Curriculum Vitae Ivan Puljiz, MD, Assist.prof.

Personal information

Date of birth: February 9, 1961

Croatian Scientist ID No.: 259724

Medical License Number 12484

Home address: Drage Stipca 6, 10000 Zagreb, Croatia Work Address: “Dr. Fran Mihaljević” University Hospital for Infectious Diseases Mirogojska 8, 10000, Zagreb, Croatia

E-mail: ac3ihc@r.postjobfree.com

Phone: +385-*-*******

Mob: +385-**-*******

Marital status: Married, wife Zdravka (53 years, graduated in pedagogue - works in Zagreb)

Children: Maša (24 years - School of Medicine Zagreb), Ante Bruno (22 years - Faculty of Law Zagreb, Josip 18 years - High school Zagreb) Education and training

1979 – 1985 Doctor of Medicine, MD

Graduate study, University of Zagreb, School of Medicine, Zagreb 1996 MD specialist in infectious diseases

“Dr. Fran Mihaljević” University Hospital for Infectious Diseases 1997-1998 Postgraduate course in “Emergency and Intensive Care Medicine” University of Zagreb, School of Medicine, Zagreb, Croatia 1999-2001 Scientific postgraduate course - University of Zagreb, School of Medicine, Zagreb, Croatia

2003 Master of Science - University of Zagreb, School of Medicine, Zagreb 2008 Doctor of Science - University of Zagreb, School of Medicine, Zagreb 2009 Senior assistant at the Department of Infectious Diseases University of Zagreb, School of Medicine, Zagreb

2013 Honorary assistant professor at the Department of Infectious Diseases University of Zagreb, School of Medicine, Zagreb Work experience

1985-1986 Obligatory internship

Health Center Imotski

1986-1991 MD in out-patient department

Health Center Imotski

1991-1996 MD resident in infectious diseases

“Dr. Fran Mihaljević” University Hospital for Infectious Diseases Clinical Hospital Center Rebro Zagreb

1996-2007 MD Specialist in infectious diseases

Department for Acute Respiratory Infectious Diseases

“Dr. Fran Mihaljević” University Hospital for Infectious Diseases 2007-2013 Head of the Clinical Department for General Infectious Diseases

“Dr. Fran Mihaljević” University Hospital for Infectious Diseases 2011-present Assistant Director for Quality Control

“Dr. Fran Mihaljević” University Hospital for Infectious Diseases 2013-present Head of Clinical Department for Infections of the Skin and Musculoskeletal System “Dr. Fran Mihaljević” University Hospital for Infectious Diseases

Personal skills and competences

Mother tongue(s) Croatian

Other language(s)

Language English

Speaking Yes

Writing Yes

Understanding (listening Yes

and reading)

Other language(s)

Language German

Speaking No

Writing No

Understanding (listening Yes

and reading)

Social skills and I am open to people and willing to hear what other are competencies saying; I try to maintain a positive, open, and objective attitude toward others; and try to balance and defuse inner tensions and handle stress

Organisational skills I am highly motivated and conscientious in personal and and competencies professional efforts; have the ability to be objective and to fairly evaluate different aspects of a situation; able to organize and motivate colleges to get things accomplished in a way that everyone feels a sense of order and direction

Technical skills and I am experienced and skilful in performing the following procedures: Competencies bronchoscopy, spirometry, lumbar puncture, pleural puncture, intensive care medicine procedures (intubation, mechanical ventilation, central venous catheter insertion), etc. Good clinical practice Yes, during various investigator trainings and online training

Clinical research A Phase III, randomized, multicenter, double-blind, double dummy, experience parallel group, comparative study to determine the efficacy, safety, and tolerability of Ceftazidime-Avibactam (CAZ-AVI, formerly CAZ104) versus Doripenem followed by appropriate oral therapy in the treatment of Complicated urinary tract infections, including acute pyelonephritis, with a Gram negative pathogen in hospitalized adults

(protocol: D4280C00004 – RECAPTURE) - Collaborating investigator A Phase III, multicentre, randomised, double-blind, comparative study to evaluate the efficacy and safety of Ceftaroline Fosamil (600 mg every 8 hours) versus Vancomycin plus Aztreonam in the treatment of patients with complicated bacterial skin and soft tissue infections with evidence of systemic inflammatory response or underlying comorbidities (protocol. D3720C00001 – COVERS)- Collaborating investigator

A Phase III, multicentre, randomized, double blind, active-controlled study to evaluate the efficacy and safety of delafloxacin compared with vancomycin + aztreonam in patients with acute bacterial skin and skin structure infections” - Principal investigator Multicenter, randomized, active-controlled efficacy and safety study comparing extended duration Betrixaban with standard of care Enoxaparin for the prevention of venous thromboembolism in acute medically ill patients - Collaborating investigator A Phase 3, multicenter, randomized, double-blind, active-controlled study to evaluate the efficacy and safety of Delafloxacin compared with Vancomycin +Aztreonam In Patients with active bacterial skin and skin structure infections (Protocol Melinta_RX3341-302). Principal investigator

A multicenter, randomized, double-blind study to compare the efficacy and safety of cadazolid versus vancomycin in subject with Clostridium difficile-associated diarrhea (CDAD) - Principal investigator

A Phase 3, multicenter, randomized, double-blind study to compare the safety and efficacy of Omadacycline IV/PO to Moxifloxacin IV/PO for treating adult subject with Community-acquired bacterial pneumonia (CABP) - Principal investigator

A Phase 3, multicenter, randomized, double-blind study to compare the safety and efficacy of Omadacycline IV/PO to Linezolid IV/PO for treating adult subject with Acute bacterial skin and skin structure infection (ABSSSI) - Principal investigator

A multicenter, randomized, double-blind clinical study to assess the safety and efficacy of intravenous S-649266 in Complicated urinary tract infections with or without Pyelonephritis or Acute uncomplicated pyelonephritis caused by gram-negative pathogens in hospitalized adults in comparison with intravenous imipenem/cilastatin - Principal investigator

Research

achievements

2002-2006 Research project “Pneumonias – diagnostic and therapeutic algorithms” (principal investigator Ilija Kuzman)

2006-2012 Research project “Immunoreactions to hantaviruses and leptospira” (principal investigator Alemka Markotić) 2008-2014 Research project “The etiology and pathogenesis of pneumonia” (principal investigator Ilija Kuzman)

Driving licence(s) Yes

Additional information Member - Croatian Medical Association, Croatian Medical Chamber, Croatian Union of Medical Doctors, Croatian Society for Infectious Diseases, European Society of Clinical Microbiology and Infectious Diseases

Reviewer for Croatian Journal of Infection (2007.present), Therapeutics and Clinical Risk Management (2013) and Virology Journal (2017)

Publication

1. Turčinov D, Kuzman I, Puljiz I. Brill-Zinsser disease still occurs in Croatia: A retrospective analysis of 25 hospitalized patients. Liječ Vjesn 2002;124:293-6. 2. Kuzman I, Kirac P, Kuzman T, Puljiz I, Bilić V. Kuzman I, Kirac P, Kuzman T, Puljiz I, Bilić V. Spontaneous rupture of the spleen in infectious mononucleosis: case report and review of the literature. Acta Med Croatica 2003;57:141-3.

3. Kuzman I, Puljiz I, Turčinov D, et al. The largest outbreak of hemorrhagic fever with renal syndrome in Croatia. Acta Med Croatica 2003;57:337-46. 4. Puljiz I, Kuzman I, Turčinov D, Markotić A, Čeljuska E. Clinical and epidemiologic characteristics of hemorrhagic fever with renal syndrome in patients treated at Dr. Fran Mihaljević University Hospital for Infectious Diseases, Zagreb. Acta Med Croatiaca 2003;57:347-53. 5. Puljiz I, Kuzman I, Bayer K, Makek N, Desnica B. Polimicrobial sepsis and perityphlitic abscess: case report and review of the literature. Acta Med Croatica 2004;58:341-5. 6. Puljiz I, Kuzman I, Markotić I, Turčinov D, Matić M, Makek N. Electrocardiographic changes in patients with hemorrhagic fever with renal syndrome. Scand J Infect Dis 2005;37:594-8.

7. Puljiz I, Beus A, Kuzman I, Seiwerth S. Electrocardiographic changes and myocarditis in trichinellosis: a retrospective study of 154 patients. Ann Trop Med Parasitol 2005;99:403-11. 8. Kuzman I, Puljiz I, Đaković-Rode O. Cure of Q fever pneumonia with moxifloxacin: case report. Scand J Infect Dis 2005;37:778-80.

9. Puljiz I, Kuzman I, Turčinov D, Makek N, Markotić A. Laboratory findings in patients with hemorrhagic fever with renal syndrome. Acta Med Croatica 2005;59:105-11. 10. Puljiz I, Kuzman I, Đaković-Rode O. Clinical and epidemiological characteristics of Q fever in hospitalised patients. Croat J Infect 2005;25:75-80. 11. Puljiz I, Kuzman I, Đaković-Rode O, Schönwald N, Miše B. Chlamydia pneumoniae and Mycoplasma pneumoniae pneumonia: comparasion of clinical, epidemiological characteristics and laboratory profiles. Epidemiol Infect 2005;29:1-8. 12. Kuzman I, Puljiz I. Legionnaires ́ diseases: a practical approach to diagnostics and treatment. Medicus 2005;14:107-13.

13. Puljiz I, Kuzman I. Influenza – always an illness of interest. Medicus 2005;14:137-46. 14. Puljiz I, Kuzman I. Avian influenza. Medicus 2005;14:151-2. 15. Puljiz I, Kuzman I, Đaković-Rode O, Vukelić D, Marušić P. Splenic Cat-scratch disease: case report and review of the literature. Infect Med 2006; 23:182-4. 16. Puljiz I, Kuzman I, Đaković-Rode O, Žužul Kasalica R. Bell`s palsy associated with Q fever. Infect Med 2006;23:619-22.

17. Vukelić D, Benić B, Bozinović D, Vuković B, Dakovic Rode O, Culig Z, Vuković J, Batinica S, Visnjić S, Puljiz I. An unusual outcome in a child with hepatosplenic cat-scratch disease. Wien Klin Wochenschr. 2006;118:615-8.

18. Puljiz I, Begovac J. Tuberculosis in HIV-infected patients in Croatia between 1986 and 2005. Coll Antropol. 2006;30 (Suppl 2):53-8.

19. Puljiz I, Kuzman I. Characteristics of clinical presentation of avian influenza in humans. Croat J Infect 2006; 26:25-30.

20. Puljiz I, Kuzman I, Đaković Rode O, Vuković B. Clinical and epidemiologic characteristics of Legionnaires ́ disease in our hospitalized patients. Croat J Infect 2007; 27:115-122. 21. Puljiz I, Kuzman I, Markotić A. Imported case of nephropathia epidemica – case report. Coll Antropol 2008;32:1263-5.

22. Kuzman I, Puljiz I, Tudorić N. Treatment of community acquired pneumonia. Medicus 2008;17:29-36.

23. Kuzman I, Puljiz I. Contemporary approach to diagnostics and treatment of Legionnaires ́ diseases. Medicus 2008;17:85-91.

24. Markotić A, Cvetko Krajinović L, Margaletić J, Turk N, Miletić-Medved M, Žmak Lj, Janković M, Kurolt I-C, Šoprek S, Đaković Rode O, Milas Z, Puljiz I, Ledina D, Hukić M, Kuzman I. Zoonoses and vector-borne diseases in Croatia – a multidisciplinary approach. Vet Ital 2009;45:55-66.

25. Višković K, Puljiz I, Đaković Rode O, Klasnić K, Kujundžić Tiljak M, Kuzman I. Community- acquired legionnaires disease in Croatia. Infect Dis Clin Pract 2010;18:23-8. 26. Puljiz I, Vranjican Z, Juri Miklaužić J, Jakovčević A. Giant cell (temporal) arteritis – case report. Croat J Infect 2010; 30:195-99.

27. Škerk V, Markotić A, Puljiz I, Kuzman I, Celjuska Tošev E, Habuš J, Turk N, Begovac J. Electrocardiographic changes in hospitalized patients with leptospirosis over a 10-year period. Med Sci Mon 2011;17:369-75.

28. Puljiz I, Kuzman I. Clinical features of influenza in high risk patient. Medicus 2011;20:45- 51.

29. Kuzman I, Puljiz I. Antiviral drugs and influenza treatment. Medicus 2011;20:87-93. 30. Puljiz I, Markotić A, Cvetko Krajinović L, Gužvinec M, Polašek O, Kuzman I. Mycoplasma pneumoniae in adult community-acquired pneumonia induces the activity of matrix metalloproteinase-9 in peripheral blood circulation. Med Sci Mon 2012;18:500-5. 31. Turčinov D, Puljiz I, Markotić A, Kuzman I, Begovac J. Clinical and laboratory findings in patients with oliguric and non-oliguric Hantavirus haemorrhagic fever with renal syndrome: an analysis of 128 patients. Clin Microbiol Infect 2013;674-9. 32. Vujalija Brajković A, Puljiz I, Zlopaša O, Bosnić D, Gašparović V. Sardoidosis or miliary tuberculosis – a case report. Croat J Inf 2013;33:91-4. 33. Puljiz I. Clinical and epidemiologic characteristics of pyogenic spondylodiscitis in hospitalized patients. Croat J Infect 2014;34:7-13. 34. Puljiz I, Bruketa T. Non-necrotisans bacterial infections of skin. Croat J Infect 2014;34:33-9.

35. Bruketa T, Puljiz I. Clinical entity of infective gangrene. Croat J Infect 2014;34:41-6. 36. Puljiz I, Vranjican Z, Papić N, Salaj M, Đaković Rode O. Chronic Q fever as a cause of vertebral osteomyelitis and discitis – a case report and literature review. Croat J Infect 2014;34:47-51.

37. Anić B, Cerovec M, Puljiz I, Težak S. Arthritis after intravesical instillation of bacillus Calmette-Guerin: A patient with an unusually severe clinical course treated with a combined anti- inflamatory and antimycobacterial regimen. J Clin Rheum 2015;21:373-5. 38. Puljiz I, Vranjican Z, Rakušić S, Jerković L. Tularemia – a case report. Croat J Infect 2016;36:87-90.

39. Puljiz I, Topić A. Campylobacter jejuni vertebral osteomyelitis. Lancet Inf Dis 2017;17:1002.

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