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PhD Physics Remote sensing, machine learning, medical imaging.

Location:
Vienna, Virginia, 22180, United States
Posted:
June 12, 2018

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Curriculum Vitae

Mark Francis Quigley, Ph.D.

Personal email: ac5uxd@r.postjobfree.com

Security Clearance: TS/SCI CI poly

https://www.linkedin.com/in/mfquigley

**** ********** **., ******, ** 22180 703-***-****

Synopsis of Experience

Remote sensing, machine learning, lidar, multispectral signal/image processing, analysis and visualization algorithm development, modeling of systems based on first principle physics. Matlab, IDL, Python, Fortran, Unix.

Current Research Appointments

Adjunct Assistant Professor

Department of Neurosurgery, Children’s National Medical Center, Washington, DC

Adjunct Assistant Professor

Department of Pediatrics, George Washington University School of Medicine

Honorary Fellow

Clinical Instructor of Radiation Oncology

Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health

Albert Einstein College of Medicine

Successful Research

Grant

Proposals

$32000 Children’s National Medical Center Bearacuda Risk Management Grant Award: Avoiding Disaster: A Novel Approach to Assessing Ventricular Volume and Shunt Function in Pediatric Patients.

$25000 grant from the American Syringomyelia and Chiari Alliance Project to expand on the MRI-based methodology I patented to differentiate between benign and malignant Chiari malformation birth defects, and to determine if non-Chiari syringomyelia may be diagnosed by the presence of abnormal movement of cerebrospinal fluid within the spine.

$5000 grant from Children’s National Medical Center in Washington, DC, to develop an MRI-based methodology to automatically measure changes in ventricular volume in hydrocephalus patients. This work also includes the first reliable measurements of CSF flow through the cerebral aqueduct, thereby distinguishing between patients with communicating vs. non-communicating hydrocephalus; a major step forward in the surgical intervention for these diseases.

NASA

High Dispersion International Ultraviolet Explorer Studies of Hot Central Stars of Planetary Nebulae, 1992.

NASA

Measuring Boron Abundances of B-Giants with IUE Spectra Using the B III Resonance Lines, 1996.

American Syringomyelia Alliance Project

Spatial and Temporal Flow Patterns in Chiari I Malformation Patients and Development of Syringomyelia, 2003 & 2004.

Patents

Method and System for Display of Medical Image Data (Patent No. 8,315,450 B2).

This patent describes an algorithm and interface to map between the spatial and temporal components of a multidimensional dataset. Applications include

Diagnosis and determination of the degree of pathology in Chiari malformation birth defect detection and quantification of cerebrospinal fluid flow abnormalities, and,

Differentiation between communicating and non-communicating hydrocephalus.

Patent Applications

All three of these patent applications are based on an algorithm to enable an m-dimensional operation to simultaneously be carried out on an n-dimensional dataset via a novel GUI-based interaction. This allows outliers of any sort to be identified, isolated, and enables statistical or visual analysis to be performed, either on the outlying populations themselves or any other subgroup of the datasets.

Automated method of measuring cerebral ventricle volumes: this enables shunt failure in hydrocephalus patients to be diagnosed at an earlier stage than is generally currently possible.

Automated method of measuring tumor volumes: methodology detects smaller changes in tumor size than are currently possible in conventional clinical practice; useful for determining efficacy of radiation or chemotherapy on malignant tumors.

Graphical method of isolating volumes with anomalous metabolite abundances using MRI spectroscopy, used for differentiation of benign and malignant tumors, and post-surgical malignant tumor remnants, also for early determination of effectiveness of radiation or chemotherapy.

Education

Ph.D.

Physics

Catholic University of America, Washington, DC

B.S.

Mathematics,

Physics, Geology

Michigan State University, East Lansing, MI

Dissertation Information

Ph.D. Thesis Title

Effective Temperatures and Elemental Abundances of Central Stars of Planetary Nebulae via non-Local Thermodynamic Equilibrium Modeling.

Professional

and Academic

Experience

Scientist

(Jan 2017- )

Harris Geospatial Solutions

Herndon, VA

Development of algorithms for automated feature definition for decision-tree and neural network training for a variety of classified projects to detect and identify objects of interest in maritime and space-based regimes.

Unclassified work included development of algorithms to extract features from very noisy lidar datasets for training neural networks to map power line locations and bare earth. This work also included development of algorithms to quantify to what degree different types of features affected the neural network identification results.

Senior Scientist

(2012-Nov 2016)

Xator, Inc.

Columbia, MD

Modeling of atmospheric transport of radiologic, chemical and biological agents for the Hazard Prediction and Assessment Capability (HPAC) software suite.

Developed automated wavelet-based algorithm to differentiate between signal and noise in 2D grid measurements of concentration vs. time of atmospheric-borne chemical agents.

Developed sensor grid to optimize 'capture' of data from chlorine release project: minimization of spatial under sampling problems.

Scientist

(2009-2012)

Leidos, Inc.

Reston, VA

Developed image and signal processing algorithms for sonar systems, including basic geometric and physical optics and automatic target recognition. Developed GUI-based suite of tools for training submarine sonar operators to recognize state of the art sonar signatures.

Developed data fusion and machine learning-based algorithms for detection of nuclear materials using combinations of radiographic and radiologic datasets. These statistical/visualization tools were designed to semi-automate the detection of radiologic materials within the global transportation grid, e.g., cargo containers on ships.

Professional

and Academic

Experience,

Cont.

Research Scientist

(2006-2009)

Naval Research Laboratory

Washington, DC

Theoretical physicist in laser-driven inertial confinement fusion research:

Main responsibility was running and maintaining 120,000-line Fortran code that models hydrodynamics and radiative transfer in high-density plasmas that result prior to and during fusion burn.

Developed user-interactive 4D visualizations (IDL) to derive optimal laser beam configuration and parameters to drive isotropic DT pellet compression to ignite fusion burn. This is a fundamental problem in the development of commercially viable energy from fusion.

Created suite of test algorithms with analytic solutions (e.g., propagation of a supersonic shock wave in an ideal gas at absolute zero) to benchmark and verify results from main modeling codes.

Developed IDL code for a large number of applications, e.g., GUI-driven tool to determine initial placement of points in the moving grid at which hydrodynamic quantities are calculated during compression and fusion burn.

Scientist & Lecturer University of Wisconsin-Madison (1997-2006)

Astrophysical Research:

Developed models of stellar atmospheres in a state of non-local thermodynamic equilibrium (very similar to my current work in fusion research). These models were used to create synthetic spectra to determine stellar properties for the research described below.

Researcher on Wisconsin H-a Mapper project to chart the distribution of warm interstellar hydrogen throughout the galaxy. Derived algorithms to remove intermittent high frequency spectral artifacts arising from optical imperfections and under sampling problems inherent in Fabry-Perot (Fourier) spectrographs.

Lecturer for: introductory astronomy course, hands-on and computer based astronomical laboratory classes, and accelerated second semester physics class.

Developed and currently teach online introductory astronomy class (2002-present).

Submitted proposal to the State of Wisconsin to develop an honors course reviewing the history of astronomy and physics within the cultural context of the time. Since I was not tenured faculty I was ineligible for the grant, despite the commendation of the dean.

Medical Imaging Research:

Developed algorithms to map between image and velocity facets of phase-contrast MRI data to detect and quantify abnormalities in the movement of cerebrospinal fluid (Chiari malformation), allowing this birth defect for the first time to be effectively diagnosed. These algorithms are also applicable to the detection of small scale blood flow abnormalities, (a factor in the development of plaque), or diagnosis of breast cancer (based upon mapping between contrast-enhanced and diffusion-weighted MRI data). These algorithms and associated software are the subject of the pending patent noted above.

Developed pulse sequence designs for projection reconstruction-based MRI scanning techniques; a methodology with mathematical similarities to CT scans. The advantage of such technology is that it reduces the time required for an MRI scan to the point where imaging of the cardiac arteries or other moving tissue may be possible.

Refereed Publications:

370 citations

Dolar MT, Haughton VM, Iskandar BJ, Quigley MF, Effect of craniocervical decompression on peak CSF velocities in symptomatic patients with a Chiari I malformation, American Journal of Neuroradiology, 25: 142-145 February 2004.

Cover article: Journal of Neurosurgery

Iskandar BJ, Quigley MF, Haughton VM, Foramen magnum CSF flow characteristics in children with Chiari I malformations before and after craniocervical decompression, Journal of Neurosurgery: (Pediatrics), 101:169-178, November 2004.

Quigley MF, Iskandar BJ, Quigley MA, Nicosia M, Haughton VM, Cerebrospinal fluid flow in the foramen magnum: temporal and spatial patterns in MR imaging in volunteers and in patients with a Chiari I malformation, Radiology, 232(1): 229-36, July 2004.

Cover article: American Journal of Neuroradiology

Haughton VM, Korosec FR, Medow JE, Dolar MT, Iskandar BJ, Peak systolic and diastolic CSF velocity in the foramen magnum in adult patients with Chiari I malformations and in normal control participants, American Journal of Neuroradiology, 24: 169-176, February 2003. Although not cited as an author my contribution to this work included the journal cover image, most of the figures in the article, one third of the text, and the principal discovery regarding the nature of CSF flow in Chiari patients.

Ignace R, Quigley MF, Cassinelli JP, Constraints from Infrared Space Observatory data on the Velocity Law and Clumpiness of the Wind of WR 136, 2003, Astrophysical Journal, 596, 538.

Ignace R, Cassinelli JP, Quigley MF, Babler B, Terminal Speeds and Ion Fractions from [Ca IV]] 3.207mm in Three Single WN Stars, 2001, Astrophysical Journal, 558, 771.

Proffitt CR & Quigley MF, Boron Abundances in Early B Stars: Results from the B III Resonance Line in IUE Data, 2001, Astrophysical Journal, 548, 249.

Mandle RJ, Quigley MF, Baltusis MA, Municipal Ground Water Development and Withdrawals in the Central Lower Peninsula of Michigan 1870-1987, 1991, United States Geological Survey Open File Report 91-215.

Invited Presentations

Advanced Direct Drive Fusion Energy Target Designs for sub-MJ lasers, 18th Topical Meeting on the Technology of Fusion Energy; Andrew J. Schmitt, Jason W. Bates, Steven Zalesak, Steven Obenschain, David E. Fyfe, Mark F. Quigley; September 2008.

Presentations

Quigley MF, Keating RF, Prediction of shunt failure facilitated by rapid (<40sec) and accurate volumetric analysis, 44th Annual Meeting of the International Society for Pediatric Neurosurgery, October 2016.

Keating RF, Jha T, Barnawi Z, Quigley MF, DeFreitas T, Myseros JS, Magge SN, Oluigbo CO, Prediction of shunt failure facilitated by rapid (<40 sec) and accurate volumetric analysis, European Association of Neurological Surgeons Annual Meeting, Athens, Greece Sept 7, 2016.

Quigley MF, Keating RF, Is CSF flow the ‘Holy Grail’ to determining the Clinic-pathological Significance of Chiari Malformation?, American Syringomyelia & Chiari Alliance Project Conference, July 2015.

Quigley MF, Meris, R, Optimization of Sensor Grids for CBRN Releases, 19th Annual George Mason University Conference on Atmospheric Transport and Dispersion, July 2015.

Quigley MF, Meris R., Optimization of Sensor Grids for CBRN Release Tests, 2014 Chemical and Biological Warfare Weaponization and Consequence Assessment Modeling Symposium, December 2014.

Quigley MF, Meris, R, Optimization of Sensor Grids for CBRN Releases, 18th Annual George Mason University Conference on Atmospheric Transport and Dispersion, July 2014.

Quigley MF, Chowdhury B, Sykes, I, Noise characteristics of FFT07 data: Development of an algorithm for automated determination of noise threshold, 17th Annual George Mason University Conference on Atmospheric Transport and Dispersion, July 2013.

Quigley MF, CSF flow abnormalities as a robust diagnostic in adult and pediatric Chiari I patients, American Syringomyelia & Chiari Alliance Project Conference, August 2013.

Quigley MF, CSF flow in normal adult and pediatric subjects: CSF flow abnormalities as a Diagnostic in Chiari I patients, Conquer Chiari Research Conference 2012: Chiari Malformation: State of the Research and New Directions, November 2012.

Quigley MF, Hypothesis on the formation of syringes; Possible applications of CSF flow abnormalities as a pre-symptomatic diagnostic for Normal Pressure Hydrocephalus and Parkinsons/Alzheimers, American Syringomyelia & Chiari Alliance Project Conference, August 2012.

Schmitt AJ, Bates JW, Fyfe DC, Obenschain SP, Zalesak ST, Quigley M, Betti R, Direct drive target designs for laser fusion energy, American Physical Society, 50th Annual Meeting of the Division of Plasma Physics, 2008.

Quigley MF, Haughton VM, Motion of the spinal cord during the cardiac cycle in adult patients with a Chiari I malformation and adult volunteers, 42nd meeting of the American Society of Neuroradiology, June 2004.

Quigley MF, Haughton VM, Motion of the spinal cord during the cardiac cycle in adult patients with a Chiari I malformation and adult volunteers, 42nd meeting of the American Society of Neuroradiology, June 2004.

Iskandar BJ, Quigley MF, Haughton VM, Understanding the flow dynamics of CSF within the foramen magnum in Chiari I children using MRI, 71st Annual Meeting of the American Association of Neurological Surgeons, San Diego, May 2003.

Haughton VM, Quigley MF, Iskandar BJ, Patterns of cerebrospinal fluid flow in the foramen magnum of normal subjects and patients with a Chiari I malformation, 41st Meeting of the American Society of Neuroradiology, April 2003.

Quigley MF, Haughton VM, Characteristics of CSF flow in Chiari I patients and normal subjects via phase contrast MRI, 88th meeting of Radiological Society of North America, December 2002.

Haughton VM, Dolar M, Korosec F, Quigley MF, Iskandar BJ, Peak systolic CSF velocity in patients with Chiari malformations and in normal subjects, Symposium Neuroradiologicum, August 2002.

Haughton VM, Iskandar BJ, Quigley MF, Mistretta CA, Patterns of cerebrospinal fluid flow in the foramen magnum of normal subjects and patients with a Chiari I malformation, 55th Nordic Radiologic Conference, April 2002.

Conference

Proceedings/

Abstracts

Haughton VM, Iskandar BJ, Quigley MF, CSF flow velocity in the foramen magnum of normal subjects with relation to age, American Society of Neuroradiology, 2004.

Turk Q, Haughton V, Iskandar BJ, Quigley MF, Effect of relative obstruction at the foramen magnum on CSF velocity: studies in an experimental model, American Society of Neuroradiology, 2004.

Iskandar BJ, Quigley MF, Haughton VM, Effect of posterior fossa decompression on CSF flow patterns in the foramen magnum of children with Chiari I malformations, American Association of Neurological Surgeons, April 2003.

Quigley MF, Carroll TJ, Mistretta CA, Haughton VM, Quantification of CSF velocity field abnormalities in patients with Chiari malformations, 10th meeting of the International Society of Magnetic Resonance in Medicine, May 2002.

Proffitt CR, & Quigley MF, 1999, Boron Abundances in Early-B Stars: The [B III] 2065.8 Angstrom Line in IUE Data, Bulletin of the American Astronomical Society, 195.5008P.

Quigley MF & Bruhweiler FC, 1995, Line Identifications in Type O Subdwarfs BD+28 4211, BD+75 325, and B0 Main Sequence Star Tau Sco, Bulletin of the American Astronomical Society.

Quigley MF, Bruhweiler FC, 1995, Spectra Characteristics and Physical Parameters of Central Stars of Planetary Nebulae via NLTE Modeling, Bulletin of the American Astronomical Society.



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