Professional Experience Product Development

Jaya Sandeep.Bhavanam

** ******* ******, #*, ******* MA 02134

857-***-**** ********.*@*****.***.***

Versatile and goal-driven with three years of experience in academia and Industry seetings (GLP, cGMP) ranging from molecular level research to Drug product development. Positive, strong self-motivator who excels in creative and team-oriented environments with outstanding communication skills and bias for action. Ability to make immediate and significant contribuitions by utilizing creative, technical, and analytical abilities while promoting healthy relationships amongst cross-functional team members.

Core Competencies

Biosimilars and Reverse Engineering

ICH Guidelines (Stability)

Formulations:

1)Pareterals(Intravitreals-Opthalmics)

2)Tablets(Milling, sieving,blending, wet and dry Granulations, Compressing and coating)

3)Capsules( Granulation,Filling)

4)Semi-solid Dosage forms (Creams, Ointments,lotions, Gels)

5)Cosmetics

Analytical Instruments:

1)pH Meter

2)Osmometer

3)Densitometer

4)Viscometer

5)Nanodrop

6)PhotostabilityChamber

7)Particles count and charectarization

by MFI

8)Dissolution Aparatus

9)Plate Reader

10)HPLC-Empower

Analytical Techniques:

1)ELISAs

2)SDS PAGE

3)Western Blotting

4)BCA Protein Assay

5)Immunohistochemistry

6)Immunoflorescence

Microbiological Techniques:

1)Mammalian Cell Culturing (Splitting, passaging, cryopreservation, Thawing) for Adherent and Semi-adherent cells

2)Cryostat preparation

3)PCR

4)Transfection and

5)Cytotoxicity Studies

Manufacturing Equipment:

1)Instron Equipment

2)GENiSYS Multi-Format Bench-Top Filling System (For vials and Syringes)

Microscopy and Spectroscopy:

1) Fluorescence Microscopy

2) Confocal Microscopy

3) UV/Visible Spectroscopy

4) Good theoretical

knowledge on

Mass Spectroscopy.

Separation and Purification Techniques:

1)Flocculation and

centrifugation techniques for separation of proteins

2)Decent theoretical

knowledge along with

practical experience in

Chromatography

techniques (TLC, Paper,

Column, Gas, Affinity, SEC

and IEX)

Writing SOP

Data Management

Literature search

Designing of Experiment

Professional Experience

Momenta Pharmaceuticals INC. Cambridge,MA

Drug Product Development Co-op Jan2017-Jun2017

Projects:

(1) Feasibility studies of Low fill volume Parenterals. (Biosimilars-Reverse Engineering-Process Development)

(2) Disintegration study of Surfactants in Buffered solutions under various stress conditions(Freeze-Thaw,Photostability,Oxidation,Hydrolysis) for studying physical properties of Buffers with degraded surfactants (Formulation Development).

Duties involved but not limited to:

Literature search, Design of Experiments, writing SOPs, Data Management using Next Docs and ELN, Data Analysis, Execute Experiments, Purchase lab supplies and Maintaining their Requisitions, requisition of POs and COAs by talking to Vendors, Revising Inventory list, presenting weekly reports to the Manager and to the Department, Active participation in Co-op Journal Club and Workshops, working for other groups in the Department to provide support whenever needed. Giving Oral and poster presentations as part of Co-op program. Worked cross-functionally with Analytical and procurement Department.

Massachusetts General Hospital (SIMCHES Research Center) Cambridge,MA

Research Assistant Nov 2016- Dec 2016

Duties involved are:

1)Maintaining and passaging Airway Basal Cell lines

2)Immunostaining Mice Airway Basal Cells and counting them using Confocal Microscopy.

3)Animal Handling -Isolating trachea by Dissecting mice and mounting them on to a slide for the Immunostain preparation.

4)Running PCR for the isolated Mice Airway Bsal cell samples

140 The Fenway, Northeastern University Boston, MA

Research Assistant Dec2015-June 2016

1) Worked on developing methods to Increase the Sensitivity of ELISAs using conjugated Antibodies.

2) Passaging Hybridoma cell lines (R11D10), Anti myosin cell lines (2G42D7) and Mice Breast cancer cell lines.

3) Purification of IgG antibodies using Protein G column and determining their presence using SDS-PAGE and Western Blotting

PharmaTrain Hyderabad, India

Instrument Trainee July 2016-sept2016

Trained in operating HPLC in the Qualitative analysis of various Dosage forms (Tablets, granules, suspensions and IV dosage forms).

Osmania University Hyderabad, India

Research Asociate Jan 2013- Dec 2013

1) Isolated Flavanoids from various Medicinal plants by Methanolic Extraction and formulated as Ointments for the study of Hair growth

2) Topically applied formulations on mice for hair growth study

Education& Licensing

Masters in Pharmaceutical Sciences (Major- Pharmaceutics and Drug Delivery Systems)-Northeastern University, Boston, MA, June2017

Relevent Corses: Pharmacokinetics and Drug Metabolism, Advanced Drug Delivery Systems, Bio Medical Chemical Analysis, Molecular Cell Biology, Downstream Processing and Biopharmaceutical Production, Experimental Design/Biostatistics

Bachelors in Pharmacy- Osmania University, India, May 2015

Relevant Courses: Pharmaceutics-1 and2 (Traditional Formulations and Analysis of -Topical (Ointments, Creams, Gels, patches), Oral(Tablets, Capsules, pills) and Parenteral Formulations), Pharmaceutical Analysis, Pharmacology, Medicinal Chemistry, Pharmacognosy

Pharmacist- Indian Pharmacy Council

Technical Proficiencies

Microsoft Excel Word PowerPoint ELN Cloud Fusion Outlook

Contact this candidate