Research Coordinator

RESUME

Melin Vranesic

Cell: 443-***-****

******@*******.***

Extensive experience in coordinating all clinical aspects of research studies, as well as regulatory requirements of institutional and sponsor review boards or FDA, etc.

Functional knowledge of Good Clinical Practices (GCP), Office of Human Research Protections (OHRP) regulations and Food and Drug Administration (FDA) regulations.

Foreign medical graduate, not licensed in the US but eligible for US medical licensing.

Legally permanent resident in the US and shall not require immigration support.

Skills:

Capable to thoroughly understand the scientific query of each assigned research project.

Proven skills in human subject outreach, identification, screening and recruitment.

Able to independently complete all aspects of human subject scheduling.

Demonstrated ability to communicate medical/health scientific topics effectively to a diverse

audience.

Excellent organizational skill and attention to details.

Through understanding of medical terminology.

Demonstrated excellent writing and communication skills.

Proficiency in the use of software applications, databases, spreadsheets, and word processing.

Able to complete work tasks accurately and in a timely manner.

Diligent in all manners of documenting and proving achieved results.

Able to work independently, report regularly and transparently, creative and proactive in resolving

issues that may arise.

High level of functionality under stress; calm, compassionate and empathetic.

Produce deliverables on short notice and/or strict deadlines.

Constantly strive to improve and streamline the workflow to achieve higher efficiency.

Cooperative and helpful with the team.

Able to seek out resources and opportunities that will benefit assigned

research studies.

Experience:

June 2016 – January 2018

Johns Hopkins University, School of Medicine, Department of Radiology, Division of

Nuclear Medicine

Baltimore, MD

Research Associate:

Recruitment and case management:

1.Human Subject Outreach, identification, screening and recruitment:

In the community via advertising and personal contact.

In the clinic through referrals and interaction with patients.

Establish collaborations and networking.

Clinical tumor board meetings.

Preliminary telephone screening to determine general eligibility.

2.Human Subject Scheduling for studies:

Submit requests to scheduling.

Check schedule/availability of scanners if necessary.

Liaise between patients, study team members, imaging center staff to ensure uninterrupted study activities.

Logistical arrangements, travel and accommodation for out of town study participants; special needs requests, reimbursements.

Assessment and testing

1.Human Subject Clinical Work-Up:

History and physical exam.

Required laboratory work-up.

Review results to confirm eligibility based on inclusion and exclusion criteria.

2.Protocol and necessary paperwork documentation preparation for studies:

Create study protocols and change in research amendments.

Ensure timely submission of all required documents and paperwork for annual FDA reports, IRB continuing reviews.

Maintain and update the accurate study and patient relevant information in EPIC and CRMS.

3.On the day of the study:

Manage study patients from the point of arrival until the point of departure.

Assist with the arterial line placement and other necessary prep activities.

Monitor the use of the correct scanning protocol.

Record study time points, verify subject’s name, DOB, subject’s anonymized code.

Prepare the necessary supplies to be used during the duration of the study, i.e. tubes for blood sampling, urine collection, etc.

Assist with the arterial catheter placement and perform the removal of the arterial line after the scan is over.

Label correctly all sample vials for biodistribution, PK, urine.

Manage the Blood Sampling Times Worksheet.

Monitor the EKG baseline pre-injection of the tracer, as well as after the PET scans per protocol.

Record subject’s vitals: HR, BP, RR, Pulse Ox at baseline pre-injection, after the PET scans, and for Pulse Ox continuously during the scans.

Ensure successful transfer of all the imaging data per protocol.

File infusion data sheet and QC information.

Perform plasma radiotracer metabolite and the plasma PK analysis of the collected samples.

Perform the processing of the whole blood biodistribution samples.

Record the gamma counter and calibration coefficient.

Filing of the annual calibration report if necessary.

Sample processing for the total bio sample collection and biodistribution.

Ensure that the data is correctly recorded in all the study datasheets and worksheets.

Data analysis, publications, grant proposals

1.Imaging data analysis:

Acquire imaging files from UV, MINIPACS, etc.

Transfer data from other servers.

Convert files if necessary, DICOM, PMT, etc.

Biological specimen samples and imaging data processing.

Quantitative image analysis using VOI, ROI, TAC.

Backup and storage for the completed studies.

Maintain a list of all completed and processed studies, trial master files, source documentation and medical data bases (eSOFT, CRMS, EPIC).

2.Data interpretation and publishing:

Participate in final data analysis.

Manuscript (co)authorship.

Collaborate on idea development for further studies.

Assist in grant writing.

Quality control and safety assurance

1.Research Bio Safety Officer for the Department Of Radiology and Division of Nuclear Medicine:

Work with the Office Of Health Safety And Environment, JH SOM.

Conduct annual bio safety surveys of all research facilities and areas in the department. (Total of 75 labs and locations.)

Assure safety and compliance with environmental and health code requirements of equipment and all materials used in research.

Co-ordinate with individual PI’s correction of all items cited during the inspection as well as facilities related maintenance issues.

2.Quality control of research cameras and scanners:

Perform periodically or as needed quality control of imaging equipment used in research for their sensitivity.

Perform calibration of cameras for the existing or new sources.

Perform phantom QC to check for drifts and accuracy of the source.

Academic and scientific education

1.Internship for undergraduate students:

Interview and participate in selection of candidates for various internship positions in the department.

Supervise and mentor the selected candidates during their internship.

Educate interns on scientific as well as clinical aspects of their assigned studies.

Evaluate performance of the interns/volunteers regularly.

2.Scientific activity in the field:

Attend scientific meetings as part of the research team.

Be competent to present results on behalf of the PI when needed.

Present findings at various forums.

Talent for networking and collaboration across field

November 2010 to June 2016

Johns Hopkins School of Medicine; The Russel H. Morgan Department of Radiology and

Radiological Sciences

Baltimore, MD

Research Assistant

Responsible for design, organization of experiments and processing of acquired data in

numerous molecular imaging studies, more specifically Imaging and Physiologic Studies in

Malaria; PET-CT Imaging Of The Cystic Fibrosis Model; PET Imaging of Cannabinoid Receptor

CB2 in Anti-Immune Therapy Inflammation In Prostate Cancer Immunotherapy; Molecular

Imaging Of The Nicotinic Acetylcholine Receptors α4β2-nAChR In Gastroparesis; PET Imaging

of the Angiotensin Subtype 1 Receptor (AT1R) in Human Kidney Transplants.

March 2004 to 2010

Johns Hopkins School of Medicine; The Russel H. Morgan Department of Radiology and Radiological Sciences.

Baltimore, MD

Post Doctoral Research Fellow

Responsible for design, organization of experiments and processing of acquired data in

numerous molecular imaging studies looking at availability of the serotonin transporter in the

human brain in different clinical conditions. Most recently I have been responsible for the design

and implementation of molecular imaging studies that are part of a research in successful

development of non-invasive imaging modalities which can be applied towards a variety of

research endeavors studying the pathobiology of malaria and development of novel

anti-malarial therapeutics supported by the Johns Hopkins Malaria Institute.

Education and Training

2010

Johns Hopkins School of Medicine; The Russel H. Morgan Department of Radiology and

Radiological Sciences.

Baltimore, MD, USA

Molecular Imaging

Post Doctoral Research Fellowship in Radiology and Radiological Sciences.

2000 School Of Medicine, University of Sarajevo

Sarajevo, Bosnia-Herzegovina

Psychiatry

Residency

1993 University of Sarajevo, School Of Medicine

Sarajevo, Bosnia-Herzegovina

Medicine

Medical Doctor

Invited Lectures:

PET Imaging of the Serotonin Transporter in Depression Post-Myocardial Infarction, Center for Mind Body Research, Dpt. Of Medicine, Johns Hopkins Bayview Campus.

PET Imaging in Stress Induced (Takotsubo) Cardiomyopathy. Center for Mind Body Research, Dpt. Of Medicine, Johns Hopkins Bayview Campus.

Imaging the Serotonin Transporter in Acute Brain Lesion, Dpts. Of Neurology, Psychiatry and Radiology, Nuclear Medicine Division, Johns Hopkins Medical Institutions.

Human Sexuality, Society and Politics Red Cross teenage peer counsellors, Training of Trainers, Seminars in Reproductive Health, Sarajevo, BH.

Trauma Awareness Training to Senior Citizens, CARE International in Bosnia-Herzegovina.

Scientific Meetings:

1st International Congress Of Psychiatry, Sarajevo, Bosnia-Herzegovina, 2003:

M. Vranesic.

Mental Health In Afghanistan..

54th Society of Nuclear Medicine Annual Meeting, Washington, D.C. 2007: M. Vranesic, Z. Szabo, J. Varga, G. Ricaurte, U. D. McCann; Radiology/Nuclear Medicine, Neurology, Psychiatry, Johns Hopkins, Baltimore, Maryland; Institute Of Nuclear medicine, University Of Debrecen, Debrecen, Hungary.

Reduction Of SERT Binding In Ecstasy Users: Reproducibility Of PET Studies.

2nd International Congress of Psychiatry, Sarajevo, Bosnia-Herzegovina 2007:

M. Vranesic, Z. Szabo, G. Ricaurte, U.D. McCann. Radiology/Nuclear Medicine, Neurology, Psychiatry, Johns Hopkins, Baltimore, Maryland.

PET In Psychiatry: Imaging Of The Serotonin Transporter In Human Brain.

9th World Congress Of Nuclear Medicine and Biology, Seoul, Korea 2006: Zsolt Szabo, Jozsef Varga, Miklos Emri, Esen Seckin, Melin Vranesic, Gary Wand, George Ricaurte, Una McCann, Johns Hopkins Medicine, U.S.A.; Institute of Nuclear Medicine University of Debrecen, Hungary.

SPM Analysis Of The Serotonin Transporter Images In Alcoholics And MDMA Users

9th World Congress Of Nuclear Medicine and Biology, Seoul, Korea 2006:

Esen Seckin, Melin Vranesic, Jinsong Xia, William Mathews, John Hilton, Sung E. Yoo, Zsolt Szabo, Johns Hopkins Medicine, U.S.A.; Center for Biological Modulators, Korea.

PET Imaging Of The AT1 Receptor In Humans.

52nd Annual Meeting of the Society of Nuclear Medicine, Toronto, Canada 2005:

Esen Seckin, Zsolt Szabo, George Ricaurte, Tamas G. Zober, Maria A. Sy, Melin Vranesic, William B. Mathews, Robert F. Dannals, Hayden T. Ravert, Peter Rosenblatt, Una McCann, Departments of Radiology/Division of Nuclear Medicine, Neurology and Psychiatry, The Johns Hopkins School of Medicine, Baltimore, MD.

Comparison Of The Binding Parameters Of [11C]MCN5256 And [11C]DASB In Human Subjects.

European Association Of Nuclear Medicine, Istanbul, Turkey 2005: E. Seckin, M. Vranesic, S. Demehri, J. Xia, W. B. Matthews, K. Hong, D. Bluemke, L. Lerman, Z. Szabo; Johns Hopkins University School of Medicine, Baltimore, MD, Mayo Clinic College of Medicine, Rochester, MN.

Angiotensin II Subtype AT1 Receptor Regulation In The Swine Model Of Renal Artery Stenosis.

2010 Annual Meeting, American College of Neuropsychopharmacology: Ikwunga Wonodi, Melin Vranesic, Henry Holcomb, Laura Rowland, Elliot Hong, Dean Wong, Gunvant Thaker, Zsolt Szabo.Correlation Between DAT1 Polymorphism, Dopamine Transporter Density And Eye Tracking: A Combined Genetic And PET Imaging Study.

2015 Annual Meeting Society Of Nuclear Medicine and Molecular Imaging, Baltimore, MD:

1.)Coughlin JM; Wang Y; Vranesic, M; Ford C; Hayes LN; Minn I; Sawa A; Pomper MG.

CNS Markers Of Inflammation And Oxidative Stress In Patients With Early Stage Schizophrenia: A Combined Study Of CSF And [11C]DPA-713 PET-Based Imaging.

2.)Jianhua Zhang, Esther Mena Gonzalez, Yan Fan, Rongfu Wang, Melin Vranesic, Zoltan Mari, Zsolt Szabo. Peking University First Hospital, Beijing, China; Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Comparison Of Two Methods For Semiquantitative Evaluation Of DaTSCAN.

3.) Mena, Z. Szabo, S. Rowe, E.S. Antonarakis, M. Eisenberger, M. Carducci, M. Vranesic, R. C. Mease, S.Y. Cho, M.G. Pomper. JHU/APL Baltimore, Maryland; University Of Wisconsin, Madison, Wisconsin.

First-In-Man Analysis Of 18F-DCFPyL, A Second Generation 18F Labeled PSMA-Targeted Radiotracer, In Patients With Metastatic Prostate Cancer.

4.)R. El Khouli, M.A. Lodge, M. Zeiger, M. Vranesic, H.A. Ziessman, Z. Szabo; Radiology/Nuclear medicine, The Johns Hopkins University, Baltimore, Maryland; Department Of Surgical Oncology, The Johns Hopkins University, School Of Medicine, Baltimore, Maryland.

Quantitative SPECT CT Of The Parathyroid With SUV Measurements.

2015 Annual Meeting, American College of Neuropsychopharmacology:

Jennifer M. Coughlin, Yuchuan Wang, Melin Vranesic, Il Minn, Nicholas Bienko, Matthew Peters, John Dougherty, Cynthia Munro, and Martin Pomper Icreased Translocator Protein Binding In The Brains Of Active And Recently Retired NFL Players: A Pilot Study Using [11C]DPA-713 PET-Based Neuroimaging.

2016 Annual Conference of the Society of Biological Psychiatry.

Coughlin JM, Wang Y, Xu X, Vranesic M, Minn I, Bienko N, Peters ME, Dougherty J, Munro CA, Mori S, Pomper MG. Measuring Inflammation In Brains Of NFL Players Using [11C]DPA-713 PET

Journal articles – peer reviewed

Published:

Jennifer M. Coughlin, Yong Du, Hailey B. Rosenthal, Stephanie Slania, Soo Min Koo, Andrew Park, Ghedem Solomon, Melin Vranesic, Inga Antonsdottir, Caroline L. Speck, Kelly Rootes-Murdy, Alexandria Lerner, Steven P. Rowe, Yuchuan Wang, Wojciech G. Lesniak, Il Minn, Arnold Bakker, Gwenn S. Smith and Martin G. Pomper. The distribution of the alpha7 nicotinic acetylcholine receptor in healthy aging: An in vivo positron emission tomography study with [18F]ASEM. NeuroImage Volume 165, 15 January 2018, Pages 118-124.

Zsolt Szabo, Esther Mena, Steven P. Rowe, Donika Plyku, Rosa Nidal Rios, Mario A. Eisenberger, Emmanuel S. Antonarakis, Hong Fan, Robert F. Dannals, Ying Chen, Ronnie C. Mease, Melin Vranesic, Akrita Bhatnagar, George Sgouros, Steve Y. Cho, Martin G. Pomper: Initial evaluation of 18F-DCFPyL for prostate-specific membrane antigen (PSMA)-targeted PET imaging of prostate cancer. Mol Imaging Biol (2015) DOI: 10.1007/s11307-015-0850-8* World Molecular Imaging Society, 2015

Una D. McCann, Zsolt Szabo, Melin Vranesic, Michael Palermo, William B. Mathews, Hayden T. Ravert, Robert F. Dannals, George A. Ricaurte. Positron Emission Tomographic Studies of Brain Dopamine and Serotonin Transporters in Abstinent 3,4-Methylenedioxymethamphetamine Users: Relationship to Cognitive Performance. Psychopharmacology (Berl). 2008 Oct;200(3):439-50. doi: 10.1007/s00213-008-1218-4. Epub 2008 Jul 27.

Xia J, Seckin E, Xiang Y, Vranesic M, Mathews WB, Hong K, Bluemke DA, Lerman LO, Szabo Z. Positron-emission tomography imaging of the angiotensin II subtype 1 receptor in swine renal artery stenosis. Hypertension. 2008 Feb;51(2):466-73. Epub 2008 Jan 2.

McCann UD, Szabo Z Vranesic M,, Seckin E, Wand G, Duval A, Dannals RF, Ricaurte GA. Quantitative positron emission tomography studies of the serotonin transporter in humans previously treated with appetite suppressants fenfluramine or dexfenfluramine. Mol Imaging Biol. 2007 May-Jun:9(3):151-7

Basoglu M, Livanou M, Crnobaric C, Franciskovic T, Suljic E, Duric D, Vranesic M. Psychiatric and cognitive effects of war in former Yugoslavia: association of lack of redress for trauma and posttraumatic stress reactions. JAMA. 2005 Aug 3:294(5):580-90.

Tao Feng, Benjamin M. W. Tsui, Xin Li, Melin Vranesic, Martin A. Lodge, Nedim C.M. Gulaldi, Zsolt Szabo. Image-Derived and Arterial Blood Sampled Input Functions for Quantitative PET Imaging of the Angiotensin II Subtype I Receptor in the Kidney.

Martin Pomper, Jennifer Coughlin, Yuchuan Wang, Emily Ambinder, Rebecca Ward, IL Minn, Melin Vranesic, Candice Ford, Cecilia Higgs, Lindsay Hayes, David Schretlen, Robert Dannals, Michael Kassiou, and Akira Sawa. In vivo markers of inflammatory response in recent onset schizophrenia: A combined study using [11C]DPA-713 PET and analysis of CSF and plasma.

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