Professor of Medicine, Laboratory Director

Bahar Uslu, MD, PhD

Scientific Director, Medical Science Professor

*** ****** ****** *** *****, CT 06511 / 516-***-**** / *****.****.**.***@*****.***

Education

Specialization: Embryologist & Histologist

Yale University, School of Medicine June 2012

New Haven, CT

Projects and Certification Programs in Embryology and Reproductive Cell Biology

PhD (Double) Marmara University, School of Medicine, Embryology and Histology Department, Istanbul, Turkey

Dissertation: In Vitro condition, effect of chitosan on fibroblast activity: Immuno-histochemical and electron microscopic study. May 2008

MD Black Sea Technical University, School of Medicine,

Trabzon, Turkey June 2001

BS Black Sea Technical University, School of Medicine,

Trabzon, Turkey June 1996

Professional Experience

Faculty, Embryologist, Lecturer & Principal Researcher

Yale School of Medicine

Department of Obstetrics, Gynecology & Reproductive Sciences

New Haven, CT September 2013 - Present

Teaching & Training: Medical Students at Yale University in Cell Biology and Embryology (e.g. Criteria for Determination of Ovarian Follicle Atresia, Early Embryo Development) and Histology (e.g. Histological Preparation Techniques)

Principal Scientist: Laboratory Tools for Improvement of Treatment and Research Techniques in Reproductive Medicine and Cell Biology. Presentation: New Ovarian Follicle Counting Method (updating historical 40 year-old method). New technique dramatically improves the accuracy of scientific results. https://www.youtube.com/watch?v=xcpUEr_lfoc

Selected articles among “The Best of Molecular Human Reproduction 2017”

Book Chapter, “The In Vitro Culture of Ovarian Follicles: A Brief History and Current Considerations,” in the pioneering publication, Oocyte Physiology and Development in Domestic Animals, edited by Rebecca L. Krisher, John Wiley & Sons, Inc.

Faculty & Embryology Laboratory Director

University of Health Science

Zeynep Kamil Women’s and Children’s Training and Research Hospital

Istanbul, Turkey August 2010- September 2013

Teaching & Training: International Attendees, Faculty Members, Postgraduate Courses: Clinical Aspects of Infertility, Assisted Reproductive Techniques and Current Procedures,

Directing of Assisted Reproductive Techniques Laboratories: Full Service

Faculty & Founding Director of Andrology Unit

University of Health Science

Van Women’s and Children’s Training and Research Hospital

Van, Turkey September, 2009 –August 2010

Teaching & Training: Faculty Members, Approach to Infertile Couples, Semen Analyses.

IUI Semen Preparation, Semen Analysis, Document and Report Laboratory Results

Clinical & Laboratory Procedures

Faculty & Medical Director of Blood Banking & Transfusion Department

University of Health Science

Van Women’s and Children’s Training and Research Hospital

Van, Turkey July, 2008 – September 2010

Teaching & Training: Transfusion Procedures, etc.

Clinical & Laboratory Procedures: Blood banking &Transfusion medicine

Faculty & Medical Director of Hematology & Immunology Laboratories

University of Health Science

Van Women’s and Children’s Training and Research Hospital

Van, Turkey July 2008-September 2010

Teaching & Training: Immuno-Modulation Programs, etc.

Clinical & Laboratory Procedures, Biomarker service, Elisa Tests,

Extensive laboratory directorship experience developed over 10+ years in the positions above including the following skills:

Oversee daily clinical laboratory operations, coordinate personnel activities, monitor workload and staff assignments.

Excellent communication skills with patients; collaborate with clinical staff and physicians including strong supervisory leadership and project management skills. Work independently and as part of a team demonstrating interpersonal skills.

Hire resource staff and handle performance evaluations, disciplinary action, layoffs and terminations as required. Schedule, train and supervise personnel, including cross training to provide backup capabilities.

Oversee and as required perform technical procedures related to the cell culture of human embryos. Perform with a variety of cutting edge biotechnological procedures involving ICSI, TESE, assisted hatching, blastocyst culture, embryo freezing, thawing and embryo biopsy.

Supervise technologists and perform all aspects of Andrology, endocrinology testing. Ensure the accuracy, completeness and timeliness of record keeping including schedules, logbooks and records of user activity, supply inventories and equipment use.

Maintain documentation, CLIA to be compliant with federal regulations and for federal audits. Write, review and approve documents such as records and validation reports.

Follow and enforce good tissue practice guidelines HC/TTP as mandated by recent FDA regulations. Experience with FDA tissue regulations and process equipment qualification and validation.

Facilitate scheduling for oocyte retrievals, embryo culture, embryo transfer and embryo cryopreservation, semen analysis, processing, and cryopreservation.

Interface with quality control, quality assurance and regulatory affairs to comply with established policies. Coordinate product testing and product release for use in the laboratory.

Oversee instruction and training of other laboratory technicians in cell culture, ICSI, TESE, assisted hatching and other SOP’s and laboratory policies.

Monitor and maintain equipment and coordinate annual lab shutdown for calibration, repairs and maintenance.

Plan with senior staff/physicians to determine long-term goals, laboratory needs and to set operating policies. Maintain cost effectiveness and usefulness of the laboratory; work with senior leadership to develop annual resource budget and strategic plans.

Design and implement new laboratory procedures to stay abreast with a constantly changing field of IVF laboratory procedures to stay competitive with the best programs.

Selected Articles & Chapters

Uslu B, Dioguardi CC, Haynes M, Miao D, Kurus M, Hoffman G, Johnson J. Quantifying growing versus non-growing ovarian follicles in the mouse. J Ovarian Res. 2017 Jan 13; 10(1); 3. Doi: 10.1186/s13048-016-0296-x.

Dioguardi CC, Uslu B, Haynes M, Kurus M, Gul M, Miao DQ, De Santis L, Ferrari M, Bellone S, Santin A, Giulivi C, Hoffman G, Usdin K, Johnson J. Granulosa Cell and Oocyte Mitochondrial Abnormalities in a Mouse Model of Fragile X Primary Ovarian Insufficiency. J.Mol Hum Reprod. doi: 10.1093/molehr/gaw023 2016 Mar 9. pii: gaw023.

Uslu B, Biltekin B, Denir S, Ozbaş-Turan S, Arbak S, Akbuga J, Bilir A. Effects of different forms of chitosan on intercellular junctions of mouse fibroblasts in vitro. IBIH Biotechnic & Histochemistry, DOI 10.3109/10520295.2015.1064998, Manuscript ID: 1064998

Uslu B, Biltekin B, Denir S, Ozbaş-Turan S, Arbak S, Akbuga J, Bilir A. Differences between Solution and Membrane Forms of Chitosan on the In Vitro Activity of Fibroblasts Balkan Medical Journal. Balkan Med J. 2015 Jan; 32(1): 69-78. Doi: 10.5152/balkanmedj.2015.15102. Epub 2015 Jan 1

Uslu B, Johnson J. Oocyte Physiology and Development in Domestic Animals, Ovarian Follicle Culture and Fertility Preservation; The In Vitro Culture of Ovarian Follicles: A Brief History and Current Considerations. Edited by Rebecca L. Krisher, First edition, John Wiley & Sons Inc., ISBN: 978**********, online ISBN: 978**********, DOI: 10.1002/978**********.ch2, 2013

Professional License and Board Certification

Embryology Laboratory Director Certificate, Assisted Reproductive Treatment, Turkish Ministry Of Health, 2011

Histology and Embryology Association Board Proficiency Certificate, THED, 2009

Medical Director of Occupational and Employer Health Certificate, Turkish Ministry of Health, 2012

ABB- ELD Embryology Laboratory Director, HCLD application accepted

Selected Honors

Rated as the Number 1 of the Top 30 Most Successful Turkish-American Women 2018 (community web page)

Nominee of “Academician of the Year 2017” by ANTIKAD (Antalya Businesswomen’s Association)

Rated as the Number 1 of the Top Reproductive Medicine Doctors 2015 in Eniyiler.net web page (best of.net) Turkey

Winner of TUBITAK BIDEB 2219 project, (https://e-bideb.tubitak.gov.tr) 2012

Winner of Turkish Ministry of Health Examination; selected for training abroad for 2011

The 2nd Best Poster Presentation award. TUBITAK-International Participatory 17th National Congress of Electron Microscopy, Gebze, TR, 2005

Selected Professional Interest & Memberships

Founder and Vice President, SOHE/hemud Society of Histologists & Embryologists

THED, Turkish Association of Histology and Embryology Member

TEMD, Turkish Electron Microscopy Society Member

IFSHC, International Federative Societies of Histochemistry and Cytochemistry Member

IFSM, International Federative Societies of Microscopy Member

EMS, European Microscopy Socıety Member

ESHRE, European Society of Human Reproduction and Embryology Member

ABB, American Board of Bio-analyses Member

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