CURRICULUM VITAE

SHALOM Z. HIRSCHMAN, M.D.

Shalom Z. Hirschman, M.D. 1

POSITIONS:

Attending Physician, Mt. Sinai Hospital, N.Y. 1971- 1997 Senior Vice-President for Graduate and Professional Education, Touro College and University System 2005-2012

Senior Vice-President for Graduate Academic Affairs, Touro College and University System 2005-2012

Founder, Touro College of Medicine, and

Purchase of New York Medical College 2006-2012

Founder, Biotechnology Consultants Group

2013-present

Description of Dr. Hirschman's medical consult work Since retiring from The Mount Sinai Medical Center, and especially since leaving New York Medical College at end of 2013, Dr. Hirschman has been dealing with requests for consultative help from patients whose medical problem has not been satisfactorily solved by their physicians or where the prescribed therapy has not been effective. Since his retirement these calls have continued because Dr. Hirschman was known to have been a key diagnostician at Mount Sinai for many years. Of course, there are many requests for help with complex infectious diseases problems. When a patient, or a physician, calls Dr. Hirschman reviews the history and medical data that are sent and offers suggestions to the patient’s physician as to how to proceed to establish a diagnosis. The patients also are helped to understand their medical problems. If the patient so requests, or there is no longer a physician caring for the patient, Dr. Hirschman will refer the patient to physicians for proper medical care. Usually, the patients seeking help have either complex medical problems or the diagnosis just has been missed. Therefore, these consultative endeavors do not constitute a traditional medical practice since there is no hands-on medical care to the patient. Shalom Z. Hirschman, M.D. 2

CURRICULUM VITAE

Shalom Zarach Hirschman, M.D.

Biotechnology Consultants Group

5240 Blackstone Avenue

Bronx, New York 10471

TELEPHONE: 917-***-****;

FAX: 718-***-****

PLACE OF BIRTH: Troy, New York

CITIZENSHIP: United States

EDUCATION: Yeshiva University .A.B 1953-57

Albert Einstein College of Medicine M.D. 1957-61

Albert Einstein College of Medicine

Graduate School of Biochemistry 1958-60

POSTDOCTORAL TRAINING:

Massachusetts Gen. Hosp., Harvard Med. Sch. Intern in Int. Med. 1961-62 Massachusetts Gen. Hosp., Harvard Med. Sch. 1st Yr. resident Int. Med. 1962-63 Nat'l Inst. Arthritis and Metabolic Dis., Lab. Molecular Biol., Res., Assoc. 1963-65 Nat'l Inst. Health, Graduate School Ph.D. equivalent 1963-66 Columbia-Presbyterian Medical Center.,Columbia University College of Physicians and Surgeons, NIH Fellow 1966-67

CERTIFICATION: Diplomate, American Board of Internal Medicine, No. 26985 1968 LICENSURE: New York License Number 088***-****

HONORS: A.B. Summa Cum Laude, Yeshiva University 1957 M.D. Summa Cum Laude, Albert Einstein College of Medicine 1961 Alpha Omega Alpha 1960

Shalom Z. Hirschman, M.D. 3

PAST & CURRENT ACADEMIC APPOINTMENTS:

Clinical: Clinical Inst. in Med., George Washington Univ. Med. Sch. 1964-65 Attending Physician, D.C. General Hospital 1964-66 Associate Attending Physician, Mount Sinai Hospital 1969-71 Research: Research Associate, Laboratory of Molecular Biology, Sect. Physical Chemistry, Nat'l Inst. Arthritis and Metabolic Dis. 1963-65 Senior Invest, Lab. Molecular Biology, Sect. Physical Chem. NIAMDD 1965-66

Senior Invest, Lab. Molecular Virology, Nat'l Cancer Inst. 1967-69 Hon. Member, Lab. Clin. Invest. NIH - NIAID 1967-69 ACADEMIC and HOSPITAL APPOINTMENTS:

Associate Professor of Medicine, The Mount Sinai School of Medicine 1968-71 Director, Division of Infectious Diseases, Mt. Sinai School of Medicine (CUNY) 1968-97 Vice-Chairman Department of Medicine, The Mount Sinai School of Medicine 1972-76 Professor of Medicine, Mt. Sinai School of Medicine (CUNY) N.Y. 1971-1997 Attending Physician, Mt. Sinai Hospital, N.Y. 1971-1997 PROFESSIONAL SOCIETIES:

American Society for Microbiology

Biophysical Society

American Association for the Advancement of Science Infectious Diseases Society of America

American College of Physicians

Royal Society of Tropical Medicine and Hygiene

Vice Chairman, Microbiology Section, NY Academy of Sciences 1974 Chairman, Microbiology Section, NY Academy of Sciences 1975 American Society for the Study of Liver Diseases

American Society for Clinical Investigation

Society for Experimental Biology and Medicine

American Federation for Clinical Research

Association of American Physicians

American College of Clinical Pharmacology

The Harvey Society

Shalom Z. Hirschman, M.D. 4

ADMINISTRATIVE POSITIONS:

Member, Committee on Interns and Residents, Department of Medicine, Mount Sinai School of Medicine 1970-1996

Member, Awards Committee, The Mount Sinai School of Medicine 1972-1996 Chairman, Infection Control Committee, The Mount Sinai Hospital 1974-1996 Member, Pharmacy and Therapeutics Committee, Mt. Sinai Hospital 1975-1996 Member, Admissions Committee, The Mount Sinai Hospital 1976-1996 Member, Transfusion Committee, The Mount Sinai Hospital 1976-1996 Member, Committee on Teaching, Depart. Med., Mt. Sinai Sch. Med. 1976-1996 Member, Committee on Teaching, Depart. Med., Mt. Sinai Sch. Med. 1976-1996 Chairman, Biosafety Committee, The Mount Sinai School of Medicine 1977-1996 Chairman, Committee on Recombinant DNA, The Mount Sinai School of Medicine 1977-1996

Member, Safety Committee, The Mount Sinai Hospital 1977-1996 Member, Quality Assurance Committee, Mount Sinai Hospital 1985-1996 FELLOWSHIPS: Special NIH Fellowship Award 1964

MILITARY SERVICE: Senior Surgeon, Lt. Commander, US Public Health Service 1963-69

MOST RECENT BIOTECHNOLOGY POSITION:

Chief Scientist 2003–2004

President and Chief Executive Officer, 1997-2003

Advanced Viral Research Corp.

ELECTED SOCIETIES: Fellow, American College of Physicians Fellow, Infectious Diseases Society of America

Fellow, Royal Society of Tropical Medicine and Hygiene Member, American Society for Clinical Investigation Member, American Association of Physicians

Member, Society for Experimental Biology And Medicine Fellow, American College of Clinical Pharmacology

Fellow, Molecular Medicine Society

BUSINESS INTERESTS AND SPECIAL EXPERTISE:

Biotechnology and biopharmaceutical analysis

Consulting services to biotechnology, healthcare and pharmaceutical firms

Consulting services to investment funds

CLINICAL Infectious Diseases - Chemotherapy

INTERESTS: Sexually transmitted diseases

Immunomodulation therapy

Shalom Z. Hirschman, M.D. 5

PAST & CURRENT Pathogenesis of Infectious Hepatitides RESEARCH: Biochemistry of Hepatitis B Virus

Molecular Biology and Pharmacology of Antimicrobial Agents Biophysical Studies on Murine Sarcoma and Leukemia Viruses Molecular Biology of AIDS Virus

Developed new powerful immunomodulator-type drug

BIOGRAPHICAL American Men and Women of Science

LISTING: American Medical Specialists

Who's Who in the East

International Dictionary of Biography

Men of Achievement

Notable Americans of the Bicentennial Era

Community Leaders and Noteworthy Americans

Who's Who in Health Care

Who's Who in America

Who's Who in Society

Who's Who in the World

Who's Who Registry, Platinum Edition

RESEARCH Member, Executive Board of Infectious Diseases, Veterans COUNCILS: Administration

Member, National Advisory Board in Microbiology, American Cancer Society New York Academy of Medicine

Member, Task Force on Tuberculosis

Member, Task Force on Cytokines and Monoclonal Antibodies Member, Committee on Infectious Diseases

Member, Committee on Therapy with Biologicals

ENDEAVORS IN EDUCATION:

Founder, Touro College, New York, New York 1970-

Founder, Touro School of Law, New York, NY 1973-

Member, Board of Trustees, Touro College, New York, New York 1971- 2003

Chairman, Academic Committee, Board of Trustees, Touro College, New York, NY 1974-78 Chairman, Budget Committee, Board of Trustees, Touro College, New York, NY 1978-82 Chairman, Academic Committee, Touro School of Law 1978-85 LIST OF PUBLICATIONS

Original Peer-Reviewed Reports

Hirschman, S.Z., Morell, A. and Scheinberg, I.H.: The Heterogenity of the Copper Containing Protein of Human Plasma, Ceruloplasmin. Ann. NY Acad. Sci. 94:960-969, 1961. Hirschman, S.Z., Feingold, M., Boylen, G.: Mercury in Housepaint as a Cause of Acrodynia. The Effect of Therapy with N-Acetyl-D, L-Penicillamine. New Eng. J. Med. 269: 889-893, 1963. Shalom Z. Hirschman, M.D. 6

Hirschman, S.Z. and Isselbacher, K.H.: The Nephrotic Syndrome as a Complication of Penicillamine Therapy for Hepatolenticular Degeneration (Wilson's Disease). Ann. Intern. Med. 62:1297-1300, 1965.

Felsenfeld, G. and Hirschman, S.Z.: A Neighbor-interaction Analysis of the Hypochromism and Spectra of DNA. J. Mol. Biol. 13:407-427, 1965.

Hirschman, S.Z. and Felsenfeld, G.: Determination of DNA Composition and Concentration by Spectral Analysis. J. Mol. Biol. 16:347-358, 1966. Hirschman, S.Z., Leng, M. and Felsenfeld, G.: The Interactions of Spermine and DNA. Bio- polymers 5:227-233, 1967.

Hirschman, S.Z., Gellert, M., Falkow, 5. and Felsenfeld, G.: The Intramolecular Heterogeneity of Lambda DNA. J. Mol. Biol. 28:469-477, 1967.

Hirschman, S.Z., Fischinger, P.J., Sazzari, J. and O'Connor, T.E.: The Effect of Cytosine Arabinoside on the Replication of the Moloney Sarcoma Virus in 3T3 Cell Cultures. J. Nat. Cancer Inst. 42:399-411, 1969.

Hirschman, S.Z., Fischinger, P.J and O'Connor, T.E.: The Inhibition by Cytosine Arabinoside of the Replication of Murine Leukemia and Sarcoma Viruses in Mouse Embryo Culture. Int. J. Cancer 4:671-677, 1969.

Hirschman, S.Z., Fischinger, P.J. and O'Connor, T.E.: Effect of Infection with Murine Sarcoma and Leukemia Viruses on Nucleic Synthesis in Mouse Cell Culture. J. Nat. Cancer Inst. 44:107-116, 1970.

Meyers, B.R., Hirschman, S.Z. and Sloan, W.: The Generalized Schwartzman Reaction in Man Following a Dog Bite. Ann. Intern. Med. 73:433-440, 1970. Meyers, B.R., Hirschman, S.Z., Bottone, E., Schneierson, 5. and Gershengorn, D.: Infections Due to Actinobacillus Actinomycetemcomitans. Am. J. Clin. Path 56:204-211, 1971. Hirschman, S.Z., Meyers, B.R. and Mildvan, D.: The Diagnostic Microbiology of Lung Biopsy: Correlation with Viral Serology. Mt. Sinai J. Med. 38:273-280, 1971. Hirschman, S.Z.: Reflections on Latent Viruses: A New Definition of an Infectious Agent: Mt. Sinai J. Med. 38:257-266, 1971.

Mildvan, D., Bottone, E., Hirschman, S.Z. and Cornell, D.: Septicemia Caused by an Organism of the Genus Erwinia. Mt. Sinai J. Med. 38:267-272, 1971. Hirschman, S.Z. and Murphy, 5.: Peritonitis Due to Salmonella typhimurium in Hepatic Cir- rhosis. Mt. Sinai J. Med. 38:470-473, 1971.

Axelrod J., Meyers, B.R. and Hirschman, S.Z.: Cephapirin: In Vitro Antibacterial Spectrum. Appl. Microbiol. 22:904-908, 1971.

Shalom Z. Hirschman, M.D. 7

Hirschman, S.Z.: Approaches to Antiviral Chemotherapy. Amer. J. Med. 51:699-703, 1971. Hirschman, S.Z., Vernace, 5. and Schaffner, F.: DNA Polymerse in Preparations Containing Australia Antigen. Lancet 1:1099-1103, 1971.

Hirschman, S.Z.: Inhibitors of RNA-dependent DNA Polymerases of Murine Leukemia Viruses: Activity of Ethidium Bromide. Science 173:441-443, 1971. Hirschman, S.Z.: Inhibitors of Viral Nucleic Acid Transcriptases. Trans. NY Acad. Sci. 33:595-606, 1971.

Meyers, B.R., Lawson, D., Hirschman, S.Z.: Ludwig's Angina. Amer. J. Med. 53:257-260, 1972. Meyer, B.R., Hirschman, S.Z. and Axelrod, J.: Current Patterns of Infection in Multiple Myeloma. Amer. J. Med. 52:87-92, 1972.

Axelrod, J., Meyers, B.R. and Hirschman, S.Z.: Cephapirin: Pharmacology in Normal Human Volunteers. J. Clin. Pharmacol. 12:84-88, 1972.

Meyers, B.R., Bottone, E., Hirschman, S.Z. and Schneierson, 5.5.: Infections Caused by Microorganisms of the Genus Erwinia. Ann. Int. Med. 76:9-14, 1972. Keusch, G.T., Douglas, D., Mildvan, D. and Hirschman, S.Z.: 14C-glucose Oxidation in Whole Blood: Clinical Test for Phagocyte Dysfunction. Infect. Imm. 5:414-415, 1972. Keusch, G.T., Jacewicz, M. and Hirschman, S.Z.: Quantitative Microassay in Cell Culture for Enterotoxin of Shigella dysenteriae 1. J. Infect. Dis. 125:539-541, 1972. Meyers, B.R. and Hirschman, S.Z.: Fatal Infections Associated With Mycoplasma pneumoniae. Mt. Sinai J. Med. 39:258-264, 1972.

Meyers, B.R. and Hirschman, S.Z.: Tobramycin: In Vitro Antibacterial Spectrum of a New Aminoglycoside. J. Clin. Pharmacol. 12:313-320, 1972. Meyers, B.R. and Hirschman, S.Z.: Pharmacologic Studies on Tobramycine and Comparison with Gentamicin. J. Clin. Pharmacol. 12:321-324, 1972. Mildvan, D., Hirschman, S.Z., Meyers, B.R. and Keusch, G.T.: Extracellular Cephalosporinases Produced by Gram-Negative Bacilli. Canad. J. Microbiol. 18:1039-1043, 1972. Hirschman, S.Z.: Inactivation of DNA Polymerases of Murine Leukemia Viruses by Calcium Elenolate. Nature New Biol. 238:277-279, 1972.

Meyers, B.R., Hirschman, S.Z. and Nicholas, P.: Cephanone: In Vitro Antibacterial Activity and Pharmacology in Normal Human Volunteers. Antimicrob. Agents. Chemother. 2:250-254, 1972. Axelrod, J., Meyers, B.R. and Hirschman, S.Z.: 7-Chlorolincomycin Therapy of Pulmonary Infections Due to Mycoplasma pneumonia. Antimicrob. Agents Chemother. 2:499-501, 1972. Meyers, B.R., Berson, B., Gilbert, M. and Hirschman, S.Z.: Clinical Patterns of Osteomyelitis Due to Gram-negative Bacteria. Arch. Intern. Med. 131:228-233, 1973. Shalom Z. Hirschman, M.D. 8

Keusch, G.T., Axelrod, J., Bottone, E., Cohen, S. and Hirschman, S.Z.: Endocarditis Due to Lactobacillus plantarum. Ann. Intern. Med. 78:33-37, 1973. Nicholas, P., Meyers, B.R. and Hirschman, S.Z.: Pharmacology of Cefazolin in Human Volunteers. J. Clin. Pharmacol. 13:325-331, 1973.

Axelrod, J., Meyers, B.R., Hirschman, S.Z. and Stein, R.: Prophylaxis with Cephalothin in Peritoneal Dialysis. Arch. Intern. Med. 132:368-371, 1973. Hirschman, S.Z., Schwartz, J., Vernace, 5., Schaffner, F. and Ganz, C.: An Electron Microscopic Study of the Structural Polymorphism of Hepatitis B Antigen. J. Infect. Dis. 128:605-617, 1973.

Mildvan, D., Ravreby, W., Meyers, B.R. and Hirschman, S.Z.: Parenteral Clindamycin Therapy of Severe Infections. Mt. Sinai J. Med. 40: 744-751, 1973. Nicholas, P., Meyers, B.R. and Hirschman, S.Z.: Cephalexin: Pharmacologic Evaluation Following Oral and Parenteral Administration. J. Clin. Pharmacol. 13:463-468, 1973. Hirschman, S.Z.: The Biochemistry of Hepatitis B. Antigen. In: The Liver and Its Diseases (F. Schaffner, 5. Sherlock, and C. Leevy, eds.). Intercontinental Medical Book Corp., New York, NY., p.126-132, 1974.

Hirschman, S.Z., Kochwa, 5., Rosenfield, R. and Schwartz, J.: Complement Mediated Changes in Morphology of Hepatitis B Antigen-Antibody Complex. Vox Sang. 26:222-226, 1974. Meyers, B.R. and Hirschman, S.Z.: Unusual Presentations of Tuberculous Meningitis. Mt. Sinai J. Med. 41:407-411, 1974.

Jaffe, G., Ravreby, W., Meyers, B.R. and Hirschman, S.Z.: Clinical Study of the Use of the New Aminoglycoside Tobramycin for Therapy of Severe Infections Due to Gram-negative Bacteria. Antimicrob. Agents Chemother. 5:75-81, 1974.

Jaffe, G., Meyers, B.R. and Hirschman, S.Z.: Pharmacokinetics of Tobramycin in Patients with Stable Renal Impairment, Patients Undergoing Peritoneal Dialysis and Patients on Hemodialysis. Antimicrob. Agents. Chemother. 5:611-617, 1974. Hirschman, S.Z.: DNA Polymerase and Hepatitis B. Antigen. J. Infect. Dis. 130:206-208, 1974. Hirschman, S.Z. and Hammer, G.: Coxsackiervirus Myopericarditis: A Microbiological and Clinical Review. Amer. J. Cardiol. 34:224-232, 1974. Hirschman, S.Z., Gerber, M. and Garfinkel, E.: Purification of Naked Intranuclear Particles from Human Liver Infected by Hepatitis B Virus. Proc. Nat. Acad. Sci., USA 71:3345-3349, 1974. Hirschman, S.Z., Gerber, M. and Garfinkel, E.: DNA Purified from Naked Intranuclear Particles of Human Liver Infected with Hepatitis B Virus. Nature 251:540-542, 1974. Shalom Z. Hirschman, M.D. 9

Hirschman, S.Z. and Funke, V.: Effect of Diethylaminoethyl-dextran on the Replication of Murine Sarcome (Moloney)-Leukemia Virus Complex in Mouse Embryo Cultures. Proc. Soc. Exp. Biol. Med. 148:527-531, 1975.

Hirschman, S.Z. and Funke, V.: Effects of Steroid Hormones on Replication of Murine Sarcoma Virus in Mouse Embryo Cultures. Proc. Sox. Exp. Biol. Med. 149:790-795, 1975. Ribner, B., Hammer, G., Meyers, B.R. and Hirschman, S.Z.: Clinical Studies with Cefazolin. Mt. Sinai J. Med. 42:142-149, 1975.

Hammer, G., Bottone, E. and Hirschman, S.Z.: 1 Mucormycosis in a Transplant Recipient. Am. J. Clin. Path. 64:295-304, 1975.

Hirschman, S.Z., Gerber, M. and Garfinkel, E.: Observations on the Core Particle of Hepatitis B Virus and the DNA Polymerase Associated with Hepatitis B Antigen. Symposium on Viral Hepatitis (National Academy of Sciences). Am. J. Med. Sci. 270:141-149, 1975. Hirschman, S.Z.: Promising Developments in Viral Hepatitis. Western J. Med. 123:224-225, 1975.

Nicholas, P., Meyers, B.R., Levy, R. and Hirschman, S.Z.: Concentration of Clindamycin in Human Bone. Antimicrob. Agents Chemother. 8:220-221, 1975. Leng, B., Meyers, B.R., Hirschman, S.Z. and Keusch, G.T.: Susceptibilities of Gram-Negative Bacteria to Combinations of Antimicrobial Agents in Vitro. Antimicrob. Agents Chemother. 8:164-171, 1975.

Hirschman, S.Z.: Integrator Enzyme Hypothesis for Replication of Hepatitis B Virus. Lancet 2:436-438, 1975.

Nicholas, P., Meyers, B.R. and Hirschman, S.Z.: Pharmacology of Cefazolin in Normal Human Volunteers. Prog. Chemother. 1:563-568, 1975.

Meyers, B.R., Leng, B. and Hirschman, S.Z.: Comparison of the Antibacterial Activities of Sisomicin and Gentamicin Against Gram-Negative Bacteria. Antimicrob. Agents Chemother. 8:757-758, 1975.

Meyers, B.R., Leng, B. and Hirschman, S.Z.: Cefamandole: Antimicrobial Activity In Vitro of a New Cephalosporin. Antimicrob. Agents Chemother. 8:737-741, 1975. Hirschman, S.Z.: Interaction of Hepatitis B Surface Antigen with ENA. Vox Sang. 30:379-390, 1976.

Meyers, B.R., Ribner, B., Yancovitz, 5. and Hirschman, S.Z.: Pharmacologic Studies with Cefamandole in Human Volunteers. Antimicrob. Agents Chemother. 9:140-144, 1976. Meyers, B.R., Hirschman, S.Z., Yancovitz, 5. and Ribner, B.: Pharmacokinetic Parameters of Sisomicin. Antimicrob. Agents Chemother. 10:25-27, 1976. Meyers, B.R. and Hirschman, S.Z.: Comparison of Activity of Sisomicin. Antimicrob. Agents Chemother. 10:25-27, 1976.

Shalom Z. Hirschman, M.D. 10

Meyers, B.R. and Hirschman, S.Z.: Comparison of Activity of Sisomicin and Gentamicin in Mouse Protection Tests with Gram-Negative Bacilli. Antimicrob. Agents Chemother. 10:84-86, 1976.

Meyers, B.R. and Hirschman, S.Z.: Clinical Pharmacology in Infectious Diseases. Mt. Sinai J. Med. 44:89-99, 1977.

Meyers, B.R. and Hirschman, S.Z.: Antimicrobial Activity in Vitro of Netilmicin and Comparison with Sisomicin, Gentamicin and Tobramycin. Antimicrob. Agents Chemother. 11:118-121, 1977. Meyers, B.R. and Hirschman, S.Z.: Pharmacokinetics of Cefamandole in Patients with Renal Failure. Antimicrob. Agents Chemother. 11:248-250, 1977. Hirschman, S.Z., Meyers, B.R. and Miller, A.: Antimicrobial Activity of Cefamandole Against Salmonella typhi. Antimicrob. Agents Chemother. 11:369-371, 1977. Hirschman, S.Z. and Garfinkel, E.: Ionic Requirements of the DNA Polymerase Associated with Serum Hepatitis B Antigen. J. Infect. Dis. 135:879-910, 1977. Meyers, B.R., Hirschman, S.Z., Wormser, G. and Siegel, D.: Pharmacokinetic Study of Netilmicin. Antimicrob. Agents Chemother. 12:122-123, 1977. Siegel, D. and Hirschman, S.Z.: Hepatic Dysfunction in Acute Measles Infection of Adults. Arch. Intern. Med. 137:1178-1180, 1977.

Meyers, B.R. and Hirschman, S.Z.: Antimicrobial Activity in Vitro of Cefaclor, A New Oral Cephalosporin. J. Clin. Pharmacol. 18:85-90, 1978. Hirschman, S.Z., Gerber, M. and Garfinkel, E.: Differential Activation of Hepatitis B DNA Polymerse by Detergent and Salt. J. Med. Virol. 2:61-76, 1978. Meyers, B.R. and Hirschman, S.Z.: Antibacterial Activity in Vitro of Cefamandole. J. Infect. Dis. 1375:25-31, 1978.

Hirschman, S.Z. and Garfinkel, E.: Inhibition of Hepatitis B DNA polymerase by Intercalating Agents. Nature 271:681-683. 1978.

Meyers, B.R., Hirschman, S.Z. Gartenberg, G. and Srulevitch, E.: Pharmacologic Studies with Cefaclor, A new oral Cephalosporin. J. Clin. Pharmacol. 18:174-179, 1978. Meyers, B.R., Shear, K., Wormser, G., Gartenberg, G., Nicholas, P. and Hirschman, S.Z.: Cefamandole Therapy in Seriously ill Hospitalized Patients. Current. Chemother. 1:258-261, 1978.

Bottone, E., Wormser, G., Tudy, J. and Hirschman, S.Z.: Cardiobacterium hominis: Review of Prior Infections and Report of Endocarditis on a Fascia Lata Prosthetic Heart Valve. Am. J. Med. Sci. 276:117-126, 1978.

Shalom Z. Hirschman, M.D. 11

Meyers, B.R., Wormser G., Gartenberg, G., Nicholas, P. and Hirschman, S.Z.: Clinical Studies with the New Cephalosporin, Cefamandole, in Hospitalized Patients. Mt. Sinai J. Med. 45:722-728, 1978.

Onorato, I., Siegel, D., Zweng, M., Bottone, E. and Hirschman, S.Z.: Fatal Poliomyelitis with Culture of Virus from Cerebrospinal Fluid. Mt. Sinai J. Med. 45:694-697, 1978. Hirschman, S.Z.: Virological, Immunological and Clinical Correlations in Viral Hepatitis. Seminars in Infect. Dis. 2:48-97, 1979.

Meyers, B.R., Wormser, G. and Hirschman, S.Z.: Rhinocerebral Mucormycosis. Premortem Diagnosis and Therapy. Arch. Intern. Med. 139:557-560, 1979. Siegel, D. and Hirschman, S.Z.: Syphilitic Osteomyelitis with Diffusely Abnormal Bone Scan. Mt. Sinai J. Med. 46:320-322, 1979.

Gartenberg, G., Meyers, B.R., Hirschman, S.Z. and Srulevitch, E.: Pharmacokinetics of Cefaclor in Patients with Stable Renal Impairment and Patients Undergoing Hemodialysis. J. Antimicrob. Chemother. 5:465-470, 1979.

Hirschman, S.Z.: The Hepatitis B Virus and Its DNA Polymerase: The Prototype Three-D Virus. Molec. Cellular Biochem. 26:47-67, 1979.

Hirschman, S.Z.: Molecular Biology of Hepatitis B Virus. N.Y. State J. Med. 80:729-731, 1980. Meyers, B.R., Hirschman, S.Z., Strougo, L. and Srulevitch, E.S.: Comparative Study of the Pharmacokinetics of Piperacillin, Ticarcillin and Carbenicillin. Antimicrob. Agents Chemother. 17:608-611, 1980.

Price, P., Hirschman, S.Z. and Garfinkel, E.: DNA Cloned from the ayw Subtype of Hepatitis B Virus. J. Med. Virol. 6:139-145, 1980.

Hirschman, S.Z., Price, P., Garfinkel, E., Christman, J. and Acs, G.: Expression of cloned hepatitis B virus DNA in human cell cultures. Proc. Natl. Acad. Sci. U.S.A. 77:5507-5511, 1980. Hirschman, S.Z. and Garfinkel, E.: Infection of Human Cells in Culture with Hepatitis B Virus. Trans. Assoc. Amer. Phys. 93:60-71, 1980.

Meyers, B.R., Hirschman, S.Z., Strougo, L. and Wormser, G.: Clinical Study of Netilmicin Therapy of Hospitalized Patients with Gram-Negative Infection. Mt. Sinai J. Med. 48:42-46, 1981.

Gerber, M.A., Garfinkel, E., Hirschman, S.Z., Thung, S.N. and Panagiotatos, T.: Immune and Enzyme Histochemical Studies of a Human Hepatocellular Carcinoma Cell Line Producing Hepatitis B Surface Antigen. J. Immunol. 126:1085-1089, 1981. Giron, J., Meyers, B.R., Hirschman, S.Z. and Srulevitch, E.S.: Pharmacokinetics of Piperacillin in Patients with Moderate Renal Failure and Patients Undergoing Hemodialysis. Antimicrob. Agents Chemother. 19:279-283, 1981.

Shalom Z. Hirschman, M.D. 12

Meyers, B.R., Wormser, J.P. and Hirschman, S.Z.: Moxalactam Therapy in Seriously Ill Hospitalized Patients. In: Current Chemotherapy and Immunotherapy. Periti P. and Grassi GG.

(eds). Vol. 1., Proc. 12th Int. Congress Chemother. Am. Soc. Microbiol., Wash., D.C., pp. 569- 571, 1981.

Giron, J., Meyers, B.R. and Hirschman, S.Z.: Biliary Concentrations of Piperacillin in Patients Undergoing Cholecystectomy. Antimicrob. Agents Chemother. 19:309-311, 1981. Hirschman, S.Z.: Replication of Hepatitis B Virus in Cultures of Human Cells. In: Viral Hepatitis. Szmuness, W., Alter, H.J. and Maynard, J.E. (eds). International Symposium. Franklin Inst. Press, pp. 97-105, 1981.

Siegel, F.P., Lopez, C., Hammer, G.S., Brown, A.E., Kornfeld, S.J., Gold, J, Hasset, J., Hirschman, S.Z., Cunningham-Rundles, C., Adelsberg, B.R., Parham, D.M., Siegel, M., Cunningham-Rundles, 5. and Armstrong, D.: Severe Acquired Immunodeficiency in Male Homosexuals Manifested by Chronic Perianal Herpes Simplex Lesions. N. Eng. J. Med. 305:1439-1444, 1981.

Jacobson, J. and Hirschman, S.Z.: Necrotizing Fasciitis Complicating Intravenous Drug Abuse. Arch. Intern. Med. 142:634-635, 1982.

Hirschman, S.Z. and Garfinkel, E.: Replication of Hepatitis B Virus DNA in Animal Cell Cultures: Synthesis of Hepatitis B Surface and e Antigens. Hepatology 25:79-85, 1982. Scheer, M. and Hirschman, S.Z.: Oral and Ambulatory Therapy of Listeria Bacteremia and Meningitis. Mt. Sinai J. Med. 49:411-414, 1982.

Meyers, B.R., Hirschman, S.Z., Giron, J. and Srulevitch, E.S.: Pharmacokinetic Studies of Single and Multiple Doses of Moxalactam in Normal Volunteers. Clin. Trials J. 19:63-73, 1982. Hirschman, S.Z. Garfinkel, E. and Sugrue, 5.: Expression of Cloned Hepatitis B Virus DNA in Transfected Animal Cell Cultures. Trans. Assoc. Amer. Phys. 95:53-62, 1982. Parisier, S.C., Lucente, F.E., Hirschman, S.Z., Som, P.M., Arnold, L.M. and Roffman, J.D.. Nuclear Scanning in Necrotizing Progressive "Malignant" External Otitis. Laryngoscope 92:1016-1020, 1982.

Hirschman, S.Z.: The Hepatitis B Virus Vaccine. Drug Therapy 8:21-28, 1983. Meyers, B.R., Jacobson, J., Masci, J., Srulevitch, E.S. and Hirschman, S.Z.: Pharmacokinetics of Amdinocillin in Healthy Adults. Antimicrob. Agents Chemother. 23:827-830, 1983. Meyers, B.R., Srulevitch, E.S., Jacobson, J. and Hirschman, S.Z.: Crossover Study of the Pharmacokinetics of Ceftriaxone Administered Intravenously or Intramuscularly to Healthy Volunteers. Antimicrob. Agents Chemother. 24:812-814, 1983. Bodenheimer, H.C., Schaffner, F., Vernace, 5., Hirschman, S.Z., Goldberg, J.D. and Chalmers, T.: Randomized Controlled Trial of Quinacrine for the Treatment of HBsAg- Positive Chronic Hepatitis. Hepatology 3:936-938, 1983.

Shalom Z. Hirschman, M.D. 13

Mendelson, M., Meyers, B.R., Hirschman, 5.Z., Shapiro, E.R. and Parisier, S.: Treatment of Invasive External Otitis. Rev. Infect. Dis. 6:5698-5704, 1984. Reichling, J.J., Rose, D.N., Mendelson, M.H. and Hirschman, S.Z.: Acute Suppurative Thyroiditis Caused by Serratia Marcescens. J. Infect. Dis. 149:281-3, 1984. Hirschman, 5.Z.: Viral Infections in Immunosuppressed Patients. N.Y. State J. Med. 84:241- 244, 1984.

Hirschman, S.Z.: Replication of Hepatitis B Virus in Cell Culture Systems. In: Advances in Hepatitis Research. Chisari FV. (ed), Masson Publishing U.S.A., Inc., New York, pp. 54-62, 1984.

Meyers, B.R., Srulevitch, E.S., Sacks, H., Hirschman, S.Z., Worner, T., Wormser, G.P. and Jacobson, J.: Pharmacokinetics of Mezlocillin in Patients with Varying Degrees of Hepatobiliary Dysfunction. In: Current Chemotherapy and Immunotherapy, pp. 23-27, 1984. Hirschman, S., Garfinkel, E. and Sugrue, S.: The Hepatitis B Virus as a Molecular Model for Chronic Infection: Synthesis of Hepatitis B e and Surface Antigens in Mouse L Cells Transfected with Closed Circular Viral DNA. Ann. N.Y. Acad. Sci. 437:131-149, 1984. Serrano, M. and Hirschman, S.Z.: Properties of Hepatitis B e Antigen Synthesized by Rat Cells Transfected with Circular Viral DNA. J. Gen. Virol. 65:1373-1383, 1984. Meyers, B.R., Srulevitch, E.S. and Hirschman, S.Z.: Comparative In Vitro Activity of Coumermycin Against Methicillin-Resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 28:706-707, 1985.

Klein, N.C., Damsker, B. and Hirschman, 5.Z.: Mycobacterial Meningitis: Retrospective Analyses from 1970-183. Am. J. Med. 79:29-34, 1985. Brambilla, C., Tackney, C., Hirschman, S.Z., Colombo, M., Dioguardi, M.L., Jagirdar, J. and Paronetto F.: Varying Nuclear Staining Intensity of Hepatitis B Virus DNA in Human Hepatocellular Carcinoma. Lab. Invest.55:475-481, 1986. Meyers, B.R., Srulevitch, E., Sacks, H., Hirschman, S.Z., Worner, T., Wormser, J. and Jacobson, J.: Pharmacokinetics of Mezlocillin in Patients With Hepatobiliary Dysfunction. J. Antimicrob. Chemother. 18:709-713, 1986.

Meyers, B.R., Mendelson, M.H., Deeter, R.G., Srulevitch-Chin, E., Tortosa Sarni, M. and Hirschman, S.Z.: Pharmacokinetics of Cefoperazone in Ambulatory Elderly Volunteers Compared To Young Adults. Antimicrob. Agents Chemother. 31:925-929, 1987. Szabo, 5., Mendelson, M.H., Mitty, H.A., Bruckner, W. and Hirschman, 5.Z.: Infections Associated With Transhepatic Biliary Drainage Devices. Am. J. Med. 82:921-926, 1987. Meyers, B.R., Mendelson, M.H., Parisier, S.C. and Hirschman, 5.Z.: Comparative Study of Monotherapy and Combination Anti-Pseudomonal Therapy in the Treatment of Malignant External Otitis (MEO): A Retrospective Analysis. Arch Otolaryngology 113:974-978, 1987. Shalom Z. Hirschman, M.D. 14

Meyers, B.M., Mendelson, M.H., Parisier, S. and Hirschman, S.Z.: Comparative Study of Monotherapy and Combination Anti-pseudomonal Therapy in the Treatment of Malignant External Otitis (MEO): A Retrospective Analysis. Arch. Otolaryngology 113:974-978, 1987. Mendelson, M.H., Finkel, L.J., Meyers, B.R., Lieberman, J.P. and Hirschman, 5.Z.: Pulmonary Toxoplasmosis in the Acquired Immunodeficiency Syndrome. Scand. J. Infect. Dis. 19:703-706, 1987.

Meyers, B.R., Mendelson, H.H., Srulevitch-Chin, E., Bradbury, K., McMurdo, L. and Hirschman, S.Z.: Pharmacokinetic Properties of Mezlocillin in Ambulatory Elderly Subjects. J. Clin. Pharmacol. 27(9):678-681, 1987.

Hirschman, S.Z., Meyers, B.R., Bradbury, K., Mehl, B., Gendelman, 5. and Kimelblatt, B.: Use of Antimicrobial Agents in a University Teaching Hospital. Arch. Int. Med. 148:2001-2007, 1988.

Hirschman, S.Z. and Zucker, M.: Recombinant DNA Related to Hepatitis B and Human Immunodeficiency Viruses in Mononuclear Cells of Patients with AIDS.

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