State University Engineering

Brittney A. Cardinell, PhD

(maiden name: Brittney A. Haselwood)

Email: ac3sk7@r.postjobfree.com Phone: 480-***-**** LinkedIn: https://www.linkedin.com/in/brittney-cardinell/ Lab Website: http://labellelab.asu.edu/ EXPERTISE

Medical diagnostics research and development, multi-disciplinary team leadership, point-of-care biosensor product design and prototyping, systems engineering, electrochemistry, mesoporous carbon, immunosensors, and assay development.

EDUCATION

Doctor of Philosophy in Biomedical Engineering (PhD) Jan 2013- Aug 2017 Arizona State University, Tempe, AZ

Master of Science in Biomedical Engineering (MS) Aug 2012- Dec 2012 Arizona State University, Tempe, AZ

Bachelor of Science in Biomedical Engineering (BSE), magna cum laude Aug 2008- May 2012 Arizona State University and Barrett, the Honors College, Tempe, AZ ENGINEERING SKILLS

• Led and project managed cross-functional and multi-disciplinary teams

• Developed medical diagnostic products at systems level with disposable test strip designs o Concept generation based on clinical and market needs, design specifications, bench testing, prototyping, and pre-clinical trials while considering FDA & ISO documentation & standards

• Expert in electrochemical biosensor and immunosensor research and development

• Knowledgeable in data and statistical analysis (e.g. ANOVA and DOE) and calibration algorithms

• Experienced with materials characterization and analysis: BET N2 isotherm pore and surface area analysis, FTIR, optical absorbance (e.g. ELISA, BCA colorimetric assays), and NMR spectroscopy

• Theoretical and limited working knowledge of characterization techniques (emphasis on biological samples): AFM, SEM, TEM, Cryo-TEM, fluorescence microscopy (e.g. FRET)

• Skilled in chemical synthesis techniques

• Well-versed in machine shop, prototyping and fabrication safety, techniques and equipment

• Previous experience with Matlab, Minitab, Design Expert, JMP, Solidworks, Pspice, and Labview INDUSTRY EXPERIENCE

Sep 2014 -

Nov 2016

Diagnostic Developer and Team Leader, Advanced Tear Diagnostics, LLC Birmingham, AL @ Arizona State University

Led funded multi-disciplinary ASU team to prototype & develop a dry eye disposable test strip diagnostic for start-up company’s 510k FDA submission.

• Developed and optimized immobilized

electrochemical immunosensors

• Synthesized novel mesoporous carbon

electrode materials

• Free radical polymerization synthesis

• Screen print manufactured test strips

• Studied Schirmer’s and osmolarity testing

• Advised on hardware and software requirements

• Project managed, mitigated risk, designed

verification and validation protocols

• Generated documentation and SOPs

• Patents and peer-reviewed publication pending

Dr. Brittney A. Cardinell- 2

ACADEMIC RESEARCH EXPERIENCE

Jan 2013 –

Jun 2017

Graduate Research Associate in Electrochemical Biosensors Research for Dr. Jeffrey T. La Belle, Arizona State University

Performed independent research to design detection assays, test strips and protocols for individual & simultaneous quantification of 4 traumatic brain injury biomarkers in whole blood.

• Created sensors to quantify 4 biomarkers in

12.5% whole blood solutions in 33 seconds

• Established synthesis protocols and SOPs

• Characterized & verified synthesized

materials

• Explored frequency and time-based

electrochemical techniques

• Pioneered new data analysis methods &

algorithms for simultaneous quantification

• Developed test strip to detect multiple

biomarkers and filter whole blood

• Obtained >$10k in research funding

• Submitted 3 patents, and 4 publications (2

more pending)

Jan 2011 –

Jun 2017

Lab Manager, La Belle Lab, Arizona State University Managed machine shop prototyping & wet chemistry biosensors lab spaces (~60 student researchers).

• Enforced EH&S regulations

• Automated new lab member training records

• Updated standard operating procedures

• Managed chemical inventory

• Supervised bio/hazardous waste disposal

• Handled purchasing & procurement

Jun 2010 –

Dec 2012

Electrochemical Biosensors Researcher and Developer, La Belle Lab, Arizona State University

Learned electrochemistry and biosensor development while establishing and leading a new research team.

• Funded by ASU/NASA Space Grant, among

other organizations for traumatic brain injury

and stress diagnostic development

• Used potentiometric, amperometric &

impedimetric electrochemical techniques

• Performed rapid label-free biomarker

detection with/without enzymes/antibodies

• Electroplated & fabricated printed circuit

boards

• Wrote grant proposals to Mayo Innovators,

DARPA (finalist), NSF & NIH

SERVICE AND VOLUNTEERING EXPERIENCE

2016 Graduate Student Mentor, Women in Engineering, Arizona State University Attended a dinner for newly accepted ASU female engineering students to share knowledge regarding classes, dorms, research and how to attain future goals. May 2013 –

Aug 2014

Volunteer Assistant Coordinator, High School Summer Scholars Research Program at Schools of Engineering, Arizona State University

A summer program for high school students to be mentored in research by ASU students and professors.

• Coordinated high school student info, final

presentations, and mentor-mentee matching

• Mentored 1 high school student in glucose

sensing & helped mentor 10 other students

Aug 2013 –

May 2014

Student Mentor, Fulton Undergraduate Research Initiative in the La Belle Lab, Arizona State University

Regularly guided a sophomore BME student to develop a blood based glutamate sensor for traumatic brain injury diagnosis. She presented her results in a BMES conference poster and was later awarded an NSF GRFP to fund her PhD work.

• Project managed without direct involvement

after training period

• Imparted helpful lab practices and critical

thinking/problem solving methodologies

• Suggested potential paths for solutions

rather than answers, to encourage creativity

and independence

Dr. Brittney A. Cardinell- 3

PUBLISHED WORKS

• Cardinell, Brittney A. and Jeffrey T. La Belle. (2017) “Enzymatic Detection of Traumatic Brain Injury Biomarker.” Biosensors and Biodetection: Methods and Protocols, 2nd Ed. of Springer’s Methods in Molecular Biology Series. Editors: Avraham Rasooly and Ben Prickril of NIH NCI. ISBN: 978-1-4939- 6910-4_7.

• Haselwood, Brittney A. and Jeffrey T. La Belle. "Development of electrochemical methods to enzymatically detect traumatic brain injury biomarkers." Biosensors and Bioelectronics 67 (2015): 752- 756.

• Dai, Mingzhi; Haselwood, Brittney; Vogt, Bryan D. and Jeffrey T. La Belle. "Amperometric sensing of norepinephrine at picomolar concentrations using screen printed, high surface area mesoporous carbon." Anal. Chim. Acta 788 (2013): 32-38.

• Two first authorships articles in progress, one second authorship in review process:

• Honikel, Mackenzie; Cardinell, Brittney A.; Lin, Chi-En; Penman, Andrew and Jeffrey T. La Belle.

“Developments Toward a Point-of-Care Tear Diagnostic Tool for Dry Eye Disease.” Biosensors and Bioelectronics (TBD).

INTELLECTUAL PROPERTY

• Noninvasive body fluid stress sensing (US 201******** A1)

• Unique self-assembled poly-amidoamine polymers and their electrochemical reactivity (US 201******** A1)

• Minimally Invasive Stress Sensors and Methods (US 201******** A1)

• Electrochemical osmolarity sensor for clinical dry eye diagnosis (Application# US 62/455,913)

• Point-Of-Care Tear Diagnostics Tool for Detecting Dry Eye Using Electrochemical Impedance Spectroscopy (disclosure submitted)

CONFERENCE PRESENTATIONS

• 2 Oral presentations: Biosensors (2012) & ASU/NASA Space Grant Research Symposium (2012)

• 14 Conference poster presentations: Biosensors, BMES, DTM, SMTA AWARDS AND HONORS

2016 Outstanding BME Graduate Research, School of Biological and Health Systems Engineering, Arizona State University

2015 Achievement Award for Contributions to Advancing ASU Laboratory Safety Culture, Engineering Environmental Health and Safety, Arizona State University 2015 Engineering Scholarship, Harold and Lucille Dunn Memorial Foundation ($500) 2015 Emeritus Faculty Fellowship, Preparing Future Faculty Graduate Program, Arizona State University ($500)

2015 Achievement Reward for College Scientists, Phoenix Chapter, ARCS Foundation ($7k) 2014 Research Support Grant, Graduate and Professional Student Association, Arizona State University ($2k)

2013 Nominated for Philanthropic Educational Grant, Philanthropic Educational Organization 2011-

2012

NASA/ASU Space Grant Internship, School of Earth and Space Exploration, Arizona State University

ORGANIZATIONS

2013 – Present Biomedical Engineering Society (BMES), member 2013- 2014 Graduate & Professional Student Association, assembly member representing the schools of engineering

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