High School State University

Quanxuan Zhang

*** ****** *** *-****: ********@***.***

Malden, MA 02148, USA

Cell: 517-***-****

Education

PhD, Organic/Polymer Chemistry Jan 2009 -

July 2013

Department of Chemistry, Michigan State University, East Lansing, Michigan, USA

MS, Polymer/Physical Chemistry Sep 2004 -

July 2007

School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong, China

BS, Chemistry Sep 2000 -

July 2004

College of Chemistry, Chemical Engineering & Material Science, Shandong Normal University, Jinan, Shandong,

China

Research Experience

Doctoral Research – Polymer chemistry, organic synthesis, and nanomaterial fabrication

• Synthesis and post-modification of functional polylactides: Initiated and developed a low cost and purification-

free protocol to synthesize novel monomers and their clickable and biodegradable polylactide block polymers for

click modification and their aqueous self-assembly study for drug delivery (colloidal material) and stimuli-

responsive materials.

• Facile synthesis of a series of α-hydroxy acids for preparing clickable polylactides: Developed one convenient

synthetic process to prepare α-hydroxy acids bearing propargyl, allyl, azido and poly(ethylene glycol) groups in

large scale through multistep synthesis without using column chromatography.

• High Tg polylactides as biodegradable plastic materials: Designed the synthesis of polyspirolactides with high

glass transition temperature (Tg) embedding cyclopentyl, cyclohexyl and cycloheptyl groups in polymer backbone

to toughen polylactides and improve their temperature range of application as biodegradable plastic materials.

• Surface modification of small silica nanoparticles: Developed a new and facile method to prepare surface-

modified and monodispersed small silica nanoparticles by condensing with novel alkynyl organosilane coupling

reagent to achieve different particle surface functionalities via click chemistry – suitable for biological adjuvant

effect and cytotoxicity study of individual particles and differentiating the adverse effects of particle aggregates.

Master’s and Undergraduate Research – Polymer synthesis and surfactant chemistry

• Design and synthesis of liquid crystalline poly(L-lactide) with huge optical rotatory property: Combining both

self-assembly property of liquid crystal and helical conformation of poly(L-lactide) for self-ordered materials with

huge optical rotation.

• Kilo-gram scale development and synthesis: Designed and optimized the synthesis of intermediate (4-

chlorobutyl ferrocene) used as solid rocket fuel propellant. Marketed by Honghui Chemicals Co. Ltd., Xiangfan,

Hubei Province.

• Surfactant chemistry and adsorption kinetics at the Air/Solution Interface: Studied the dynamic surface tension

and adsorption kinetics of non-ionic surfactant (Brij35) and its potential drug release application.

Summary of Qualifications

• Technical skills: Multistep bench-scale and kilogram-scale organic synthesis; monomer and polymer material

synthesis and purification; Proficient in various polymerization methods and techniques; Air-free/Glovebox

technique; characterization techniques of polymer material (NMR, IR, HRMS, GPC, UV-vis, DSC, TGA, XRD,

TEM, optical microscopy, Dynamic light scattering, Circular dichroism, Fluorescence).

• Leadership: Received ‘Excellent Leadership Award’ by the university from freshman to junior years and by the

province/state in my senior year for serving as president of undergraduate student association of the college and

organizing meetings and events for over 1000 faculty members, staff and students.

• Collaboration and team work: Actively participated in the collaborations as one of the major contributors with

colleagues and researchers from Department of Pathobiology and Diagnostic Investigation (Prof. Harkema),

Department of Pharmacology and Toxicology (Prof. Kaminski) and Department of Chemical Engineering and

Materials Science (Prof. Worden) at MSU. Three manuscripts related to these collaborations are currently

published.

• Multi-disciplinary research experience: Ranging from physical chemistry to organic and polymer chemistry;

from synthetic polymer materials to nanomaterial fabrication; from chemistry to biological study.

Quanxuan Zhang

• Personality: Well organized, self-motivated and easygoing; promote research projects to completion efficiently;

developed outstanding communication and interpersonal skills during research and teaching in graduate school.

Internships

• Chemistry Teacher of Educational Practice, Shandong Experimental High School (Best High School in the

Province), Jinan, Shandong, China, 2004

Awards and Honors

• Dissertation Completion Fellowship, Michigan State University, 2013

• Travel Award, ACS MSU-Local Section, 2012

• Outstanding Graduate of Shandong Province, China, 2004

• Third-Prize of National (China) and Gold Metal of Shandong Province in the Third Challenge Cup Students’

Enterprise Contest, Program Title “Improvement of Synthesis of 2,2’-Azobisisobutyronitrile”, 2003

• Excellent Leadership Award of Shandong Normal University, 2001- 2003

• Third-Prize Academic Scholarship of Shandong Normal University, 2003

• Second-Prize Academic Scholarship of Shandong Normal University, 2001-2002

• Excellent Student of Shandong Normal University, 2001

Publications

1. Development and Synthesis of a Library of α-Hydroxyacids for Preparation of Clickable Polylactides

Zhang, Q.; Baker, G. L. Manuscript in preparation.

2. A Scalable Synthetic Route to Selectively Monofunctionalize α,ω-Diols

Zhang, Q.; Baker, G. L. Manuscript in preparation.

3. Redox- and Thermo-responsive Polylactide Biomaterials via Smart Click Modification

Zhang, Q.; Baker, G. L. Manuscript in preparation.

4. The Adjuvant Effect of Emerging Nanomaterials: A Double-Edged Sword

Ren, H.; Zhang, Q. (Corresponding Author); Baker, G. L. Invited Book Chapter for ACS Symposium Series, 2013,

Accepted.

5. Induced T Cell Cytokine Production is Enhanced by Engineered Nanoparticles

Chen, W.; Zhang, Q.; Kaplan, B. L. F.; Baker, G. L.; Kaminski, N. E. Nanotoxicology, Just accepted.

6. Engineered Silica Nanoparticles Act as Adjuvants to Enhance Allergic Airway Disease in Mice

Brandenberger, C.; Rowley, N. L.; Jackson-Humbles, D. N.; Zhang, Q.; Lewandowski, R. P.; Wagner, J. G.; Chen, W.;

Kaminski, N. E.; Baker, G. L.; Worden, R. M.; Harkema, J. R.* Particle and Fibre Toxicology, 2013, 10:26.

7. Biomembrane disruption by silica-core nanoparticles: effect of surface functional group measured using a tethered

bilayer lipid membrane

Liu, Y.; Wang, Z.; Zhang, Q.; Baker, G. L.; Worden, R. M. BBA-Biomembranes, 2014, 1838, 429-437.

8. Synthesis and Characterization of Side Chain Polymer with Helical PLLA Segments Containing Mesogenic End Group

Chen, H.; Xue, Q.; Li, Z.; Sun, L.; Zhang, Q. Polymer, 2011, 52, 400-408.

9. (4-Fluoro-3-nitro-phenyl) ferrocene

Zhang, Q.; Xue, Q.; Qie, L. Acta Cryst., 2007, E63, m335-m336.

10. Adsorption Kinetics of Brij35 at Air/Solution Interface

Wang, Z.; Liu, F.; Zhang, Q.; Sun, D.; Li, G.; Zhang, G. Indian Journal of Chemistry, 2005, 44A, 2051-2054.

Poster Presentations

1. Modification of Silica Nanoparticles Surface via "Click" Chemistry and Their Adjuvant Effects

Zhang Q.; Chen, W.; Kaplan, B. L. F.; Kaminski, N. E.; Baker, G. L. Aug 2012, 244th ACS National Meeting,

Philadelphia, PA

2. Facile Surface Grafting to Stable Monodisperse Small Silica Nanoparticles via Click Chemistry and Their Adjuvant

Effect

Zhang Q.; Chen, W.; Kaplan, B. L. F.; Kaminski, N. E.; Baker, G. L. Mar 2012, 243rd ACS National Meeting, San

Diego, CA

3. Synthesis and Characterization of Liquid-Crystal Polylactide Copolymer

Zhang, Q.; Yu, D.; Ren, Z.; Xue, Q. July 2006, 25th Chinese Chemical Society Congress, Changchun, Jilin, China

4. Study of Liquid Crystal Property of Liquid-Crystal Polylactide Copolymer

Zhang, Q.; Yu, D.; Ren, Z.; Xue, Q. July 2006, 25th Chinese Chemical Society Congress, Changchun, Jilin, China

References

Quanxuan Zhang

Prof. Gregory L. Baker Prof. William D. Wulff Professor Xuefei Huang Prof. Jack R. Harkema

(PhD Advisor) (PhD Advisor) (PhD Committee) (Collaborator)

(Deceased in Oct 2012) 517-***-**** ext. 373 517-***-**** ext. 329 517-***-****

*****@*********.***.*** ******@*********.***.*** ********@***.***

Michigan State University Michigan State University Michigan State University

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