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Sharon Hill, PA 19079 Email: ac0cre@r.postjobfree.com

Judith M. Phillips

Education PhD, Comparative Biomedical Sciences, Cornell University, Ithaca, NY, January 2009

DVM, Cornell University College of Veterinary Medicine, Ithaca, NY, May 2006

BA, Chemistry, Kenyon College, Gambier, OH, May 2000

summa cum laude with high honors in chemistry

Honors Phi Zeta Veterinary Honor Society (Cornell University, 2005)

Robert J. Tomsich Science Award (Kenyon College, 2000)

For scientific excellence and overall contributions to the strength of research efforts at the College

Carl Djerassi Award in Chemistry (Kenyon College, 2000)

For the student who best exemplifies the liberally educated scientist

American Chemical Society Junior Award (ACS and Kenyon College, spring 1999)

Phi Beta Kappa, Beta of Ohio (Kenyon College, 1999)

Research Summer 2012–present

Experience University of Pennsylvania Philadelphia, PA

Research Associate

Continuing work with Dr. Susan Weiss on murine coronavirus pathogenesis

Summer 2009–Spring 2012

University of Pennsylvania Philadelphia, PA

Postdoctoral Researcher

Worked with Dr. Susan Weiss on murine coronavirus pathogenesis.

Summer 2008–Spring 2009

Cornell University Ithaca, NY

Postdoctoral Associate

Continued working with Dr. Volker Vogt on avian retrovirus assembly.

Spring 2002–Summer 2008

Cornell University Ithaca, NY

DVM/PhD Dual Degree Program

Worked with Dr. Volker Vogt on avian retrovirus assembly

Studied Gag protein assembly using both cultured cells and an in vitro assembly system.

Developed in vitro oxidation assay and used it to determine the role of the p10 domain of Gag in avian retrovirus assembly.

Supervised undergraduate students in developing an in vitro assembly system for simian immunodeficiency virus Gag protein.

Summer 2001

Cornell University Ithaca, NY

Leadership Program for Veterinary Students

Worked with Dr. Kenneth Simpson on experimental infection of cats with multiple strains of Helicobacter pylori.

Assisted with endoscopic biopsies and performed DNA extraction from tissue samples and PCR-and restriction-based diagnosis of infection.

After Leadership Program, continued project through Spring 2002.

Fall 1999–Spring 2000

Kenyon College Gambier, OH

Senior Honors in Chemistry

Worked with Dr. Elizabeth Ottinger on tandem binding of Src kinase to SH2- and SH3-binding motifs.

Performed protein purification and manual solid-phase peptide synthesis and analyzed protein-peptide binding using fluorescence polarimetry.

Summer 1999

Kenyon College Gambier, OH

Kenyon Summer Science Scholar

Introduction to project described above.

Fall 1998–Spring 1999

Kenyon College Gambier, OH

Student Research Assistant

Worked with Dr. Joan Slonczewski on projects involving pH-dependent gene expression in Escherichia coli and Helicobacter pylori.

Performed basic bacteriology, sample preparation, and two-dimensional SDS-polyacrylamide gel electrophoresis with isoelectric point focusing.

Presentations American Society for Virology, Annual Meeting, June 2016. Talk: “Zinc Metalloprotease Activity Promotes Murine Coronavirus Fusion.”

The XIIIth International Nidovirus Symposium, June 2014. Poster: “Metalloprotease activity contributes to murine coronavirus fusion.”

American Society for Virology, Annual Meeting, July 2013. Poster: “Ceacam1a-Independent Spread of Neurovirulent Strains of Mouse Hepatitis Virus is Independent of Canonical Receptor-Independent Spread.”

The XIIth International Nidovirus Symposium, June 2011.

Talk: “Ceacam1a-independent spread of MHV in mouse brain and culture.”

Retroviruses, Cold Spring Harbor Meeting, May 2008.

Poster: In vitro assembly properties of SIVmac Gag protein.

American Society for Virology, Annual Meeting, July 2007. Talk: A molecular switch required for immature assembly of RSV leads to a six-fold domain swap in the immature virus particle.

Retroviruses, Cold Spring Harbor Meeting, May 2007.

Talk: same as above

Retroviruses, Cold Spring Harbor Meeting, May 2005.

Talk: Interaction between the C-terminal part of p10 and the CA domain of RSV Gag is required for immature assembly.

Retroviruses, Cold Spring Harbor Meeting, May 2004.

Poster: Investigation of dimeric RSV CA NTD structure using cysteine cross-linking.

Retroviruses, Cold Spring Harbor Meeting, May 2003.

Poster: Assembly and budding of RSV Gag-leucine zipper proteins in avian cells.

Publications Phillips JM, Gallagher T, Weiss SR. “Neurovirulent murine coronavirus JHM.SD uses cellular zinc metalloproteases for virus entry and cell-cell fusion.” J Virol. 91(8): in press.

Zhang R, Li Y, Cowley TJ, Steinbrenner A, Phillips JM, Yount BL, Baric RS, Weiss SR. 2015. “The nsp1, nsp13, and M proteins contribute to the hepatotropism of murine coronavirus JHM.WU.” J Virol. 89(7): 3598-609.

Fehr AR, Athmer J, Channappanavar R, Phillips JM, Meyerholz DK, Perlman S. 2015. “The nsp3 macrodomain promotes virulence in mice with coronavirus-induced encephalitis.” J Virol. 89(3): 1523-36.

Bush DL, Monroe EB, Bedwell GJ, Prevelige PE Jr, Phillips JM, Vogt VM. 2014. “Higher-order structure of the Rous sarcoma virus SP assembly domain.” J Virol. 88(10): 5617-29.

Zhao L, Birdwell LD, Wu A, Elliott R, Rose KM, Phillips JM, Li Y, Grinspan J, Silverman RH, Weiss SR. 2013. “Cell-type-specific activation of the oligoadenylate synthetase-RNase L pathway by a murine coronavirus.” J Virol. 87(15): 8408-18.

Phillips JM, Kuo I-T, Richardson C, and Weiss SR. 2012. “A novel full-length isoform of murine pregnancy-specific glycoprotein 16 (psg16) is expressed in the brain but does not mediate murine coronavirus (MHV) entry.” J Neurovirol. 18(2): 138-43.

Phillips JM and Weiss SR. 2011. “Pathogenesis of neurotropic murine coronavirus is multifactorial.” Trends Pharmacol Sci. 32(1): 2-7.

de Marco A, Davey NE, Ulbrich P, Phillips JM, Lux V, Riches JD, Fuzik T, Ruml T, Kräusslich HG, Vogt VM, Briggs JA. 2010. “Conserved and variable features of Gag structure and arrangement in immature retrovirus particles.” J Virol 84(22):11729-36.

Bender SJ, Phillips JM, Scott EP and Weiss SR. 2010. “Murine coronavirus receptors are differentially expressed in the central nervous system and play virus strain-dependent roles in neuronal spread.” J Virol 84(21): 11030-44.

Phillips JM, Murray PS, Murray D, Vogt VM. 2008. “A molecular switch required for retrovirus assembly participates in the hexagonal immature lattice.” EMBO J 27(9):1411-20.

Slonczewski JL, McGee DJ, Phillips J, Kirkpatrick C, Mobley HL. 2000. “pH-dependent protein profiles of Helicobacter pylori analyzed by two-dimensional gels.” Helicobacter. 5(4):240-7.

Blankenhorn D, Phillips J, Slonczewski JL. 1999. “Acid- and Base-Induced Proteins during Aerobic and Anaerobic Growth of Escherichia coli Revealed by Two-Dimensional Gel Electrophoresis.” Journal of Bacteriology. 181(7):2209-2216.

Teaching St. Joseph’s University, Philadelphia, PA

Human Anatomy and Physiology, Fall 2015–Spring 2016 and Fall 2016

Biology I: Cells, Summer 2016

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