteria for cases and control group.

Establish the databases and connect databases from hospital record

Extract DNA and analysis phenotypes of single nucleotide polymorphisms

(SNPs)

Explore relationship between environmental risk factors and SNPs

Redefine and select cases and controls for GWAS study

Re-analysis DNA and SNPs data for GWAS study

Establish gene-gene interaction using multifactor dimensionality reduction

software

Writing peer-review publication for environment-gene interaction of

dementia

(2) Prostate cancer study: interaction between genetic variations and

environmental exposure on the risk of prostate cancer

Connect databases of lab exam and Health Professional Follower-up Study

(HPFS, cohort study of Harvard U )

Analysis the interaction of T. vaginalis infections and TLR4 polymorphisms

Writing peer-review paper of T. vaginalis infections and TLR4

polymorphisms

Literature review of TLR4 polymorphisms and prostate cancer from

PubMed

Meta-analysis of TLR4 polymorphisms and prostate cancer

Writing peer-review paper of Meta-analysis of TLR4 polymorphisms and

prostate cancer

2004~2008 PhD candidate research Assistant, National Science Council /Environmental

Protection Agency (EPA), Taipei, Taiwan

Project:

Traffic associated childhood asthma in relation to human rhinovirous and

oxidative damage

Proposal writing, establish questionnaires, study design, samples

collection, oxidative damage analysis, establish databases, data analysis,

report writing.

2004 Research assistant, Bureau of Health Promotion in Taiwan

Project:

The changing profile and cost-benefit analysis of thalassemia and Down

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syndrome in Taiwan

Data analysis about cost-benefit of thalassemia and Down syndrome

2003~ 2004 College lecturer, Community university for public health education in

post-SARS (Severe Acute Respiratory Syndrome) period

Teaching epidemiology of infectious diseases for community students

2002 Research assistant, Chin-Shan Community Cardiovascular Study in Taipei,

Taiwan

Data collection, data analysis for smoking effect on myocardial infarction

1997~2001 Research assistant, Chung-Shan Medical University

Projects:

(1) Exposure assessment of polycyclic aromatic hydrocarbons (PAHs) in

Taichung city

Monitor and collect the air pollution in Taichung city, paper writing,

samples collection, lab analysis for PAHs, data analysis

(2) Monitoring the water quality of main river in Taichung city

Monitor and collect the water pollution in Taichung city, paper writing,

samples collection, lab analysis for water, data analysis

Publication

Book

Nutrition, Diet, the Eye and Vision – chapter: Glycemic index and age-related macular

degeneration 2013 (under review)

Dissertation: Thioredoxin Modulates Cigarette Smoke-Induced Expression of Remodeling Factors

in Human Airway Epithelial Cells 2009

Peer-reviewed

Chen Marcelo*, Huang YL*, Shui Irene M, Huang YC, Giovannucci E, Chen YC, Chen YM.

Variation in the Glycine N-methyltransferase Gene and Prostate Cancer Risk in the Health

Professionals Follow-up Study (under review)

Lin YL, Yip PK, Lai LC, Chen SY, Chen JH, Yang SY, Huang YL, Chen FT, Sun Y, Wen LL, Chiu

YM, Chen WJ, Chen YC*, “Genetic Polymorphisms of Clusterin (CLU) Gene Are Associated with

a Decreased Risk of Alzheimer’s Disease.” European Journal of Epidemiology 27(1):73-75, 2012.

Lin KP, Chen SY, Lai LC, Huang YL, Chen TF, Chen JH, Sun Y, Wen LL, Yip PK, Chu YM, Chen

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WJ, Chen YC, “Genetic polymorphisms of a novel vascular susceptibility gene, Ninjurin2 (NINJ2),

are associated with a decreased risk of Alzheimer’s disease” PLoS ONE 6(6), e20573, 2011.

Huang YL, Page J, Chen JH, Lin YL, Xu JF, Koutros S, Berndt S, Chanock S, Witte JS, Chen

YC.Toll-Like Receptor 4 Polymorphisms and Prostate Cancer Risk: Systematic Review and

Meta-analysis. (under review)

Chen YC*, Huang YL*, Platz EA, Zheng L, Alderete J, Giovannucci E, Sutcliffe S. Toll-Like

Receptor 4 Polymorphisms Modify the Association between T. vaginalis Serostatus and Prostate

Cancer Risk. (under review)

Huang YL, Chen NT, Tuan-Mu YN, Chen QW, Ma YC, Lin JM, Chen ML, Chang CW, Chuang

CY, Sung FC. Traffic air pollution associated with childhood asthma in Taipei, Taiwan. (under

review)

Li YF, Tseng PJ, Lin CC, Hung CL, Lin SC, Su WC, Huang YL, Sung FC and Tai CK. NAD(P)H:

Quinone oxidoreductase 1, glutathione S-transferase M1, environmental tobacco smoke exposure,

and childhood asthma. Mutation Research/Genetic Toxicology and Environmental Mutagenesis,

2009 (678):53-58

Chuang CY, Huang YL, Chang MW. Combination of ultrasound and ultrasound and contrast agent

mediates gene transfer to cell nuclei of human bronchial epithelial cells. (In preparation)

Huang YL, Chuang CY, Sung FC, Chen CY. Thioredoxin overexpression mediates remodeling

factors in stress responses to cigarette smoke. J Toxicol Environ Health, part A.2008 (7):1490-1498

Chuang CY, Chang CH, Huang YL. Thioredoxin mediates remodeling factors of human bronchial

epithelial cells upon interaction with house dust mite-stimulated eosinophils. Inhal Toxicol 2009

Feb;21(2):153-67

Abstract

Chen YC*, Huang YL *, Platz EA, Zheng L, Alderete JF, Giovannucci E, Sutcliffe S. Toll-Like

Receptor 4 Polymorphisms Modify the Association between T. vaginalis Serostatus and Prostate

Cancer Risk. American Association for Cancer Research (AACR) 101st Annual meeting,

Washington DC, USA, April 17-21, 2010. (AACR scholar-in-training award)

Huang YL, Chuang CY, Sung FC, Chen CY, Chou CC. Thioredoxin mediates TGF-β1 against

oxidative stress of cigarette smoke in human airway epithelium. Society of Toxicology (SOT) 48th

Annual Meeting & ToxExpoTM, Baltimore, USA, March 15-19, 2009. (Oral presentation)

Huang YL, Chen NT, Tuan-Mu YN, Cheng QW, Ma YC, Lin JM, Chen ML, Chang CW, Chuang

CY, Sung FC. Traffic air pollution associated with childhood asthma in Taipei, Taiwan. The

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135th American Public Health Association (APHA) Annual Meeting, Washington D.C., USA,

November 3-7, 2007. (Oral Presentation)

Lin WY, Huang YL, Chang CC, Chuang CY. Characterization of IL-15 expression for the

regulation to cigarette smoke exposure in human airway epithelial cells. Conference of the 18th

International Society for Environmental Epidemiology (ISEE), Paris, France, September 2-6, 2006.

Huang YL, Lin WY, Chang CC, Chuang CY. Cigarette smoke extract stimulates IL15 expression

in human lung carcinoma cells. Conference of the 18th International Society for Environmental

Epidemiology (ISEE), Paris, France, September 2-6, 2006.

Huang YL, Wang YC, Sung FC. Association between mortality from chronic pulmonary disease

and stroke and 1998 epidemic of pneumonia and influenza in Taipei, Taiwan. The 2nd North

American Congress of Epidemiology, Seattle, USA, June 21-24, 2006.

Huang YL, Lin WY, Chang CC, Chuang CY. Thioredoxin mediated smoke-induced cytotoxicity on

airway epithelial cell. The 21th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan,

March 18-19, 2006. (Oral Presentation)

Lin WY, Huang YL, Chang CC, Chuang CY. Characterization of IL-15 expression and regulation

in primary human airway epithelial cells and lung mucoepithelial carcinoma cells. The 21th Joint

Annual Conference of Biomedical Sciences, Taipei, Taiwan, March 18-19, 2006.

Huang YL, Sung FC, Chuang CY. Mainstream smoked-induced cytotoxicity on airway epithelial

cell. Taiwan Public Health Association Annual Meeting, Taipei Taiwan, October 22-23, 2005.

(Awarded the Best Poster)

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