Dahai Zhang

**** ********** ********, *********, **, V6Z 2W9

604-***-****

ac222r@r.postjobfree.com

PROFILE

Dedicated, goal-oriented, well-published, experienced and versatile molecular and cellular biologist Expertise in liver disease and diabetes

Love challenge and passionate for new things

ACADEMIC AND RESEARCH EXPERIENCE

University of British Columbia, Vancouver, BC, Canada Ph.D. in the laboratory of Dr. Brian Rodrigues 03/2011-12/2016

• Initiated and completed two projects that discovered heparanase’s novel functions in the development of diabetes and diabetic heart complication

• Collaboratively published multiple manuscripts in high-impacted journals

• Developed and mastered many in vivo and in vitro techniques

• Well trained independency of conducting scientific research, particularly experienced in animal models

Yale University School of Medicine, New Haven, CT, USA Post Graduate Associate in the laboratory of Dr. Yasuko Iwakiri 12/2008-01/2011

• Research activities include designing and conducting projects that investigated the role of Reticulon B in liver fibrosis/cirrhosis

• Trained molecular and cellular technical skills and animal work University of Texas at Dallas, Dallas, Texas, USA

Master student in the laboratory of Dr. Li Zhang 08/2006-08/2008

• Participated in projects that investigated oxygen sensing regulatory pathways in yeast

• Responsible for setting up laboratory in a new building and equipment purchases Academy of Military Medical Science, Beijing, China 01/2006-05/2006 Bachelor Thesis

• Research in drug development. Designed a protein construct using recombinant technology, fusing urokinase and tenecteplase that is used for treating thrombosis Jilin University, Changchun, China 09/2002-06/2006

• Successfully completed 4 years of intensive training in various disciplines of bioscience including molecular biology, cellular biology and biochemistry SELECTED PUBLICATIONS:

1. Lal, N., Chiu, P.C., Wang, F.L., Zhang, D.H., Jia, J., Wan, A., Vlodavsky, I., Hussein, B., Rodrigues, B., Loss of VEGFB and its signaling in the diabetic heart is associated with increased cell death signaling. Am J Physiol Heart Circ Physiol. 312: H1163-H1175, 2017 2. Zhang, D.H., Wang, F.L., Lal, N., Chiu, P.C., Wan, A., Jia, J., Bierende, B., Flibotte,S., Sinha, S., Asadi, A., Hu, X.K., Taghizadeh, F., Pulinilkunnil, P., Vlodavsky, I., Johnson, J., Kieffer, T.J., Hussein, B. and Rodrigues, B., Heparanase overexpression induces glucagon resistance and protects animals from chemically-induced diabetes. Diabetes. 66:45-57, 2017 3. Wang, F.L., Jia, J., Lal, N., Zhang, D.H., Chiu, P.C., Wan, A., Vlodavsky, I., Hussein, B., and Rodrigues, B. High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature. Cardiovasc Res. 112(3):656-668, 2016 2

4. Chiu, P.C., Wan, A., Lal, N., Zhang, D.H., Wang, F.L., Vlodavsky, I., Hussein, B. and Rodrigues, B. Cardiomyocyte VEGF Regulates Endothelial Cell GPIHBP1 to Relocate Lipoprotein Lipase to the Coronary Lumen During Diabetes Mellitus Arterioscler. Thromb. Vasc. Biol. 36:145-55, 2016

5. Chiu, P.C., Wang, F.L., Lal, N., Wang, Y., Zhang, D.H., Hussein, B., Wan, A., Vlodavsky, I., and Rodrigues, B. Endothelial cells respond to hyperglycemia by increasing the LPL transporter GPIHBP1. Am J Physiol Endocrinol Metab. 306(11):E1274-83, 2014. 6. Wang, Y., Chiu, A., Neumaier, K., Wang, F.L.,, Zhang, D.H., Hussein, B., Lal, N., Wan, A., Vlodavsky, I., and Rodrigues, B. Endothelial Cell Heparanase Taken Up by Cardiomyocytes Regulates Lipoprotein Lipase Transfer to the Coronary Lumen following Diabetes. Diabetes 63(8):2643-55, 2014

7. Zhang, D.H., Wang, Y., Chiu, P.C., Wang, F., Puthanveetil, P., Lili, Che., Rodrigues, B. Hyperglycemia-induced secretion of endothelial heparanase stimulates a vascular endothelial growth factor autocrine network in cardiomyocytes that promotes recruitment of lipoprotein lipase. Arterioscler. Thromb. Vasc. Biol 33(12):2830-8, 2013 8. Wang, Y., Zhang, D.H., Chiu, A., Wan, A., Rodrigues, B. Endothelial heparanase regulates heart metabolism by stimulating lipoprotein lipase secretion from cardiomyocytes. Arterioscler. Thromb. Vasc. Biol 33(5): 894-902, 2013

9. Gao, L., Utsumi, T., Tashiro, K., Liu, B., Zhang, D.H., Swenson, S.E., and Iwakiri, Y. Reticulon 4B (Nogo-B) facilitates hepatocyte proliferation and liver regeneration. Hepatology 57(5):1992- 2003, 2013

10. Puthanveetil, P., Zhang, D.H., Wang, Y., Wang, F., Wan, A., Abrahani, A., Rodrigues, B. Diabetes triggers a PARP1 mediated death pathway in the heart through participation of FoxO1. J Mol Cell Cardiol. 53(5):677-86, 2012

11. Wang, F., Wang, Y., Zhang, D.H., Puthanveetil, P., Johnson, J.D., Rodrigues, B. Fatty Acid- Induced Nuclear Translocation of Heparanase Uncouples Glucose Metabolism in Endothelial Cells. Arterioscler. Thromb. Vasc. Biol 32:406-414, 2012. 12. Puthanveetil, P., Wang, Y., Zhang, D.H., Wang, F., Kim, M.S., Innis, S., Pulinilkunnil, T., Abrahani, A., Rodrigues, B. Cardiac Triglyceride Accumulation Following Acute Lipid Excess Occurs through Activation of a FoxO1-iNOS-CD36 Pathway. Free Radic. Biol. Med. 51:352- 363, 2011.

13. Zhang, D.H., Utsumi, T., Chung, C., Huang H, Sangwung, P., Hao, A., Shibao, K., Yamguchi, K., Okamoto, K., Groszmann, L.R., Jozsef, L., Sessa, C.W., and Iwakiri, Y. Reticulon 4B (Nogo- B) is a Novel Regulator of Hepatic Fibrogenesis. Hepatology 53:1306–1315, 2011. 14. Yang, T., Lu, J., Zhang, D.H., Meng, Q.H., Jiang, C., Li, D., Wang, Y., Teng, L.R. Determination of Vitamin C with Folin-B Near-infrared Spectrum. Chinese J Anal Chemistry 33:1593-1595, 2005.

15. Lu, J,Zhang, D.H., Jiang, C., Jia, L., Yang, T., Wang, Z., Meng, Q. Analysis of Vc in vegetables by Folin B spectrophotometry. Science and Technology of Food Industry 26(8), 2005

ABSTRACTS:

1. Dahai Zhang, Brian Rodrigues. Endothelial Heparanase Secretion Induced by High Glucose Up- regulates Fatty Acid Utilization by the Heart through LPL and VEGF (Canada-China Symposium in Atherothromosis, Diabetes and Obesity 2013)

2. Dahai Zhang, Brian Rodrigues. Endothelial Heparanase Secretion Induced by High Glucose Up- regulates Fatty Acid Utilization by the Heart through LPL and VEGF (American Diabetes Association 2012)

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3. Dahai Zhang, Panjamaporn Sangwung, Teruo Utsumi, and Yasuko Iwakiri. EMMPRIN/CD147 facilitates liver fibrosis in cirrhotic rats by a novel mechanism (AASLD 2011) 4. Lili Gao, Teruo Utsumi, Bo Liu, Keitaro Tashiro, Dahai Zhang, Scott Swenson, and Yasuko Iwakiri. Lack of Reticulon 4B (Nogo-B) delays liver regeneration by enhancing transforming growth factor beta1 expression in mice (AASLD 2011) 5. Dahai Zhang, Teruo Utsumi, Hui-Chun Huang, Panjamaporn Sangwung, Kazunori Shibao,Chuhan Chung, Roberto J. Groszmann and Yasuko Iwakiri. Loss of Nogo-B Ameliorates Hepatic Fibrosis (AASLD 2010)

6. Dahai Zhang, Teruo Utsumi, Carlo Spirli, Mario Strazzabosco, Yasuko Iwakiri. Nogo-B is A Novel Regulator of Cholangiocyte Proliferation (AASLD 2010) 7. Dahai Zhang, Hui-Chun Huang, Kazunori Shibao, Chuhan Chung, Roberto J. Groszmann and Yasuko Iwakiri Nogo-B is induced in human and experimental cirrhosis, and its absence ameliorates portal pressure after bile duct ligation (AASLD 2009) EDUCATION

University of British Columbia, Vancouver, Canada 02/2017 Ph.D. in Pharmaceutical Sciences, Pharmacology

Yale University School of Medicine, New Haven, USA 01/2011 Post Graduate Associate, Internal Medicine, Liver Center University of Texas at Dallas, Dallas, USA 08/2008 M.S., Molecular and Cellular Biology

Jilin University, Changchun, China 07/2006

HONORS AND AWARDS:

• Mitchell-Dwivedi Graduate Award in Pharmaceutical Sciences, 2016

• National Outstanding Self-Funded Foreign Students Award from China, 2013

• Distinguished Presentation Award for CCSADO, 2013

• Canadian Diabetes Association Doctoral Award, 2013-2015

• Subhash C. VERMA Memorial Prize in Pharmaceutical Sciences, 2013

• Faculty of Pharmaceutical Science Graduate Teaching Assistant Award, 2012

• Presidential Poster of Distinction in American Association of Study of Liver Diseases, 2009

• “Star of Academy” of Jilin University, 2006

• Finalist First Prize in the 9th “Challenge Cup” National Contest of College Students’ Scientific and Technological Works, Fudan University, Shanghai, 2005

• Finalist in the “Challenge Cup” Jilin Province Contest of College Students’ Scientific and Technological Works, 2005

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