Expertise in wet lab chemistry, proficient in HPLC.

Prakriya Shrestha

**** * ***** ** **** ***, Chicago, IL 60605 • 312-***-**** • *********@*****.***

Experience Summary:

• Eight years of pharmaceutical experience in quality control laboratory executing qualitative and quantitative analysis of pharmaceutical products and pharmaceutical raw materials

• Proficiency with Ultra High-Performance Liquid Chromatography (Agilent/Waters/Shimadzu

[Nexera-X2]), Headspace-Gas Chromatography (PerkinElmer), Mass Spectrometry (Agilent), UV/Vis Spectroscopy (Shimadzu), Fourier Transform Infra-red (Shimadzu), Nuclear Magnetic Resonance (NMR), Karl Fischer Titrator

• Possess in-depth knowledge on cGMP, GLP, ICH and FDA guidelines.

• Good interpersonal skills, commitment, result oriented, hard working with zeal to learn new technologies and commence challenging tasks

• Readiness to learn and adapt new advancing technologies

• Dedicated and self-motivated achiever who is committed to success and skilled at juggling multiple tasks in a high-pressured environment

Education:

Southern Illinois University Edwardsville (SIUE) Edwardsville, IL Masters of Science in Chemistry Graduated: May, 2019 GPA: 4.0/4.0

Kathmandu University Dhulikhel, Nepal

Masters in Pharmacy Graduated: November, 2015

GPA: 3.70/4.0

Kathmandu University Dhulikhel, Nepal

Bachelor in Pharmacy Graduated: August, 2009

GPA: 3.42/4.0

Research Experience

SIUE Edwardsville, IL

Advisor: Dr. Kevin R. Tucker Spring 2018- Spring 2019 Ionization efficiency for environmentally relevant compounds using atmospheric pressure photoionization versus electrospray ionization.

• Perform optimization of Agilent Mass Spectrometry parameters manually using electrospray ionization

(ESI) and atmospheric pressure photo ionization (APPI) for analysis of different antibiotics and endocrine disrupting compounds

• Develop method for detection of low concentration of different antibiotics and endocrine disrupting compounds using LC/MS/MS utilizing two different ionization sources, ESI and APPI

• Studied fragmentation pattern of different antibiotics and endocrine disrupting compounds in different ionization sources, ESI and APPI

• Perform Solid Phase Extraction (SPE) for analysis of antibiotics and endocrine disrupting compounds in wastewater

Kathmandu University Dhulikhel, Nepal

Advisor: Dr. Rajani Shakya 2013-2015

Formulation and In-Vitro Evaluation of Gastroretentive Floating Pulsatile Metoprolol Tartrate Microsphere.

• Formulated Metoprolol Tartrate microsphere using different polymer matrix

• Characterized the physico-chemical properties of the formulated microsphere

• Studied the pulsatile release pattern of the Metoprolol Tartrate from the formulated microsphere Shrestha, Page 2of 2

Professional Experience:

SIUE Edwardsville, IL

Teaching Assistant August 2017- May 2019

• Conduct General Chemistry lab and Organic Chemistry lab

• Comprehensively demonstrate wet lab techniques involved to perform experiments using principles of acid base titrations, gravimetric analysis, spectrophotometric analysis, chromatography, etc

• Train students on general chemistry, basic organic chemistry skills and introduce to instrumentation techniques such as UV Vis Spectrophotometer, Gas Chromatography and Infrared Spectrophotometer.

• Teach and enforce safety measures to students in lab

• Assist students in lab and help solve problems within their assigned lab reports

• Grade lab reports and exams with attention to detail Deurali Janta Pharmaceuticals Pvt. Ltd Dhapasi, Nepal Quality Control Officer Nov. 2009- July 2017

• Implemented Quality System process according to the Current Good Manufacturing Practice (cGMP), Good Laboratory Practice (GLP) and International Organization of Standards (ISO) guidelines and insured the quality as per the rules and regulation of Department of Drugs Administration (DDA), Nepal

• Performed qualitative and quantitative analysis of different raw materials, in process materials and finished products by using different instruments as Karl Fisher Titrator, UV visible Spectrophotometer, Dissolution Test Apparatus, Viscometer, HPLC and GC

• Ensured implementation of Total Quality Management (TQM), performed internal audit, assisted in the development of appropriate corrective and preventative action (CAPA) to prevent recurrence of error.

• Took part in production control activities such as sampling of raw materials, packaging materials, excipients, in-process materials, bulk products.

• Prepared product specification, in-process specification, raw material specification, packaging materials specification, testing procedure and SOPs.

• Recorded and prepared reports of test results in a timely manner

• Worked with R & D team for developing manufacturing and analysis protocols for development of new products along with the stability analysis of the finished products.

• Performed method validation for new method of analysis of drug.

• Developed and implemented corrections and corrective actions for the quality issues, by coordination with quality assurance, production and management.

• Performed stability study and monitored the shelf life of products Honors and Activities:

• Received Graduate Teaching Assistantship at SIUE Fall 2017- Spring 2019

• Received badging for GC, HPLC and GMP/GLP in SIUE Spring 2018

• Received SIUE Research Grant for Graduate Students 2018

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