Longxi (Jesse) Xiao, PhD

**** ********* **** **, ******, DE 19711

Cell: 302-***-****, Email: acald1@r.postjobfree.com

EDUCATION

Ph.D. Materials Science and Engineering GPA: 3.7/4.0 2007~Aug 2013

University of Delaware, Newark, DE

Dissertation Title: Mechano-Responsive Hydrogels Crosslinked by Self-Assembled Block

Copolymer Micelles

Advisor: Prof. Xinqiao Jia

B.S. Polymer Science and Engineering GPA:3.4/4.0 2004~2007

Fudan University, Shanghai, P. R. China

RESEARCH EXPERIENCE

• Created nanoparticle reinforced thermoplastic polymers for drug delivery application.

• Experienced in the synthesis of polymers using anionic polymerization, emulsion

polyermzation, ATRP, RAFT, ring opening polymerization techniques.

• Expertise in the characterization and analysis of polymers using DSC, TGA, DMA, FT-

IR, NMR, GPC, and et al.

• Rheological studies on polymer fluids, hyaluronic acid hydrogel formation equipped with

UV curing, viscosity measurement on different fluids and model fit.

• Formulated functionalized block copolymer nanoparticle/micelles. Studied self-assembly

and dissociation under external force using TEM, FCS, DLS, Fluorometer, SAXS, and

rheo-SANS.

• Developed drug encapsulation and release vehicles using mechano-responsive hydrogel.

• Synthesized and characterized hydrogels using AFM, SEM, DMA and Confocal

microscopy.

• Cell culture and ELISA study on the cell proliferation and growth factor release.

SKILLS

Synthesis Techniques:

Anionic Polymerization, Emulsion polymerization, Suspension polymerization, Atom Transfer

Radical Polymerization (ATRP), Reversible Addition Fragmentation chain Transfer (RAFT)

polymerization, Ring opening Polymerization, Nanoparticle formulation, Small molecule

synthesis and purification.

Software:

MATLAB, AutoCAD, Autodesk, Chemdraw, Microsoft office, and Materials Studio.

Materials Characterization:

Rheometer, SANS, XPS, SAXS, NMR, GPC, GC, HPLC, MS, DMA, FT-IR, UV-Vis,

Fluorometer, DSC, TGA, DLS, TEM and FCS.

COMMUNICATION SKILLS

• Taught graduate level courses in the department of Materials Science and Engineering

from 2009 to 2012, MSEG630/CHEG600 “Introduction to the science and engineering of

polymer systems” and MSEG833 “Polymer Synthesis and Characterization Laboratory”

• Coauthor on more than 13 publications and speak at national ACS conference annually.

LEADERSHIP & MANAGEMENT SKILLS

• Managed departmental shared facilities (GPC, NMR, FT-IR, DSC, Freeze dryer,

Fluorometer, DMA, Rheometer and UV-Vis Spectrometer);

• Trained junior graduate students on polymer synthesis and characterization;

• Supervised and mentored several undergraduate students on their senior thesis;

• Served as the Chemical Safety Officer in the Department of Materials Science and

Engineering.

ACADEMIC HONORS AND AWARDS

2004 2006

First Class Scholarship, Fudan University

2005 2006

Wangdao Scholar Award, Fudan University

2006 2007

Zhong Hai You Scholarship, Soong Ching Ling Foundation

2009 2010

College of Engineering Excellence in Teaching Award, Univ. of Delaware

Materials Sci & Eng Chairperson’s Outstanding Student Award, Univ. of Delaware 2011 2012

PROFESSIONAL AFFILIATION

2008 present American Chemical Society (ACS), Materials Research Society (MRS)

SELECTED PUBLICATIONS

Peer-Reviewed Journal Publications and Preprints

1 Xiao, L.; Tong, Z.; Chen, Y.; Sabanayagam, C.; Pochan, D.; Jia, X. “Hyaluronic acid

hydrogels crosslinked by reactive block copolymer micelles for anti-inflammatory

application”, Biomacromolecules, 2013, Accepted.

2 Yang, X.; Xiao, L.; Jia, X. "Designing Mechano–Responsive Materials with Elastomeric

Properties for Biomedical Applications" SurFACTS in Biomaterials, 2013, 18, 7-8

3 Gurski, L.A.; Xu, X.; Labrada, L.N.; Nguyen, N.T.; Xiao, L.; van Golen, K.L.; Jia, X.;

Farach-Carson, M.C. “Hyaluronan (HA) interacting proteins RHAMM and hyaluronidase

impact prostate cancer cell behavior and invadopodia formation in 3D HA-based hydrogels”,

PLoS One, 2012, 7(11), e50075.

4 Xiao, L.; Zhu, J.; Pochan, D. J.; Londono, J. D.; Jia, X. “Mechano-Responsive Hydrogels

Synthesized by Block Copolymer Micelles”, Soft Matter, 2012, 8, 102**-*****.

5 Teller, S.; Farran, A.; Xiao, L.; Jiao, T.; Duncan, R.; Clifton, R.; Jia, X. “High Frequency

Viscoelastic Shear Properties of Vocal Fold Tissues: Implications for Vocal Fold Tissue

Engineering”, Tissue Eng. A, 2012, 18, 2008-2019.

6 Xiao, L.; Jia, X. “Novel hydrogels of block copolymer micelles: synthesis, characterization

and application”, Polym. Prepr.2012, 53, 152.

7 Xiao, L.; Jia, X. “Self-assembled nanoparticles derived from diblock and multiblock

copolymers as modular drug delivery vehicles”, Polym. Prepr.2011, 52, 107.

8 Xiao, L.; Liu, C.; Zhu, J.; Pochan, D. J.; Jia, X. “Hybrid, Elastomeric Hydrogels Crosslinked

by Multifunctional Block Copolymer Micelles”, Soft Matter, 2010, 6, 5293-5297.

9 Xiao, L.; Liu, C.; Jia, X. “Mechano-Responsive Hydrogels with Sacrificial Bonds and

Hidden Length”, Polym. Prepr.2010, 51, 244.

10 Grieshaber, S. E.; Xiao, L.; Liu, C.; Jia, X. “Mechano-Responsive Hydrogels via Biomimetic

Approaches”, Polym. Mat. Sci. Eng. Prepr.2010, 102, 318.

11 Xiao, L.; Liu, C.; Jia, X. “Synthesis and Characterization of Mechano-Responsive

Hydrogels”, Polym. Prepr.2009, 50, 652.

12 Wang, X.; Xiao, L.; Jia, X. “Core-Stablized Block Copolymer Micelles for Controlled

Release of Cancer Therapeutics”, Polym. Mat. Sci. Eng. Prepr.2009, 101, 1339

13 Wang, X.; Xiao, L.; Liu, C.; Jia, X. “Block Copolyester Micelles as Nanocarriers for

Sustained Release of Camptothecin”, Polym. Prepr.2009, 50, 349.

PRESENTATIONS AND POSTERS

1. Xiao, L.; Jia, X. “Novel hydrogels of block copolymer micelles: synthesis, characterization

and application”, Oral Presentation, 244th American Chemical Society (ACS) National

Meeting, Philadelphia, PA, August, 2012.

2. Xiao, L.; Liu, C.; Jia, X. “Hybrid, elastomeric hydrogels crosslinked by multifunctional

block copolymer micelles”, Oral Presentation, 242th American Chemical Society (ACS)

Annual Meeting, Boston, MA, August 22-26, 2010.

3. Xiao, L.; Liu, C.; Jia, X. “Synthesis and characterization of Mechano-responsive hydrogels”

Poster Presentation, 241th American Chemical Society (ACS) Annual Meeting, Washington,

DC, August, 2009.

REFERENCES

Xinqiao Jia

PhD, Associate Professor

Department of Materials Science and Engineering, Biomedical Engineering Program

206 DuPont Hall, University of Delaware, Newark, DE 19716

Phone: 302-***-****, Email: acald1@r.postjobfree.com

Darrin J. Pochan

PhD, Professor

Department of Materials Science and Engineering, Delaware Biotechnology Institute

207 DuPont Hall, University of Delaware, Newark, DE 19716

Phone: 302-***-****, Email: acald1@r.postjobfree.com

Sarah Grieshaber

PhD, Product Technologist

SABIC Innovative Plastics

Evansville, IN, 47711, USA

Phone: 973-***-****, Email: acald1@r.postjobfree.com

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