Amritha Sreekumar, M.Sc

IISER Mohali, Punjab, India

Phone number: 917********* email: ac9p4r@r.postjobfree.com Curriculum Vitae

Current position

Junior Research Fellow, IISER Mohali

I am working at Immunobiology lab in IISER Mohali under the joint guidance of Dr. Kausik Chattopadhyay and Dr. Arunika Mukhopadhaya. Vibrio parahaemolyticus is the causative organism responsible for the major marine food-poisoning cases reported all over the globe. TDH is identified as its prominent virulence factor. Currently, we were looking at the innate immunomodulatory responses evoked by TDH in various macrophage cell lines. We aim to understand the downstream signaling cascades triggered upon the TDH mediated pathogenesis.

Education and training

September 2016 – August 2017 Project fellow, IISER Mohali

I worked as project fellow at Cytolysin study group in IISER Mohali under the guidance of Dr. Kausik Chattopadhyay. We were keen to understand the mechanistic details involved in membrane channel formation by bacterial pore-forming toxins.

August 2013 - May 2016 Master of Science (Biological Sciences), IISER Mohali CPI: 7.5

The course work emphases on the study of advanced experimental, theoretical and computational aspects in the field of Biological Sciences. August 2011 – May 2013 Bachelor of Science (Science), Indian Institute of Science CPI: 6.6

Courses of study encompassed fundamental core courses of Mathematics, Physics, Chemistry and Biology. Theoretical courses were supplemented with corresponding lab courses.

June 2008 – March 2010 High School Degree, Government Model Higher Secondary School

(Science) CPI: 9.2

Date of birth: June 17, 1992

Place of birth: Kerala, India

Nationality: Indian

TOEFL score: 91

Amritha Sreekumar, M.Sc

IISER Mohali, Punjab, India

Phone number: 917********* email: ac9p4r@r.postjobfree.com Fellowships/Awards

August 2017 – July 2019

Junior Research Fellowship, Council of Scientific & Industrial Research (CSIR)

- In Life sciences, All-India Rank 310

May 2016 – May 2019

Graduate Aptitude Test in Engineering

- In Life sciences, All-India Rank 517

August 2011 – May 2016

INSPIRE Fellowship by DST, Government of India

- To assist the study at IISER Mohali

May 2014 – August 2014

Summer Research Fellowship of Indian Academy of Sciences (IAS)

- Summer Research Project at National Institute of Research in Reproductive Health, NIRRH, Mumbai, India

- Supervisor: Dr. Bhakti R. Pathak, Scientist (Structural Biology), NIRRH March 2008

Award for Academic Excellence, State Government of Kerala, India Projects undertaken

May 2015-Aug 2016

Masters Thesis

The Role of Low pH in the Structure-Function mechanism of membrane pore- forming toxin – Helicobacter pylori TlyA

Elucidating the virulence mechanism of the non-conventional hemolysin of Helicobacter pylori- HP TlyA

Supervisor: Dr. Kausik Chattopadhyay, Associate professor (Biology) Protein Science, Design & Engineering lab, IISER Mohali May-July, 2014-08-16

Cloning and Expression of CRISP 3-ICR domain in Pichia pastoris Guide: Dr. Bhakti R Pathak, National Institute for Research in Reproductive Health, Mumbai, India)

Amritha Sreekumar, M.Sc

IISER Mohali, Punjab, India

Phone number: 917********* email: ac9p4r@r.postjobfree.com June – August, 2013

The evaluation of the role of C H···F hydrogen bonds in crystal altering the packing modes in the presence of strong hydrogen bond Guide: Dr. Angshuman Roy Chowdhury, IISER Mohali, India May – July, 2012

Construction of Phylogenetic tree of closely related Bacterial species using Bioinformatic tools.

Mentor: Dr. Somdutta Sinha, IISER Mohali, India

Skills

Cloning, Protein purification and characterization, Fluorimetric and spectrometric techniques, Surface Plasmon Resonance, Analytical Ultracentrifugation, Isothermal Titration Calorimetry, Differential Scanning Calorimetry, HPLC, FPLC etc.

Cell-culture and tissue culture maintenance, ELISA, Western Blotting, RT PCR etc.

Expert in animal handling (strains Balb/c and C57BL/6) Publication

G. Kaur, S. Singh, A. Sreekumar, A.R. Choudhury, The evaluation of the role of C H···F hydrogen bonds in crystal altering the packing modes in the presence of strong hydrogen bond, Journal of Molecular Structure

(2015), doi: 10.1016/j.molstruc.2015.10.105

A.K. Mondal., A. Sreekumar., N. Kundu., R. Kathuria., P. Verma.,S.Gandhi and K. Chattopadhyay., Structural basis and functional implications of the membrane pore-formation mechanisms of bacterial pore- forming toxins, Biochemical and Biophysical Roles of Cell Surface Molecules, Advances in Experimental Medicine and Biology 1112, https://doi.org/10.1007/978-***-**-****-0_19 Contact details of referees

1. Dr. Angshuman Roy Choudhury

Assistant professor (Chemistry)

Indian Institute of Science Education and Research (IISER) Mohali, India Phone: +91-172-*******

Email: ac9p4r@r.postjobfree.com

2. Dr. Bhakti R. Pathak

Scientist 'E',

Structural Biology

Phone: +(91-22-241*-****

Email: ac9p4r@r.postjobfree.com

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