Gali Steinberg-Tatman

**** ******* *** *** - *** Diego, CA 92121 - Cell: 858-***-**** -

acb3g2@r.postjobfree.com

PROFILE

Dr. Gali Steinberg Tatman is a research scientist, an educator, and a

patent agent. Gali is highly diligent, detail-oriented, and resourceful

professional with proven experience in multi-step organic synthesis,

medicinal chemistry, and modern analytical techniques along with a

successful seven-year track record at a biotech company, Illumina. At

Illumina, Gali played an instrumental role in the development of a

proprietary bead decoding system. She holds a Ph.D. degree in Organic

Chemistry from the Weizmann Institute of Science, and was a postdoctoral

fellow at Arizona State University and Purdue University. Gali has managed

large cross-functional teams including scientists from all levels. She has

a versatile range of research expertise across synthetic/medicinal

chemistry, biochemistry, and biophysics. Her superior communication and

presentation skills are evidenced by her teaching, which requires an

articulate approach to explaining complex scientific subjects. In

addition, Gali is fluent in Russian and Hebrew and conversant in Spanish

and French.

PROFESSIONAL EXPERIENCE

PATENT LAW EXPERIENCE

Life Technologies, Carlsbad, CA

Consultant 2013-present

Performed computer-based literature and structure searching in the chemical

and related art groups. Worked closely with attorneys in the litigation

department.

TEACHING EXPERIENCE

Mesa College, San Diego, CA 2007-Present

Adjunct Chemistry Professor

Instructed chemistry college courses consisting of both lectures and

laboratory courses.

Southwestern College, Chula Vista, CA 2011-Present

Adjunct Chemistry Professor

Instructed chemistry college courses consisting of both lectures and

laboratory courses

RESEARCH EXPERIENCE

Illumina, San Diego, CA 2000-2007

Senior Scientist

Conducted oligonucleotide immobilization on glass beads including

development and optimization of bead chemistry. Optimized oligonucleotide

loading and hybridization efficiency to maximize bead sensitivity and

dynamic range. Cultivated capabilities in solid phase chemistry synthesis,

oligonucleotides (synthesis, purification, ligation), imaging systems (FACS

and CCD-coupled optical fiber arrays), and genotyping assays. Supervised

and developed research associates, pursued cross-functional research, and

interacted extensively with suppliers and vendors.

> Proved integral to the creation of a proprietary bead decoding system.

> Formulated a synthetic modification of silica beads which enabled

sequential attachment of two different oligonucleotides.

> Received a patent for attaching biological compounds to solid supports

using triazine.

> Authored two articles which were published in scientific journals.

Purdue University, Dept. of Medicinal Chemistry and

Molecular Pharmacology, West Lafayette, IN 1999-2000

Post-doctoral Fellow

Designed and synthesized novel prodrugs experiencing selective activation

under reducing conditions, releasing alkylating agents. Implemented

synthesis of both folic acid derivatives and cephalosporin derivatives.

Charted design and synthesis of prodrugs. Demonstrated strengths in

working with heterocyclic compounds, cephalosporins, folates, and amino

acids (couplings, protecting groups). Evaluated in vitro cytotoxicity of

prodrugs in human cancer cell lines (HT 29 and MCF 7/0).

> Identified a good synthetic path which circumnavigated by-products that

lowered yield of the desired product.

Arizona State University, Dept. of Chemistry and Biochemistry, Tempe, AZ

1994-1998

Post-doctoral Fellow

Imitated photosynthetic process using artificial reaction centers.

Developed expertise in liposome behavior and preparation, including highly

complex liposomal systems containing FoF1-ATP synthase and organic

molecules. Operated laser systems including picosecond transient

fluorescence and nanosecond transient absorption. Implemented protein and

enzyme isolation and purification, as well as detection of ATP formation

and pH changes within the liposomes. Developed knowledge of working with

radioactive materials, separation, and selective detection.

> Seamlessly designed an artificial photosynthetic reaction center to

ensure proper interaction among components and performed rigorous testing

to verify correct operation.

Weizmann Institute of Science, Dept. of Organic Chemistry, Rehovot, Israel

1987-1994

Graduate Research Studies

Analyzed the influence of chromophore-protein interactions in rhodopsin

binding sites on absorption maxima and thermal processes in the photo

cycle. Implemented organic synthesis and utilized various spectroscopic

methods, such as NMR, FTIR, and absorption spectrophotometry. Coordinated

HPLC, gel electrophoresis, and various methods of protein purification.

EDUCATION

Postdoctoral Research Associate, 1999-2000 - PURDUE University, Dept. of

Medicinal Chemistry and Molecular Pharmacology, West Lafayette, IN

Project: Design and synthesis of novel prodrugs that undergo selective

activation under reducing conditions (making use of bioreductive alkylating

agents)

Postdoctoral Research Associate, 1994-1998 - ARIZONA State University,

Dept. of Chemistry and Biochemistry, Tempe, AZ

Project: Artificial photosynthesis (in liposomes)

Ph.D., 1994 - WEIZMANN Institute of Science, Dept. of Organic Chemistry,

Rehovot, Israel

Project: Synthesis and spectroscopic properties of Rhodopsins and

Bacteriorhodopsins

M.Sc. in Organic Chemistry, 1989 - Weizmann Institute of Science, Dept.

of Organic Chemistry, Rehovot, Israel

B.Sc. in Chemistry, with High Honors, 1985 - UNIVERSITY of California,

Santa Barbara, California

CERTIFICATIONS (LICENSES)

Patent Agent, U.S.P.T.O. Reg. No. 71238

LANGUAGES

Fluent in Russian, and Hebrew. Conversant in Spanish and French.

PUBLICATIONS

1. G. Steinberg, N. Friedman, M. Sheves and M. Ottolenghi "Isomer

composition and spectra of the dark and light adapted forms of artificial

bacteriorhodopsins" (1991), Photochemistry and Photobiology, 54, 969-976.

2. G. Steinberg, M. Ottolenghi and M. Sheves "pKa of the protonated Schiff

base of bovine rhodopsin" (1993), Biophysical Journal, 64, 1499-1502.

3. R. Govindjee, S. Balashov, T. Ebrey, D. Oesterhelt, G. Steinberg, and M.

Sheves "Lowering the intrinsic pKa of the chromophore's schiff base can

restore its light induced deprotonation in the inactive Tyr-57 -Asn

mutant of bacterioprhodopsin" (1994), Journal of Biological Chemistry,

269, 143**-*****.

4. J.K. Delaney, T.L. Brack, G.H. Atkinson, M. Ottolenghi, G. Steinberg,

and M. Sheves "Primary picosecond molecular events in the photoreaction

of the BR5.12 artificial bacteriorhodopsin pigment" (1995), Proceedings

of the National Academy of Sciences USA, 92, 2101-2105.

5. G. Steinberg, M. Sheves, S. Bressler and M. Ottolenghi "Factors

affecting the formation of an M-like intermediate in the photo cycle of

13-cis-Bacteriorhodopsin" (1994), Biochemistry, 33, 124**-*****.

6. B. Yan, E. N. Spudich, M. Sheves, G. Steinberg and J. L. Spudich

"Complexation of the signal transducting protein Htrl to sensory

rhodopsin I and its effect on thermodynamics of signaling state

deactivation" (1997), Journal of Physical Chemistry, 101, 109-113.

7. G. Steinberg-Yfrach, P. A. Liddell, S.C. Hung, A. L. Moore, D. Gust and

T. A. Moore "Conversion of light energy to proton potential in liposomes

by artificial photosynthetic reaction centres" (1997), Nature, 385, 239-

241.

8. A.L. Moore, T.A. Moore, D. Gust, J.J. Silber, L. Sereno, F. Fungo, L.

Otero, G. Steinberg-Yfrach, P.A. Liddell, S.C. Hung, H. Imahori, S.

Lardosa, D. Tatman and A.N. Macpherson "Model systems for observing

photoredox reactions of carotenoids" (1997), Pure and Applied Chemistry,

69, 2111-2116.

9. G. Steinberg-Yfrach, J.L. Rigaud, A. L. Moore, D. Gust and T. A. Moore

"Light driven production of ATP catalysed by FoF1 - ATP synthase in an

artificial photosynthetic membrane" (1998), Nature, 392, 479-482.

10. G. Steinberg, W. Frasch, A. L. Moore, D. Gust and T. A. Moore

"Threshold effects by the phosphate potential in spinach thylakoids and

in artificial photosynthetic membranes", in preparation.

11. G. Steinberg, R. F. Borch "Synthesis and Evaluation of Pteroic Acid-

Conjugated Nitroheterocyclic Phosphoramidates as Folate Receptor-Targeted

Alkylating Agents" (2001), Journal of Medicinal Chemistry, 44, 69-73.

12. G. Steinberg, H. Liu and R. F. Borch "Synthesis of cephalosporin

mustard prodrugs", in preparation

13. G. Steinberg, K. Stromsborg, D. Barker and C. Zhao "Strategies of

covalent attachment of DNA to glass beads" (2004), Biopolymers, 73, 597-

605.

14. G. Steinberg-Tatman, M. Huynh, D. Barker and C. Zhao "Synthetic

modification of silica beads that allows for sequential attachment of two

different oligonucleotides" (2006), Bioconjugate Chemistry, 17, 841-848.

PATENTS

. Chanfeng Zhao, Igor Kozlov and Galina Steinberg-Tatman "Methods for

attaching biological compounds to solid supports using triazine" issued

as U.S. patent No. 7,863,058 on 01/04/2011

. G. Steinberg and M. Sheves "Bacteriorhodopsin derivatives and their

preparation" issued as Israeli patent No. 102549 on 07/19/1992

SELECTED PRESENTATIONS

. Invited seminar: Light driven synthesis of ATP using proton motive force

generated by artificial reaction centers in liposomes. G. Steinberg-

Yfrach, P. Liddell, J. L. Rigaud, D. Gust, A. Moore and T. Moore, Seventh

Western Photosynthesis conference, January 1998, Pacific Grove, CA.

. Invited seminar: Light driven synthesis of ATP using proton motive force

generated by artificial reaction centers in liposomes. G. Steinberg-

Yfrach, P. Liddell, J. L. Rigaud, D. Gust, A. Moore and T. Moore,

Weizmann Institute of Science, June 1997, Rehovot, Israel.

. Invited seminar: Photochemistry of artificial reaction centers in

liposomes - Transmembrane proton transfer. G. Steinberg-Yfrach, P.

Liddell, S.C. Hung, D. Gust, A. Moore and T. Moore, American Society for

Photobiology, June 1996, Atlanta, GA.

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