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Project Management Computer Science

San Mateo, California, 94403, United States
May 30, 2017

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*** ****** ***** ****, ***** San Francisco, CA 94403 • 919-***-**** SUMMARY

A bioinformatics scientist with 15 years experience in project management, data analysis, software / tool development in biotechnology industry. A problem-solver in applied bioinformatics and a solution provider in customer support in biomarker discovery, next generation sequencing (NGS), microarray data, pathogenic detection assay design and downstream analyses to make data biologically meaningful:

Experienced in bioinformatics tool/pipeline development, -omics data analysis, high performance computing

(HPC) and relational database design and implementation.

Proven ability in project management, scientific collaborations and training across functional groups.

Experienced in providing bioinformatics solutions for NGS data, microarray data, molecular pathogen detection assay design, genetic mutations, gene network/pathway, genome assembly and functional annotation.

Proven track records for customer support with ability to clearly communicate technical information across a broad range of disciplines and partners supported by multi-disciplinary knowledge in biology (PhD), computer science (MS) and statistics trainings.


ThermoFisher Scientific (Life Technologies), South San Francisco Mar 2013 – Present Staff Scientist – Bioinformatics, Genetics Science Division and Custom Assay Design

Designed and developed tools for high accuracy and comprehensive molecular pathogen detection panels and assays.

Initiated and managing scientific collaborations to develop smart algorithms for genotyping products.

- save ~20% of manufacturing costs with improved accuracy.

Functioned as a NGS informatics consultant for NGS customers and provided bioinformatics solutions.

- Presented findings at Cold Spring Harbor Conference. Bayer CropScience, Morrisville, NC Jan 2012 – Aug 2012 Sr. Bioinformatics Scientist, Bioinformatics Infrastructure & Algorithms Development

Planned and developed a biomarker discovery pipeline for tetraploid organisms with Illumina data from scratch, including software and hardware infrastructure establishment.

Implemented an innovative algorithm to identified genetic mutations to speed up projects. Ion Torrent, by Life Technologies, Foster City, CA Feb 2009 – Dec 2011 Staff Scientist – Bioinformatics, NGS Bioinformatics Support and Project Management

Managed projects to develop and test NGS pipeline functionalities and assure quality control for LifeScopeTM release.

- Winner of Company Award for innovative ideas.

Established an efficient customer support platform and supported three teams of Field Bioinformatics Scientists that cover 95% of global customer bases.

- Reduced trouble-shooting and problem-solving turn-around time from 48 hours to 12 hours

Trained field bioinformatics scientists and customers on LifeScopeTM applications and supporting Ion Torrent PGM instruments.

Hands-on NGS data analyst for internal and external biotech and pharmaceutical customers. Almac Diagnostics Inc. (UK), Durham, NC Oct 2006 – Jan 2009 Senior Scientist – Bioinformatics, Cross-functional Project Management and Microarray Services

Initiated and managed projects to standardize analysis of microarray data for oncology customers.

Responsible for high quality customer project delivery (e.g., expression arrays, exon arrays) and downstream analysis.

Interfaced with customers as bioinformatics consultant for issues and questions on data analyses.

- Fostered customer allegiance by high quality results and timely deliverables. BASF, Research Triangle Park, NC Jul 2003 – Sep 2006 Bioinformatics Scientist, Bioinformatics Tool Development and Database Integration

Developed pipelines for genome assembly and functional annotation with proprietary and public data.

Led and developed a Laboratory Information Management System (LIMS) and improved vector annotation efficiency and accuracy.

Innovatively provided bioinformatics support to projects and customers. GlaxoSmithKline, Inc., Research Triangle Park, NC Jun 2002 – Jun 2003 Data Manager (contractor), Data Mining and Pipeline Integration

Carried out data-mining to extract data of interest for IP application.

Tested and validated a high-throughput bioinformatics application using software engineering knowledge by generating test plan, test cases and test report.

Syngenta Biotechnology, Inc., Research Triangle Park, NC Oct 2001 – May 2002 Computational Biologist (contractor), Industrial Oracle Database Design and Implementation

Designed and implemented the first rice (Oryza sativa) functional genomics database in Oracle and enabled large-scale data mining for gene prioritization with complex datasets. EDUCATION

Ph.D., Biology, Old Dominion University (previous part of College of William and Mary), Norfolk, VA.

M.S., Computer Science, Old Dominion University, Norfolk, VA.

M.S., Zoology, Institute of Zoology, Chinese Academy of Sciences, Beijing. Managed a three-year project supported by China NSF (Approval number: 39300014) and supervised three team members.

B.S., Zoology, Northwestern University, China.


Practical Performance Improvement and Product Commercializing Process, Thermo Fisher Scientific.

Life Technologies Supervisor Training.

Almac Diagnostics: Leadership and management training.

Principal Investigator (PI) of China National Science Foundation. TECHNICAL HIGHLIGHTS

Bioinformatics: Public and commercial databases and bioinformatics software/tools for oncology, genetics, microarray data, Sanger sequences and NGS (e.g., whole genome re-sequencing, exome / targeted re-sequencing

(DNA-seq), RNA-seq, BWA, Bowtie, SAM / BAM, BCF / VCF, Samtools, GATK, CLC Bio, Resolver, Partek, GenBank, EBI databases and tools, SAS / JMP, GO, GeneGO, IPA, etc.) Statistics: Experimental design, hypothesis testing, ANOVA, statistical data analysis and interpretation. Programming Languages: Perl, Java, C/C++, SAS, R and MATLAB (familiar) Databases: Oracle, ODBC/DBI, PL/SQL, object oriented programming (OOP), relational database design Operating Systems: HPC (PBS, SGE and LSF), Cloud Computing, Unix, Linux and Windows SELECTED POSTERS & PUBLICATIONS

Webb A. et. al., RNA sequencing of transcriptomes in human brain regions: protein-coding and non-coding RNAs, isoforms and alleles. BMC Genomics (2015) 16:990.

Wang, D. et. al., Whole transcriptome analysis and characteristics of human autopsy brain regions from smokers and non-smokers. RNA Biology, Cold Spring Harbor Conference. Nov, 2014.

Wang, D. et. al., Biomarker discovery and RNA-seq findings on the effects of nicotine in human brain regions. NCH & OSU Human Genetics Community Symposium. May 20, 2014, Columbus, Ohio.

Wang, D. and Sun, Y., Genome-wide discovery of malaria resistance transcriptome re-sequencing and structural variation. Presented in Life Technologies Bioinformatics Group and Customer Forum, 2009.

Sun, J., Wang, D., Sun, Y., et al, Next generation sequencing (NGS) software assessments with SOLiD data: from results to business acumen. Life Technologies Bioinformatics Forum, 2009.

Wang, D. and Yan, J. Uncovering the expression patterns and biomarker discovery of triple negative breast cancer, Frontier in Cancer Prevention Research Conference, Philadelphia, PA, 2007.

Wang, D. and Tarpey, R., An optimized protocol to accurately assemble public and proprietary transcripts using CAP3 through bioinformatics simulation and validation. BASF Plant Science Seminar, 2006.

Wang, D. and Ingham, D. Automatic Vector Annotation: a high-throughput bioinformatics tool for vector component annotation. BASF Plant Science Seminar, 2004.

Wang, D. Database design and implementation for rice functional genomics to enable gene prioritization. Master Project of Computer Science, Old Dominion University, 2001.

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