XIANGQUN YE

** **** ***** **

Apt *** 313-***-****

Detroit, MI, 48202-2672 abxxet@r.postjobfree.com

EDUCATION

(09/1995-07/2000)

Ph.D. Major in Zoology, School of Life Sciences

Xiamen University, China

(09/1991-07/1995)

B.S. Department of Veterinary Medicine

Anhui Science and Technology University, China

Internship

Zhengyangguan Poultry Co. Ltd., Anhui Province, China (01/1995-06/1995)

Hefei veterinary clinic, Anhui Province, China (07/1995-08/1995)

PROFESSIONAL EMPLOYMENT

Research Associate (05/2010-present)

Department of Pathology, Wayne State University, Detroit, MI, US

Carry out research on the role of nuclear receptor PPARγ and AMPK in metabolism.

Visiting scholar (08/2007-04/2010)

Department of Microbiology, Tumor biology and cell biology, Karolinska Institute, Sweden

Carried out research on the role of SOCS (suppressor of cytokine signaling) in the outcome of

Mycobacterial infection in vitro and in vivo in animal model.

Director of Gene Diagnostic Laboratory (07/2003-07/2007)

Shantou University Medical College, Guangdong Province, China

Associate Professor (adjunct) (07/2003-08/2012)

Shantou University Medical College, Guangdong Province, China

Research on the polymorphism & antiviral activity of avian IFN-induced gene

Research and development of PCR-based gene diagnostic kit

Lecturer & Associate Professor (08/2000-06/2003)

School of Life Sciences, Xiamen University, China

PUBLICATIONS

1. Lin Zhang, Xiangqun Ye, Yilan Li, Todd Leff AMPK 2 functions as a transcriptional co-repressor of

HNF4a to directly regulate expression of the PEPCK gene. (In preparation).

2. Zhihua cai, Yueling Zhang, Xiangqun Ye Phylogenetic relationships of the genus Eurytrema from domestic and

wild animal based on 18S rRNA sequences. Parasitology Research, 2012, 111(4): 1637-1644 (corresponding

author)

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Xiangqun Ye

3. Berit Carow*, Xiangqun Ye*, Dolores Gavier-Widén, Sabin Bhuju, Wulf Oehlmann, Mahavir Singh, Markus

Sköld, Lech Ignatowicz, Akihiko Yoshimura, Hans Wigzell and Martin E. Rottenberg SOCS1 protects

against mycobacterial-induced lethal inflammation by targeting on IFN-γ but hampers effective bacterial

clearance. The Journal of Biological Chemistry, 2011, 286: 268**-***** (*Co-first author, arrange in

alphabetical order)

4. Xiangqun Ye, Yueling Zhang, Zongcheng Tan, Kangsheng Li A Novel Single-tube Real-time Multiple Allele-

specific PCR for Genotyping of Chicken Mx gene G2032A SNP. British Poultry Science, 2010, 51(3): 361-367

5. Xiangqun Ye, Zongcheng Tan, Yueling Zhang, Kangsheng Li Single Nucleotide Polymorphisms in the

Chicken Mx gene at Position 2032 by Real-time Allele-specific PCR Melting-curve Analysis. Journal of Poultry

Science, 2010, 47:133-138

6. Yueling Zhang, Fang Yan, Zhong Hu, Xianliang Zhao, Shaoying Min, Zhiheng Du, Shan Zhao, Xiangqun Ye

and Yuanyou Li Hemocyanin from shrimp Litopenaeus vannamei shows hemolytic activity. Fish & Shellfish

Immunology, 2009, 27(2):330-335

7. Yan Zhang, Xiangqun Ye IFN-inducible GTPases and its role in immunity against intracellular pathogens.

Chemistry of Life, 2008, 5: 153-156 (corresponding author)

8. Fang Yan, Yueling Zhang, Huoqiang Luo, Zhong Hu, Tongwang Huang and Xiangqun Ye The Phenoloxidase

Activity of Hemocyanin from White Leg Shrimp Litopenaeus vannamei. Fisheries Science, 2008, 27(1): 78-83

9. Zongcheng Tan, Yueling Zhang, Zhong Hu, Xiangqun Ye Prokaryotic expression of omp1 gene encoding the

major outer membrane protein of Chlamydia trachomatis serovar F and its sequence analysis. Chinese Journal

of Zoonoses, 2008, 29(1): 25-28 (corresponding author)

10. Xiangqun Ye, Yinmu Cai, Xiaoyang Jiao, Yin’e Wu Molecular Epidemiology of Ureaplasma urealyticum in

Patients with Urogenital Infections. Chinese Journal of Nosocomiology, 2007, 17(6): 109-112

11. Wang Yun, Xiangqun Ye, YiLiang, Wu Zhenghong Zuo Comparison of four promoters for transient

expression of RFP reporter gene in cultured Bombyx mori cells (Bm-e-HNU5). Acta Entomologica Sinica,

2006,49(2):167-171

12. Xiangqun Ye, Zhenghong Zuo, Wenfeng Peng Phylogenetic study on Eurytrema from domestic and wild

animal. Acta Parasitol. Med. Entomol. Sin, 2005, 12(2): 71-76

13. Lingwei Ruan, Xiangqun Ye, Muyan Gui. Advances in the research on silkworm microsatellite DNA.

Chinese Bulletin of Entomology, 2005, 42(1): 14-17

14. Xiangqun Ye, Zhenghong Zuo, Wenchuan Yang et al. Genomic polymorphism of five Eurytrema from

domestic and wild animal. Chinese Journal of Zoonoses, 2004, 20(2): 135-139

15. Muyan Gui, Xiangqun Ye, Zhenghong Zuo et al. Delivery of foreign DNA to silkworm, Bombyx mori by

sperm-mediated gene transfer methods. Acta Sericologica Sinica, 2003 (4) 628-633

16. Muyan Gui, Xiangqun Ye, Chunxu Wu, et al. Construction of a homologous recombinant plasmid vector

pMD-Fib-IE-EGFP carrying EGFP as reporter gene. Journal of Xiamen University, 2002, 41 (5) 628-633

17. Xiangqun Ye Studies on antagonism between Exorchis ovariolobularis and Schistosoma japonicum in

Oncomelania hupensis. Chin J Parasit Dis, 2001, 19(5): 276-281

18. Xiangqun Ye The histology, histo-chemistry and scanning electron microscopy study the rediae of Exorchis

ovariolobularis. Journal of Xiamen University. 2001, 40(1): 1-6

19. Mei Chen, Qingquan Chen, Xiangqun Ye et al. The pathogenicity of Gnathostoma hispidum to swine.

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Xiangqun Ye

Chinese Journal of Zoonoses. 2001, 17(6): 94 95

20. Xiangqun Ye Observation on the life cycle of Exorchis ovariolobularis and its development in its natural

molluscan host. Acta Parasitol. Med. Entomol. Sin. 2000, 7(2): 90-95

21. Deshan Zhong, Xiangqun Ye, Lou Zhu, et al. Multi-factor experiment on pollution protecting in cultivating

domestic fungus in old-used house. Domestic Fungus, 1994 (3): 33-34

PRESENTATIONS

Xiangqun Ye SOCS-1 hampers effective mycobacterial clearance by macrophages and the activation of

macrophages and dendritic cells. Seventh International Conference on the Pathogenesis of Mycobacterial

Infections, Stockholm, Sweden. May 2008

Xiangqun Ye SOCS-1 inhibit BCG-induced inflammation but impair effective bacterial clearance in

macrophages and dendritic cells. 10th Anniversary Symposium of MTC, Karolinska Institute

Xiangqun Ye Molecular cloning and sequence analysis of avian IFN-induced Mx gene. International

Symposium on Recent Advance in Molecular, Clinical and Social Medicine. Shantou, China. Dec 2005

TECHNICAL EXPERTISE

Molecular Biology:

Conventional and Real-time RT-PCR

Gene cloning, plasmid construction

Protein expression, western blot

RNA interfere

Immunological techniques:

Immunization and Antibody Production (Raising of polyclonal antibody in experimental animals).

Immunoprecipitation.

Immunostaining.

Enzyme Linked Immuno Sorbent Assay (ELISA)

Flow Cytometry

Chromatin Immuoprecipitation (ChIP)

Biochemical and histological techniques:

Protein purification

SDS-PAGE

Paraffin embedding, sectioning and tissue staining.

Medical Microbiology:

Isolation. culture, identification and preservation of medically important bacteria, viruses and fungi,

Successfully completed the course entitled: “Biosafety in Microbiological Laboratories” organized by

Swedish Institute for Infectious Disease Control, Karolinska Institute, Sweden.

Work experience in BSL-3 lab.

Animal related work and training:

Institutional Courses organized by the Div. of Laboratory Animal Resources and the Animal Investigation

C ommittee, Wayne State University and got certificate for: “Investigating the Mouse and Rat training

session.”

Maintenance and monitoring of gene knock-out mouse colonies, genotyping with PCR

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Xiangqun Ye

GRANTS

National Natural Science Foundation of China (No.30400258): The polymorphism and antiviral activity of

avian IFN-induced Mx gene.

Natural Science Foundation of Fujian Province (No.B0110008): Studies on new species of Eurytrema which

is epidemic in domestic and wild animals.

HONORS AND MEMBERSHIPS

Member, Chinese Society for Cell Biology

Member, Chinese Society for Zoology

2000 Outstanding Graduate Student Awarded, Xiamen University

2002 Outstanding Young Teacher Awarded, Xiamen University

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