Project Research
Resume:
SEEMA JAGOTA
*********@*****.***
WORK EXPERIENCE
Air Liquide Inc Aug 2016 - Oct 2018
GC-MS, GC-TCD, GC-FID analysis of samples received from the clients. Process the data and preparing reports for the Clients. Maintaining the Instruments.
SOLEXEL Inc. Milpitas Oct 2015- Apr 2016
Worked with product/integration team to analyze the root causes of different downstream process/material failures.
Specialized in Wet-chemical etching of Silicon. Versatile working experience with semiconductor device fabrication processes such as Physical vapor deposition, Screen print, resist print
Design of Experiments (DOE) and Statistical Process Control (SPC) for quality control of the process.
EOL testing such as IV, Sun-Voc, EL, PL.
Enthusiastic, creative team player, excellent written and communication skills, highly skilled in creation of technical documentation SOPs.
Strong technical presentation, project management and execution skills.
Post-Doc
NASA Ames Research Center Nov 2010 - June 2014
Studied planetary atmospheric organic chemistry.
Synthesized organic polymer at different pressure with in-organic gases,
The organic polymer is analyzed to look for biomarkers such as lipids. Lipids are a group of molecules that include fats and waxes, and they generally preserve better in sediments over long periods of time than molecules like DNA and protein
SKILL SETS
Chemistry Skills: Strong Peptide and Organic synthesis skills, air-free synthesis
Knowledge and experience in multi-step organic synthesis Proficient in purification and structure elucidation of organic compounds Experience in converting natural products to fluorescent probes via conjugation with a single dye
UV-VIS Spectrometer, TLC, HPLC, FT-IR, Circular Dichroism, GC-MS, TEM, SEM,
Bio-chemistry: Cell culture, SDS-Page, FRET, Fluorescence spectrometer, Fluorescence microscopy, Thioflavin T assay, Protein Microarray, Optical microscopy
Research Fellow
Stanford University Oct 2006- Jun2009
Transgenic Caenorhabditis elegans model was used to evaluate the pharmacological effect of peptides and small molecules on Aβ-initiated toxicity. The data suggested that peptides and polyphenols should be considered during future design of drugs for AD.
Graduate Research Fellow
Council of Scientific and Industrial Research (CSIR) Jan 2004 – Sep 2006
TITLE: Effect of Peptidic and Non-Peptidic molecules on Aβ assembly and toxicity
Brief Synopsis of Research
Genetic, biochemical and pathological evidence support that aggregate β-amyloid (Aβ) peptide into fibrillar, a structure that is rich in β-sheets which implicated as the cause of Alzheimer’s disease. Therefore, an attractive therapeutic strategy is to prevent or alter Aβ aggregation.
Thesis work mainly focused on to study the effect of small molecules and peptides on Aβ aggregation and its toxicity in neurons by various biophysical techniques.
Shasun chemicals and Drugs Ltd, Chennai, India, Aug 2002-Mar 2003
Management Trainee
Responsibility:
Synthesis of small library of compounds with each member specifically designed
Synthesis of Novel Chemical Entities as drug candidates
Indian Institute of Technology (IIT), Chennai, India Mar 2002-July 2002
Project Associate
Responsibility:
Worked in vermicomposting of sugar industry wastes (pressmud, bagasse, trash etc.)
EDUCATION
PhD, Chemistry, Council of Scientific and Industrial Research (CSIR), India / Stanford University, July 2010
MS, Organic Chemistry, Bombay University, India
ACADEMIC SCHOLARSHIP
Junior and Senior Research Fellow (2003-2008) Council of Scientific and Industrial Research, New Delhi, India
Graduate Aptitude Test (GATE), Score 92.67%, 2002
Merit Fellowship in MS
PUBLICATIONS & PRESENTATIONS
S. Jagota, J. Kawai, B. N. Khare, D. W. Deamer, C. P. McKay Surface-active molecules in the laboratory simulated Titan's organic haze. Planetary and Space Science 103: 167-173
S. Jagota, J. Rajadas (2012) Effect of phenolic compounds against Aβ aggregation and Aβ-induced toxicity in transgenic C. elegans. Neurochem Res. 37: 40-8
S. Jagota, J. Rajadas (2012) Role of Pro, Gly Lys, and Arg containing peptides on amyloid-beta aggregation. Int J Pept Res Ther 18: 53-61.
S. Jagota, J. Rajadas (2013) D-peptide inhibitors of beta-amyloid aggregation and toxicityTransgenic C. elegans, Med Chem Res. 22 (8): 3991-4000
J. Kawai, S. Jagota, T Kaneko, Y. Obayashi, Y.Yoshimura, B. N. Khare, D. W. Deamer, C.McKay, K. Kobayashi (2013) Self-assembly of tholins in environments simulating Titan liquidospheres: Implications for formation of primitive coacervates on Titan International Journal of Astrobiology 12, 282-291.
J. kawai, S. Jagota, T. Kaneko, Y. Obayashi, B.N. Khare, K. Kobayashi (2013) Titan tholinsamino acid precursors and their solubility in possible Titan liquidospheres Chemistry Letters, 42, 633-635.
S. Jagota, J. kawai, D. Deamer, B.N. Khare, C. P. McKay, D. Beeler Self-assembled monolayers (SAMs) formation at the air-water interfaces by the amphiphilic like organic molecules present in the Titan tholin COSPAR, 2012.
S. Jagota, J. kawai, D. Deamer, B.N. Khare, C. P. McKay, D. Beeler Laboratory investigation of Titan tholin to find amphiphilic molecules and to explore their self-assembly behavior in the formation of Vesicles and Membrane Bilayers AbGradCon, 2012
B. N. Khare, S. Jagota, C.D. Burkhard, S. Mcpherson, C.P. McKay Investigations of mixing ratio of Methane on Titan and determination of the possible dissolved ingredients in Methane Lake. AOGS, 2010
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