Dr. Pratima Malekar, PhD

Am Hechenberg *, ***** Mainz

+49-176-********, ac5kpr@r.postjobfree.com

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Curriculum Vitae

PERSONAL DATA

Date of Birth 22.01.1978, Kurnool (Indian)

Nationality German

JOB EXPERIENCE

04/2002 – 03/2004 Junior Research Fellow, Department of Biochemistry All India Institute of Medical Sciences, New Delhi, India 04/2004 – 05/2005 Senior Research Fellow, Department of microbiology All India Institute of Medical Sciences, New Delhi, India 06/2005 – 05/2010 PhD Student, Cardiology Department, Innere Medizin III Ruprecht-Karls University, Heidelberg

09/2010 – 10/2012 Postdoctoral Fellow (Medical Faculty Post-Doc Programm) Cardiology Department, Innere Medizin III, Ruprecht-Karls University, Heidelberg

10/2012 – 02/2017 Parental Leave and German Course B1, Volkshochschule, Mainz 03/2017 – 06/2017 German Course B2, Volkshochschule, Mainz 06/2017 – 10/2017 Clinical Research Associate

Pharma Academy, Mannheim

Certified: ICH GCP, Regulatory Affairs, Pharmacovigilance STUDIES / ACADEMIC QUALIFICATION

06/2005 – 05/2010 PhD, (Score: Magna cumlaude); Supervisor: Prof. Dr. Stefan E Hardt, Cardiology Department, Innere Medizin III

Ruprecht-Karls Universität, Heidelberg

05/1999 – 07/2001 M.Sc. (Virology), Sri Venkateswara University, Tirupati, India 06/1996 – 04/1999 B.Sc. (Triple Major: Microbiology, Biochemistry and Chemistry) Sri Venkateswara University, Tirupati, India

Dr. Pratima Malekar, PhD

Am Hechenberg 2, 55129 Mainz

+49-176-********, ac5kpr@r.postjobfree.com

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LANGUAGE SKILLS

Deutsch(EU-Level B2)

English (EU-Level C2)

Telugu (Mother Tongue)

Hindi, Marathi (EU-Level B2)

HONORS, AWARDS

05/2010 Obtained prestigious young investigator award from the Medical faculty Ruprecht-Karls University Heidelberg

01/2002 Joint CSIR-UGC National Eligibility test for Lectureship

(Council of scientific and Industrial Research –University Grants commission India)

PUBLICATIONS

Pratima Malekar, Hagenmueller Marco, Adamma Anyanwu, Sebastian Buss, Markus Streit, Weiss CS, Wolf D,Riffel J,Bauer A, Hugo A Katus, Stefan E Hardt. Wnt-Signaling is critical for maladaptive cardiac hypertrophy and accelerates myocardial remodeling. Hypertension 2010 IF: 7.36

Sebastian Buss, Sebastian Muenz, Johannes Riffel, Pratima Malekar, Celine Johanssen, Florian Bea, Raffi Bekeredjian, Martina Schinke-Braun, Seigo Izumo, Hugo A Katus, Stefan E Hardt. Beneficial effects of mTOR inhibition on left ventricular remodelling after myocardial infarction.

Journal of the American College of Cardiology, 2009 Dec 15, 54(25):2435-46. IF: 11.43

Hagenmueller M, Pratima Malekar, Fieger C, Weiss CS, Sebastian Buss, David Wolf, Hugo A Katus, Stefan E Hardt. Depletion of mammalian target of rapamycin (mTOR) via siRNA mediated knockdown leads to stabilization of beta-catenin and elicits distinct features of cardiomyocyte hypertrophy.

FEBS LETT. 2010 Jan 4 ;584(1): 74-80. IF: 3.26

Sebastian Buss, Johannes Riffel, Pratima Malekar,Hagenmueller Marco, Ascel C, Zhang M, Weiss C,Hugo A Katus, Stefan E Hardt. Chronic Akt blockade aggravates pathological hypertrophy and inhibits physiological hypertrophy. Am J Physiol Heart Circ Physiol. 2012 Jan;302 (2):H420-30. IF: 3.62

Weiss CS, Marco M. Ochs,Hagenmueller M, Marcus R. Streit, Pratima Malekar, Johannes H. Riffel,Sebastian J. Buss,Karl H. Weiss,Junichi Sadoshima,Hugo A. Katus,Stefan E. Hardt DYRK2 Negatively Regulates Cardiomyocyte Growth by Mediating Repressor Function of GSK-3β on eIF2Bε. PLOS ONE, 2013 IF:3.53

Dr. Pratima Malekar, PhD

Am Hechenberg 2, 55129 Mainz

+49-176-********, ac5kpr@r.postjobfree.com

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SCIENTIFIC PRESENTATIONS

Pratima Malekar, Sebastian Buss, Markus Streit, Marco Hagenmüller, Celine Johanssen, Hugo A. Katus, Stefan E. Hardt “Activation of Wnt-signaling leads to cardiac hypertrophy and left ventricular dysfunction”. Deutsche Gesellschaft fur Kardiologie-Herz-und Kreislauf- forschung e.v.73rd Annual Meeting of the German Cardiac society March-2008 (oral presentation)

Sebastian M, Pratima Malekar, Johanssen C, Buss S, Hansen A, Bekeredjian R, Korsoglou G, Hugo A Katus, Kuechrer HF, Stefan E Hardt. “Inhibition of protein synthesis via mTOR dependent pathway prevents adverse left ventricular remodeling and reduces infarct size after experimental myocardial infarction” Journal of American Cardiology Congress, 55th Annual Scientific Session, Feb-2006, 47; 820-7,74A. (Poster Presentation) TECHNICAL SKILLS

Adept in basic molecular cloning and generation of transgenic animal models

Cell culture especially working with primary cells (Isolation of neonatal cardiomyocytes), Transfection assays

Adept in basic cell biological assays including Western Blotting, Immunoprecipitation, ELISA Immunohistochemistry and Immunocytochemistry, Flow Cytometry.

Molecular biology techniques such as RT-PCR, Quantitative PCR, RFLP

Animal handling and general surgical techniques for isolation of mouse samples for histology and other biochemical assays. Certificate course on “Laboratory Animal Science and methods of Animal Experimentation”.

SOFT SKILLS

Conceptually designing, planning and execution of experimental work.

Guiding young PhD students, medical students, trainees within the lab.

Writing/ presenting reports, Manuscripts

Conflictmanagement Training 2017

Dr. Pratima Malekar, PhD

Am Hechenberg 2, 55129 Mainz

+49-176-********, ac5kpr@r.postjobfree.com

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REFERENCENS

Prof. Dr. Stefan E Hardt, MD

Kardiologie im Friedrichspalais

Hoheneggerstraße 9, 76646 Bruchsal

E-mail: ac5kpr@r.postjobfree.com

Tel: +49-725*-*****

Dr. Sebastian J Buss, MD

Das Radiologische Zentrum

Alte Waibstadter Straße 2 a, 74889 Sinsheim

E-mail: ac5kpr@r.postjobfree.com

Tel: +49-622*-*******

Dr. Claudia Metz

PharmaAcademy Mannheim

Weinheimer Straße 62, 68309 Mannheim

E-mail: ac5kpr@r.postjobfree.com

Tel: +49-157*-*******

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