Sarah A. Bradner *

Sarah A. Bradner, PhD

*** ****** **. ***. *, Cambridge, MA 02140

Email: ac8ed5@r.postjobfree.com Mobile: 860-***-**** Qualification Summary

Data-driven research background and trained for both analytical and intuitive thinking. I approach problems through visualization and connection of patterns found within interdisciplinary scientific theory. By developing this approach, I systematically implement facile mechanistic motifs for advanced material outputs. My research background bridges material science and biology to gain multiscale understanding of natural systems aimed towards bioinspired structure-function properties. Through top-down and bottom-up consideration of design inputs, I have developed a strong background in polymer science, biopolymer processing, and nano to macroscale characterization. Material Development: Biopolymer processing, structure-function relationships, fibrous materials, polymer self- assembly, polymer-solvent dynamics, bioinspired material design, peptide material functionalization for bioactive response, silk fibroin platforms: gel, fiber, film, and hard materials. Characterization: FTIR, DMA, instron testing, TGA, polarized microscopy/birefringence, SEM Biomedical Engineering: In vitro and in vivo data processing and analyses, drug delivery material design, cell culture

Mechanical Design: Medical Device Fabrication, Prototyping, product development, scale-up PROFESSIONAL

Tufts University 2014-2019

Dept. of Biomedical Engineering- Research Assistant/Teacher Assistant

- Developed methodology for a silk hydrogel microfiber platform for application in fibrous tissue engineering scaffolds, stabilized drug delivery, and conductive fibers. Adapted compression molding techniques and post-processing methodology for repeatable and robust material outputs.

- Systematically functionalized the material platform to elucidate and decouple structural alterations.

- Characterized multiscale structure-function polymeric relationships and role in macroscale bulk material properties.

- Advanced microfiber design in textile brain and twist fiber to bundle assembly

- Developed rapid fabrication method for gel fibers via hydrodynamic coaxial spinning for comparison with batch fabrication methodology

- Fabricated fibers with length-scale relevance for muscle skeletal tissue engineering and produced custom strainers for static bioreactor culture.

- Adapted fibers in interdisciplinary project to develop a bioinspired fish swimming robot design and presented work at the Robosoft international conference.

- Developed aqueous based processing for fabricating novel ear tubes with resorbable and drug-eluting technology

- Assisted with initial stages PavMed ear tube device product development

- Optimized ear tube fabrication for scale-up micromold biopolymer injection design Union College 2011-2014

Dept.of Bioengineering- Research Assistant

- Worked under the advisement of Dr. Ashok Ramasubramanian

- Utilized chick embryo culture for experimental manipulation requiring micromanipulation and dexterity

- Developed methodology for assessing biomechanical role of extracellular matrix component, Hyaluronic acid, and head/neck flexure on cardiac looping

- Collaborated with Professor Takashi Buma in Electrical Engineering to characterize heart matrix through optical coherence tomography

Yale University Summer 2013

Dept. of Biomedical Engineering

- Worked under the advisement of Dr. Laura Niklason and Dr. Xiangru Xu Sarah A. Bradner 2

- Performed RNA isolation of human aortic tissue

- Quantified and characterized elastin expression in aging human aorta through RT-qPCR EDUCATION

Tufts University, Medford, MA

Ph.D., Biomedical Engineering Fall 2014-Present

Advisor: David L. Kaplan

GPA: 3.63

Thesis Topic: Systematic Silk Hydrogel Microfiber Design: Platform for Meticulous Fibrous Biomaterial Scaffolds Union College, Schenectady, NY

B.A.Sc., Bioengineering with Departmental Honors 2014 Minor: Electrical Engineering

Coursework: Graphics & Image Processing, Biomechanics, Electrical Circuits, Discrete Systems, Molecular Biology of the Cell, Probability & Digital Communications, Biomechanics of Human Motion, Biomedical Instrumentation, Orthopedic Biomechanics, Mechanobiology, Semiconductors Devices and Circuits, Medical Devices, Molecular Biotechnology, Biomaterials and Regenerative Medicine, Analytical Tools for Biomedical Engineering, Physical Chemistry of Polymers, Creative Design Process of Products, Lean Six Sigma. AWARDS

Integrative Graduate Education and Research Traineeship: Soft Material Robotics 2015 – 2017 Lean Six Sigma Black Belt Recipient May 2017

Soft Materials Robotics IGERT Innovation Challenge Prize Recipient 1st place October 2017 TEACHING EXPERIENCE

Tufts University, Medford, MA

Teaching Assistant- Biomaterials and Regenerative Medicine Fall 2015 RELATED EXPERIENCE

Instrumentation Laboratory, Bedford, MA

Lean Six Sigma Consulting March – May 2017

Applied Lean Six Sigma and implemented company changes in the Change Proposal Process utilized in quality control of company instruments.

PUBLICATIONS

Ramasubramanian, A.; Chu Lagraff, Q.B.; Buma, T.; Chico, K.T.; Carnes, M.E., Burnett, K.R.; Bradner, S.A. and Gordon, S.S. On the role of intrinsic and extrinsic forces in early cardiac S looping. Developmental Dynamics., 2013, 242(7), pp.801-816. Ramasubramanian, A.; Capaldi. X.; Bradner S.A.; Gangi. L,; On the Biomechanics of Cardiac S-looping: insights from modeling and perturbation studies. The Journal of Biomechanical Engineering. In press. 2018 Bradner, S.A.; Partlow, B.P.; Cebe, P., Omenetto, F.G.; Kaplan, D.L., Fabrication of elastomeric silk fibers. Biopolymers, 107(9).2017

Donatelli, C. M.; Bradner, S.A.; Mathews, J.; Sanders, E.; Culligan, C.; Kaplan, D.L.; Tytell, E.D.; Prototype of a fish inspired swimming silk robot. In 2018 IEEE International Conference on Soft Robotics (RoboSoft), pp. 60-65. IEEE, 2018. Bradner, S.A; Galaiya, D.; Raol, N.; Kaplan, D.L.; Hartnick, C.J.; Silk Protein Bioresorbable, Drug-Eluting Ear Tubes: Proof of Concept. Advanced Healthcare Materials. 2018

Sarah A. Bradner 3

Bradner, S.A; McGill, M.; Golding, A.; Grudt, R.; Kaplan, D.L, Silk Hydrogel Microfibers for Biomimetic Fibrous Material Design. In review, Macromolecular Materials and Engineering. 2018 Bradner, S.A; Kaplan D.L.; Suprafibrillar Architectures for Complex Bone-Tendon Matrix Dynamics: Biomimetic Design for Advanced Functional Materials. In preparation. 2018 PRESENTATIONS

Bradner, S.A.; The Role of Extracellular Matrix in Heart Development. Oral Presentation. National Conference on Undergraduate Research, LaSalle, WI, USA. 2013.

Bradner, S.A., ; Partlow, B.P.; Cebe, P.; Omenetto, F.G. and Kaplan, D.L., Fabrication of Elastomeric Silk Fibers. Oral presentation. Materials Research Symposium, Boston, MA, USA. 2017 Donatelli, C. M.; Bradner, S.A.;Mathews, J.;Sanders, E.; Culligan, C.; Kaplan, D.L.; Tytell, E.D., Prototype of a fish inspired swimming silk robot. Poster presentation. IEEE RAS International Conference on Soft Robotics, Livorno, Italy. 2018 Bradner, S.A; McGill, M.; Golding, A.; Grudt, R.; Kaplan, D.L, Silk Hydrogel Microfibers for Biomimetic Fibrous Material Design. In Progress. Poster presentation. Biomedical Engineering Society Annual Meeting, Atlanta, GA, USA. 2018 COMMUNITY OUTREACH

Bridge to Engineering Success at Tufts (BEST) Silk Workshop August 2017 Tufts University, Medford, MA

Tufts University Biomedical Engineering Research Scholars (TUBERS) Silk Workshop July 2018 Tufts University, Medford, MA

MENTORSHIP ROLES

Tufts University Undergraduates:

Luke Hanley 2015-2016

Allison Kumarasena 2017

High School Students:

Kenneth Wiggins Summer 2016

PROFESSIONAL AFFILIATIONS

Member Gamma Phi Beta Society 2012-Present

Member of Biomedical Engineering Society 2013-Present Member of Institute of Electrical and Electronics Engineers 2018-Present

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