Chemist

JOSE MACALL

jose_macall@yahoo

EXPERIENCE

SMALL BUSINESS, Contractor, March 2009 – January 2013

Worked in a small landscaping business.

CATALENT PHARMA SOLUTIONS, Sr. Associate, December 2008 – March 2009

Developed, and validated HPLC analytical methods for drug stability. Also monitored drug

stability other using analytical techniques such as UV-Vis, fluorescence, FTIR, and Karl Fischer.

Performed and documented all work within pertinent US Pharmacopeia protocols, cGLP standards,

and Six Sigma methods. Wrote certificates of analysis, and project reports.

AZURE INSTITUTE, Associate Scientist, August 2004 – February 2007

Under general supervision synthesized, isolated and characterized analogs of organometallic red-

ox mediators for electrochemical blood glucose meters. Synthesized, isolated and characterized

drugs of abuse in milligram to multi-gram scales. Coupled and purified (by size exclusion

chromatography, and dialysis) novel adducts of drugs of abuse (as haptens) and different

immunogenic proteins, at milligram scales. Responsible for all chemistry laboratory operations and

safety within ISO 9000 guidelines.

HEWLETT-PACKARD INKS RESEARCH, Temporary Laboratory Tech., April 2004 – June 2004

Prepared experimental ink formulations. Tested inks for various physical properties (such as

viscosity, density, surface tension, and pH). Prepared reports for ink-chemists. Perform and

document all work to meet cGLP standards.

TEACHING, Tutor, October 2003 – March 2004

Tutored high school science, math, and English in El Salvador.

DUPONT PHARMACEUTICALS, Staff Scientist, May 2001 – November 2002

Under general supervision designed, synthesized, isolated, and characterized targeted small

molecule libraries (50-100 compounds at a milli-mole scale) using: proprietary structure-activity

relation software; combinatorial solution-phase chemistry; high throughput HPLC-MS

(preparatory and analytical) systems; high throughput robotics; and organic synthesis techniques.

The targets for said libraries were G protein-coupled receptors (GPCRs) and for an agonist for the

VII-a factor in the coagulation cascade of human blood. Synthesized, purified and characterized

gram to multi-gram quantities of synthetic intermediates and high-purity biological assay

standards. Worked in interdisciplinary team of biochemists, synthetic, analytical, and

computational chemists.

COMBICHEM, Temporary Lab. Tech. to Staff Scientist, May 1998 – April 2001

Managed a reagent tracking system. Trained employees for the compound management group.

Formatted, shipped and archived all the compounds synthesized in-house. Managed the

compounds’ electronic data. Designed and implemented procedures to insure the accuracy,

precision and timeliness of the compound management group. Designed and implemented

modifications to workstations and instruments to integrate them into the company's production

line. Helped design the company’s production line, and database tracking system. Evaluated,

bought, and maintained, workstations and instruments. Performed all work within cGLP

guidelines.

BIOSYSTEMATECH, Laboratory Technician, May 1997 – April 1998

Edged glass surfaces, and carried out the synthesis of nucleotides (at milli-mole scale), and of

organosilicon molecular self-assembled mono layers (at micro mole scale) on glass surfaces.

Evaluated the surface properties of different elastomers. Designed, constructed and tested simple

microfluidics devices with elastomers.

L.A. WATER RECLAMATION DISTRICTS, Temporary Lab. Tech., January 1997 – April 1997

Performed analysis (such as dissolved oxygen, turbidity, suspended solids, volatiles content,

nitrogen content, chlorine content, pH, and bacterial load) of water to monitor the water-

purification process of various water reclamation plants. Prepared daily reports of the plant’s

status. Prepared laboratory reagents and standards. Solely responsible for all weekend, and holy

day laboratory operations.

EDUCATION

Bachelor of Science in Chemistry, University of California San Diego, June 1995

SKILLS IN ORGANIC SYNTHESIS, PURIFICATION, AND IN ANALYSIS

• Organic Synthesis: combinatorial solution-phase (milli-mole scale), multi-step synthesis (gram

to multi-gram scales) and inert environments synthesis (milligram to multi-gram scales)

• Characterization: NMR (C-13 and H), analytical HPLC (UV, ELSD, or MS), GC-MS, and

elemental analysis

• Purification: Preparatory HPLC (UV, ELSD, or MS), flash chromatography, and crystallization

• Hazardous Waste Operations Emergency Responder (Hazwoper) Certified in 2001

SKILLS IN OPERATING, AND IN MAINTAINING

• Analytical instruments: Sciex and Waters HPLC, and Agilent GC-MS

• Flash chromatography systems: Isco and Jones

• Automated synthesis systems: Argonaut and Tecan

• Automated liquid handling systems: Tecan, and Bohdan

• Software packages: Empower, Isis Base, ChemDraw, Chem3D, Scifinder, Reaction Browser,

MS-Office, various in-house data bases, and proprietary software for elucidating structure-

activity relationships

REFERENCE

Available upon request.

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