Assistant Research
Resume:
FARHAN ASAD SYED, PhD
**** ****** *** • Shrewsbury, Massachusetts 01545
Contact Telephone No: 507-***-**** • aca24h@r.postjobfree.com
LinkedIn: http://www.linkedin.com/pub/farhan-syed/37/32a/897/
BRIEF BIOGRAPHY
Accomplished scientist with over 13 years of combined industry and academic experience.
Experienced biologist / drug discovery scientist / significant contributions to scientific literature/
education in fields of aging research and endocrinology.
Effective collaborator and team player, enjoy working in a member of cross functional teams to
forward business objectives.
Looking for opportunities in Pharmaceutical / Biotech / Research Institutes
POSITIONS HELD IN INDUSTRY AND ACADEMIA
1. Senior Scientist III (2010-2013), Abbott/ Abbvie Pharmaceuticals, Worcester, MA
2. Senior Scientist II (2009-2010), Abbott /Abbvie Pharmaceuticals, Worcester, MA
Research Assistant Professor in Medicine (2008 – 2009), Mayo Clinic, Rochester, MN
3.
Research Associate in Aging Research (2005 – 2008), Mayo Clinic, Rochester, MN
4.
Senior Research Fellow, Endocrinology (2001 – 2005), Mayo Clinic, Rochester, MN
5.
6. Research Fellow, Rheumatology/Immunology (2000-2001), Mayo Clinic, Rochester, MN
CORE COMPETENCIES
Strategic Development • Team Leadership • Situational Leadership • Coaching • Product Development
Training • Mentoring • Public Speaking / Presentations • Oral / Written Communication • Editing
AREAS OF EXPERTISE
Aging / Osteoporosis / Age-related Bone Loss • Biomarker discovery
Bone / Fat Stem Cell Biology • Autoimmune Diseases • Rheumatology
• Endocrinology • Cancer Biology • DNA Damage • Free Radical Biology
EDUCATION
Alma Mater: Aligarh Muslim University, Aligarh, Uttar Pradesh, India
Doctor of Philosophy in Biochemistry and Molecular Toxicology / Free Radicals (2000)
Master of Science in Biochemistry (1995)
Bachelor of Science in Biochemistry, with Honors (1993)
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FARHAN ASAD SYED • Page 2 • aca24h@r.postjobfree.com
AWARDS / HONORS / PROFESSIONAL AFFILIATIONS
Young Investigator Award (2005) from the American Society for Bone and Mineral Research
Elected member of Sigma–Xi Society for significant scientific contributions (2008), Mayo Clinic
Invited speaker, Bone and Joint Seminar Series (2010), University of Massachusetts Medical
School
Member American Society for Bone and Mineral Research
Member Endocrine Society
TECHNICAL SKILLS
1. Preclinical In-vivo Aging / Inflammatory Models
2. Preclinical Models of Bone and Fat Metabolism
3. In-vivo Imaging Techniques
4. Cell Culture
5. Histology / Histomorphometry
6. Biomarkers
7. Free radical assays
8. DNA damage quantification using in-vitro assays and ex-vivo assays
SIGNIFICANT CONTRIBUTIONS
ABBOTT LABORATORIES (now ABBVIE) Worcester, Massachusetts • Dec 2009 – Sep 2013
Leveraged experience and expertise to set up novel bone assays and bone histomorphometry
capabilities on-site.
Enhanced site capabilities by collaborating with subject matter experts.
Introduced novel methodology to study relationship between inflammation and bone loss.
Introduced assays and defined paradigms to study bone anabolism with biologic s/ small
molecules
Developed robust model for assessing effects of glucocorticoids / SGRM compounds on bone
formation/ adipocyte accumulation /growth plate cartilage inhibition
In –vitro and In-vivo mechanistic models to assess effects of biologic TNF / small molecule
inhibitors on bone cells and tissues
Identification and validation of inflammatory and bone biomarkers for future clinical applicability
M AYO CLINIC, Rochester, Minnesota • 2001 – 2009
Recognized expert in animal models of aging and bo ne diseases.
Developed assays and characterized novel genetically modified animal models using array of
basic and translational approaches.
Recognized as in-house expert in bone histomorphometry and provided bone expertise to
academic labs in United States and abroad.
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FARHAN ASAD SYED • Page 3 • aca24h@r.postjobfree.com
Fostered collaboration with internal and external colleagues and established international network
of cooperating researchers.
Published extensively during this period (over 15 publications and 20 scientific abstracts)
Reviewed papers for journals and senior staff.
Gave conferences talks and presented at Society’s plenary sessions.
Elected as honorary member of Sigma Xi Society for recognition of scientific contributions.
PROFESSIONAL EXPERIENCE:
Senior Scientist III, Abbott Laboratories (now Abbvie), Worcester, MA
December 2009- September 2013
Joined Abbott Laboratories as a Senior Scientist to provide bone expertise and develop the bone
analytical capabilities at their Worcester site. This site developed Humira, the well-known Anti-
TNFα biologic extensively used to treat Rheumatoid Arthritis. I have been supervising the
development of reliable ways of assessing inflammatory bone changes in animal models of
inflammation such as those for Rheumatoid Arthritis and Lupus. I have also help develop a robust
model for assessing suppression of bone formation on treatment with glucocorticoids which are
extensively used for inflammatory conditions in the clinic.
In this period, I have also been involved with basic studies looking at effects of inflammatory
cytokines on osteoclastogenic mechanisms
I have also been involved in working with multiple project teams and foster interactions with
academia to move the project science forward in a time effective and efficient fashion.
POST-DOCTORAL / RESEARCH FACULTY RESEARCH EXPERIENCE: 8 YEARS (2000-
2009)
1. Research Fellow in Rheumatology, Mayo Clinic, Rochester, MN, USA (September 2000 -
September 2001).
I studied the Immunoglobulin repertoire in human colon cancers with the aim of developing a
possible therapy. During this period, I gained experience in Immunological and Molecular
Biological Techniques and routinely carried out Laser Capture of cells from colon cancer tissue
specimens, Histochemical staining, PCR, cloning and sequencing of Immunoglobulin chains and
their analysis using web based programs.
2. Research Associate in Endocrinology/ Assistant Professor of Medicine, Mayo Medical
School, Mayo Clinic, Rochester, MN, USA (September 2001-2009).
W ith Dr. Sundeep Khosla and Dr. Lawrence Riggs extensively studied effects of estrogen
signaling using genetically modified murine models of estrogen receptors, namely the Estrogen
Receptor α Knock Out (ERKO), Non Classical Estrogen Receptor alpha Knock -In (NERKI) and
established the distinct roles of classical and non-classical estrogen signaling via the Estrogen
Receptor alpha in these models both in bone and fat cells.
Another area of focus during this time was the effects of sex steroids on aging bone and bone
marrow stromal progenitor cell commitment to osteoblasts and /or adipocytes with hormone
therapy. During this period also developed protocols for bone cortical explant cells and their
trans-differentiation to adipocyte like cells in the presence of biochemicals / drugs
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FARHAN ASAD SYED • Page 4 • aca24h@r.postjobfree.com
PRE-DOCTORAL RESEARCH EXPERIENCE: 5 YEARS (1995-2000).
W orked in the field of free radical biology with special emphasis on macromolecular damage.
Studied the potential prooxidant / antioxidant roles for Bilirubin and Bileverdin and established
their capacity to cause DNA damage by generation of oxygen free radicals (see publicat ions).
RESEARCH PUBLICATIONS/ INVITED REVIEWS/ BOOK CHAPTERS IN THE BONE / AGING FIELD
(Listed select publications of a total of 16)
NOTE: Name is listed as S.F. Asad on initial publications from India on PubMed
1. V.H. Urbieta Caceres, F.A. Syed et al, (2012). Age-dependent Renal Cortical Microvascular Loss
in Female Mice. Am. J. Physiol. Endocrinol. Metab.,302, E979-986
2. F.A. Syed, U.I.L. Modder et al, (2010). Effects of chronic estrogen tre atment on modulating age
related bone loss in female mice. J. Bone. Miner. Res., 25, 2438-2446.
3. F.A. Syed, M.J. Oursler et al, (2008). Effects of estrogen therapy on bone marrow adipocytes in
postmenopausal osteoporotic women. Osteoporosis Int., 19, 1323-1330. (This paper was cited
by the Osteo Bone Key in 2008).
4. F.A. Syed, U.I.L. Moedder et al, (2005). Skeletal effects of estrogen are mediated by opposing
actions of classical and non-classical estrogen receptor pathways. J. Bone Miner. Res., 20, 1992-
2001.
5. F.A. Syed, J. Iqbal et al, (2010). Clinical, Cellular and Molecular Phenotypes of the Aging Bone.
Interdiscip. Top. Gerontol, 37, 175-192.
6. F.A.Syed, M.E. Mc-GeeLawrence et al, (2013). Anim al Models of Bone Disease. In: Animal
Models for the Study of Human Disease. Michael Conn (Eds). Academic Press.(in press)
RESEARCH PUBLICATIONS/ INVITED REVIEWS/ BOOK CHAPTERS IN THE DNA DAMAGE /
BIOCHEMISTRY / MOLECULAR BIOLOGY FIELD
(Listed select publications of a total of 10)
NOTE: Name is listed as S.F. Asad on initial publications from India on PubMed
1. S. F Asad, S. Singh, A. Ahmad and S. M. Hadi (1999). Bilirubin-Cu (II) complex degrades DNA.
Biochim. Biophys. Acta., 1428, 201-208.
2. A. Ahmad, S. F. Asad, S. Singh and S. M. Hadi (2000). DNA breakage by resveratrol and Cu (II):
reaction mechanism and bacteriophage inactivation. Cancer Lett., 154, 29-37.
3. S. M. Hadi, S. F. Asad, S. Singh and A. Ahmad (2000). A putative mechanism for anticancer and
apoptosis inducing properties of plant derived polyphenolic compounds .IUBMB Life, 50, 167 -171.
4. S. F. Asad, S.Singh, Aamir Ahmad, Nizam U. Khan and S.M. Hadi (2001). Prooxidant and
Antioxidant activities of Bilirubin and its metabolic precursor Biliverdin: A structure –activity study.
Chemico-Biological Interactions, 137, 59-74.
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FARHAN ASAD SYED • Page 5 • aca24h@r.postjobfree.com
ABSTRACTS IN NATIONAL & INTERNATIONAL MEETINGS (of a total of 25)
1. F.A.Syed, S. Bryant, R. Mario et al, (2012) “Identification of an Optimal Time Point and Anti-
Inflammatory Compound for Testing Bone Healing in a mouse CIA Model of Rheumatoid
Arthritis.” Presented at the 99th Annual Conference of the American Society of Immunologists,
Boston, MA, May 2012.
2. B. Harvey, F. Syed, Z. Kaymakcalan (2011) "TNF-mediated Up-regulation of RANKL in
Fibroblast-like Synoviocytes Leads to Human Osteoclast Differentiation." Presented at the 13th
International TNF Conference, Hyogo, Japan, May 2011. [Plenary Poster Presentation].
REFERENCES: Available upon request
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