Biotech Process Specialist

Tyler Charles Hassenpflug

** ****** ****** • Albany, NY 12203• 518-***-**** • *****.***********@*****.***

December 10, 2013

Synectics

Andover, MA 01810

Dear Hiring Manager,

I am interested in applying for the Process Technician position. I believe that I am an excellent

candidate for this position based on my manufacturing process development experience along with my

personal passion for the development of biologics. I possess strong work ethic, excellent

communication and interpersonal skills, and an advanced knowledge in the process development and

purification of mammalian cell culture process. Please accept this letter and accompanying resume for

my consideration for the position.

I currently work in the clinical-scale manufacturing and development team at Regeneron

Pharmaceuticals. During my time at Regeneron, I have gained experience in mammalian cell cultures,

protein purification and process development. I was a key contributor in the planning and execution of

campaigns and studies critical to clinical-scale manufacturing and development. This includes

technology transfer from small-scale process development and full-scale manufacturing. I was

appointed as the downstream manufacturing representative for tech transfer of various cell lines from

process development to clinical scale manufacturing. As the downstream representative for tech

transfer, I was responsible for training other manufacturing personal on new types of chromatography

and filtration processes as well as performing and executing these processes during manufacturing

campaigns.

Additionally, I was responsible for designing and executing experiments to help improve the

mammalian cell manufacturing process. Working in both clinical and commercial-scale manufacturing

as well as closely with process development has taught me flexibility while managing simultaneous

projects with changing priorities in strict time constraints. Through projects, I have had to work

independently as well as collaboratively in a cross-functional environment for over three years. I feel

that the skills I have obtained from Regeneron will make me a valuable asset to Synectics.

Overall, my career goal is to contribute to the development of life changing medications. I am

looking to meet new challenges and develop my career in the greater Boston area. I am extremely

interested in new developments and trends of biologics and to be a key contributor to the next generation

product. Thank you for your consideration and I look forward to hearing from you and discussing the

positive contributions I would offer to your team.

Sincerely,

Tyler Hassenpflug

Tyler Charles Hassenpflug

71 Ormond Street • Albany, NY 12203• 518-***-**** • *****.***********@*****.***

Objective: To obtain a position as a Process Technician at Synectics

Industrial Experience:

Biotech Specialist, Regeneron Pharmaceuticals, June 2010 - Present

Intimate familiarity and training in cGMP/FDA regulated facilities.

Detailed operation experience in both upstream and downstream processing of mammalian cell

cultures in clinical and commercial manufacturing.

Expertise with seed train, cell culture, and downstream operations including harvest,

chromatography, viral filtration and Tangential Flow Filtration (UF/DF).

Trained and oversaw new manufacturing personnel on key manufacturing operations.

Supported technology transfer from process development to large scale manufacturing through

providing risk assessments and presented process characterization reports.

Performed equipment start-up, commissioning, installation and qualification activities for

manufacturing equipment.

Revised and authored SOP’s abd manufacturing records in accordance with cGMP standards.

Experience in planning and executing process improvements and addressing deviations utilizing the

life cycle project approach.

Managed cross-functional department interfaces for deviations, CAPA’s and Change Control

executions.

Author and reviewer of validation protocols, manufacturing records and Preventative Maintenance

Procedures (PMP).

Skilled in conducting and evaluating studies on the critical variable parameters of the operation of

equipment and systems.

Gathered and analyzed trends of data results for further studies

Education:

The College of Saint Rose, Albany, New York

Bachelor of Arts in Science, Biology

Experience:

Undergraduate research under the supervision of Dr. Paul Benzing, Math and Science Department, The

College of Saint Rose, Albany, New York, Spring 2009 – Fall 2009

Performed baseline ecological assessments along a highly utilized river along the city border

to determine and evaluate the benefits from restoration efforts

Assessed river quality by both sampling and visualization according to the National

Resources Conservation Service’s assessment protocol

Concluded that the river would benefit from restoration efforts, provided a baseline for

further research, and delivered strong supportive evidence for river restoration funding to the

city officials

Results were presented at Vassar College Research Symposium

Publications:

TC Hassenpflug and A Leis “Assessment of benthic macroinvertebrates, water quality, and

channel condition at three locations along the Normanskill River” Journal of Undergraduate

Research at the College of Saint Rose, 1(2010): 112-125.

Skills:

Microsoft Office, Unicorn, LIMS, Blue Mountain, Qumass eDoc Compliance, C++, Banner

Tyler Charles Hassenpflug

71 Ormond Street • Albany, NY 12203• 518-***-**** • *****.***********@*****.***

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