Manager Project

Tanushree Phadke

** ****** ****, *********.******@*****.***

Belmont MA 02478 Work permit: H1B Visa Phone: 978-***-****

Experience

Principal Research Associate, Editas Medicine, Cambridge, MA Mar 2017 - Present

Senior Research Associate, Editas Medicine, Cambridge, MA Aug 2014 - Mar 2017

Planned and executed scientific experiments independently for platform evolution and presented lead findings both internally and at scientific conferences (poster session- ASGCT 2016, Genome Engineering 2018).

Gain understanding of cross functional input to IND and Project Management scope by supporting research group with documentation, research report operations, organization and action item follow up in support of IND filing.

Worked with external collaborators (MIT, UCSF, Genomic Vision) on experiment planning, sample submission coordination, data collection and interpretation for developing novel approaches along with vendor management.

Involved in data generation, curation, writing for publication and patent filing.

Served as a project manager for coordinating sequencing submissions to sequencing core group and worked with bioinformatics team to build a robust analysis pipeline for deeper analysis of complex repair events.

Facilitated running internal group meeting by reserving meeting room and updating SharePoint document with schedule updates.

Part of a cross-functional move co-ordination team to help with moving buildings and facilitate smooth transition and efficient workflow.

Volunteered to run lab operations when transitioning between Lab manager hires and helped with reagent ordering.

Being an early member of the company, actively involved in developing the language and concepts around company values and being a role model in promoting a culture of sharing and inclusiveness.

Trained new lab members on routine protocols and processes within the organization.

Managed and trained intern/co-ops/temp’s to perform routine experiments and provide career counseling.

Scientific Associate II, Novartis (NIBRI), Cambridge, MA Dec 2009 - Aug 2014

Actively involved in technology development, optimization, preliminary data analysis, automating NGS processes using liquid handling along with data management and sample tracking using Laboratory Information Management System (LIMS) and handing off data to internal project teams across multiple programs.

Research Associate II, U.S Genomics, Woburn, MA Sept 2008 - Oct 2009

Worked on developing an automated system to perform Genome Sequence Scanning for rapid bacterial strain typing.

Associate Scientist I, Biogen Idec, Cambridge MA Apr 2008 - Sept 2008

Performed microarray expression profiling using Affymetrix/Nugen technologies and automated liquid handling instruments for internal early discovery and late stage clinical programs.

Intern & Research Associate, MGI Pharma, Lexington, MA May 2007 - Mar 2008

Involved in both early discovery and clinical development research by rotating in multiple group working on isolating C4+/CD25+ cells from spleenocytes, GST-fusion protein production, developing and testing batch variability between vials of drug, testing blood samples from patients with Cervical Dysplasia in clinical trials, studying the impact of oral dosing vs injection on the immune response.

Northeastern University, Dept. of Pharmaceutical Sciences June 2006 - April 2007

Worked on developing a drug delivery system by loading nano-liposome therapeutics in erythrocytes.

Computers Skills

Geneious, Spotfire Decisionsite, Graphpad PRISM, Vector NTI, BLAST, Primer 3, Operating systems-Windows, MAC OS & Linux, MS Office, MS OneNote, MS Project, MS SharePoint, Smartsheet, Slack, Jira, C/C++ (Elementary), Basic SHELL scripting and other advanced tools for data analysis.

Tanushree Phadke

55 Thayer Road, *********.******@*****.***

Belmont MA 02478 Phone: 978-***-****

Education

Harvard extension school, Cambridge MA 2011 - 2015

Epigenetics, Introduction to Genomics, Biology of Cancer, Viruses: Molecular Machines Persisting at the Boundaries of Life, Genome Editing

Northeastern University, Boston, MA Aug 2007

Masters of Science in Biotechnology- Pharmaceutical Track QPA: 3.82

Mumbai University, Thadomal Shahani College of Engineering, Mumbai, India May 2005

Bachelor of Engineering- Biomedical, Distinction (summa cum laude)

Awards and Recognition

Creditas award (Community), Editas Medicine (Awarded for taking ownership and helping with Lab management responsibilities in the absence of a Lab manager) July 2015

Creditas award (Passion), Editas Medicine (Awarded for best Halloween costume) Oct 2015

Star award, Novartis (Awarded for going above and beyond in taking the time to engage with a post doc demonstrating the NGS pipeline for shRNA pooled screens) Apr 2013

Spotlight award, Novartis (Awarded for helping out with NGS expertise on Miseq) Mar 2013

Star award, Novartis (Awarded for cross training a colleague on splinkerette pcr procedures, sequencing on Miseq and post-run data analysis) Jan 2013

Publication

“Characterization of the interplay between DNA repair and CRISPR/Cas9-induced DNA lesions at an endogenous locus.” Nature Communications, Article number: 13905 (2017), doi:10.1038/ncomms13905

“Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers.” PNAS, vol. 111 no. 8, 3128–3133, doi: 10.1073/pnas.131*******

“Multidimensional pooled shRNA screens in human THP-1 cells identify candidate modulators of macrophage polarization.” PLoS ONE 12(8): e0183679. https://doi.org/10.1371/journal.pone.0183679

Extra-Curricular Activities

Member of Novartis Badminton club and participant at MASSBAD DOUBLES tournament 2010 - 2017

Volunteer for Math Olympiads tutoring at Morse School Cambridge MA Spring 2016

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