Project Research

CV_Rana Adhikary

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CURRICULUM VITAE

PERSONAL DETAIL:

NAME: Rana Adhikary

FATHER’S NAME: Utpal Adhikary

DATE OF BIRTH: 10th April, 1989

GENDER: Male

NATIONALITY: Indian

RELIGION: Hinduism

CASTE CATEGORY: General

CONTACT DETAIL:

ADDRESS: 20/G/3, Shibtala lane, P.O. Bhadrakali,

Dist. Hooghly, West Bengal, PIN- 712232

CONTACT: +91-908*******

E -MAIL: ********@*****.***

ACADEMIC DETAIL:

DEGREE/

EXMAINATION

BOARD/

UNIVERSITY

NAME OF

INSTITUTION

YEAR OF

PASSING

SUBJECTS TAKEN TOTAL

MARKS/

% OF

MARKS

DIV/

Grade

Secondary

examination

(10th level)

WBBSE Uttarpara

Amarendra

Vidyapith

2005 Bengali, English,

Maths, Physical Sc, Life

Sc, Geography, History.

561/800

70.125%

1st

Higher Secondary

examination

(10+2 level)

WBCHSE Bhadrakali High

School

2007 Bengali, English,

Physics, Chemistry,

Biological Sc, Maths,

Environmental Sc.

334/500

66.8%

1st

Graduation

(B.Sc.)*

University of

Calcutta

Uttarpara Raja

Peary Mohan

College

2010 Physiology (Honours);

Zoology (General) and

Chemistry (General).

524/800

65.5%

1st

Post-graduation

(M.Sc

University of

Calcutta

Rashbehari

Siksha Prangan

(Rajabazar

Science college)

2012 Human Physiology

678/1000

67.8%

1st

**Completed post-graduation (M.Sc.) in Human Physiology from Department of Physiology, University of Calcutta with Specialization in Immunology and Microbiology; and also performed a project work entitled “Characterization of a clinical isolate of Streptococcus pneumoniae”. AWARDS AND ACHIEVEMENTS:

CSIR-UGC NET (LS): AIR-025 in December 2015 (97.57 percentile) AIR-045 in June 2016 (97.03 percentile)

GATE, 2013: AIR-562 (95.65 percentile); Biochemistry and Microbiology CV_Rana Adhikary

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COMPUTER KNOWLEDGE:

Proficient in basic use of Computer.

Operation of statistical softwares.

PRESENT STATUS:

Pursuing Ph.D. from Immunology laboratory, Department of Physiology in ‘University of Calcutta (Rashbehari Sikshya Prangan)’.

Working as Guest lecturer in Physiology, Department of Microbiology, Physiology and Zoology in ‘Saint Paul’s Cathedral Mission College’.

Working as Guest lecturer in Physiology, Department of Food and Nutrition in ‘Prasanta Chandra Mahalanobis Mahavidyalaya’.

TEACHING EXPERIENCE:

RESEARCH EXPERIENCE:

Three years of research experience in Immunology laboratory, Department of Physiology, University of Calcutta, under a research project, entitled – “Studies on the anti- inflammatory, anti-oxidant, immunomodulatory, anti-microbial and anti-arthritic properties of some common indigenous Indian medicinal plants”, sponsored by Department of Science and Technology (DST) [Grant No. 117(Sanc.)/ST/P/S&T/9G-8/2012, Dated- 25.04.2013], Govt. of West Bengal.

BROAD AREA OF RESEARCH EXPOSURE:

Infectious diseases, i.e. pneumonia, and endotoxemic shock.

Signaling associated with phagocytosis and intracellular survival of bacteria.

Effects of melatonin and different photoperiods on septic diseases.

Rheumatoid and septic arthritis in murine models.

Effect of receptor neutralization on inflammatory diseases. DURATION OF TEACHING SUBJECTS TAUGHT

POTENTIAL AREA OF

TEACHING

FROM TO

September,

2016

Present Physiology (Theoretical and

practical) for B.Sc. (as per

syllabus of University of

Calcutta, under 1+1+1 New

regulations)

Biochemistry and Molecular

biology; Haematology;

Immunology; Neuroscience;

Endocrinology, Reproductive

and Developmental Biology;

Cell signaling

CV_Rana Adhikary

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Natural products from Medicinal plants (polyphenols) in inflammatory diseases and arthritis.

KEY SKILLS:

Protein extraction from cells and tissues, purification, protein estimation, SDS-PAGE, Immunoblotting, Activity gel assay and ELISA.

DNA and RNA extraction from prokaryotes and eukaryotes, DNA and RNA purification and quantitation, PCR and agarose gel electrophoresis.

Immunological techniques, i.e. determination of antibody titer, DTH response, PFC, antigen-antibody reactions by precipitation, agglutination and hemagglutination, ELISA and others.

Microbiological techniques, i.e. bacterial staining, spore staining, characterization of the microbial organisms, testing of antibiotic susceptibilities, MIC, MBC, checkerboard assay and DAD.

Clinical biochemistry parameter assessments, determination and quantitation of antioxidants and pro-oxidants, enzyme kinetics and determination of Km, effect of pH and temperature on enzyme kinetics.

Basic histological and haematological techniques, Preparation and staining of blood film, identification of blood corpuscles, separation of lymphocytes, monocytes and neutrophils, DC of WBC, TC of RBC and WBC, Hemoglobin estimation, Blood group determination.

Testing and analysis of natural drugs (plant extracts), and in vivo as well as in vitro application of such drugs. Analysis of anti-oxidant, anti-inflammatory, anti-microbial and immunomodulatory actions of such drugs.

Basic skills in animal handling (rodents, e.g. mice), force feeding (p.o.), intravenous (i.v.) and intraperitoneal (i.p.) treatments, animal sacrifice and collection of different tissues. INSTRUMENTS OPERATED AND HANDLED:

Laminar air flow, bio-safety cabinet, and CO2 incubator

Phase contrast microscope

GENEI agarose gel system and UV illuminator

PCR system 9700 Thermocycler (Bio-Rad, MJ-Mini thermocycler)

Bio-Rad Microplate reader

Bio-Rad Mini-PROTEAN tetra gel, Trans-blot system and Gel documentation system

Dual beam UV-1800 UV-VIS spectrophotometer (Shimadzu, Kyoto, Japan)

Bio-Rad Spectrophotometer and Photoelectric colorimeter CV_Rana Adhikary

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TOTAL PUBLICATIONS AND IMPACT POINTS:

PUBLICATION

YEAR

CONTRIBUTION AS AN AUTHOR

NUMBER OF

PUBLICATION

IN EACH

YEAR

IMPACT

FACTOR

1st (to date)

Author

2nd

author

3rd

author

4th

author

2014 1 1 1 2 5 12.018

2015 1 - 1 1 3 4.451

2016 - 2 - - 2 4.506

2017 1 2 1 1 5 10.395

2018 1 - - - 1 0.59

Total = 4 5 3 4 16 31.96

Total no. of publications in 2014-2018 (Avg. in each year) = 16 (3.2) Total impact points in 2014-2018 (Avg. in each year) = 31.96 (6.39) CAREER SUMMARY TO DATE:

Appointed as a contractual lecturer in Prasanta Chandra Mahalanobis Mahavidyalaya in October, 2017

Joined as guest lecturer in Prasanta Chandra Mahalanobis Mahavidyalaya in August, 2017

Joined as guest lecturer in St. Paul’s Cathedral Mission College in September, 2016 upon termination of the DST, Govt. of West Bengal project

Awarded CSIR-UGC NET (LS), rank-045 in June, 2016 and rank-025 in December, 2015

Registered for Ph.D. (Science) from University of Calcutta, in September, 2014

Appointed as Junior Research Fellow under a DST, Govt. of West Bengal research project (three years) in July, 2013

Awarded GATE (Life Sc.), rank-562 in March, 2013

Awarded M.Sc. (Human Physiology, Spl.: Immunology and Microbiology) in 2012

Awarded B.Sc. (Physiology) in 2010

SEMINARS AND CONFERENCES:

Participated in Author Workshop jointly organized by Springer and University of Calcutta on November 20, 2014.

Presented article on A review on recent advances in human embryonic stem cell research: Advantages and disadvantages, in a UGC-DSA funded seminar on Emerging Trends in Biological Research in India held on March 6, 2012. CV_Rana Adhikary

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RESEARCH PUBLICATIONS:

1. Tumor necrosis factor receptor 1 (TNFR1) neutralization ameliorated carrageenan-induced inflammation in mice supplemented with herbal antioxidants. Rana Adhikary, Ajeya Nandi, Sahin Sultana and Biswadev Bishayi, International Journal of Pharmaceutical Sciences and Research, 2018. Vol.9, Issue 7: 1000-17. [Impact factor: 0.54]

2. Clitoria ternatea flower petals: Effect on TNFR1 neutralization via downregulation of synovial matrix metalloproteases. Rana Adhikary, Sahin Sultana and Biswadev Bishayi, Journal of Ethnopharmacology, 2017. Vol. 218, 209-22. [Impact factor: 2.981] 3. Protective effects of methanolic extract of Adhatoda vasica Nees leaf in collagen-induced arthritis by modulation of synovial toll-like receptor-2 expression and release of pro-inflammatory mediators. Rana Adhikary, Arnab Majhi, Sayantika Mahanti and Biswadev Bishayi, Journal of Nutrition and Intermediary Metabolism, 2015. Vol.1, Issue 3: 1-11. [Impact factor: Not assigned till 2017] 4. Immunomodulatory and anti-oxidant properties of methanolic extract of Adhatoda vasica Nees leaf after particulate antigen stimulation in mice. Rana Adhikary, Arnab Majhi, Sayantika Mahanti and Biswadev Bishayi; Journal of Pharmacy Research, 2014. Vol.8, Issue 10: 1520-37. [Impact factor: 0.74] 5. Altered expression of CXCR1 (IL-8R) in macrophages utilizing cell surface TNFR1 and IL-1 receptor during Staphylococcus aureus infection. Biswadev Bishayi, Rana Adhikary, Sahin Sultana and Ajeya Nandi; Microbial Pathogenesis, 2017. [Impact factor: 1.888] 6. Neutralization of MMP-2 and TNFR1 regulated the severity of S. aureus-induced septic arthritis by differential alteration of local and systemic proinflammatory cytokines in mice. Sahin Sultana, Rana Adhikary, and Biswadev Bishayi; Inflammation, 2017. [Impact factor: 2.618] 7. Beneficial effects of exogenous melatonin in acute Staphylococcus aureus and Escherichia coli infection- induced inflammation and associated behavioral response in mice after exposure to short photoperiod. Biswadev Bishayi, Rana Adhikary, Ajeya Nandi and Sahin Sultana; Inflammation, 2016. Vol. 39, Issue 6: 2072-93. [Impact factor: 2.618] 8. Neutralization of MMP-2 protects Staphylococcus aureus infection induced septic arthritis in mice and regulates the levels of cytokines. Sahin Sultana, Rana Adhikary, Ajeya Nandi and Biswadev Bishayi; Microbial Pathogenesis, 2016. Vol. 99, 148-61. [Impact factor: 1.888] 9. Levofloxacin - ceftriaxone combination attenuates lung inflammation in a mouse model of bacteremic pneumonia caused by multidrug resistant Streptococcus pneumoniae via inhibition of cytolytic activities of pneumolysin and autolysin. Arnab Majhi, Rana Adhikary, Aritra Bhattacharya, Sayantika Mahanti and Biswadev Bishayi; Antimicrobial Agents and Chemotherapy, 2014. Vol. 58, Issue 9: 5164-80. [Impact factor: 4.415]

10. Exogenous interleukin-10 and ciprofloxacin treatment reduces inflammation and helps to improve cognitive behaviour in acute and chronic restraint stressed mice infected with Escherichia coli. Sayantika Mahanti, Arnab Majhi, Rana Adhikary, Sourish Ghosh, Anirban Basu and Biswadev Bishayi; Indian Journal of Biochemistry and Biophysics, 2017. Vol. 54: 241-57. [Impact factor: 1.02] CV_Rana Adhikary

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11. In vitro susceptibility of a penicillin-resistant and tolerable isolate of Streptococcus pneumoniae to combination therapy. Arnab Majhi, Ajeya Nandi Rana Adhikary, Sayantika Mahanti and Biswadev Bishayi; Journal of Infection in Developing Countries, 2015. Vol. 9, Issue 7: 702-9. [Impact factor: 1.67]

12. Combination therapy with ampicillin and azithromycin in an experimental pneumococcal pneumonia is bactericidal and effective in down regulating inflammation in mice. Arnab Majhi, Kiran Kundu, Rana Adhikary, Madhubanti Banerjee, Sayantika Mahanti, Anirban Basu and Biswadev Bishayi; Journal of Inflammation, 2014. Vol. 11, Issue 5. [Impact factor: 1.975] 13. Expression of CXCR1 (IL-8 receptor A) in splenic, peritoneal macrophages and resident bone marrow cells after acute live or heat killed Staphylococcus aureus stimulation in mice. Biswadev Bishayi, Ajeya Nandi, Rajen Dey, Rana Adhikary; Microbial Pathogenesis, 2017. Vol. 109, 131-150. [Impact factor: 1.888]

14. Effect of exogenous MCP-1 on TLR-2 neutralized murine macrophages and possible mechanisms of CCR-2/TLR-2 and MCP-1 signalling during Staphylococcus aureus infection. Biswadev Bishayi, Debasish Bandyopadhyay, Arnab Majhi and Rana Adhikary; Immunobiology, 2015, Vol. 220, Issue 3: 350-62. [Impact factor: 2.781]

15. Expression of CXCR1 (Interleukin-8 receptor) in murine macrophages after Staphylococcus aureus infection and its possible implication on intracellular survival correlating with cytokines and bacterial anti-oxidant enzymes. Biswadev Bishayi, Debasish Bandyopadhyay, Arnab Majhi and Rana Adhikary; Inflammation, 2014. Vol. 38, Issue 2: 812-27. [Impact factor: 2.618] 16. Possible role of Toll-like receptor-2 in the intracellular survival of Staphylococcus aureus in murine peritoneal macrophages: Involvement of cytokines and anti-oxidant enzymes. Biswadev Bishayi, Debasish Bandyopadhyay, Arnab Majhi and Rana Adhikary; Scandinavian Journal of Immunology, 2014. Vol. 80, Issue 2: 127-43. [Impact factor: 2.27] DECLARATION:

I, RANA ADHIKARY, hereby declare that all statements made and informations furnished in this application are true and complete to the best of my knowledge and belief. I also declare that I have not concealed any material information which may debar my candidature for the position applied for. In the event of suppression or distortion of any fact or educational qualification, etc. made in my application form, I understand that I will be denied selection and if already selected to the said position my services will be cancelled/ terminated forthwith.

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