RUTH ALEXIS BUCSH

**** **** **** ***** **.

Wildwood, MO 63011

Home: 636-***-**** Cell: 314-***-****

E-mail: ac7dho@r.postjobfree.com

Objective: Re-entry position using my laboratory experience.

SKILLS SUMMARY

Chemistry: Synthesis on gram to kilogram scale, GC, HPLC (standard and reverse phase)

Biochemistry: SDS-PAGE, PCR, Western blotting, UV and colorimetric assay

Chromatography: ion exchange, affinity, size exclusion

Regulatory: Knowledge of FDA regulations, ethical treatment of animals in research.

EDUCATION

Biotechnology I and II labs 2014, 2015

University of Missouri-St Louis

Bachelors of Science-Biochemistry 2010

Eastern Michigan University, Ypsilanti, MI (Magna cum laude)

Masters of Science - Medicinal Chemistry 1986

University of Michigan, Ann Arbor, MI

Bachelor of Science – Chemistry 1982

Michigan Technological University, Houghton, MI

PROFESSIONAL EXPERIENCE

Data Manager, University of Michigan 1998 to 2000

Comprehensive Cancer Center, Ann Arbor, MI

Verified patient eligibility in clinical trials. Entered study data from source documents into Case Report Forms and Oracle database. Assisted in writing adverse event reports.

Associate Scientist, Parke-Davis Pharmaceutical 1988 to 1996

Research Division, Ann Arbor, MI

SAR of quinolone antibiotics. Synthesis of novel acetyl cholinesterase inhibitors. Patented route to stereochemically pure oximes.

PUBLICATIONS

Kynurenic Acid Derivatives Inhibit the Binding of Nerve Growth Factor (NGF)

to the Low-Affinity p75 NGF Receptor, J. C. Jaen, E. Laborde, R. A. Bucsh, B. W. Caprathe, R. J. Sorenson, J. Fergus, K. Spiegel, J. Marks, M. R. Dickerson, and R. E. Davis, J. Med. Chem., 1995, 38, 4439-4445.

Synthesis and Antimicrobial Evaluation of a Series of 7-[3-Amino (or Amino-methyl)-4-aryl (or cyclopropyl)-1-pyrrolidinyl]-4-quinolone- and 1,8-naphthyridone-3-carboxylic Acids, R. A. Bucsh, J. M. Domagala, E. Laborde, and J. C. Sesnie, J. Med. Chem., 1993, 36, 4139-4151.

New 8-(Trifluoromethyl)-Substituted Quinolones. The Benefits of the 8-Fluoro Group with Reduced Phototoxic Risk, J. P. Sanchez, A. J. Bridges, R. A. Bucsh, J. M. Domagala, R. D. Gogliotti, S. E. Hagen, C. L. Heifetz, E. T. Joannides, J. C. Sesnie, M. A. Shapiro, and D. L. Szotek, J. Med. Chem, 1992, 35, 361-367.

Quinolone Antibacterials: Preparation and Activity of Bridged Bicyclic Analogues of the C7-Piperizine, J. S. Kiely, M. P. Hutt, T. P. Culbertson, R. A. Bucsh, D. F. Worth, L. E. Lesheski, R. D. Gogliotti, J. C. Sesnie, M. Solomon, and T. F. Mich, J. Med. Chem., 1991, 34, 656-663.

Synthesis of 7-(Alkenyl, Cycloalkenyl, and 1,2,3,6-Tetrahydro-4-pyridinyl) quinolones, J. S. Kiely, E. Laborde, L. E. Lesheski, and R. A. Bucsh, J. Heterocyclic Chem., 1991, 28, 1581-1585.

Preparation of Stereochemically Pure Oximes with Muscarinic Activity, R. Bucsh, J. Jaen, E. Laborde, and A. Thomas, U. S. 5,514,812, May 7, 1996.

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