ZHIPING LI CV Page *

Zhiping Li

** ********* ****

Wynnewood

PA 19096

Cell Phone: 202-***-****

Email: ac0wkf@r.postjobfree.com

CAREER SUMMARY:

• 20 years of experience in Oncology and/or Hematology research.

• 6 years of clinical experience in Internal Medicine/Hematology. EDUCATION:

1996-1999 Ph. D. in Hematology Beijing Medical University (Peking University Health Science Center). Beijing, China 1987-1990 Master Degree in Internal Medicine Shanxi Medical University, Taiyuan, Shanxi, China. 1982-1987 Bachelor in Medicine (M. D. equivalent) in Clinical Medicine Shanxi Medical University, Taiyuan, Shanxi, China.

EXPERIENCE:

Research Assistant Professor, December 2005 – March 2017 Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA

• Project leader in studying the role of cyclin D1 in cellular migration, DNA damage response, and DNA methylation.

• Project leader in investigating the role of Dach1 in tumorigenesis in vivo (DMBA induced tumors, MMTV-PyVT induced mouse model for mammary tumors, TRAMP mouse model for prostate tumors). Postdoctoral Fellow, December 2002 – November 2005 Department of Oncology, Georgetown University, Washington, DC

• Project leader in studying the role of cyclin D1 in cellular migration. Postdoctoral Fellow, January 2000 – December 2002

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY

• Project leader/co-leader in searching for BCL-6 target genes and studying the negative auto-regulation of BCL-6. Lecturer/Clinical Assistant Professor, July 1992 – August 1996 Institute of Hematology, Shanxi Medical University. Taiyuan, Shanxi, China. Clinical practice and teaching medical school students and residency Residency, July 1990 – June 1992

Institute of Hematology, Shanxi Medical University. Taiyuan, Shanxi, China. SKILLS & EXPERTISE:

• over 20 years of experience in molecular & cellular biology, very strong in a variety of experiments and continued bench work in my research. More specific technical expertise in the following areas: cell culture including preparation, culture, and immortalization of mouse embryonic fibroblasts (MEFs), mouse bone marrow macrophages, cell proliferation & apoptosis, transfection and transduction, RNA interference (siRNA & shRNA), immunohistochemistry, ELISA, FACS, PCR, methylation specific PCR, qRT-PCR, gene cloning & subcloning, Southern blot, Northern blot, Western blot, immunoprecipitation, chromatin immunoprecipitation (ChIP) assay, methylated DNA immunoprecipitation (MeDIP) assay, kinase assay, gel shift assay (EMSA), laser capture cell microdissection (LCM), microscopy (fluorescence microscopy, confocal microscopy, electron microscopy), cell based assays (cell adhesion assay, cell spreading assay, cellular invasion and cell migration assay, GFP based DNA repair assay).

• mice handling including transgenic mice, gene knockout mice (cyclin D1 knockout mice, cyclin E knockin mice, Dach1 knockout mice, Dach1 floxed mice), cre/loxP mice (Rosa26-CreERT2, PB-Cre4), mT/mG reporter mice, MMTV-PyVT mice, TRAMP mice.

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PUBLICATIONS

Original papers:

1. Xiaoming Ju, Xuanmao Jiao, Mathew C. Casimiro, Gabriele Di Sante, Shengqiong Deng, Zhiping Li, Agnese Di Rocco, Tingting Zhan, Adam Hawkins, Tanya Stoyanova, Sebastiano Andò, Alessandro Fatatis, Michael P. Lisanti, Leonard G. Gomella, Lucia R. Languino, and Richard G. Pestell. v-Src Oncogene Induces Trop2 Proteolytic Activation via Cyclin D1. Cancer Research. 2016; 76(22): 6723-34. 2. Mathew C. Casimiro, Gabriele Di Sante, Xiaoming Ju X, Zhiping Li, Ke Chen, Marco Crosariol, Ismail Yaman, Michael Gormley M, Hui Meng, Michael P. Lisanti, Richard G. Pestell. Cyclin D1 Promotes Androgen- Dependent DNA Damage Repair in Prostate Cancer Cells. Cancer Research. 2016; 76(2): 329-38. 3. Mathew C. Casimiro, Gabriele Di Sante, Marco Crosariol, Emanuele Loro, William Dampier, Adam Ertel, Zuoren Yu, Elizabeth A. Saria, Alexandros Papanikolaou, Zhiping Li, Chenguang Wang, Sankar Addya, Michael P. Lisanti, Paolo Fortina, Robert D. Cardiff, Aydin Tozeren, Erik S. Knudsen, Andrew Arnold, Richard G. Pestell. Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis. Oncotarget. 2015; 6(11): 8525-38. 4. Ke Chen, Kongming Wu, Xuanmao Jiao, Liping Wang, Xiaoming Ju, Min Wang, Gabriele Di Sante, Shaohua Xu, Qiong Wang, Kevin Li, Xin Sun, Congwen Xu, Zhiping Li, Mathew C. Casimiro, Adam Ertel, Sankar Addya, Peter A. McCue, Michael P. Lisanti, Chenguang Wang1, Richard J. Davis, Graeme Mardon, and Richard G. Pestell. The Endogenous Cell-Fate Factor Dachshund Restrains Prostate Epithelial Cell Migration via Repression of Cytokine Secretion via a CXCL Signaling Module. Cancer Research 2015; 75(10): 1992-2004. 5. Daniela Sicoli, Xuanmao Jiao, Xiaoming Ju, Marco Velasco-Velazquez, Adam Ertel, Sankar Addya, Zhiping Li, Sebastiano Ando, Alessandro Fatatis, Bishnuhari Paudyal, Massimo Cristofanilli, Mathew L. Thakur, Michael P. Lisanti, and Richard G. Pestell. CCR5 Receptor Antagonists Block Metastasis to Bone of v-Src Oncogene–Transformed Metastatic Prostate Cancer Cell Lines. Cancer Research 2014; 74(23): 7103-14. 6. Zhiping Li, Ke Chen, Xuanmao Jiao, Chenguang Wang, Nicole E. Willmarth, Mathew C. Casimiro, Weihua Li, Xiaoming Ju, Sung Hoon Kim, Michael P. Lisanti, John A. Katzenellenbogen, and Richard G. Pestell. Cyclin D1 Integrates Estrogen-Mediated DNA Damage Repair Signaling. Cancer Research 2014; 74(14): 3959-70. 7. Kongming Wu, Ke Chen, Chenguang Wang, Xuanmao Jiao, Liping Wang, Jie Zhou, Jing Wang, Zhiping Li, Sankar Addya, Poul H. Sorensen, Michael P. Lisanti, Andrew Quong, Adam Ertel, and Richard G. Pestell. Cell Fate Factor DACH1 Represses YB-1–Mediated Oncogenic Transcription and Translation. Cancer Research 2014; 74(3): 829-39. 8. Zuoren Yu, Liping Wang, Chenguang Wang, Xiaoming Ju, Min Wang, Ke Chen, Emanuele Loro, Zhiping Li, Yuzhen Zhang, Kongming Wu, Mathew C. Casimiro, Michael Gormley, Adam Ertel, Paolo Fortina, Yihan Chen, Aydin Tozeren, Zhongmin Liu, and Richard G. Pestell. Cyclin D1 Induction of Dicer Governs MicroRNA Processing and Expression in Breast Cancer. Nature Communications 2013; 4: 2812. 9. Mathew C. Casimiro, Chenguang Wang, Zhiping Li, Gabriele Di Sante, Nicole E. Willmart, Sankar Addya, Lei Chen, Yang Liu, Michael P. Lisanti, and Richard G. Pestell. Cyclin D1 Determines Estrogen Signaling in the Mammary Gland In Vivo. Molecular Endocrinology 2013; 27(9): 1415-28. 10. Ke Chen, Kongming Wu, Michael Gormley, Adam Ertel, Jing Wang, Wei Zhang, Jie Zhou, Gabriele Di Sante, Zhiping Li, Hallgeir Rui, Andrew A. Quong, Steven B. McMahon, Haiteng Deng, Michael P. Lisanti, Chenguang Wang, Richard G. Pestell. Acetylation of the cell-fate factor dachshund determines p53 binding and signaling modules in breast cancer. Oncotarget 2013; 4(6): 923-35.

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11. Ke Chen, Kongming Wu, Shaoxin Cai, Wei Zhang, Jie Zhou, Jing Wang, Adam Ertel, Zhiping Li, Hallgeir Rui, Andrew Quong, Michael P. Lisanti, Aydin Tozeren, Ceylan Tanes, Sankar Addya, Michael Gormley, Chenguang Wang, Steven B. McMahon, and Richard G. Pestell. Dachshund Binds p53 to Block the Growth of Lung Adenocarcinoma Cells. Cancer Research 2013; 73(11): 3262-74.

12. MP Myklebust, Zhiping Li, TH Tran, H Rui, ES Knudsen, H Elsaleh, Ø Fluge, B Vonen, HE Myrvold, S Leh, KM Tveit, RG Pestell and O Dahl. Expression of cyclin D1a and D1b as predictive factors for treatment response in colorectal cancer. British Journal of Cancer 2012; 107(10): 1684-91. 13. Mathew C. Casimiro, Marco Crosariol, Emanuele Loro, Adam Ertel, Zuoren Yu, William Dampier, Elizabeth A. Saria, Alex Papanikolaou, Timothy J. Stanek, Zhiping Li, Chenguang Wang, Paolo Fortina, Sankar Addya, Aydin Tozeren, Erik S. Knudsen, Andrew Arnold, and Richard G. Pestell. ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice. The Journal of Clinical Investigation 2012; 122(3): 833-43. 14. Hui Meng, Lifeng Tian, Jie Zhou, Zhiping Li, Xuanmao Jiao, Wayne W. Li, Markus Plomann, Zhishun Xu, Michael P. Lisanti, Chenguang Wang & Richard G Pestell. PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b. Cell Cycle 2011; 10(1): 73-81. 15. Zhiping Li, Xuanmao Jiao, Chenguang Wang, L. Andrew Shirley, Hany Elsaleh, Olav Dahl, Min Wang, Evi Soutoglou, Erik S. Knudsen, and Richard G. Pestell. Alternative Cyclin D1 Splice Forms Differentially Regulate the DNA Damage Response. Cancer Research 2010; 70(21): 8802-11. 16. Manran Liu, Mathew C. Casimiro, Chenguang Wang, L. Andrew Shirley, Xuanmao Jiao, Sanjay Katiyar, Xiaoming Ju, Zhiping Li, Zuoren Yu, Jie Zhou, Michael Johnson, Paolo Fortina, Terry Hyslop, Jolene J. Windle, and Richard G. Pestell. p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo. Proceedings of the National Academy of Sciences USA 2009; 106(45): 19035–19039. 17. Jaime Lindsay, Xuanmao Jiao, Toshiyuki Sakamaki, Mathew C. Casimiro, Lawrence A. Shirley, Thai H. Tran, Xiaoming Ju, Manran Liu, Zhiping Li, Chenguang Wang, Sanjay Katiyar, Mahadev Rao, Kathleen G. Allen, Robert I. Glazer, Changhui Ge, Pamela Stanley, Michael P. Lisanti, Hallgeir Rui, Richard G. Pestell. ErbB2 induces Notch1 activity and function in breast cancer cells. Clinical and Translational Science 2008; 1(2): 107-115. 18. Zuoren Yu, Chenguang Wang, Min Wang, Zhiping Li, Mathew C. Casimiro, Manran Liu, Kongming Wu, James Whittle, Xiaoming Ju, Terry Hyslop, Peter McCue, and Richard G. Pestell. A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. Journal of Cell Biology 2008; 182(3): 509-17. 19. Jiao X, Katiyar S, Liu M, Mueller SC, Lisanti MP, Li A, Pestell TG, Wu K, Ju X, Zhiping Li, Wagner EF, Takeya T, Wang C, Pestell RG. Disruption of c-Jun Reduces Cellular Migration and Invasion through Inhibition of c-Src and Hyperactivation of ROCK II Kinase. Molecular Biology of the Cell 2008; 19(4):1378-1390. 20. Zhiping Li, Chenguang Wang, Xuanmao Jiao, Sanjay Katiyar, Mathew C. Casimiro, George C. Prendergast, Michael J. Powell, Richard G. Pestell. Alternate Cyclin D1 mRNA Splicing Modulates p27KIP1 Binding and Cell Migration. Journal of Biological Chemistry 2008; 283(11): 7007-15. 21. Zhiping Li, Xuanmao Jiao, Chenguang Wang, Xiaoming Ju, Yinan Lu, Liangping Yuan, Michael P. Lisanti, Sanjay Katiyar, Richard G. Pestell. Cyclin D1 induction of cellular migration requires p27Kip1. Cancer Research 2006, 66(20): 9986-94.

22. James Hulit, Richard J. Lee, Zhiping Li, Chenguang Wang, Sanjay Katiyar, Jianguo Yang, Andrew A. Quong, Kongming Wu, Chris Albanese, Robert Russell, Dolores Di Vizio, Andrew Koff, Saiinder Thummala, Hui Zhang, Jennifer Harrell, Hong Sun, William J. Muller, Giorgio Inghirami, Michael P. Lisanti and Richard G. Pestell. p27Kip1 Repression of ErbB2-Induced Mammary Tumor Growth in Transgenic Mice Involves Skp2 and Wnt/ß-Catenin Signaling. Cancer Research 2006, 66(17): 8529-41.

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23. Chenguang Wang, Zhiping Li, Yinan Lu, Runlei Du, Sanjay Katiyar, Jianguo Yang, Maofu Fu, Jennifer E. Leader, Andrew Quong, Phyllis M. Novikoff, and Richard G. Pestell. Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function. Proceedings of the National Academy of Sciences USA 2006; 103(31): 11567-72.

24. Zhiping Li, Chenguang Wang, Xuanmao Jiao, Yinan Lu, Maofu Fu, Andrew A. Quong, Chip Dye, Jianguo Yang, Maozheng Dai, Xiaoming Ju, Xueping Zhang, Anping Li, Peter Burbelo, E. Richard Stanley, Richard G. Pestell. Cyclin D1 regulates cellular migration through the inhibition of thrombospondin-1 and ROCK signaling. Molecular and Cellular Biology 2006, 26(11): 4240-56.

25. Chenguang Wang, Saijun Fan, Zhiping Li, Maofu Fu, Mahadev Rao, Yongxian Ma, Michael P. Lisanti, Chris Albanese, Benita S. Katzenellenbogen, Peter J. Kushner, Barbara Weber, Eliot M. Rosen and Richard G. Pestell. Cyclin D1 Antagonizes BRCA1 Repression of Estrogen Receptor {alpha} Activity. Cancer Research 2005; 65(15): 6557-67 26. Maofu Fu, Chenguang Wang, Mahadev Rao, Xiaofang Wu, Toula Bouras, Xueping Zhang, Zhiping Li, Xunmao Jiao, Jianguo Yang, Anping Li, Neil D. Perkin, Bayar Thimmapaya, Andrew L.Kung, Alberto Munoz, Michael P. Lisanti, and Richard G. Pestell. Cyclin D1 represses p300 transactivation through a CDK-independent mechanism. Journal of Biological Chemistry 2005; 280(33):29728-42.

27. Maofu Fu, Mahadev Rao, Toula Bouras, Chenguang Wang, Kongming Wu, Xueping Zhang, Zhiping Li, Tso-Pang Yao, and Richard G. Pestell. Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. Journal of Biological Chemistry 2005; 280(17): 169**-*****. 28. Zhiping Li, Xing Wang, Raymond Yick-Loi Yu, B. Belinda Ding, J. Jessica Yu, Xu-Ming Dai, Akira Naganuma, E. Richard Stanley, and B. Hilda Ye. BCL-6 negatively regulates expression of the NF-κB1 p105/p50 subunit. Journal of Immunology 2005; 174(1): 205-214.

29. James Hulit, Chenguang Wang, Zhiping Li, Chris Albanese, Mahadev Rao, Dolores Di Vizio, Salimuddin Shah, Stephen W. Byers, Radma Mahmood, Leonard H. Augenlicht, Robert Russelll, Richard G. Pestell. Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice. Molecular and Cellular Biology 2004; 24(17): 7598-7611.

30. Chenguang Wang, Nagarajan Pattabiraman, Jian Nian Zhou, Maofu Fu, Toshiyuki Sakamaki, Chris Albanese, Zhiping Li, Kongming Wu, James Hulit, Peter Neumeister, Phyllis M. Novikoff, Michael Brownlee, Philipp E. Scherer, Joan G. Jones, Kathleen D. Whitney, Lawrence A. Donehower, Emily L. Harris, Thomas Rohan, David C. Johns, and Richard G. Pestell. Cyclin D1 Repression of Peroxisome Proliferator-Activated Receptor Expression and Transactivation. Molecular and Cellular Biology 2003; 23(17): 6159-73. 31. Xing Wang, Zhiping Li, Akira Naganuma, and B. Hilda Ye. Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomas. Proceedings of the National Academy of Sciences USA 2002; 99(23): 150**-***** (Xing Wang and Zhiping Li are co-first authors). 32. Zhiping Li, Jinlan Li, Jiayu Fu, Shanshan Chen. The significance of the adhesion between CD34+ stem/progenitor cells to fibronectin in the pathogenesis of chronic myelogenous leukemia. Chinese Journal of Hematology 2000; 21(3): 138-140

33. Zhiping Li, Jinlan Li, Jiayu Fu, Shanshan Chen. Effect of mixed human umbilical cord plasma on the culture of human umbilical vein endothelial cells. Journal of Beijing Medical University 1999; 31(3): 280-282. 34. Xiue Liu, Zhenhua Qiao, Linhua Yang, Zhiping Li. Prognostic significance of the expression of lymphocyte related surface marker on blasts of patients with acute myeloblastic leukemia. Chinese Journal of Medicine 1999; 38(10): 704. ZHIPING LI CV Page 5

35. Xiue Liu, Zhiping Li, Chun Wang, Zhenhua Qiao, Bo Yang. Analysis of immunophenotype in 71 cases of adult patients with acute leukemia. Journal of leukemia (Chinese) 1998; 7(1): 19-21. 36. Zhiping Li, Zhenhua Qiao, Xiue Liu, Chun Wang, Jinmei Zhang, Yanping Ma, Jiayan Ran. Analysis of immunophenotype in 35 cases of adult patients with acute lymphocytic leukemia. Journal of Leukemia (Chinese) 1997; 6(1): 30-32.

37. Zhiping Li, Jiayan Ran, Laiyuan Wang, Zhenqiong Zheng, Ruilin Ma. The observation of immunologic function in patients with nutritious megaloblastic anemia. Chinese Journal of Hematology 1992; 13(12): 645-646. Reviews in journals:

1. Mathew C. Casimiro, Marco Crosariol, Emanuele Loro, Zhiping Li, and Richard G. Pestell. Cyclins and Cell Cycle Control in Cancer and Disease. Genes Cancer 2012; 3(11-12): 649–657. 2. Marco A Velasco-Velázquez, Zhiping Li, Mathew Casimiro, Emanuele Loro, Nora Homsi & Richard G Pestell. Examining the role of cyclin D1 in breast cancer. Future Oncology 2011; 7(6): 753-65. 3. Zhiping Li, Chenguang Wang, George Prendergast, Richard G. Pestell. Cyclin D1 functions in cell migration. Cell Cycle 2006; 5(21): 2440-2442.

4. Richard G. Pestell and Zhiping Li. Antisense to Cyclin D1 Inhibits VEGF-Stimulated Growth of Vascular Endothelial Cells: Implication of Tumor Vascularization. Clinical Cancer Research 2006; 12: 4459-62. 5. Maofu Fu, Chenguang Wang, Zhiping Li, Toshiyuki Sakamaki, Richard G. Pestell. Minireview: Cyclin D1: Normal and Abnormal Functions. Endocrinology 2004; 145(12):5439-47. Charpters in books:

Chenguang Wang, Zhiping Li, Maofu Fu, Toula Bouras, Richard G Pestell. Signal tranduction mediated by cyclin D1: from mitogens to cell proliferation: A molecular target with therapeutic potential. Rakesh Kumar, ed. Molecular Targeting

& Signal Transduction. Kluwer Academic Publisher 2004 (217-237). REFERENCES: available upon request.

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