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Assistant Engineering

Quebec City, Quebec, Canada
February 28, 2019

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Date of Birth: **/**/****

Mobile: +1-581-***-****


D6707, Pavillon Alphonse-Marie-Parent,

****, *** ** *'Universite, Universite Laval,

Québec (QC) Canada G1V 0A7

Jifu Mao


University Laval (UL) Quebec, Canada 09/2012-10/2017 PhD in Experimental Medicine (GPA: 3.89/4.33)

Thesis title: Functional polypyrrole core-shell particles and flexible membranes for biomedical applications Supervisor: Prof. Ze Zhang

Beijing University of Chemical Technology (BUCT) Beijing, P.R. China 09/2009-07/2012 M.E. in Department of Material Science & Engineering (GPA: 3.5/4.0; Rank: 34/398) Thesis title: Biomineralization of modified carbon nanotubes and preparation the nanofibrous composite scaffold Supervisor: Prof. Qing Cai

Beijing University of Chemical Technology (BUCT) Beijing, P.R. China 09/2005-07/2009 B.E. in Department of Biomaterials (GPA: 3.2/4.0; Rank: 7/57) Thesis title: Preparation of Poly[(amino acid ester) phosphazenes] microparticles via electrospray for drug delivery Supervisor: Prof. Qing Cai


Research Center of the Quebec University Hospital-Laval University Quebec, Canada 09/2017- Present Postdoctoral Fellow

Supervisor: Prof. Mahmoud Rouabhia and Prof. Ze Zhang RESEARCH SKILLS

Polymer Science and Engineering:

Polymer Synthesis: Emulsion polymerization (polypyrrole (PPy) and its copolymers), Interfacial polymerization (PPy), Electropolymerization (PPy), Ring-opening polymerization (PLA, PCL, polyphosphazene).

Preparation of (nano) polymeric materials: Template method, Electrospinning, Electrospray, Phase Separation, surface modification (biomacromolecules covalent grafting, biomineralization).

Characterization of polymeric materials (skilled operation): Conventional methods: SEM, TEM, DSC, TGA, FTIR, XPS, XRD, GPC, NMR, Contact angle test, AFM Specific methods: Four point probe and electrochemistry tests (CV, EIS) Biomedical Engineering:

Biomaterials: Long-time engaged in biomaterials research including artificial heart valve, stent grafts, tissue engineering, biomineralization, materials-cell interaction.

Cell culture: Received the biosafety laboratory training; Familiar with the working in culture room; Cell culture operation independently.

Histology: Familiar with histological section work (embedding, cutting, staining, immunohistochemical analysis)


Principal Investigated Project:

“Functionalized electrically conductive polymers for biomedical applications”, Natural Sciences and Engineering Research Council of Canada

Participated projects:


1. “Flexible conductive polymer membranes”, Natural Sciences and Engineering Research Council of Canada. 2. “Cell response and wound healing through electrical stimulation mediated by conductive scaffold”, Canadian Institutes of Health Research.

3. “Cell response to electrical stimulation mediated by conductive scaffold”, Canadian Institutes of Health Research. China:

1. National Basic Research Program of China (2012CB933904). 2. National Natural Science Foundation of China (No. 50873012, NO. 51102008 and No. 51073016). 3. National High Technology Research and Development Program of China (2011AA030102). 2

Research Center of the Quebec University Hospital-Laval University (Postdoc) Faculty of Dentistry Université Laval Québec, Canada 09/2017- Present Project 1: Pre-clinic research on modified textile based vascular prosthesis (sponsored by ST. JUDE MEDICAL).

Characterization of sealant modified commercial fabric vascular prosthesis (Vascutek and Cooley).

Histological and immunohistochemical evaluation of the textile based vascular explanted from dogs. Project 2: Electrical stimulation of human skin cells using flexible polypyrrole (PPy) for wound healing applications.

Preparation of fiber reinforced flexible PPy membrane.

Culture of cells relevant to wound healing in response to electrical stimulation.

Research Center of the Quebec University Hospital-Laval University (PhD) Hôpital Saint-François d'Assise Université Laval Québec, Canada 09/2012-10/2017 Project 1: Functionalized electrically conductive polymers and biomaterials for biomedical applications.

Template-assisted interfacial polymerization (TIP) was designed for the first time to prepare a soft and mechanically processable PPy membrane. The PPy membrane presents an excellent flexibility and processablity at both room temperature and -196 C. This membrane might be incorporated with fabric to enhance the mechanical properties for nerve repair, wound healing, and using as patches to rewire/repair infarcted heart tissue.

A novel reactivity-driven mechanism was proposed to synthesize the core-shell functionalized conductive polymer particles. A novel modular approach was proposed to immobilize biomolecules to a micro/nano structured surface via combination of the functionalized PPy particles and flexible PPy membrane. The functionalized conductive PPy might be introduced as a washable coating to fabric by covalent grafting. And this coating layer can also incorporate biomolecules to gain specific functions. Project 2: Research on artificial heart valves and pericardia (collaborated with Prof. Robert Guidoin)

Evaluation of clinically retrieved heart valves with textile ring in comparison with as-manufactured commercial heart valves to investigate the noncalcific structural deteriorations, emphasizing the importance of textile protection.

Evaluation of bovine, equine, porcine, kangaroo and donkey pericardia to seek potential alternative tissues suitable to manufacture the leaflets of percutaneous aortic valves.

Advanced Composite Center (MSc)

State Key Laboratory of Organic-Inorganic Composites (BUCT) Beijing, China 09/2009 - 07/2012 Project: Guided Tissue Regeneration Membranes Consist of Biodegradable Nanofibers with Gradient Structure.

Prepared PLGA and PLLA nanofibrous and macroporous 3D scaffolds via phase separation combined with particle-leaching.

Fabricated the WMNTs-CaP composite by biomimetic mineralization of modified MWNTs from simulated body fluid with continuous CO2 bubbling. Incorporation of WMNTs-CaP into the nanofibrous and macroporous 3D scaffolds to improve the compressive properties.

Advanced Composite Center (BS) BUCT Beijing, China 10/2008 - 06/2009 Project: Fundamental research on preparation of Poly[(amino acid ester) phosphazenes] microparticles via electrospray for drug delivery.


Journals Cited by SCI:

1. Jifu Mao, M Rouabhia, Z Zhang. A novel modular approach to prepare a multi-biofunctional surface by using flexible and electrically conducting polypyrrole membranes and functional particles. J Mater Chem B 2019 5(7):755-762 (IF= 4.776).

2. Jifu Mao, Z Zhang. Polypyrrole as electrically conductive biomaterials: synthesis, biofunctionalization, potential applications and challenges. Adv Exp Med Biol. 2018;1078:347-370 (IF= 1.760). 3. Jifu Mao, CJ Li, HJ Park, M Rouabhia, Z Zhang. Conductive polymer waving in liquid nitrogen. ACS Nano 2017(10): 104**-*****. (IF= 13.709).

4. Jifu Mao, Z Zhang. One-step synthesis of reactivity-driven core-shell electrically conducting structured particles for biomedical applications. J Mater Chem B 2016(4):5429-5436. (IF= 4.776). 5. Jifu Mao, Z Zhang. Conductive Poly(pyrrole-co-(1-(2-carboxyethyl)pyrrole)) core-shell particles:synthesis, characterization, and optimization. Polymer 2016(105):113-123. (IF= 3.483). 6. Jifu Mao, S Duan, AN Song, Q Cai, XL Deng, XP Yang. Macroporous and nanofibrous poly(Lactide-co-Glycolide)(50/50) scaffolds via phase separation combined with particle-leaching. Mater Sci &Eng C 2012(32):1407-1414. (IF= 5.080).

7. Q Cai, Jifu Mao, XL Li, XP Yang. Macroporous and nanofibrous PLLA scaffolds reinforced with calcium phosphate-coated multiwalled carbon nanotubes. Mater Lett 2014(128):238-241. (IF= 2.687) 8. N Mighri, Jifu Mao, F Mighri, A Ajji, M Rouabhia. Chitosan-coated collagen membranes promote chondrocyte adhesion, growth, and interleukin-6 secretion. Materials 2015(8):7673-7689. (IF= 2.467) 9. M Rouabhia, N Mighri, Jifu Mao, HJ Park, F Mighri, A Ajji, Z Zhang. Surface treatment with amino acids of 3

porous collagen based scaffolds to improve cell adhesion and proliferation. Can J Chem Eng 2018(10), 2236-2242

(IF= 1.265)

10. S Duan, XP Yang, Jifu Mao, B Qi, Q, Cai, H Shen, F Yang, XL Deng, SG Wang. Osteocompatibilitity evaluation of poly(glycine ethyl ester-co-alanine ethyl ester)phosphazene with honeycomb-patterned surface topography. J. Biomed. Mater. Res. A. 2013(101): 307-317. (IF= 3.231) 11. D, Shun, XP Yang, F Mei, Y Tang, XL Li, YZ Shi, Jifu Mao, HQ Zhang, Q Cai. Enhanced osteogenic differentiation of mesenchymal stem cells on poly (l lactide) nanofibrous scaffolds containing carbon nanomaterials. J. Biomed. Mater. Res. A. 2015(103): 1424-1435. (IF= 3.231) 12. YY Zhou, LW, Jifu Mao, Q Cai, RG Jin. Preparation of polyphazene microparticles via electrospray. Acta Polymerica Sinica 2010;1:125-130. (IF= 0.656)

Other Journals:

1. Jifu Mao, YL Wang, E Philippe, I Vesely, T Cianciulli, D How, J-M Bourget, Z Zhang, L Germain, R guidoin. Microstructural alterations owing to handling of bovine pericardium to manufacture bioprosthetic heart valves: a potential risk for cusp dehiscence. Morphologie 2017(101):77-87. 2. SY Meng, Jifu Mao, EN Rouse, G Le-Bel, J-M Bourget, R Reed, D How, L Germain, Z Zhang, R Guidoin. Assessment of Red Kangaroo pericardium as a material source for the manufacture of percutaneous heart valves. Morphologie. (In Press)

3. R Guidoin, Jifu Mao, R Zegdi, J Lin, D How, E Philippe, T Cianciulli, L Wang, Z Zhang. Transcatheter heart valve crimping and expansion: commentary. J Med & Surg Pathol 2017(2): 144. 4. R Guidoin, R Zegdi, J Lin, Jifu Mao, O Rochette-Drouin, D How, XN Guan, P Bruneval, L Wang, L Germain, Z Zhang. Transcatheter heart valve crimping and the protecting effects of a polyester cuff. Morphologie 2016(100.331): 234-244.

5. J-M Bourget, R Zegdi, J Lin, P Wawryko, Y Merhi, C Convelbo, Jifu Mao, YJ Fu, TT Xu, NO Merkel, L Wang, L Germain, Z Zhang, R Guidoin. Correlation between structural changes and acute thrombogenicity in transcatheter pericardium valves after crimping and balloon deployment. Morphologie 2017(101.332): 19-32.


YJ Fu, Jifu Mao, B Li, QH Zou, B Liu, M Nutley, A Verdant, F Dagenais, J Lin, J-M Bourget, SJ Niciforovic, Z Zhang, G Dionne, G Samis, P Langis, L Wang, J-F Bonneville, P Jetty, L Germain, Y Douville, R Guidoin. Early adverse events following the deployment of Cook Zenith stent-grafts in the descending thoracic aorta-examination of the explanted devices. Cardiovascular Explants: Biofunctionality, Biodurability, and Biocompatibility. Springer

(In Press)

Under review:

1. Jifu Mao, A Rassoli, YW Tong, E Rouse, G Le-Bel, D How, L Germain, N Fatouraee, Z Zhang, R Reed, R Guidoin. Donkey pericardium compares favorably with commercial xenopericardia considered to manufacture transcutaneous heart valves. Biomed Mater (Under review) (IF= 2.897, 二区) ACADEMIC ACTIVITIES

34th Annual Meeting of the Canadian Biomaterials Society 05/2018 Victoria, British Columbia, Canada

Oral 1: Electrospun fiber reinforced flexible polypyrrole membrane for biomedical applications Oral 2: Multi-biofunctional surface constructed by flexible and conductive polypyrrole membranes and functional particles

37th Canadian High Polymer Forum 08/2016

Gananoque, Ontario, Canada

Oral: Highly flexible free-standing conductive polypyrrole membrane

The 10th World Biomaterials Congress 06/2016

Montreal, Canada

Poster: A flexible free-Standing conductive polypyrrole membrane with asymmetric surface structures for biomedical application.

32nd Annual Meeting of The Canadian Biomaterials Society 05/2015 Toronto, Ontario, Canada

Oral: Chemical synthesis of carboxyl functionalized polypyrrole particles and covalent attachment of antibody for biosensor

31st Annual Meeting of The Canadian Biomaterials Society 06/2014 Halifax, Nova Scotia, Canada

Poster: Covalent attachment of antibody to electrically conductive poly(pyrrole-co-(1-(2-carboxyethyl) pyrrole)) particles

30th Annual Meeting of The Canadian Biomaterials Society 05/2013 Ottawa, Ontario, Canada

Poster: Synthesis and characterization of functionalized polypyrrole particles

2013 Annual Meeting of the Society For Biomaterials 04/2013 Boston, the United States (US)

Poster: Preparation and characterization of functional polypyrrole particles 4

The 9th World Biomaterials Congress 06/2012

Chengdu, P.R. China

Poster: Biomimetic mineralization of modified multi-walled carbon nanotubes from simulated fluid with continuous CO2 Bubbling.


Supervising Assistant, University Laval Québec, Canada 09/2012 - present Test and lab manager: training and supervising the summer students (14 medical students from Shanghai Jiaotong University; 3 students work on textile-based vascular graft from Europe) and junior graduates (4 PhD candidates from Medicine Faculty of Laval University, 2 exchange PhD students from College of Textiles of Donghua University) on instruments operation, research design and the experiments. Teaching Assistant, Beijing University of Chemical Technology Beijing, P.R. China 12/2010 - 01/2011 Undergraduate Course: Biomaterials Lab


Committee member (Treasurer), The Quebec City Student Chapter of the Canadian Biomaterials Society University Laval, Quebec, Canada 10/2014-07/2017

Vice-president, Psychological Association of Beijing University of Chemical Technology BUCT, Beijing, China 09/2010-09/2012


34th Annual Meeting Of The Canadian Biomaterials Society Travel Award 05/2018

Bourse d'excellence du Département de Chirugie 05/2017

Bourse de la Fondation du CHU de Québec (C$ 5,500) 11/2016

Bourse de la Fondation du CHU de Québec (C$ 5,000) 11/2015

Bourse de recrutement au doctorat Pierre J. Durand (C$ 10,000) 09/2012

Beijing Outstanding graduate (5%) 06/2012

Excellent Cadre of Graduate Students 11/2011

The First Prize of Graduates Scholarship (5%) 10/2010

Excellent Graduate Student 10/2010

Excellent Cadre of Students 01/2010

Outstanding Undergraduate Thesis (10%) 06/2009

The Third Prize of People’s Studentship 04/2009

The Second Prize of People’s Studentship (10%) 09/2008

The First Prize of People’s Studentship (5%) 04/2008

Merit Undergraduate Student 11/2007

The Third Prize of People’s Studentship 11/2007

Excellent League Member 05/2007

The Second Prize of People’s Studentship (10%) 04/2007

The Third Prize of People’s Studentship 10/2006


Computing skills: Programming languages: National Computer Rank Examination Certificate Grade2(C) Other Software: Microsoft Office, Photoshop CS4, and Chemical Analysis Software

Languages: Chinese (native), English (excellent), French (basic)

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