Chemical Engineering Assistant

SHWETA MAPARI

**** ********* ***** (willing to relocate anywhere in the US) Phone: 785-***-****

Apt # 19-3, Lawrence, KS-66047 https://www.linkedin.com/in/shweta-mapari-aab71577/ ******.******@*****.*** EDUCATION

• Master of Science (with thesis) in Chemical Engineering GPA:3.46/4 University of Kansas, Lawrence, USA Aug 2015-Feb 2019

• Bachelor of Technology in Pharmaceutical Sciences and Technology GPA:7.39/10 Institute of Chemical Technology, Mumbai, India Aug 2009-June 2013 RESEARCH PROJECTS

• Antibiotic Molecular Design Using Artificial Bee Colony Optimization (Master’s Thesis) University of Kansas, Lawrence, Kansas Jan 2017 – Feb 2019

Developed quantitative structure property relationships (QSPRs) for minimum inhibitory concentration (MIC) and Log P values of different fluoroquinolones using 2D and 3D molecular descriptors

Formulated an optimization problem with structural feasibility constraints and an objective to derive novel antibiotic structures

Devised computer-aided molecular design (CAMD) based solution to optimization problem using Artificial Bee Colony algorithm

• Antibiotic Molecular Design Using Multi-Objective Optimization University of Kansas, Lawrence, Kansas June 2016 – Jan 2017

Developed QSPRs for MIC and toxicity values of different fluoroquinolones using 3D molecular descriptors

Formulated an optimization problem with the two QSPRs as objectives and structural feasibility constraints

Implemented CAMD approach to solve the optimization problem using Artificial Bee Colony algorithm

• Formulation Development of Self Micro-emulsifying Drug Delivery System (SMEDDS) Institute of Chemical Technology, Mumbai, India June 2014 – April 2015

Assisted in formulating a new drug delivery system for Camptothecin, a potent anticancer drug, using a hetero-lipid oil phase

Due to the side effects of Camptothecin, its oral dosage form has certain limitations

By incorporating it in the appropriate formula of SMEDDS, its solubility and bioavailability can be augmented which could lead to enhanced pharmacological activity.

• Formulation Development and Characterization of Clarithromycin Nanosuspension Institute of Chemical Technology, Mumbai, India Dec 2012 – May 2013

Developed a novel, nanotechnology-based drug delivery system intended for intravenous administration and treatment of bacteria which prominently dwell in macrophages

Designed nanosuspension of Clarithromycin, an antibacterial agent using industrially scalable high-pressure homogenization technique with use of stabilizers, lecithin and succinylated gelatin

Utilized freeze drying technique to enhance stability of the nanosuspension

Confirmed the integrity of dried products via particle size analysis, DSC study, XRD study and in vitro drug release study

Optimization of the particles size was done to be around 570 nm and the nanosuspension was considered as a promising drug delivery system with targeted delivery to macrophage

EXPERIENCE

• Graduate Teaching Assistant

University of Kansas, Lawrence, Kansas Aug 2015 – Dec 2018

(Courses: Fluid Dynamics, Introduction to Computers in Engineering, Chemical Engineering Design, Mass Transfer, Thermodynamics)

Led weekly discussion sessions for a group of 60 students

Guided students with homework problems and conceptual queries during office hours

Graded homework and exams

• In Plant Trainee

Meditab Specialities, a plant of Cipla Pvt. Ltd. in Satara, India May 2012 – June 2012

Studied functioning of different departments of the plant such as Stores, Quality Control and Quality Assurance

Learned industrial scale manufacturing of liquid oral dosage form and the stepwise packing of the product on packing line

SKILLS

• Familiar with ELISA, PCR, HPLC, UV-VIS Spectroscopy techniques

• Formulation techniques: Freeze drying (Lyophilization), Zeta Sizer, DSC, XRD

• Software: Microsoft office, R (programming language for statistics), COMSOL, GAMS, e- Dragon, Python

PUBLICATIONS

• Mapari, Shweta, Rex Gaumer, and Kyle V. Camarda. "Antibiotic Molecular Design Using Multi-Objective Optimization." In Computer Aided Chemical Engineering, vol. 44, pp. 169-174. Elsevier, 2018.

• Mapari, Shweta, Pankaj Patil. “Nanocarriers for the treatment of HIV and Fungal Infections” In Int J Pharm Bio Sci, 6(1): pp. 149 – 169, 2015.

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