CHANDRA SEKHAR P.E.

ac12yh@r.postjobfree.com

** ******* **** ****: 908-***-****

FLEMINGTON N.J. 08822 Cell: 908-***-****

SUMMARY:

• Pharmaceutical professional with extensive experience in the successful execution of Domestic and International capital engineering projects involving biotech, fine chemicals and secondary manufacturing facilities with expertise in potent compound handling. Over 30 years experience in Chemical, Manufacturing buildings, Warehouse, and Infrastructure projects.

• Experienced in mixed-use development and infrastructure projects from feasibility studies to preliminary engineering, design basis, detailed design, and construction support.

• Experienced in working with multi-disciplinary project teams and ensuring the technical quality of the deliverables.

• Able to provide the personnel management, organization, and technical leadership necessary to accomplish the goals of such projects.

• Able to perform design reviews and oversee the design and plans preparation for site developments, infrastructure and buildings projects and water distribution systems.

• Skilled leader that can identify technical talent, motivate performance and team mentoring abilities to achieve exceptional group dynamics.

• Polished communicator, skilled in clearly presenting technical information to technical and nontechnical executives in briefings, written reports, and demonstrations.

• Core competencies include: Team Leadership, Project Planning & Management, Personnel Management, Design Management, Construction Support/Coordination, Scheduling & Budgeting, Contract & Proposal Writing.

• Selection of contract manufacturing operations.

EXPERIENCE:

Consultant, T.C. Engineering, 10 Jacobus Lane, Flemington, NJ 08822

- 2010 to present

At present working as a consultant at Capsugel for OSD expansion at Tampa Florida

Reviewed detailed design and construction activities for commercial facility at Bend Oregon. This is a 25 million dollar pharmaceutical spray drying facility.

Developed CIP pilot studies for the facility in North Carolina and implemented the system for the commercial operations.Client: Capsugel

Develop various options to move the Medical Devices Manufacturing facility from one location to another. This study involved the understanding of the various manufacturing steps to develop an ideal layout and a cost estimate for the relocation. Client ; Johnson & Johnson

Involved in various proposals for Teva pharmaceutical for API expansion in Puerto Rico & Genzyme for capital expansion.

Centocor, JOHNSON & JOHNSON, Horsham, PA 19044

Project Director - 2005 to 2009

Directed the implementation of various technical projects that involved heavy interaction with several departments, divisions and operating companies. Developed advanced project delivery techniques to incorporate business risk, commissioning and construction objectives into plant concepts and designs, resulting in accelerated project delivery. Single point of contact for projects, responsible for selection and management of A/E and CM firms, resource allocation and budget administration. Developed equipment and functional specifications and verified equipment performance in the field before acceptance. Specific projects details include:

• Led the modification of the Glaxo facility, a third party contract manufacturer in Conshohocken to make Remicade. This project involved the modifications of four bio- reactors from fed batch to perfusion mode and the installation of Chromatography and UF/DF skids for the protein separation. Secured FDA approval. On-time delivery of the project saved over 1 million dollars in project cost from a total cost of $65 million. Took responsibility to provide individual support and leadership for successful implementation of project’s qualification, start-up and validation for Biologics processing facilities.

• Supervised the design for the Syringe filling line for CNTO 148 and CNTO1275 at Gurabo, Puerto Rico facility.

• Managed the Fed Batch expansion Clinical Manufacturing Facility in Spring House. Pennsylvania. This unique design incorporates a clean side as well as mechanical side thereby reducing the clean space. The bio-reactor size is 10,000 liters and the design includes a space for two 2000 liters disposable bio reactors. The lay out includes a Micro biology lab for seed and inoculums, main Bio reactor .centrifuge for cell separation and space for product capture and viral separation. Media preparation, Utilities area for WFI, Compressors and a steam plant. Waste deactivation system was also included in the design.

• Developed cost effective strategy to relocate Auto injector assembly machine from Switzerland to USA. Projected saving $500,000. Total cost $5 million.

Process consultant (Contractor) – Centocor, Johnson & Johnson, 2004 to 2005

• Responsible for third party site evaluations as possible manufacturing facilities for Centocor.

• Worked with an external vendor responsible for a grass root facility study, which involved site lay out, equipment selection, process review, utilities review such as WFI, clean steam generation and process simulation.

Schering Plough Corp, Union, NJ. 07803

Director – Engineering Projects Worldwide Engineering Services, 1973 to 2004

Responsible for the planning, conceptual design & construction of all Chemical, Biotech, and Pharmaceutical Capital projects worldwide, including budget, schedule and resource allocation. Instrumental in the development and implementation of cost effective advanced engineering technologies critical to meeting Schering’s core business objectives. Ongoing interaction with key areas of the Organization such as R&D, Manufacturing, Sourcing, Legal, Finance, Safety and Risk Management. Overall responsibility in setting up the project procedures, selection of A/E and CM Firms. Supervised up to 10 engineers. Specific accomplishments include:

Completed the grass roots API facility in Singapore for the production of Claritin and Steroids in record time. Total cost $250 million.

• Directed the design of the Pharmaceutical facility in Japan for the manufacture of Claritin and Zetia. Total cost $50 million.

• Responsible for the design of the sterile and tablet manufacturing facility in Singapore for Interferon, Remicade and Zetia. Total cost $230 million.

• Directed the construction of the first commercial Biotech facility for Interferon in Union, NJ and Ireland. Total cost $100 million.

• Completed the first multipurpose API plant, Waste Water treatment and the associated infrastructure in Rathdrum, Ireland. Total cost $60 million.

• Completed the construction of Mammalian cell culture facility in Switzerland. Total cost $25 million.

• Completed the secondary manufacturing facility in Belgium and France. Total cost $50 million.

• Completed the chemical manufacturing facility for Florfenicol in China. Total cost $10 million.

• Collaborated with R&D and external Engineering firms in the development of the process to destroy Trichloroacetic acid in the wastewater on a commercial scale.

• Assist senior management in the evaluation of chemical facilities with a goal toward acquisition.

• Consistently met or under-ran the approved capital projects in various countries. (Singapore, Ireland, Switzerland, France, Belgium, Mexico, Canada and China)

Manager Chemical Projects, 1990 - 1991

Responsible for directing, planning and support functions related to various engineering capital projects worldwide. Supervised up to 6 engineers.

• Successfully took over management of the R&D pilot plant upgrade in a turn around situation. Total cost $20 million

• Utilized process detail knowledge to negotiate timesaving process changes and cost–saving equipment. Total annual savings $2 million.

Project Manager, 1980 – 1990

Responsible for conceptual design and management of capital projects in Mexico, Switzerland, Ireland and Union, NJ. Assisted management in cost estimation and facility studies.

• Completed a chemical pilot plant in Switzerland. Total cost $8 million.

• Developed a semi continuous extraction plant in Mexico for the Steroids plant. Total cost $15 million.

• Designed and installed the commercial scale facility to produce Nitrosan in Mexico. Total cost $4 million.

• Completed the first commercial scale Interferon facility in Union NJ (40000 liter fermentor scale). Total cost $15 million

• Constructed the Pharmaceutical development facility in Kenilworth NJ. Total cost $20 million.

EDUCATION:

Master’s Degree in Environmental Engineering – New York University

Master’s Degree in Chemical Engineering – IIT, India

AFFLIATIONS:

Member of AICHE, ISPE and NSPE. Licensed Professional Engineer in NJ

PUBLICATIONS:

Publications in Chemical Engineering Magazine.

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