Jaime Cruz-Lobo, MD, PhD

Piedras Negras **

Coyoacan

Santa Cecilia

Mexico City, DF

04930

Cell: 011-52-1-55-3232-6769

ac0j8w@r.postjobfree.com

PERSONAL STATEMENT:

I am an M.D. and Ph.D in Magnetic Resonance Techniques. Employed for more than 10 years as an investigator. I am highly proficient in Biomedical Research. I am highly knowledgeable in creating and managing research projects involving humans and experimental animals as subject of research. My experience allows me to conceptualize and complete complex investigations including multi-institutional trials. My professional development also includes the following endeavors. (1) Teaching Research Methodology at the undergraduate and graduate levels. (2) Training of young professionals in research procedures. (3) Writing manuscripts reporting the results of my research in peer-reviewed scientific journals. (4) Peer-reviewing research manuscripts for publication. The main focus of my investigations is the assessment of metabolic parameters in cancer masses at their original place in the body. To achieve this assessment, I use noninvasive methods based on nuclear magnetic resonance. My research recently confirmed that some of these metabolic parameters have the ability to predict response to treatment in cancer. Since 2010 I have been acting Director General of a multi-million dollar company.

education:

Columbia University, College of Physician & Surgeons, Hatch Center for MR Research, Department of Radiology, Columbia University, New York, NY 10032

Postdoctoral Research Scientist on Spectroscopy N.M.R.

Ph.D March 2004- March 2008

Columbia University, College of Physician & Surgeons, Hatch Center for MR Research, Department of Radiology, Columbia University, New York, NY 10032,

Postdoctoral Research Scientist on NMR

Ph.D March 2001- March 2004

Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA

Postdoctoral Associate (NMR and Medical Spectroscopy)

Trained under Dr Smith, Oncologist and Dr Truman Brown in MR Technique

October 1999 - March 2001

Instituto Nacional de Enfermedades Respiratorias INER, Calzada de Tlalpan 4502, Col. Tlalpan 14080 Mexico City

Research and Teacher Assistant for Experimental HIV Treatments

1995 - 1997

Hospital Español, Av. Ejercito Nacional 613 Col. Irrigacion 11550 Mexico City, Mexico

Senior Selective

1994-1995

Universidad Anahuac, Av. Lomas Anahuac S/N, Huixquilucan Edo. Mexico 52760 Mexico

Doctor of Medicine, 1990-1996

Pre-medicine course 1990

La Salle’s Preparatory Pedregal, Calle Transmisiones 51, Hacienda de San Juan, 14370 Ciudad de México, CDMX

Bachillerato

1983 - 1986

OTHER EDUCATION AND TRAINING

University and ETH Zurich, Institute for Biomedical Engineering Sternwarstrasse 7, CH-8092, Zurich Switzerland

21st Course of the International Zurich Magnetic Resonance Spectroscopy

Under supervision of the doctors of the university, trained on the full capacity of a Phillips 1.5 T and 3T NMR scanner.

November 2003

Philips Medical Systems Cleveland Training Center, 95 Miner Road, Cleveland, OH, 444143

The MR Advanced Course Off-Site Program

March 2003

Kaplan Educational Center, 1222 Walnut Street, 2nd Floor, Philadelphia, PA, USA, 19107

United States Medical Licensure Examination, USMLE Step I-II preparations

1997-1999

Honors and Awards:

Alumni Society Federation of Anahuac University Award for Excellence as Medical Student (Premio a la Excelencia otorgado por FESAL de la Universidad Anahuac), October 1991

LICENSURE AND CERTIFICATIONS:

unrestricted medical physician and surgeon:

Unrestricted Medical Physician and Surgeon (Cedula Profesional Como Medico Cirujano)

Mexico License # 2445455

Research:

“31P & 1H NMR Spectroscopy in Human Cancer”

Columbia University, College of Physician & Surgeons, Hatch Center for MR Research, New York City, NY, 2001-2008

“1H NMR Spectroscopy of hyper-acute global brain anoxia in primates”

Columbia University, College of Physician & Surgeons, Hatch Center for MR Research, New York City, NY, 2001-2003

“31P & 1H in Amyotrophic Lateral Sclerosis”

Columbia University, College of Physician & Surgeons, Hatch Center for MR Research, New York City, NY, 2001-2002

“NMR Studies of Human Cancer”

Fox Chase Cancer Center, NMR and Medical Spectroscopy, Philadelphia, PA, 1999-2001

“Predicting Human Tumor Response by 31P MR Spectroscopy”

Fox Chase Cancer Center, NMR and Medical Spectroscopy, Philadelphia, PA, 1999-2001

"Effect of Glycine on Patients with AIDS Treated with AZT and DDI over a Period of Two Years".

Research Department at the Pharmacology Laboratory, National Institute of Respiratory Diseases, Mexico (Unidad de Investigación, Laboratorio de Farmacología del Instituto Nacional de Enfermedades Respiratorias, Mexico), 1995-1996

"Protective Effect of Glycine in the Microalbuminemia of Diabetic Type II Rats".

Research Department at the Pharmacology Laboratory, National Institute of Respiratory Diseases, Mexico (Unidad de Investigación, Laboratorio de Farmacología del Instituto Nacional de Enfermedades Respiratorias, Mexico), 1996

"Study 'in vivo' and 'in vitro' of the Inhibition by Glycine of the Non-enzymatic Glycation of Proteins in Diabetic Rats".

Research Department at the Pharmacology Laboratory, National Institute of Respiratory Diseases, Mexico (Unidad de Investigación, Laboratorio de Farmacología del Instituto Nacional de Enfermedades Respiratorias, Mexico), 1996

MEETINGS AND PRESENTATIONS:

Arias-Mendoza F, Payne G, Zakian K, Stubbs M, Cruz-Lobo J, Schwarz A, Shukla-Dave A, Howe F, Brown TR, et al. Treatment response predictor using 31P MRS for CHOP and R-CHOP therapy in diffuse large B-cell lymphoma. Annual meeting of AACR, San Diego, California, 2008

Coon AL, Arias-Mendoza F, Colby GP, Cruz-Lobo J, Mocco J, Mack WJ, Komotar RJ, Brown TR, Connolly ES. Correlation of cerebral metabolites with functional outcome in experimental primate stroke using in vivo 1Hmagnetic resonance spectroscopy. AJNR Am J Neuroradiol. 2006 May;27(5):1053-8.

Colby GP, Coon AL, Arias-Mendoza F, Mack WJ, Komotar R, Cruz-Lobo J, Brown TR, Connolly ES. Immediate Changes in Cerebral Brain Metabolism Following Circulatory Arrest in Primates: A 1H-Magnetic Resonance Spectroscopy Study. Congress of Neurological Surgeons 55th Annual Meeting. 2005. Boston, MA.

Coon, A.L., Arias-Mendoza, F., Mack, J., Colby, G.P., King, R., Cruz-Lobo, J., Brown, T.R. and Connolly, E.S.; Magnetic Resonance Spectroscopic Footprint of Hyper-Acute Global Brain Anoxia in Primates. Annual Meeting of the Stroke Society, 2003.

Coon AL, Arias-Mendoza F, Cruz-Lobo J, Berardocco F, Mocco J, Colby GP, King R, Mack WJ, Brown TR, Connolly ES. In Vivo Characterization of Experimental Primate Stroke Using 1H Magnetic Resonance Spectroscopy. Congress of Neurological Surgeons 52nd Annual Meeting. 2002. Philadelphia, PA.

Coon AL, Arias-Mendoza F, Mack WJ, King R, Colby GP, Cruz-Lobo J, Ziv

E, Brown TR, Connolly ES. In Vivo Characterization of Experimental Primate

Coon AL, Arias-Mendoza F, Mack WJ, King R, Colby GP, Cruz-Lobo J, Ziv E, Brown TR, Connolly ES. In Vivo Characterization of Experimental Primate Stroke Using 31P-Magnetic Resonance Spectroscopy. American Association of Neurological Surgeons Annual Meeting. 2003. San Diego, CA.

Coon AL, Arias-Mendoza F, Mack WJ, Colby GP, King RG, Cruz-Lobo J, Brown TR, Connolly ES. Magnetic Resonance Spectroscopic Footprint of Hyper-Acute Global Brain Anoxia in Primates. American Association of Neurological Surgeons Annual Meeting. 2003. San Diego, CA.

Arias-Mendoza F, Coon A, Cruz-Lobo J, King RG, Ziv E, Mack WJ, Colby GP, DeLaPaz RL, Connolly ES, Brown TR. In Vivo Characterization of Experimental Primate Reperfused Stroke Using 1H and 31P-MR Spectroscopy. International Society for Magnetic Resonance in Medicine. 2003. Toronto, Canada

Coon, A.L., Arias-Mendoza, F., Mack, J., Colby, G.P., King, R., Cruz-Lobo, J., Brown, T.R. and Connolly, E.S.; Magnetic Resonance Spectroscopic Footprint of Hyper-Acute Global Brain Anoxia in Primates. Annual Meeting of the Stroke Society, 2003.

Coon, A.L., Arias-Mendoza, F., Cruz-Lobo, J., Berardocco, F., Mocco, J., Colby, G.P., King, R., Mack, J., Brown, T.R. and Connolly E.S.; Characterization of Experimental Primate Stroke Using 1H Magnetic Resonance Spectroscopy. Annual Meeting of the Society of Neurological Surgeons, Philadelphia, PA, USA, 2002.

Coon, A.L., Arias-Mendoza, F., Mack, J., King, R., Colby, G.P., Cruz-Lobo, J., Ziv, E., Brown, T.R. and Connolly, E.S.; In vivo Characterization of Experimental Primate Stroke Using 31P Magnetic Resonance Spectroscopy. Annual Meeting of the American Association of Neurosurgery, USA, 2002.

Arias-Mendoza, F., Stoyanova, R., Cruz-Lobo, J., Ziv, E. and Brown, T.R.; Principal Component Analysis Of 31P MR Spectroscopy of Human Non-Hodgkin's Lymphomas in situ. Workshop On in vivo Functional and Molecular Assessment of Cancer, Santa Cruz, CA, USA, 2002.

Robinson, J.N., Clearly-Goldman, J., Fineberg, B., Mulkern, R., Tempany, C., Arias-Mendoza, F., Cruz-Lobo, J. and Brown, T.R.; Antenatal Detection of Fetal Lactate With Non-Invasive Testing Using 2D-Localized Proton Magnetic Resonance Spectroscopy. 24th Annual Scientific Meeting of The Society For Maternal-Fetal Medicine (Submitted).

Arias-Mendoza, F., Cruz-Lobo, J., Berardocco, F. and Brown, T.R.; Investigation of The Tumor Content of Phospholipid-Related Compounds Measured by in vivo 31P MR Spectroscopy in Advanced Breast Carcinoma, Annual Meeting of The International Society Of Magnetic Resonance In Medicine, Honolulu, HI, USA, 2002.

Arias-Mendoza,F., Cruz-Lobo, J., and Brown, T.R.; Is bone marrow MRI More Specific Than Bone Scintigraphy to Predict Metastasis? Annual Meeting of the International Society of Magnetic Resonance in Medicine, Honolulu, HI, USA, 2002.

Sentinel Lymph Node Mapping in Breast Cancer and Melanoma, Philadelphia, PA, May 2000

XXXVII General Medicine Review at the Mexican Medicine Faculty of La Salle University, Mexico (Curso de Extensión Universitaria de La Universidad La Salle, Mexico), June-September 1996.

Seminar on Surgical Application of Laser ND: YAG, Mexico City, Mexico, April 1995

First Geriatric Medicine Meeting, Mexico City, Mexico, January 1995

Mexican-Canadian Joint Seminar on AIDS, Mexico City, Mexico, January 1995

XXVII Medical and Surgical Meeting of The National Institute of Respiratory Diseases, Mexico City, Mexico, September 1995

XXX Mexican National Conference of Neumology and Thoracic Surgery, Cancun, Mexico, April 1995, presentations: "Effect of Glycine on Patients with AIDS Treated with AZT and DDI over a Period of Two Years". "Protective Effect of Glycine in the Microalbuminemia of Diabetic Type II Rats". "Study 'in vivo' and 'in vitro' of the Inhibition by Glycine of the Non-enzymatic Glycolation of Proteins in Diabetic Rats

Anahuac University medical School Annual Meeting, Mexico City, Mexico, April 1994, presentation: "Thymus: Anatomic and Pathological Characteristics"

First International Meeting of Bioethics, Mexico City, Mexico, September 1991

XIII, XII, XI Mexican Medicine Faculty of La Salle University Annual Meetings, Mexico City, Mexico, March 1989, March 1988, March 1987

Publications:

Williamson J, Launer L, Miller M, Cruz-Lobo, J, research team participant at Columbia University, et al, Cognitive Function and Brain Structure in Persons with Type 2 Diabetes Mellitus after intensive lowering of blood pressure and lipid levels; A Randomized Clinical Trial - THE MIND ACCORD STUDY, JAMA 324-333, Vol 174, 2014

Freda P, Shen W, Heymsfield S, Gallagher D, Cruz-Lobo J, research team participant at Columbia University; see addendum.; Lower Visceral and Subcutaneous but Higher Intermuscular Adipose Tissue Depots in Patients with Growth Hormone and Insulin-Like Growth Factor I Excess Due to Acromegaly; J Clin Endocrinol Metab (2008) 93 (6): 2334-2343.

Prabhakaran, S., Wright, C.B., Yoshita, M., Delapaz, R., Brown, T.R., DeCarli, C. and Sacco, R.L., Cruz-Lobo J, research team participant at Columbia University; Prevalence and Determinants of Subclinical Brain Infarction: The Northern Manhattan Study. Neurology 70(6); 425-30, 2008.

Brickman A.M., Schupf N., Manly J.J., Luchsinger J.A., Andrews H., Tang M.X., Reitz C., Small S.A., Mayeux R., DeCarli C., Brown T.R., Cruz-Lobo J, research team participant at Columbia University, Brain morphology in older African Americans, Caribbean Hispanics, and Whites from northern Manhattan., Arch Neurol. Aug;65(8):1053-61, 2008.

Ciaccio, EJ, Ashikage H, Kaba RA, Cervantes D, Hopenfield B, Wit AL, Peters NS, McVeigh ER, Garan H, Coromilas J, Cruz-Lobo J, research team participant at Columbia University; see addendum, Model of Reentrant Ventricular Tachycardia based upon Infarct Border Zone Geometry Predicts Reentrant Circuit Features as Determined by Activation Mapping, Heart Rhythm, 2007 August, Vol 8, 1034-1045

Arias-Mendoza F, Stoyanova R, Smith MR, Berardocco F, Brown TR, Cruz-Lobo J, research team participant at Fox Chase Cancer Center; see addendum, Application of principal component analysis to study spectral patterns in 31P MR spectra of non-Hodgkin's lymphoma in vivo. NMR in Biomedicine, Vol 19, No. 4, pp. 504-512, 2006

Coon, A. L, Arias-Mendoza, F., Colby, G.P., Cruz-Lobo, J., Mocco, J., Mack, W.J., Komotar, R.J., Brown, T.R. and Connolly Jr., E.S.; Correlation of Cerebral Metabolites With Functional Outcome In Experimental Primate Stroke Using in Vivo 1H-Magnetic Resonance Spectroscopy. AJNR Am J. Neuroradiol. 27; 1053-58, May 2006.

Arias-Mendoza F, Zakian K, Stoyanova R, Schwartz A, Howe FA, Koutcher JA, Leach MO, Griffiths JR, Heerschap A, Glickson JD, Nelson SJ, Evelhoch JL, Charles HC, Brown TR, Cruz-Lobo J, research team participant at Fox Chase Cancer Center; see addendum. In vivo 31P MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial. NMR Biomed, 2006

Wright, C.B., Paik, M.C., Brown, T.R., Stabler, S.P., Allen, R.H., Sacco, R.L. and DeCarli, C, Cruz-Lobo J, research team participant at Columbia University, Total Homocysteine Is Associated With White Matter Hyperintensity Volume - The Northern Manhattan Study. Stroke 36(6); 1207-1211, June 2005.

Robinson, J.N., Goldman, J.C., Arias-Mendoza, F., Cruz-Lobo, J., Tempany, C., Mukern, R.V., Feinberg, B.B. and Brown, T.R, Detection of Fetal Lactate With Two Dimensional-Localized Proton Magnetic Resonance Spectroscopy. Obstetrics and Gynecology, 104: 1208-1210, 2004.

Arias-Mendoza F, Zakian K, Schwartz A, Howe FA, Koutcher JA, Leach MO, Griffiths JR, Heerschap A, Glickson JD, Nelson SJ, Evelhoch JL, Charles HC, Brown TR, Cruz-Lobo J, research team participant at Columbia University; see addendum, Methodological Standardization of a Multi-Institutional In Vivo trial of Localized 31P MR Spectroscopy in Human Cancer Research. In Vitro and Normal Volunteer Studies, NMR Biomed, 2004 17:382-291

Arias-Mendoza F, Brown TR, Cruz-Lobo J, research team participant at Columbia University, see addendum, In vivo measurement of phosphorus markers of disease, Disease Markers 19 (2004) 49–68 49 IOS Press

Shukla-Dave A, Poptani H, Loevner LA, Mancuso A, Serrai H, Rosenthal DI, Kilger AM, Nelson DS, Zakian KL, Arias-Mendoza F, Rijpkema M, Koutcher JA, Brown TR, Heerschap A, Glickson, JD, Cruz-Lobo J, research team participant at Fox Chase Cancer Center; see addendum, Prediction of treatment response of head and neck cancers with P-31 MR spectroscopy from pretreatment relative phosphomonoester levels. Acad Radiol, Vol. 9, No. 6: pp 688-94. Jun 2002

Cruz-Lobo J, et al, Effect of Glycine on Patients with AIDS Treated with AZT and DDI over a Period of Two Years. Neumologia y Cirugia de Torax, Vol. 55, No. 1 (Sup). Jan-March 1996

Cruz-Lobo, et al, Protective Effect of Glycine in the Microalbuminemia of Diabetic Type II Rats. Neumologia y Cirugia de Torax, Vol. 55, No. 1 (Sup). Jan-March 1996

Cruz-Lobo, J et al, Study 'in vivo' and 'in vitro' of the Inhibition by Glycine of the Non-enzymatic Glycolation of Proteins in Diabetic Rats. Neumologia y Cirugia de Torax, Vol. 55, No. 1 (Sup). Jan-March 1996

Employment Experience:

Robinson Fabrics 2010-Present

Edgar Allan Poe 54, Polanco, Mexico, DF. CP. 11560

Director General, 2010 - Present

Centro de Estudios de la Asociacion Psicoanalitica Mexicana (APM) 2009 - 2012

Bosque de Caobas 67, Bosques de las Loma Deleg. Miguel Hidalgo, Mexico City, DF

Professor of Research Methodology at the PhD Program. January 2009 – 2012.

Columbia University 2001 - 2008

Columbia University, College of Physician & Surgeons, Hatch Center for MR Research, Department of Radiology, Columbia University, New York, NY 10032

Research Associate, March 2004 –April 2008

Acting as Clinical Administrator for 1.5T & 3T MRI Scanner at Hatch Center for MR Research, July 2003- March 2008

Postdoctoral Research Scientist, March 2001 - March 2008

Fox Chase Cancer Center, 1999 - 2001

Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA

Postdoctoral Associate, NMR and Medical Spectroscopy

October 1999 - March 2001

Unidad de Investigación, Laboratorio de Farmacología del Instituto Nacional de Enfermedades Respiratorias INER 1995 - 1997

Calzada de Tlalpan 4502, Colonia Sección XVI, Mexico City DF, 14080

Research Assistant, HIV research, August 1995-January 1997

Escuela de Medicina Física y Rehabilitación Adele Ann Yglesias de Hospital American British Cowdray "ABC" 1995 - 1996

Rafael Rebollar N 35, Colonia San Miguel Chapultepec, 11850, Mexico City DF

Professor of Anatomy, Physiology and Bio-chemistry, August 1995-January 1997

Escuela Nacional de Danza del Instituto Nacional de Bellas Artes "INBA" 1995 - 1996

Calle Río Churubusco 79, Coyoacan, Country Club Churubusco, 04220 Ciudad de México, CDMX

Attending Doctor

September 1995-February 1996.

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