Medical University
Resume:
XIANGQUN YE
Apt *** 313-***-****
Detroit, MI, 48202-2672 **********@*****.***
EDUCATION
(09/1995-07/2000)
Ph.D. Major in Zoology, School of Life Sciences
Xiamen University, China
(09/1991-07/1995)
B.S. Department of Veterinary Medicine
Anhui Science and Technology University, China
Internship
Zhengyangguan Poultry Co. Ltd., Anhui Province, China (01/1995-06/1995)
Hefei veterinary clinic, Anhui Province, China (07/1995-08/1995)
PROFESSIONAL EMPLOYMENT
Research Associate (05/2010-present)
Department of Pathology, Wayne State University, Detroit, MI, US
Carry out research on the role of nuclear receptor PPARγ and AMPK in metabolism.
Visiting scholar (08/2007-04/2010)
Department of Microbiology, Tumor biology and cell biology, Karolinska Institute, Sweden
Carried out research on the role of SOCS (suppressor of cytokine signaling) in the outcome of
Mycobacterial infection in vitro and in vivo in animal model.
Director of Gene Diagnostic Laboratory (07/2003-07/2007)
Shantou University Medical College, Guangdong Province, China
Associate Professor (adjunct) (07/2003-08/2012)
Shantou University Medical College, Guangdong Province, China
Research on the polymorphism & antiviral activity of avian IFN-induced gene
Research and development of PCR-based gene diagnostic kit
Lecturer & Associate Professor (08/2000-06/2003)
School of Life Sciences, Xiamen University, China
PUBLICATIONS
1. Lin Zhang, Xiangqun Ye, Yilan Li, Todd Leff AMPK 2 functions as a transcriptional co-repressor of
HNF4a to directly regulate expression of the PEPCK gene. (In preparation).
2. Zhihua cai, Yueling Zhang, Xiangqun Ye Phylogenetic relationships of the genus Eurytrema from domestic and
wild animal based on 18S rRNA sequences. Parasitology Research, 2012, 111(4): 1637-1644 (corresponding
author)
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Xiangqun Ye
3. Berit Carow*, Xiangqun Ye*, Dolores Gavier-Widén, Sabin Bhuju, Wulf Oehlmann, Mahavir Singh, Markus
Sköld, Lech Ignatowicz, Akihiko Yoshimura, Hans Wigzell and Martin E. Rottenberg SOCS1 protects
against mycobacterial-induced lethal inflammation by targeting on IFN-γ but hampers effective bacterial
clearance. The Journal of Biological Chemistry, 2011, 286: 268**-***** (*Co-first author, arrange in
alphabetical order)
4. Xiangqun Ye, Yueling Zhang, Zongcheng Tan, Kangsheng Li A Novel Single-tube Real-time Multiple Allele-
specific PCR for Genotyping of Chicken Mx gene G2032A SNP. British Poultry Science, 2010, 51(3): 361-367
5. Xiangqun Ye, Zongcheng Tan, Yueling Zhang, Kangsheng Li Single Nucleotide Polymorphisms in the
Chicken Mx gene at Position 2032 by Real-time Allele-specific PCR Melting-curve Analysis. Journal of Poultry
Science, 2010, 47:133-138
6. Yueling Zhang, Fang Yan, Zhong Hu, Xianliang Zhao, Shaoying Min, Zhiheng Du, Shan Zhao, Xiangqun Ye
and Yuanyou Li Hemocyanin from shrimp Litopenaeus vannamei shows hemolytic activity. Fish & Shellfish
Immunology, 2009, 27(2):330-335
7. Yan Zhang, Xiangqun Ye IFN-inducible GTPases and its role in immunity against intracellular pathogens.
Chemistry of Life, 2008, 5: 153-156 (corresponding author)
8. Fang Yan, Yueling Zhang, Huoqiang Luo, Zhong Hu, Tongwang Huang and Xiangqun Ye The Phenoloxidase
Activity of Hemocyanin from White Leg Shrimp Litopenaeus vannamei. Fisheries Science, 2008, 27(1): 78-83
9. Zongcheng Tan, Yueling Zhang, Zhong Hu, Xiangqun Ye Prokaryotic expression of omp1 gene encoding the
major outer membrane protein of Chlamydia trachomatis serovar F and its sequence analysis. Chinese Journal
of Zoonoses, 2008, 29(1): 25-28 (corresponding author)
10. Xiangqun Ye, Yinmu Cai, Xiaoyang Jiao, Yin’e Wu Molecular Epidemiology of Ureaplasma urealyticum in
Patients with Urogenital Infections. Chinese Journal of Nosocomiology, 2007, 17(6): 109-112
11. Wang Yun, Xiangqun Ye, YiLiang, Wu Zhenghong Zuo Comparison of four promoters for transient
expression of RFP reporter gene in cultured Bombyx mori cells (Bm-e-HNU5). Acta Entomologica Sinica,
2006,49(2):167-171
12. Xiangqun Ye, Zhenghong Zuo, Wenfeng Peng Phylogenetic study on Eurytrema from domestic and wild
animal. Acta Parasitol. Med. Entomol. Sin, 2005, 12(2): 71-76
13. Lingwei Ruan, Xiangqun Ye, Muyan Gui. Advances in the research on silkworm microsatellite DNA.
Chinese Bulletin of Entomology, 2005, 42(1): 14-17
14. Xiangqun Ye, Zhenghong Zuo, Wenchuan Yang et al. Genomic polymorphism of five Eurytrema from
domestic and wild animal. Chinese Journal of Zoonoses, 2004, 20(2): 135-139
15. Muyan Gui, Xiangqun Ye, Zhenghong Zuo et al. Delivery of foreign DNA to silkworm, Bombyx mori by
sperm-mediated gene transfer methods. Acta Sericologica Sinica, 2003 (4) 628-633
16. Muyan Gui, Xiangqun Ye, Chunxu Wu, et al. Construction of a homologous recombinant plasmid vector
pMD-Fib-IE-EGFP carrying EGFP as reporter gene. Journal of Xiamen University, 2002, 41 (5) 628-633
17. Xiangqun Ye Studies on antagonism between Exorchis ovariolobularis and Schistosoma japonicum in
Oncomelania hupensis. Chin J Parasit Dis, 2001, 19(5): 276-281
18. Xiangqun Ye The histology, histo-chemistry and scanning electron microscopy study the rediae of Exorchis
ovariolobularis. Journal of Xiamen University. 2001, 40(1): 1-6
19. Mei Chen, Qingquan Chen, Xiangqun Ye et al. The pathogenicity of Gnathostoma hispidum to swine.
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Xiangqun Ye
Chinese Journal of Zoonoses. 2001, 17(6): 94 95
20. Xiangqun Ye Observation on the life cycle of Exorchis ovariolobularis and its development in its natural
molluscan host. Acta Parasitol. Med. Entomol. Sin. 2000, 7(2): 90-95
21. Deshan Zhong, Xiangqun Ye, Lou Zhu, et al. Multi-factor experiment on pollution protecting in cultivating
domestic fungus in old-used house. Domestic Fungus, 1994 (3): 33-34
PRESENTATIONS
Xiangqun Ye SOCS-1 hampers effective mycobacterial clearance by macrophages and the activation of
macrophages and dendritic cells. Seventh International Conference on the Pathogenesis of Mycobacterial
Infections, Stockholm, Sweden. May 2008
Xiangqun Ye SOCS-1 inhibit BCG-induced inflammation but impair effective bacterial clearance in
macrophages and dendritic cells. 10th Anniversary Symposium of MTC, Karolinska Institute
Xiangqun Ye Molecular cloning and sequence analysis of avian IFN-induced Mx gene. International
Symposium on Recent Advance in Molecular, Clinical and Social Medicine. Shantou, China. Dec 2005
TECHNICAL EXPERTISE
Molecular Biology:
Conventional and Real-time RT-PCR
Gene cloning, plasmid construction
Protein expression, western blot
RNA interfere
Immunological techniques:
Immunization and Antibody Production (Raising of polyclonal antibody in experimental animals).
Immunoprecipitation.
Immunostaining.
Enzyme Linked Immuno Sorbent Assay (ELISA)
Flow Cytometry
Chromatin Immuoprecipitation (ChIP)
Biochemical and histological techniques:
Protein purification
SDS-PAGE
Paraffin embedding, sectioning and tissue staining.
Medical Microbiology:
Isolation. culture, identification and preservation of medically important bacteria, viruses and fungi,
Successfully completed the course entitled: “Biosafety in Microbiological Laboratories” organized by
Swedish Institute for Infectious Disease Control, Karolinska Institute, Sweden.
Work experience in BSL-3 lab.
Animal related work and training:
Institutional Courses organized by the Div. of Laboratory Animal Resources and the Animal Investigation
C ommittee, Wayne State University and got certificate for: “Investigating the Mouse and Rat training
session.”
Maintenance and monitoring of gene knock-out mouse colonies, genotyping with PCR
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Xiangqun Ye
GRANTS
National Natural Science Foundation of China (No.30400258): The polymorphism and antiviral activity of
avian IFN-induced Mx gene.
Natural Science Foundation of Fujian Province (No.B0110008): Studies on new species of Eurytrema which
is epidemic in domestic and wild animals.
HONORS AND MEMBERSHIPS
Member, Chinese Society for Cell Biology
Member, Chinese Society for Zoology
2000 Outstanding Graduate Student Awarded, Xiamen University
2002 Outstanding Young Teacher Awarded, Xiamen University
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