Siqin(Christine) Li

** **** ***. *** *; Worcester MA 01605

508-***-****; ac33f8@r.postjobfree.com

EDUCATION

Worcester Polytechnic Institute (WPI), Worcester, MA May, 2018 Master of Science, Bioinformatics and Computational Biology Related courses: Bioinformatics, Introduction to Computer Essentials for Bioinformatics Analysis, Applied Statistics, Cell Biology, Statistical Methods for Data Science, Big Data Management, Biological and Biomedical Database Mining, Machine Learning China Agricultural University (CAU), Beijing, China June, 2015 Master of Science, Agricultural Engineering

Minor in Computer Science and Technology

SKILLS

Bioinformatics Tools and Databases: Bioconductor, SAMtools, MACS2, Bedtools, Picard, HOMER, USCS Genome Browser, IGV, BLAST, T-Coffee, ModWeb, GRAMM-X, Phylogeny.fr, UCSF Chimera, Modeller, Cytoscape, PDB, Ensembl, UniProt, SCOP, NCBI Programming: Python, R, C, SQL, Spark, Pig, Linux Command Line and Scripting Softwares: Matlab, SPSS, SAS, Jupyter Notebook, GitHub, MongoDB, Markdown, LaTeX, EndNote, WEKA Other: Translation between English and Chinese (Level 3 in China Accreditation Test for Translators and Interpreters) RESEARCH EXPERIENCE

Genome Studies of Chromatin Accessibility and Gene Expression during iPSC Skeletal Muscle Induction and Differentiation

ATAC-Seq analyses of chromatin accessibility and transcription factor representation March, 2018 (expected)

Identified open chromatin domains in each cell stage, iPS, S1 and S2

Annotated peaks based on genomic context

Identified stage-specific TF DNA binding motifs

ISO-Seq analysis of RNA expression and alternative RNA splicing

• Co-locate RNA transcript identified by ISO-seq with open chromatin regions by ATAC-seq

•Identify differentially expressed genes during stages and genes that produce RNAs with alternative exon usage

•Generate exon maps of alternative spliced forms of RNAs Investigation of Phylogenetic and Structural Interaction of ALDH2 for its Related Disease Animal Model, WPI December, 2016

Constructed phylogenetic tree to compare the evolutional relationship among various species

Simulated the 3D structure of ALDH2 and its ligand and visualization of their interaction Anomaly Detection on Thyroid Disease Dataset November, 2017

• Preprocessed the raw data with feature selection and dimensionality reduction

• Used classification methods, decision tree and random forest to detect patients referred to the clinic is hypothyroid and the most import feature for the detection

• Applied clustering methods, k-means, hierarchical method and DBSCAN for the anomaly detection

• Evaluated such methods using precision, recall and confusion matrix The Design and Implementation of the Supermarket Information Management System, HUST September, 2011

Generated purchase orders and sales orders for daily transaction management using Visual Basic and SQL Server, managed inventory and product related information and queried inventory and sales orders PUBLICATION

Siqin, Li, et al. "Rheological properties of flaxseed meal and soybean protein isolate blend by extrusion." International Journal of Agricultural and Biological Engineering 10.4 (2017): 224-233. AWARDS

Merit Student, National Scholarship, National Encouragement Scholarship, SUNCUE Scholarship First Prize in University Mathematical Competition

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