Web Services Information Technology

Leiming Zhu. PhD

** ******* ****, **** ****, CT *6333

cell: 860-***-**** email: ******@*****.***

SUMMARY

Highly motivated software engineer to provide client with high quality software that is reliable, scalable and maintainable. Experienced in web-based software design and development on both backend and front end with Java and Javascript.

PROFESSIONAL EXPERIENCE

Cox Automotive, Groton, CT, Sept 2012 – Sept 2017

Senior Software Developer

Involved in the development of titling and registration systems for three states. One product uses PrimeFaces technology, and the other two use angularJS as front end and Restful Web services in back-end. Major Technologies used: J2EE, JSF, Web services (SOAP and Restful). Hibernate; Javascript, Angular, CSS, Bootstrap.

PFIZER, INC., Groton, CT, April 2002 – May 2012

Senior Professional

Developed and maintained several critical cheminformatics applications and supported chemistry data cartridge databases from multiple vendors.

Designed and created multiple web services for chemical structure validation/curation and identification. These web service applications facilitate the smooth transition to a service-oriented architecture (SOA) framework for Pfizer chemistry informatics. Major Technologies used: J2EE, JSP, JSF, Web services; Spring Core.

Lead the technical evaluation of data cartridges from major vendors including Accelrys, MDL, Daylight, ChemAxon, Bingo and created an evaluation report for Research Informatics leadership; which lead to the recommendations of new chemistry data cartridge selection. Involved in the design of structure databases for the balance of best performance and best communications between systems. All these cartridges are on Oracle.

As a SME, supported and managed major company chemical structure databases.

PHARMACIA COOPERATION, St. Louis, MO, Oct 1998 – March 2002

Senior Research Scientist

Fragment-based drug design using NMR technology.

- Implemented and validated a saturation-transfer based pulse sequence for lead screening.

- Wrote a program for designing the cocktail mixtures of the global NMR screening library. Developed a web- based application for analyzing the screening data. Technologies used: Java, Perl

- Screened for 2 research projects using the newly designed library and pulse sequences, and proposed good quality leads for further refinements.

Developed or implemented several pulse sequences for protein-drug interaction studies. Combining with the typical 3D hetero-nuclear (15N and 13C) experiments, we finished spectral assignments and structure determination of a protein/ligand complex.

THE SCRIPPS RESEARCH INSTITUTE, La Jolla, CA, July 1996 – Oct 1998

Postdoctoral Fellow

Conducted research focused on structure determination and refinement for DNA-protein complexes and methodology development to improve the quality of structure refinement.

Refined the structures of TFIIIA/DNA complex and E. Coli thioredoxin using residual dipolar data.

Developed a NOESY-HSQC simulation program, SPIRIT for structure refinement.

Developed pulse sequences for the accurate HA-CA, HA-CO and CA-CO J-coupling and residual dipolar coupling measurement.

UNIVERSITY of WASHINGTON, Seattle, WA, June 1994 – July 1996

Postdoctoral Fellow

Conducted research focused on drug-DNA complexes and unusual DNA structure motif.

Discovered a novel stable [GGA]2 structure motif, which occurs at the centromeres of human chromosome.

Solved a cisplatin cross-linked DNA structure, which, for the first time, explained all chemical and physical properties for this DNA complex to the important anticancer drug.

Elucidated the cross-relaxation effect on the J-coupling measurement in biomolecules using spectral simulations.

Developed a 2D NOESY simulation program for partially relaxed spectra (BIRDER); the program not only interpreted the asymmetric spectra for typical NOESY, but also increase the accuracy of the structure refinements.

TECHNICAL SKILLS

Information Technology:

Languages:

Java (Sun Certified Programmer), C#, Javascript, Angular 1.x/4, Groovy, C, Perl, Fortran

IDE/Tools:

Eclipse, Web Storm, Visual Studio Code, Jbuilder, Ant, Gradle, CVS, SVN, Git, Jenkins

J2EE:

Restful/Soap Webservice, EJB Design, JDBC, Hibernate, Servlet, JSP, JSF, Struts

Servers:

Weblogic Application Server, Jboss, Tomcat Server, Axis

Database:

RDB design, Data warehousing, ETL, Oracle SQL*PLUS, PL/SQL

Data Integration:

Composite Software, MuleSoft

SDLC

Agile, Scrum

Chemical Software

Accelrys/MDL:

Accord SDK, Accord for Oracle data cartridge, StructureChecker, Pipeline Pilot. ISIS/Host, RCG database/data cartridge, ChimePro, Cheshire.

ChemAxon:

JChem, Marvin

Open Sources:

Bingo data cartridge, Chemistry Development Kit.

Pharmaceutical Drug Discovery

Fragment-based drug design using NMR; Structure determination using NMR

EDUCATION

Ph.D., Department of Chemistry, University of Washington (Seattle, WA)

M.S., Center of Measurement & Analysis, Fudan University (Shanghai)

B.S., Department of Nuclear Science, Fudan University (Shanghai)

PUBLICATIONS/PRESENTATIONS

1.“Development and use of a molecular structure ontology,” Henry E. Dayringer, Leiming Zhu, Matthias Nolte and Chris L. Waller, 237th ACS National Meeting, Salt Lake City, 2009

2. “Use of Standalone StructureChecker in Pfizer Structure Validation and Other Applications,” Leiming Zhu, Accord User Group Meeting, Santa Fe, March, 2008

3."Solution Structure and Backbone Dynamics of the Catalytic Domain of Matrix Melloproteinase-2 Complexed with a Hydroxamic Acid Inhibitor," Y. Feng, J. Likos, L. Zhu, H. Woodward, G. Munie, J. McDonald, A. Stevens, S. Howard, G. D. Crescenzo, D. Welsch, H. Shieh, and W. Stallings, Biochim Biophys Acta. 1598(1-2), 10-23(2002)

4."Assessment of Zinc finger orientations by residual dipolar constants," V. Tsui, L. Zhu, T.-H. Huang, P. E. Wright and D. A. Case, J. Biomol. NMR, 16, 9-21 (2000)

5. "1H, 13C and 15N resonance assignments for a truncated catalytic domain of matrix metalloproteinase-2," Y. Feng, J. Likos, L. Zhu, H. Woodward, J. McDonald, A. Stevens, S. Howard and D. Welsch, J. Biomol. NMR, 17, 85-86 (2000)

6.“HA-C, HA-C', CA-C' J and Residual Dipolar Coupling Measurements using Spin-State Separated Methods," L. Zhu, J. Chung, J. Dyson and P. Wright, 40th ENC, Orlando, FL, 1999

7."A NOESY-HSQC Simulation Program, SPIRIT," L. Zhu, H. J. Dyson and P. E. Wright, J. Biomol. NMR, 11, 11-29 (1998)

8."Sheared Purine-Purine Pairing in Biology," S.-H. Chou, L. Zhu and B. R. Reid, J. Mol. Biol., 267, 1055-1067 (1997).

9."Hairpin Loops Consisting of Single Adenine Residues Closed by Sheared A-A and G-G Pairs Formed by the DNA triplets AAA and GAG: Solution Structure of the d(GTACAAAGTAC) Hairpin," S.-H. Chou, L. Zhu, Z. Gao, J.-W. Cheng and B. R. Reid, J. Mol. Biol., 264, 981-1001 (1996).

10."A Single G-to-C Change Causes Human Centromere TGGAA Repeats to Fold Back into Hairpins," L. Zhu, S.-H. Chou and B. R. Reid, Proc. Natl. Acad. Sci. USA, 93, 121**-***** (1996).

11."On the Relative Ability of Centromeric GNA Triplet to Form Hairpins versus Self-paired Duplexes," S.-H. Chou, L. Zhu and B. R. Reid, J. Mol. Biol., 259, 445-457 (1996).

12."The Spin Dynamics of Heteronuclear Multiple Spin Systems Formulated in the Strong Narrowing Limit," L. Zhu, J. Magn. Reson., B111, 262-271 (1996)

13."Solution Structure of a Cisplatin-induced DNA Interstrand Cross-link," H. Huang, L. Zhu, B. R. Reid, G. P. Drobny and P. B. Hopkins, Science, 270, 1842-1845 (1995)

14."Structure of Single-cytidine Hairpin Loop Formed by the DNA Triplet GCA," L. Zhu, S.-H. Chou, J. Xu and B. R. Reid, Nature Struc. Biol., 2, 1012-1017 (1995)

15."The Structure of a Novel DNA Duplex formed by Human Centromere d(TGGAA) Repeats with Possible Implications for Chromosome Attachment during Mitosis," L. Zhu, S.-H. Chou and B. R. Reid, J. Mol. Biol., 245, 623-637 (1995)

16."Errors in Measuring and Interpreting the Values of Coupling Constants J from PE.COSY Experiments," L. Zhu, B. R. Reid and G. P. Drobny, J. Magn. Reson., A115, 206-212 (1995).

17."DNA Duplexes Flanked by Hybrid duplexes: the Solution Structure of a Hybrid Chimeric Junction in [r(cgcg)d(TATACGCG)]2" L. Zhu, M. Salazar and B. R. Reid, J. Mol. Biol., 34, 2372-2380 (1995).

18."An Improved NOESY Simulation Program for Partially Relaxed Spectra: BIRDER," L. Zhu, and B. R. Reid, J. Magn. Reson., B106, 227-235 (1995).

19."A possible folding motif in human centromere TGGAA repeats: The solution structure of d(GTGGAATGCAATGGAAC) hairpin," L. Zhu, S.-H. Chou and B. R. Reid, 36th ENC, Boston, MA, 1995

20."Errors in measuring and interpreting J coupling constants from PE.COSY experiments," L. Zhu, B. R. Reid and G. P. Drobny, 36th ENC, Boston, MA, 1995

21."Modulation of J-couplings by Cross-relaxation in DNA Sugars," L. Zhu, B. R. Reid, M. Kennedy and G. P. Drobny, J. Magn. Reson., A111, 195-202 (1994)

22."The Unusual Structure of the Human Centromere (GGA)2 Motif: Unpaired Guanosine Residues Stacked between Sheared GA Pairs," S.-H. Chou, L. Zhu and B. R. Reid, J. Mol. Biol., 244, 259-268 (1994).

23."The Solution Structure of the r(gcg)d(TATACCC):d(GGGTATACGC) Okazaki Fragment Contains Two Distinct Duplex Morphologies Connected by a Junction," M. Salazar, O. Y. Fedorov, L. Zhu and B. R. Reid, J. Mol. Biol. 241, 440-455 (1994).

24."Si-29 MAS n.m.r. Studies of the Distribution of Si and Al in the Framework of Zeolite LaHY," Q. Li, L. Dai, J. Xiong, L. Zhu and Z. Xue, Zeolites, 14, 367-373 (1994)

25."The Effect of Cross-Relaxation on the Spectrum of a Scalar Coupled Three-Spin System," L. Zhu, B. R. Reid, M. Kennedy and G. P. Drobny, 35th ENC, Pacific Grove, CA, 1994

26."An Improved 2D NOESY Simulation Program: BIRDER," L. Zhu and B. R. Reid, 35th ENC, Pacific Grove, CA, 1994

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