Synthetic Chemistry, Protein Cheimistry, GC, LC-mass,NMR

Degang Liu

Chemistry and Biochemistry Scientist

TEL: 317-***-****

Email: ac3lpe@r.postjobfree.com

EDUCATION

****-**** ********** ****** ** Biochemistry, IUPUI, USA.

****-**** **. *. ** Chemistry, Lanzhou University, Lanzhou City, China.

1999-2003 B. S. in Chemistry, Lanzhou University, Lanzhou City, China.

RESEARCH EXPERIENCE

2012-present Research Associate, School of Medicine, Indiana University.

1.Using high through screening technologies (fluorescent polarization (FP), ELISA, BLI, MST, SPR, mass spectra etc.). I successfully found and design several different type inhibitors of uPAR/uPA. ELISA, SPR, BLI, MST and ITC technology were used to further measure the binding/inhibiting property of inhibitors.

2.Discovered small molecule inhibitors that selectively target the Ral GTPase. The inhibitors bind Ral in its inactive state and are characterized biochemically. This study was the first report targeting the Ral pathway, which created a new approach and offer excellent leading compounds for future development of novel therapeutics that inhibit oncogenic Ras signaling. The study was published in most prestigious journal, Nature.

3.Training technicians, undergraduate students and new postdoctoral fellows in lab.

2010-2012 Postdoctoral Fellow, School of Science, IUPUI.

1.Study the mechanism how SPL repairs DNA damaged by UV. Bringing out a new theory which corrected the universally accepted hypothesis of SPL mechanism since 1999.

2.Study the methyl-methyl interaction in the duplex DNAs as the major stabilizing force to stable the special conformation of 2-deoxy-1-(3-toluenyl)-b-d-ribofuranose in solution. The discovery provide the first experimental evidence for the importance of this type of interaction.

2003-2008 Ph. D. in Chemistry, Lanzhou University. Mentor: Dr. Ying Li.

1.Developed a higher efficient synthesis of pedamide in 14 steps and 8% total yield.

2.Made critical contributions in the synthesis method development for a nitrogen mustard.

3.Developed synthetic scheme for precursor of drug candidates or drug candidates in collaboration with pharmaceutical companies in China.

1999-2003 B. S. in Chemistry, Lanzhou University

Discover the synthetic scheme of natural flavans. Finished the total synthesis of three natural flavans.

INDUSTRY EXPERIENCE

2009-2010 Advanced Research Scientist (synthetic chemistry), Asymchem, Inc. (USA), Tianjin, China.

1.As a group leader and project leader, I finished projects (2 R&D, 2 GMP and 1 FTE) with high efficiency.

2.Successfully leading projects in researching lab, kilo-scale plant and GMP plant.

Highlighting research skills in Chemistry and Biochemistry:

1.15 publications in prestigious scientific journals including Nature, JACS, ACS Chemical Biology etc.

2.12+ years’ experience on Synthetic Chemistry and 5+ years’ experience on Biochemistry.

3.Synthesis of organic compounds/drugs or complex natural products.

4.Complex NMR. Structure determination of organic compounds/drugs.

5.UV, IR and CD spectra.

6.HPLC, GC, LC-MS, LC-MS/MS, GC-MS. Method development and quantitative assay with HPLC and GC. Analyzing data of MS or MS/MS.

7.Protein expression with bacteria and the following purification.

8.Assay of high through screening/drug candidates screening such as FP, ELISA, MST, HTRF, alpha screen, etc. based on biochemistry or immunochemistry.

9.SPR, BLI, MST, ITC. I am very familiar with assay to detect binding property between the ligand and analyte. Also I am proficient with the assay to test inhibiting properties of inhibitors to conjugates of proteins by competitive assay.

10.I am skilled in conducting research, compiling data, data interpretation, and writing reports.

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