ERIC FALDE

New Brighton, MN *****

(***) ***- ***5 ac168o@r.postjobfree.com

WORK EXPERIENCE

September 2016 - Present Boston Scientific, Maple Grove, MN Senior Scientist/Engineer Interventional Cardiology R&D Develop drug coated balloon catheter formulations and characterization models. Design and improve test methods, set specifications, and contribute to test method validations in for a deadline-driven project. Direct and perform experiments, analyze and communicate complex concepts to improve a highly regulated medical device. Collaborate as a cross-functional core team member on a product development project. Communicate with regulatory bodies in pre-submissions, submissions, and responses.

January - August 2016 Boston University, Boston, MA Research Fellow Biomedical Engineering/Chemistry

Manufactured and characterized point-of-care sensors and conducted a small clinical trial. Developed and tested point-of-care sensors for quantifying milk fat in order to improve infant feeding strategies. Wrote manuscripts, patent applications, and designed a clinical trial for an IRB application that was approved. Supervised and trained graduate students.

September 2010-December 2015 Boston University, Boston, MA Research Assistant Biomedical Engineering

Advised by Prof. Mark Grinstaff, synthesized and characterized biocompatible polymers and electrospun into superhydrophobic non-woven meshes, formulated drugs and excipients for optimal dosage profile, assessed both in vitro and in vivo anti-cancer efficacy. Quantified drug release using HPLC, fluorescence, and LC/MS-IT. Assessed polymer and drug state using DSC, SEM, and confocal imaging. Designed and tested surface tension sensor meshes for point-of-care surfactant quantification. Developed a short-cycle device optimization protocol. Wrote manuscripts, patent applications, and SOPs, and presented to national conferences. October 2006-August 2010 Schulze Diabetes Institute, Minneapolis, MN Research Assistant Islet Processing Research and Development The department focuses on creating and perfecting techniques of processing pancreas and islets for transplant to treat diabetes. Responsibilities included designing, performing, analyzing, and reporting experiments using islets and islet models, and developing novel primary cell culture and assessment methods using 19F NMR. Encapsulated islets using alginate and fibrin gels, along with oxygen sensors for real-time assessment. Assessed product quality for both clinical transplant and commercial sales. June-December 2008 Genentech, Inc., South San Francisco, CA Co-Op Processing Development Engineering

The department researches, develops, and assists in implementation of new and improved process steps in mammalian and bacterial cell culture, purification, and instrumentation. Responsibilities included testing and characterizing a novel UV-light viral inactivation device for protein purification, and testing WAVE perfusion bioreactors for high-density culture in the seed train. Gained experience with in vitro viral quantification assays, design of experiment (DoE) using JMP, CHO cell culture and protein quality assessment in the cGMP environment.

SKILLS

• Chemical formulation, polymer chemistry, synthetic chemistry, drug delivery, HPLC, SEC/GPC, NMR, DSC, TGA, DLS, CD, FT-IR, ion trap LC/MS, UV-Vis and fluorescence spectroscopy, rheometry, tensiometry, goniometry, SEM imaging, confocal imaging, cell culture, ELISA, SDS-PAGE, qPCR

• Minitab, SOLIDWORKS, MATLAB, R, JMP, COMSOL, AutoCAD, Python, Aspen HYSYS, Microsoft Office, HTML

• Design control, design validation, design verification, quality systems and ISO 13845, sampling plans, process validation, test method validation, design of experiments (DoE) PATENT APPLICATIONS

• US 14/816,613: Portable sensors for determination of liquid surface tension and methods and uses thereof. Filed August 3, 2015

• US 14/233,570: Doping agents and polymeric compositions thereof for controlled drug delivery. Filed July 19, 2012 EDUCATION

2010-2015 Doctor of Philosophy in Biomedical Engineering, December 2015 Boston University, Boston, MA.

Thesis Title: “Detection and Drug Delivery from Superhydrophobic Materials” 2005-2010 Bachelor of Chemical Engineering, Cum Laude, May 2010 University of Minnesota-Twin Cities, Minneapolis, MN. PUBLICATIONS

• Falde EJ, Yohe ST, Colson YL, Grinstaff MW. Superhydrophobic Materials for Biomedical Applications. Biomaterials, 104, 87-103 (2016)

• Falde EJ, Freedman JD, Herrera VLM, Yohe ST, Colson YL, Grinstaff MW. Layered superhydrophobic meshes for controlled drug release. J. Control. Release 214, 23–29 (2015).

• Falde EJ, Yohe ST, Grinstaff MW. Surface tension triggered wetting and point of care sensor design. Adv. Healthcare Mater. 4, 1654–1657 (2015).

• Yohe ST, Freedman JD, Falde EJ, Colson YL, Grinstaff MW. A mechanistic study of wetting superhydrophobic porous 3D meshes. Adv. Func. Mater. 23, 3628-3637, (2013).

• Suszynski TM, Avgoustiniatos ES, Stein SA, Falde EJ, Hammer BE, Papas KK, Assessment of tissue-engineered islet graft viability by fluorine magnetic resonance spectroscopy, Transplant. Proc., 43, 3221-3225 (2011).

• Suszynski TM, Wildey GW, Falde EJ, Cline GW, Maynard KS, Ko N, Sotiris J, Naji A, Hering BJ, Papas KK. The ATP/DNA ratio is a better indicator of islet cell viability than the ADP/ATP ratio. Transplant. Proc. 40, 346-350 (2008). CONFERENCE PRESENTATIONS

• “Detection of Urinary Bile Acids with a Simple Electrospun Mesh” Materials Research Society Fall Meeting, Boston, MA, December 4, 2014

• Awarded “Winner, Materials and Concepts for Biomedical Sensing Presentation”

• “Drug Release From Superhydrophobic, Layered, Electrospun Meshes” Society for Biomaterials Fall Symposium 2012, New Orleans, LA, October 4, 2012

AWARDS AND HONORS

Materials and Concepts for Biomedical Sensing Presentation Award, Materials Research Society, Fall 2014 Graduate Assistantship in Areas of National Need (GAANN) Fellowship in Nanotechnology, 2012 REFERENCES

Mark W. Grinstaff, Ph.D.

Professor of Chemistry, Biomedical Engineering and Medicine, Boston University ac168o@r.postjobfree.com

Klearchos K. Papas, Ph.D.

Professor of Surgery and Medical Imaging, University of Arizona ac168o@r.postjobfree.com

Stefan T. Yohe, Ph.D.

Technical Development Scientist in Drug Delivery, Genentech, Inc. ac168o@r.postjobfree.com

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