organic chemistry

[pic] Curriculum Vitae Updated: **-**-****

Applicant is Available from First September-2013

Name: Dr. RIAZ HASAN, (Indian)

************@*****.***

**********@**********.***

Mobile # 096*-*********

Passport # J-6967872 valid up to 2022 (INDIA)

Total Experiences:

Teaching: Teachings Organic & Medicinal Chemistry at UG/PG Students (8.8

years)

Research: Organic Synthesis and QSAR for NCE's/API's (10

years)

Qualification: Ph. D Bioregulation Chemistry

(Organic Synthesis/QSAR)

www.applife.kais.kyoto-u.ac.jp

Title of PhD Thesis: "Synthesis and Mode-of-Action of

Insecticidal Pyrazolines"

Objective: QSAR based design, synthesis, stereochemistry. Molecular

modeling and mode of action studies of pyrazoline compounds to make them

more attractive candidate for commercialization. About 200 compounds were

prepared for lead generation and activity optimization work. One of the

candidate was commercialized in 1996 by the mutual understanding between

university and Rohm and Hass of Japan

Ph. D Supervisors: Prof. Toshio Fujita, Prof. Tamio Ueno,

Prof. Keiichiro Nishimura, www.kyoto-u.ac.jp

Laboratory of Bioregulation Chemistry, Division of

Applied Life Sciences, Kyoto University, JAPAN, Kyoto-

606

Applicant is an Inventor on Basic Chemical Research

Developed benzyloxy pyridine compounds as a novel class of insecticide. One

of the representative candidate showed LC50 at 2ppm (to develop this

molecule about 300 molecules were prepared for lead generation and

optimization)

Patent Received at Otsuka Chemical JP:

New safe compound excellent in insecticidal and acaricidal effects even on

insect pests having developed resistance to chemicals, not showing

environmental pollution and toxicity to mammals and fishes. Treated as an

attractive candidate for future commercialization

Patent No. : JP -10101647A2

Title : Benzyloxypyridine-A new class

of Insecticides

Class : New Chemical Entities (NCE)

Inventor : Riaz Hasan, Employment No. 30375

Intellectual Property : Otsuka Chemical Co., Limited, JAPAN.

Qualifications details :

Sec. Exam. (1980) WBSE, WB All 10th Subjects

I Sc (1982) LN M Univ., BH All 10+2

Subjects

B. Sc (1986) R. K Univ., UP (58.5% )

Chemistry Main

M. Sc (1989) G.B. Pant Univ. UP (76%)

Organic Chemistry/SAR

Ph. D (1995) Kyoto Univ., JAPAN

Organic Synthesis /QSAR

Major Achievements:

# Availed Graduate Scholarship to pursue Master Degree at G B Pant

University, Pantnagar, India (1987onward for 2 years)

# Availed GATE- Scholarship (Govt. India) and admitted for PhD in

Organic Chemistry at IIT-Delhi, India (March, 1991)

# Availed MONBUSHO Scholarship (Govt. of Japan) for PhD in

Bioregulation Chemistry at Kyoto University, Japan (Jan, 1992)

# CSIR Postdoctoral Fellowship (Govt. India) Award-IA 26953 (March,

1997& June 2003) by Government of India to carryout independent

research work on the project submitted by me that reviewed and

approved by CSIR- Delhi, India

# Research Contribution to make Pyrazoline compounds more attractive

candidate for its commercialization as safer insecticide:1996 Kyoto

University, JAPAN

# Developed the synthetic route for a successful synthesis of Co Enzyme

Q-10: 2003 (Strides Arcolab Limited)

# Developed Benzyloxypiridines as novel and attractive insecticidal

candidate for commercialization, 1995-97, (Otsuka Chemical, Japan),

Applicant Skill Set:

SET-A

O Basic of searching STN: Database available from CAS covering Int.

journals, patent, patent families, technical reports etc. (CA plus,

CAS Registry, Structure Search etc) for preparation of novel

compounds, formulations and their IPR claim.

O Utilizing free websites for literature/patent search for example

espacenet.com, US freepatentsearch.com etc Literature/Patent search

through Chemical Abstract/bound periodicals & Journals available in

Institutional or university libraries (using formula index, subst.

index, sub index. chem. name, CAS No. etc.

O Literature/Patent search through Chemical Abstract/bound periodicals

& Journals available in Institutional or university libraries (using

formula index, subst. index, sub index. chem. name, CAS No. etc.

O Literatures and patent reading to shape up the desired project for

discussion and implementation.

O Supervise for directional literature/research planning and thrust

Write up of the findings of scientific data's in JOURNALS or as

PATENTS for Publication and (IPR)

SET-B

O Synthesis of Off-Patented Molecules/Generic Drugs,

O Org. Synthesis, of Biologically Active Molecule/New Chemical Entities

O Herbal Extraction and semi-synthesis for structural modifications

O Structure elucidation and & stereo chemical Investigation

O Elucidation of biological activities of organic compounds

O Structure-Activity Relationship (QSAR) to study various

physicochemical. Parameters responsible for biological activity

O Activity prediction and Molecular Modeling.

O Ability to read and interpret instrumental data such as NMR, IR, LC-

Mass, GC, HPLC and others that required in the course of development

of the molecules for IPR work.

Employment History in India and Abroad

Academic Experience (8.8 years)

Assistant Professor, Dept. of Chemistry, Faculty of Science, Tabuk

University, Tabuk (December, 26, 2010 onwards- and continue -2013)

Assistant Professor, Dept. of Chemistry, Selaqui Academy of Higher

Education, under Uttarakhand technical University, Dehradun, India (July,

26, 2010- September, 4, 2010)

Assistant Prof., Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy,Al-

Arab Medical Univ. Benghazi (October, 2007- October, 2009 )

Assistant Professor cum Pool Scientist, Department of Chemistry at G.B.

Pant University, India (Sept.1997-March1999)

Graduate Teaching Assistant (GTA) Department of Chemistryat G.B. Pant

University, India (June 1987-Oct., 1989)

Industrial Experience (10 years)

Group Leader Research &Development, Organic Synthesis, Strides Arcolab Ltd,

Bangalore, (April, 2005-May 2007)

Senior Manager, Research &Development, Kopran Research Labratories Ltd,

Mumbai (February, 2004-February, 2005)

Faculy member/head Chemistry, Kyoto Foundation Bariatu, Private Chemistry

Learning Centre, India, (including the period served for industries:

Samilabs ltd (8 months) and Indswiftlab (1 yr) oratories ltd in India)

April 2000-January 2004

Senior Scientist, Dr. Reddy Research Foundation, Drug Discovery Unit,

Hyderabad, India (March, 1999-March, 2000),

Pool Scientist, Department of Chemistryat G.B. Pant University, India

(Sept.1997-March1999),

Visiting Scientist, Otsuka Drug Discovery Group, Naruto Chemical Research

Centre, Japan (April, 1995-March, 1997)

Work details carried out by the applicant (in Universities):

Dept. of Chemistry, Faculty of Science, Tabuk University, Tabuk, Saudi

Arabia

Position: Assistant Professor

(December, 26, 2010- continue)

Teaching: General Chemistry and organic chemistry (Practical and

Theory)/Preparation of course

Specification

Level: Graduate students

Research: Research and training on organic synthesis and

application of QSAR to design new

medicinal analogs of heterocyclic origin

Dept. of Chemistry, Selaqui Academy of Higher Education, under Uttarakhand

technical University,

Dehradun, India)

Position: Assistant Professor

(July, 26, 2010- September, 4, 2010)

Teaching Subjects: Organic chemistry (Practical and

theory)/Preparation of course Specification

Level: B.Sc engineering students

Research Supervision: not initiated

Department of Pharmaceutical Chemistry, Al-Arab Medical University,

Benghazi, Libya

Position: Assistant Professor

(September, 2007- October, 2009)

Teaching: Medicinal chemistry, organic chemistry (Practical and

theory)

Level: Faculty of Pharmacy, Graduate and Post graduate

students

Research Supervision: Organic synthesis and application of QSAR to

design new medicinal analogs

of heterocyclic origin

Department of Chemistry, at G.B. Pant University, India

Position: Assistant Professor cum Pool Scientist),

(September, 1997-March, 1999)

Teaching: organic chemistry (Practical and theory) and chemistry of

pesticides

Level: Graduate and Post graduate students

Research Supervision: Synthesis of novel pyrazoline, phenylhydrazone

and chalcone compounds

and evaluation of their biologicalactivity

.

Department of Chemistry at G.B. Pant University, India

Position: Graduate Teaching Assistant (GTA)

(June 1987-October, 1989)

Teaching: Practical organic chemistry

Level: Graduate and Post graduate students

Work details carried out by the applicant(in Industries):

Strides Arcolab Limited, Bangalore

Position: Group Leader

(April, 2005- June 2007)

Project preparation and implementation on derivatives of Hydrocartosone and

Cortisone eg. Prednisolone, Prednisone and their derivatives at 21-

position.

Extraction and purification of solanesol from tobacco waste

Project prepn. and process development of Co-Enzyme Q-10 (Ubiquinone)

Project preparation and process dev. of Hydralizine and Tranexamic acid

Project preparation and process development on lamivodine and

Emtricitabine, Oseltamivir.

Designed Non-Infringing process to prepare Lamivudine, imtricitabine,

hydralyzine and tranexamic acid for IPR work.

New Initiatives: Prepared projects on DST- Initiatives to Pharmaceutical

Industry (www.dst.govt.in) to explore NCE and novel process development of

some patented drugs for Intellectual Property Right (IPR).

Kopran Research Laboratories, Mumbai

Position: Sr. Manager Research & Development

(February 2004-February, 2005)

Project preparation and process development of Attorvastatin

Project preparation and process development of clarithromycin,

Preparation of cyano compound used for attorvastatin.

Implemented more economical route to prepare attorvastatin

Project preparation and implementation on non-infringing process of

clarithromycin.

Chemistry faculty, Kyoto Foundation, Bariatu, India

Position: Faculty member and Head, Chemistry

(April, 2000-January, 2004)

Teaching Organic Chemistry to Graduate Students and take up chemical

consultancy work for product/process development of biopharmaceutical

drug/candidates at Samilabs Limited and Ind-swift laboratories

DRF, Hyderabad, India

Position: Senior Scientist

(March, 1999-March, 2000)

Synthesis of novel open chain type of analogs of Linozolide

Synthesis of novel bicyclic and tricyclic analogs of Lenozolide

Development of new pharmacophore for anti-inflamatory activity

Synthesis of metabolites of different generic drugs for in house

pharmacokinetic studies.

Otsuka Chemical Limited, Naruto Discovery Centre Japan

Position: Visiting Scientist

(April, 1995-March, 1997)

Preparation of metabolites of carbofuran Insecticide

Development of novel insecticidal analogs of pyrazoline, pyrazolone and

benzyloxy pyridine. Developed benzyloxy pyridine compounds as a novel

class of insecticide. One of the representative candidate showed LC50 at

2ppm (to develop this molecule about 300 molecules were prepared for lead

generation and optimization)

Patent Received at Otsuka Chemical JP:

New safe compound excellent in insecticidal and acaricidal effects even on

insect pests having developed resistance to chemicals, not showing

environmental pollution and toxicity to mammals and fishes.

Patent No. : JP -10101647A2

Title : Benzyloxypyridine-A new class

of Insecticides

Class : New Chemical Entities (NCE)

Inventor : Riaz Hasan, Employment No. 30375

Intellectual Property : Otsuka Chemical Co., Limited, JAPAN.

Kyoto University, Japan

Position: Ph. D-MONBUSHO Research Student

April, 1992-March 1995)

Title of PhD Thesis: "Synthesis and Mode-of-Action of Insecticidal

Pyrazolines"

Objective: QSAR based design, synthesis, stereochemistry. Molecular

modeling and mode of action studies of pyrazoline compounds to make them

more attractive candidate for commercialization. About 200 compounds were

prepared for lead generation and activity optimization work.

Presentation in the International Conferences from PhD work:

1. Enantiomeric investigation of pyrazoline esters as potent insecticide:

An International meeting of Japan Society for Bioscience Biotechnology

and Agro Chemistry, 1994, Tokyo, JAPAN.

2. Quantitative Structure-Activity Relationship of Insecticidal

Pyrazoline: An International meeting and 22nd Symposium on Structure-

Activity Relationship, Nov. 16, 1994, Tokyo, JAPAN.

3. Effect of N-Arylcarbamoylpyrazoline derivatives on calcium uptake and

release in rat brain synaptosomes: an International meeting of

Pesticide Science March 28, 1995, Tokyo, JAPAN.

4. Synthesis of Insecticidal Pyrazoline and their Mode-of-Action: An

international meeting of Kyoto University, January 28, 1995, Kyoto

University, Kyoto, JAPAN.

5. Pyridinols Ethers as novel insecticide: An International meeting of

Japan Society for Bioscience, Biotechonology and Agrocihemistry, Nov

4, 1996, Tokoshima, JAPAN.

International Publications from PhD work:

1. Quantitative Structure-Activity Relationship (QSAR) of Insecticidal

Pyrazolines: Pesticide Science

(ENGLAND) 1994, 42, 291-298.

2. Stereochemical Basis for the Insecticidal Activity of Carbamoylated

and Acylated Pyrazolines: Pesticide

Science (ENGLAND) 1995, 46, 105-112.

3. Structural Effects of N-Arylcarbamoylpyrazolines on calcium uptake in

Rat Brain Synaptosomes: Pesticide

Science (ENGLAND) 1996, 46, 221-225.

Membership of Professional Bodies:

O Japan Society for Bioscience, Biotechnology and Agro chemistry

O Pesticide Science Society of Japan

O Pesticide Science Society of India.

O Indian Council of Chemists

O Indian Chemical Society.

Trainings:

Two months training on quality control at IFFCO-R&D, Bareilly, India

Two months training on "Application of radioisotopes to conduct Mode-of-

action of drugs on freshly prepared rat brain synaptosomes at radioisotopes

research centre, Kyoto University.

Two months training at cGLP at Otsuka Chemical R&D Centre to avoid

infringement on IPR claims by other organization on date/priority basis.

Literature Search by STN at Kyoto University, Otsuka Japan and kopran.

Proficiency in Languages:

English (IELTS), Hindi, Bengali, Urdu, Japanese, Arabic

References:

Dr. Tamio Ueno

Supervisor & Professor Emeritus

Email: ********@*****.***.**.** www.applife.kais.kyoto-u.ac.jp

Laboratory of Bioregulation Chemistry

Kyoto University, Sakyu-ku, Kyoto,

University, JAPAN. www.kyoto-u.ac.jp

Tel: # 075-***-****

Fax : # 075-*******.

Prof. Akamatsu Mikki ::;www.applife.kais.kyoto-u.ac.jp

********@****.*****-*.**.**

Laboratory of Bioregulation Chemistry

Kyoto University, Sakyu-ku, Kyoto,

University, JAPAN. www.kyoto-u.ac.jp

Tel: # 075-***-****

Fax : # 075-*******.

Dr. Hisham Reda

Professor and coordinator, Department of Chemistry

Tabuk University, KSA

Mobile:059*******,

***********@*******.***

Permanent Address: Dr. RIAZ HASAN (DOB: 04-09-1964, INDIAN)

************@*****.***

**********@**********.***

Mobile # 0091-993-***-****

Plot#423/A, Yellow Gate, Behind Gurunannak, Handicap Center, Bariatu,

RANCHI, JH, INDIA

Passport # (J-6967872 valid up to 2022 (INDIA)

Driving License# 009189/95, valid up to 2015 (INDIA)

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