Experienced in biomedical research and technical editing/writing

Jennifer Cheng, PhD, RAC

**-** ***** ******, *** 3F, Flushing, NY 11354

Email: ********.*********@*****.*** Cell: 484-***-**** U.S.Citizen

SUMMARY

Scientist with 9 years of experience in basic research who is looking to transition to preclinical or clinical research.Excellent written and oral communication skills. Detail-oriented in data analysis/interpretation and documentation. Proficient with Microsoft Office and GraphPad Prism. Adapts quickly to new environments.

EDUCATION

New York Medical College, Valhalla, NY

Doctor of Philosophy in Pharmacology, May 2009

Carnegie Mellon University, Pittsburgh, PA

Bachelor of Science in Biological Sciences, May 2005

Concentration in Biochemistry, Minor in Chemistry

CERTIFICATION

Regulatory Affairs Certification (RAC US)

ADDITIONAL TRAINING

NC RAC US Workshop Course - May - September 2012 - Durham, NC

NIH Translational Science Training Program - August 30-31, 2012 - Bethesda, MD

NIEHS Management Boot Camp - January 25-26, 2012 - Research Triangle Park, NC

PROFESSIONAL EXPERIENCE

Special Volunteer, December 2012 - Present

Intramural Research Training Award Postdoctoral Fellow, October 2010 - December 2012

National Institute of Environmental Health Sciences

Research Triangle, NC

Lab Chief: Darryl C. Zeldin, MD

. Design, execute, coordinate and troubleshoot projects characterizing the roles of lipid mediators (20-HETE, COX-2, EETs) in the pathogenesis of vascular/pulmonary/immunological diseases, inflammation and atherosclerosis, using various molecular biology and biochemical techniques

. Organize, analyze and interpret data files

. Ensure studies and procedures are performed per SOP's

. Write, edit and review scientific articles that are submitted to journals and organizations (currently in the process of writing manuscripts to report project results)

. Discuss and present research data to members of the institute and international conference attendees

. Coordinate studies with intramural and extramural investigators and visit labs to learn and discuss experiments

Postdoctoral Fellow, June 2009 - October 2010

Graduate Student Research Associate, September 2005 - May 2009

New York Medical College

Valhalla, NY

Lab Chief: Michal L. Schwartzman, PhD

. Started and completed three main projects investigating the mechanistic role of 20-HETE, a lipid mediator, in the development of hypertension

. Drafted and submitted manuscripts and scientific articles

. Mentored and trained students and interns

. Reviewed manuscripts that were submitted to journals, as well as grant applications

. Conducted oral and poster presentations of work at multiple international conferences

. Maintained compliance with SOP's for experimental procedures

Research Assistant, September 2003 - May 2005

Carnegie Mellon University

Pittsburgh, PA

Lab Chief: Brooke McCartney, PhD

. Participated in a project looking at interactors of the Drosophila APC2 tumor suppressor

o Set up crosses between genetically mutated strains, screened and analyzed Drosophila

embryonic cuticles for phenotypic changes

o Researched potential interactors on Flybase network and managed a comprehensive list of

positive hits

Laboratory Technician, Summers 2001 - 2003

Minerals Technologies, Inc.

Easton, PA

. Performed quality control for paper samples on a weekly basis

. Used the scanning electron microscope for surface porosity and aspect ratio analyses of calcium carbonate particles in paper

. Performed thermal analyses on coatings of different calcium carbonate particles

TEACHING EXPERIENCE

Teaching Assistant of Pharmacology, January 2007 - May 2009

New York Medical College

Valhalla, NY

. Presented pharmacological concepts and case studies to 2nd-year medical students

. Monitored students' progress in class and proctored quizzes/exams

HONORS & AFFILIATIONS

Regulatory Affairs Professionals Society, 2012 - Present

North Carolina Regulatory Affairs Forum, 2011 - Present

American Heart Association, 2007 - Present

Winter Eicosanoid Conference Travel Award, 2007, 2011, 2012

Graduate Faculty Council Award (Ph.D.), May 2009

American Heart Association Northeast Affiliate Predoctoral Fellowship, July 2007 - June 2009

NYMC Graduate Student Research Forum: 2nd Place, Poster Division, March 2007

Outstanding Undergraduate Research Award, May 2005

SKILLS

Laboratory: mouse/rat experimentation (ie. dosing, tissue collections), ELISA, Bioplex assay, Western blot, RNA/protein extraction, real-time RT-PCR, lipid extraction and analysis, immunohistochemistry, immunoprecipitation, flow cytometry, cell culture

Operating Systems: Windows 7/Vista/XP, Mac Os

Software: Endnote (X6), Microsoft Office, Adobe Photoshop, Adobe Acrobat, GelPro Analysis, Analyst 1.4.2, ImageJ, Reference Manager, Graphpad Prism

LANGUAGES

English (Fluent), Mandarin Chinese (Fluent), Japanese (Intermediate)

PUBLICATIONS

Wu CC, Mei S, Cheng J, Ding Y, Weidenhammer A, Garcia V, Zhang F, Gotlinger K, Manthati VL, Falck JR, Capdevila JH, Schwartzman ML. Androgen-sensitive hypertension associates with vascular CYP4A12-20-HETE synthase. J Am Soc Nephrol. 2013 May 2.

Trivedi DB, Loftin CD, Clark J, Myers P, Degraff LM, Cheng J, Zeldin DC, Langenbach R. Beta-arrestin deficiency attenuates abdominal aortic aneurysm formation in mice. Circ Res. 2013

Apr 26;112(9):1219-29.

Li H, Edin ML, Bradbury JA, Graves JP, Degraff LM, Gruzdev A, Cheng J, Dackor RT, Wang PM, Bortner CD, Garantziotis S, Jetten AM, Zeldin DC. COX-2 inhibits Th9 differentiation during allergic lung inflammation via downregulation of IL-17RB. Am J Respir Crit Care Med. 2013 Apr 15:187(8):812-22.

Graves JP, Edin ML, Bradbury JA, Gruzdev A, Cheng J, Lih FB, Tomer KB, Morrison JP, Clayton NP, Masinde TA, Qu W, Zeldin DC. Characterization of four new mouse cytochrome P450 enzymes of the cyp2j subfamily. Drug Metab Dispos. 2013 Apr;41(4):763-73.

Li H, Edin ML, Gruzdev A, Cheng J, Bradbury JA, Graves JP, Degraff LM, Zeldin DC. Regulation of T helper cell subsets by cyclooxygenases and their metabolites. Prostaglandins Other Lipid Mediat. 2012 Nov 28.

Cheng J, Garcia V, Ding Y, Wu CC, Thakar K, Falck JR, Ramu E, Schwartzman ML. Induction of Angiotensin-converting enzyme and activation of the Renin-Angiotensin system contribute

to 20-hydroxyeicosatetraenoic Acid-mediated endothelial dysfunction. Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1917-24.

Dackor RT, Cheng J, Voltz JW, Card JW, Ferguson CD, Garrett RC, Bradbury JA, Degraff LM, Lih FB, Tomer KB, Flake GP, Travlos GS, Ramsey RW Jr, Edin ML, Morgan DL, Zeldin DC. Prostaglandin E2 protects murine lungs from bleomycin-induced pulmonary fibrosis and lung dysfunction. Am J

Physiol Lung Cell Mol Physiol. 2011 Nov;301(5):L645-55.

Wu CC, Cheng J, Zhang FF, Gotlinger KH, Kelkar M, Zhang Y, Jat JL, Falck JR, Schwartzman ML. Androgen-dependent hypertension is mediated by 20-hydroxy-5,8,11,14-eicosatetraenoic acid-

induced vascular dysfunction: role of inhibitor of kappaB kinase. Hypertension. 2011 Apr;57(4):788-94. Epub 2011 Feb 14.

Sodhi K, Wu CC, Cheng J, Inoue K, Goli M, Falck JR, Abraham NG, Schwartzman ML. CYP4A2-induced hypertension is 20-HETE- and angiotensin II-dependent. Hypertension. 2010 Nov;56(5):871-8. Epub 2010 Sep 13.

Kusmic C, L'abbate A, Sambuceti G, Drummond G, Barsanti C, Matteucci M, Cao J, Piccolomini F, Cheng J, Abraham NG. Improved myocardial perfusion in chronic diabetic mice by the up-regulation of pLKB1 and AMPK signaling. J Cell Biochem. 2010 Apr 1; 109(5): 1033-44.

Cheng J, Wu CC, Gotlinger KH, Zhang F, Falck JR, Narsimhaswamy D, Schwartzman ML. 20-hydroxy-5,8,11,14-eicosatetraenoic acid mediates endothelial dysfunction via IkappaB kinase-dependent endothelial nitric-oxide synthase uncoupling. J Pharmacol Exp Ther. 2010 Jan; 332(1): 57-65. Epub 2009 Oct 19.

Cheng J, Schwartzman ML. Cytochrome P450-Eicosanoids: endothelial dysfunction and arterial hypertension. Internal Medicine: Clinical and Laboratory. 2007/2008; 15/16: 20-21.

Cheng J, Ou JS, Singh H, Falck JR, Narsimhaswamy D, Pritchard KA Jr, Schwartzman ML. 20- Hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling. Am J Physiol Heart Circ Physiol. 2008 Feb; 294(2): H1018-26.

Patschan S, Chen J, Polotskaia A, Mendelev N, Cheng J, Patschan D, Goligorsky MS. Lipid mediators

of autophagy in stress-induced premature senescence of endothelial cells. Am J Physiol Heart Circ Physiol. 2008 Mar; 294(3): H1119-29.

Ishizuka T, Cheng J, Singh H, Vitto MD, Manthati VL, Falck JR, Laniado-Schwartzman M. 20- Hydroxyeicosatetraenoic acid stimulates nuclear factor-kappaB activation and the production of inflammatory cytokines in human endothelial cells. J Pharmacol Exp Ther. 2008 Jan;324(1): 103-10.

Singh H, Cheng J, Deng H, Kemp R, Ishizuka T, Nasjletti A, Schwartzman ML. Vascular cytochrome P450 4A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertension. Hypertension. 2007 Jul; 50(1): 123-9.

CONFERENCES

Winter Eicosanoid Conference (Baltimore, MD), 2007, 2010-2012

High Blood Pressure Research (Atlanta, GA; Chicago, IL; Washington, DC), 2007-2010

FASEB (Washington, DC), 2006

Drosophila Research Conference (San Diego, CA), 2005

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