RUTH ALEXIS BUCSH
Wildwood, MO 63011
Objective: Re-entry position using my laboratory experience.
Chemistry: Synthesis on gram to kilogram scale, GC, HPLC (standard and reverse phase)
Biochemistry: SDS-PAGE, PCR, Western blotting, UV and colorimetric assay
Chromatography: ion exchange, affinity, size exclusion
Regulatory: Knowledge of FDA regulations, ethical treatment of animals in research.
Biotechnology I and II labs 2014, 2015
University of Missouri-St Louis
Bachelors of Science-Biochemistry 2010
Eastern Michigan University, Ypsilanti, MI (Magna cum laude)
Masters of Science - Medicinal Chemistry 1986
University of Michigan, Ann Arbor, MI
Bachelor of Science – Chemistry 1982
Michigan Technological University, Houghton, MI
Data Manager, University of Michigan 1998 to 2000
Comprehensive Cancer Center, Ann Arbor, MI
Verified patient eligibility in clinical trials. Entered study data from source documents into Case Report Forms and Oracle database. Assisted in writing adverse event reports.
Associate Scientist, Parke-Davis Pharmaceutical 1988 to 1996
Research Division, Ann Arbor, MI
SAR of quinolone antibiotics. Synthesis of novel acetyl cholinesterase inhibitors. Patented route to stereochemically pure oximes.
Kynurenic Acid Derivatives Inhibit the Binding of Nerve Growth Factor (NGF)
to the Low-Affinity p75 NGF Receptor, J. C. Jaen, E. Laborde, R. A. Bucsh, B. W. Caprathe, R. J. Sorenson, J. Fergus, K. Spiegel, J. Marks, M. R. Dickerson, and R. E. Davis, J. Med. Chem., 1995, 38, 4439-4445.
Synthesis and Antimicrobial Evaluation of a Series of 7-[3-Amino (or Amino-methyl)-4-aryl (or cyclopropyl)-1-pyrrolidinyl]-4-quinolone- and 1,8-naphthyridone-3-carboxylic Acids, R. A. Bucsh, J. M. Domagala, E. Laborde, and J. C. Sesnie, J. Med. Chem., 1993, 36, 4139-4151.
New 8-(Trifluoromethyl)-Substituted Quinolones. The Benefits of the 8-Fluoro Group with Reduced Phototoxic Risk, J. P. Sanchez, A. J. Bridges, R. A. Bucsh, J. M. Domagala, R. D. Gogliotti, S. E. Hagen, C. L. Heifetz, E. T. Joannides, J. C. Sesnie, M. A. Shapiro, and D. L. Szotek, J. Med. Chem, 1992, 35, 361-367.
Quinolone Antibacterials: Preparation and Activity of Bridged Bicyclic Analogues of the C7-Piperizine, J. S. Kiely, M. P. Hutt, T. P. Culbertson, R. A. Bucsh, D. F. Worth, L. E. Lesheski, R. D. Gogliotti, J. C. Sesnie, M. Solomon, and T. F. Mich, J. Med. Chem., 1991, 34, 656-663.
Synthesis of 7-(Alkenyl, Cycloalkenyl, and 1,2,3,6-Tetrahydro-4-pyridinyl) quinolones, J. S. Kiely, E. Laborde, L. E. Lesheski, and R. A. Bucsh, J. Heterocyclic Chem., 1991, 28, 1581-1585.
Preparation of Stereochemically Pure Oximes with Muscarinic Activity, R. Bucsh, J. Jaen, E. Laborde, and A. Thomas, U. S. 5,514,812, May 7, 1996.