PhD. of Cardiology

CURRICULUM VITAE

Dr. Jinqi Fan, Male

Date of Birth: November 1984

Dept. of Cardiology, The second affiliated hospital of Chongqing Medical University Chongqing Cardiac Arrhythmias Service Center

Address: 76 Linjiang Road, Yuzhong District, Chongqing City, P.R. CHINA Current Research Interests

1. Molecular mechanisms involved in the ACE2/Ang-(1-7)/Mas signaling pathway in cardiomyocytes.

2. Regulation of cardiovascular remodeling by the counter-regulatory axis of the renin-angiotensin system (ACE/Ang II/AT1R vs. ACE2/Ang-(1-7)/Mas)

3. Myofibroblast-mediated mechanisms of pathological remodelling of the heart 4. The role of cardiac fibroblast in atrial fibrillation 5. Fibroblast ion channel current regulation in profibrillatory atrial remodeling 6. Long Noncoding RNAs and MicroRNAs in Cardiovascular Pathophysiology 7. The ACE2/Ang-(1-7)/Mas axis and the gap remodeling in atrial fibrillation Key Words: Arrhythmia; Atrial fibrillation; cardiac fibrosis; ion channel; Ang-(1-7); inflammation; repair;Pitx2; Cardiovascular genetics; Myocardial regeneration Education

09/2010-07/2013: Ph.D. in Dept. Cardiology, The second affiliated hospital of Chongqing Medical University, Chongqing Cardiac arrhythmias service center, Chongqing, PR.CHINA 09/2008-07/2010: Master degree candidate (Cardiology), The second affiliated hospital of Chongqing Medical University, China.

09/2003-07/2008: B.Sc. in the Second Clinical Medical College (Clinical Medicine), Chongqing Medical University, Chongqing, China.

Employment

07/2013-present: Teaching assistant, the second affiliated hospital of Chongqing Medical University, Chongqing Cardiac arrhythmias service center, Chongqing, P.R. CHINA. Participating in Projects

Project 1: Double molecular targeted improvement of atrial substrate in an experimental research. 2012, the National Natural Science Foundation of China (NSFC, Grant No. 81170166, Yin YH),

¥500,000, as Principal Member

Project 2: The effects of Ang II and Ang- (1-7) on calcium balance and calcium handling associated protein in Atrial fibroblasts of rats and its interaction mechanism. 2015, the National Natural Science Foundation of China (Grant No. 81570302, Yin YH), ¥570,000, as Principal Member.

Project 3: Effects of HERGG628S/G alpha i2 double gene transfer on atrial electrophysiology in an animal model of atrial fibrillation. The Research Fund for the Dectoral Program of Higher Education (Grant No. 200***********, Yin YH), ¥60,000, as Principal Member Research Grant

Molecular mechanisms of Ang- (1-7) antagonizing Ang II-induced atrial remodeling connexin, 2015, the National Natural Science Foundation of China (Grant No. 81500250, Jinqi Fan), ¥180,000, as Project Manager. https://isisn.nsfc.gov.cn/egrantindex/funcindex/prjsearch-list Recognition, Awards and Scholarships

12/2012: Second prize, Scientific Research Award for outstanding achievements, the Ministry of Education of China (Science and technology progress award, Ranked 8th/12) 12/2012: First prize, Medical science and technology achievement, Chongqing Municipal Health Bureau (Ranked 6th/12)

12/2012: National Utility Model Patent, China. (NO. ZL 2012 2 0210234.5) 01/2013: PhD National scholarships by the China State Commission of Education. Publication list

1. Fan J, Zou L, Cui K, Woo K, Du H, Chen S, Ling Z, Zhang Q, Zhang B, Lan X, Su L, Zrenner B, Yin Y. Atrial overexpression of angiotensin-converting enzyme 2 improves the canine rapid atrial pacing-induced structural and electrical remodeling: Fan, ACE2 improves atrial substrate remodeling. BASIC RES CARDIOL. 2015;110(4):499.

2. Hu X, Fan J, Chen S, Yin Y, Zrenner B. The Role of Continuous Positive Airway Pressure in Blood Pressure Control for Patients with Obstructive Sleep Apnea and Hypertension: A Meta-Analysis of Randomized Controlled Trials. J Clin Hypertens (Greenwich), 2015.Jan 13. doi: 10.1111/jch.12472. (2014, SCI, IF=2.958,Co-first author) PMID:25582849 3. Tao X, Fan J, Kao G, Zhang X, Su L, Yin Y, Zrenner B. Angiotensin-(1-7) attenuates angiotensin II-induced signaling associated with activation of a tyrosine phosphatase in Sprague-Dawley rats cardiac fibroblasts. Biol Cell, 2014, 106(6), 182-192. (IF: 3.872, Co-first author) PMID:24641355 4. Fan J, Du H, Yin Y, Ling Z, Wu J, Xiao P Zrenner B. Efficacy and safety of zotarolimus-eluting stents compared with sirolimus-eluting stents in patients undergoing percutaneous coronary interventions - A meta-analysis of randomized controlled trials. Int J Cardiol, 2013, 167(5): 2126-33. (2014, SCI, IF: 6.175) PMID: 22703941

5. Du H, Fan J, Ling Z, Woo K, Su L, Chen S, Liu Z, Lan X, Zhou B, Xu Y, Chen W, Xiao P Yin Y. Effect of nifedipine versus telmisartan on prevention of atrial fibrillation recurrence in hypertensive patients. Hypertension,2013, 61(4): 786-92. (2014, SCI, IF: 7.632, Co-first author) 6. Fan J, Cao H, Su L, Ling Z, Liu Z, Lan X, Xu Y, Chen W Yin Y. NT-proBNP, but not ANP and C-reactive protein, is predictive of paroxysmal atrial fibrillation in patients undergoing pulmonary vein isolation. J Interv Card Electrophysiol, 2012, 33(1): 93-100. (SCI, 2014 IF: 1.552, first author)

7. Xiao P, Gao C, Fan J, Du H, Long Y, Yin Y. Blockade of angiotensin II improves hyperthyroid induced abnormal atrial electrophysiological properties. Regulatory Peptides 2011;169:31-38. 8. Cai L, Yin Y, Ling Z, Su L, Liu Z, Wu J, Du H, Lan X, Fan J, Chen W, Xu Y, Zhou P, Zhu J Zrenner B. Predictors of late recurrence of atrial fibrillation after catheter ablation. Int J Cardiol, 2013, 164(1): 82-7.

9. Chen S, Dong Y, Fan J Yin Y. Rate vs. rhythm control in patients with atrial fibrillation - an updated meta-analysis of 10 randomized controlled trials. Int J Cardiol,2011, 153(1): 96-8. Research Directions

Connexins remodeling is an important part of atrial electrical remodeling and an important cause of atrial conduction delay and anisotropic. Our preliminary results showed that Angiotensin-(1-7)

[Ang-(1-7)] as an endogenous antagonist of angiotensin II (Ang II) not only improved atrial fibrosis remodeling, but also can significantly improve connexin remodeling induced by rapid atrial pacing. However, its mechanism mediated has not been fully elucidated. Therefore, our post-study will focus on the effects of dynamic regulation between protein tyrosine kinase c-Src and protein tyrosine phosphatase SHP-1 on functional status, expression levels and spatial distribution of connexins.

(Supported by National Natural Science Foundation of China, Grant No. 81500250) Atrial interstitial fibrosis is one of the basic mechanisms of occurrence and maintenance of atrial fibrillation, atrial fibroblasts are regarded as the direct executor of interstitial fibrosis remodeling, and become a new research hot spot. Ang- (1-7) as an endogenous antagonist of Ang II can improve myocardial remodeling, but its mechanism mediated has not been fully elucidated. Inspired from the different effects of Ang II and Ang-(1-7) on calcium ions and NADPHs, we will focus on dynamic regulation of calcium ion balance, aswell as other potential ion channel, such Nav1.5 sodium channels and Na /Ca(2+)-exchanger, and so on, and will explore theirs roles and mechanisms in fibroblasts proliferation and phenotype transformation. From atrial fibroblasts and animal models of two aspects, we aim to eventually clarify the mechanisms of Ang-(1-7) improving atrial fibrosis and remodeling. (Supported by National Natural Science Foundation of China, Grant No. 81570302)

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