Formulation Chemist

Harriet Cooper, PhD

*** ** ******* ***, **********, NJ 07095

Tel. 732-***-**** (home), 609-***-**** (cell), acbdxe@r.postjobfree.com

Profile

focused formulation chemist eager to apply state-of-the-art enabled formulation technologies to

new problems

Highlight of Skills

● Formulation development using state-of-the-art enabled technologies such as spray-drying, nanoparticles,

micro-encapsulation

● Stability assessment of formulated products

● Physical characterisation of formulations such as particle size measurement

● Analytical techniques, including NMR, HPLC, LC-MS, GC-MS, UV, IR, TGA, DSC, XRPD, microscopy

● Extensive experience in handling communication and logistics with external partners

● Familiar with Excel and Powerpoint

Experience

Merck, Rahway, NJ, Chemist III in Basic Pharmaceutical Sciences, Aug 2011 – July 2013

● Developed a formulation for a protein drug which extended stability from 2 weeks to 2 months

● Stability and solubility studies of small molecules and biologics, including identifying degradants

● Supported animal studies with formulation and protocol preparation, including handling logistics with

external partners

Carbozyme, Princeton, NJ, Consultant Chemist, May 2010 – June 2011

● Delivered method for natural gas sweetening including presentation for investors

● Developed methods for carbon capture using membranes

Hepatochem, Princeton, NJ, Chemist, February – May 2010

● Delivered milligram quantities of novel drug metabolites

●

Education

Ph.D. in Chemistry, Princeton University, Princeton, New Jersey, January 2010

DIC (Diploma of Imperial College, Master’s degree) in Chemistry, Imperial College, 2003

MSci (undergraduate degree) in Chemistry, Imperial College, London, UK, 2000

Publications

Parallel and Competitive Pathways for Substrate Desaturation, Hydroxylation and Radical Rearrangement by the Non-

heme Diiron Hydroxylase AlkB, Harriet L.R. Cooper, Girish Mishra, Xiongyi Huang, Marilla Pender-Culip, Rachel

Narehood Austin, John Shanklin, John T. Groves, J. Am. Chem. Soc., 2012, 134 (50), pp 20365–20375

Molecular Probes of the Mechanism of Cytochrome P450. Oxygen Traps a Substrate Radical, Harriet L.R. Cooper,

John T. Groves, Archives of Biochemistry and Biophysics, 2011, Volume 507, pp 111–118

Diagnostic radical clock probes for heme and non-heme monooxygenases, Harriet L.R. Cooper, Doctoral Dissertation,

Princeton University, January 2010

Presentations

Princeton Research Symposium, Princeton, NJ, September 2008, poster title: The Nature of Metallooxygenases

Revealed by Radical Clocks

ICBIC 13 (13th international conference for bioinorganic chemistry), Vienna, Austria, July 2007, poster title: A

Manganese Porphyrin Mimics Cytochrome P450

Gordon-Keenan Graduate Research Seminar, Ventura, CA, February, 2006, poster title: A New Fluorinated Probe for

Enzyme and Model Oxygenation Reactions

Biotage Microwave Assisted Organic Synthesis Symposium, Princeton, NJ, October 2004, invited speaker, title:

Porphyrin Catalyzed Oxidation Reactions in the Microwave

ACS national meeting, Philadelphia, PA, August 2004, poster title: New Diagnostic Probes for Enzyme and Model

Oxygenation Reactions

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