Plant Development
Resume:
YoungChul Park
Suwanee, GA 30024-6107
Cell: 770-***-****
***********@*****.*** U.S. citizen
SUMMARY
• New analytical method development and validation for bioactive metabolites, pharmaceutical ingredients, biocides and
pesticides using LC-MS/MS and HPLC to investigate raw materials, complex formulations, in-process samples, finished
products and contribute to a variety of troubleshooting projects. Design and develop new qualification and quantification
method, spectral data interpretations and reporting
• Expertise in development of isolation chemistry for extraction, isolation, identification, purification, quantification methods
and validations of known and unknown bioactives, biodegradations, residue biocide, pesticides and chemical structure
elucidations in leachates, finished products, natural flavors, seeds, plants, organisms, natural products using LC-
MS/MS, GC-MS, HPLC and 2D-NMR experiments, comprehensive chromatographic methods
• Expertise in multi residues and trace level (ppb to ppt) biocide and pesticide analytical method development and
validation in plant, soil and surface water and leachates and other environmental matrices for GLP studies for regulatory
product registration, biocidal products directive (BPD) submissions in compliance with SOP, EPA, OECD, ICH guidelines
• Expertise in analytical and technical supports for R&D to manufacturing, transferring and implementing innovative
methods to investigate raw materials, complex formulations, in-process samples, finished products and contribute to a
variety of troubleshooting projects. Design and develop new qualification and quantification method, spectral data
interpretations and reporting.
EMPLOYMENT HISTORY
February 2011 ~ April 2013 (2 years and 3 months) Research Associate
Lonza Microbial Control, Innovation & Global Technology Center, Lonza
Separation Science Group
1200 Bluegrass Lakes Parkway, Alpharetta, GA 30004
Job Description
Provided analytical supports, GLP and non-GLP studies and problem solving for global regulatory product registration, R&D,
manufactures, application labs, biochemical and alleochemical business functions, external customers within committed
timelines. Lead and perform analytical R&D projects, and involved in cross-functional projects. Provide analytical
consultation to internal and external customers. Keep up with the current knowledge of chromatography and mass
spectrometry, and other separation science technologies. Interact within scientific associations and scientific meetings and
professional publications.
Responsibility
• New analytical method development and validation for pharmaceutical ingredients (API), microbial fermentations,
biocides, pesticides, natural ingredients, alleochemical, complex formulations, finished products using LC-MS/MS,
HPLC, and NMR.
• Method development and validations for multi residues and trace levels (ppb & ppt levels) of biocides and pesticides
analysis in soil, surface water, leachates and other complex matrices using LC-MS/MS, HPLC in compliance of EPA,
OECD, ICH, USP, FDA guidelines
• GMP, and GLP studies for batch analysis, long term storage stability, accelerated storage stability to support regulatory
product registration (from 6 months to 24 months)
• Material characterization, assay, product certification, impurity analysis, partition coefficient for supporting toxicology,
regulatory and external clients.
• Routine analytical and troubleshooting supports for process technology, QC, manufacturing, external clients
• Chemical structure determination of unknown metabolites, natural products, degradations using LC-MS/MS, 2-D NMR
experiments.
• Deformulation chemistry (Reverse engineering) including unknown compounds identification using LC-MS/MS, 2 D NMR
experiments, IC, XRD, XRF, FT-IR and other wet chemistry
September 2010 ~ February 2011 (6 months) Research Scientist
DianaPlantSciences (former Exelixis Plant Sciences),
18183 SW Boones Ferry Rd, Portland, OR 97224
Job Description
Maintain current knowledge of chromatography and mass spectrometry and other analytical technology, Interact with
scientific associations, scientific meetings and professional publications, Identify issues and scientifically-valid solutions to
support R&D development, Analysis and interpret analytical and related study results, and data. Communicate events and
issues to departmental and project teams.
Responsibility
• Analytical method developments and validation for nutraceutical ingredients, natural actives, bioactive secondary
metabolites biocides, pesticides, finished products, raw materials using HPLC, LC-MS/MS, GC
• Multi residues and trace level (ppb and ppt levels) analysis in plant and plant cell cultures by LC-MS/MS, HPLC, GC
• R&D downstream processing optimization for Lyophilization, Extraction, Isolation, Purification, Identification,
Characterization and Certification of Analysis (COA) of bioactive metabolites, oligomers and polymers in plants, plant
cell cultures and natural products using LC-MS/MS, NMR, HPLC, prep-HPLC, GC, GC-MS, 2D NMR spectroscopy, Size
Exclusion Chromatography, Column Chromatography, TLC, pH meter, other wet chemistry
• Material characterization, assay, product certification, storage stability, impurity analysis
• Prep-scale extraction method development and validation from bioreactor cell suspension (1L – 100 L)
January 2007 ~ August, 2010 (3 years and 8 months) Research Scientist
Exelixis Plant Sciences, Exelixis Pharmaceuticals
Metabolic Engineering Department
16160 SW Upper Boones Ferry Rd, Portland, OR 97224
Job Description
Maintain current knowledge of chromatography and mass spectrometry and other analytical technology, Interact with
scientific associations, scientific meetings and professional publications, Identify issues and scientifically-valid solutions to
support R&D development, Analysis and interpret analytical and related study results, and data. Communicate events and
issues to departmental and project teams.
Responsibility
• New analytical method and validation for natural products, nutraceutical ingredients, pharmaceutical ingredient, raw
material, intermediates, finished products, trace level (ppb and ppt) of biocides, pesticides, phytohormone, bioactive
metabolites in compliance with SOPs using LC/MS-MS, HPLC, GC, NMR
• Chemical structure elucidation of unknown metabolites, natural compounds, degradations using LC-MS/MS, 2-D NMR
• Multi residues and trace level (ppb and ppt) phytohormone and pesticides analysis in natural extracts by LC-MS/MS
• R&D downstream processing optimization for Lyophilization, Extraction, Isolation, Purification, Identification,
Characterization and Certification of Analysis (COA) of bioactive metabolites, oligomers and polymers in plants, plant
cell cultures and natural products using LC-MS/MS, NMR, HPLC, prep-HPLC, 2D NMR spectroscopy, Size Exclusion
Chromatography, Column Chromatography, TLC, pH meter, other wet chemistry
• Prep-scale extraction method development and validation in bioreactor cell suspension (1L – 100 L)
• Material characterization, assay, product certification, storage stability, impurity analysis
• Deformulation Chemistry (Reverse Engineering)
May, 2004 ~ December, 2006 (2 years and 8 months) Post-Doctoral Fellowship
Harbor Branch Oceanographic Institution, Division of Biomedical Marine Research
5600 US 1 North, Fort Pierce, FL, 34946
Achievements
• Extraction, purification, characterization, identification of natural products, bioactive metabolites and chemical structure
elucidation using interpretation of spectral data with advanced analytical methods such as HPLC, ESI-LC-MS/MS, 2-d
NMR experiments, and semi organic synthetic derivatization method
• Extraction and bioassay guided fractionation to isolate antimicrobial, antifungal metabolites from marine-derived fungi,
bacteria in bioreactor and marine organisms
• Professional analytical skills
Finnigan LTQ-Electro Spray Ionization Liquid Chromatography/Tandem Mass Spectrometry (ESI-LC/MS/MS): an
Xcalibur with a certificate of achievement for Finnigan LTQ Operations Course from Thermo Electron Institute in
2005
JEOL 600 MHz Nuclear Magnetic Resonance (NMR) spectroscopy (1H, 13C): 2D NMR experiments (HMBC,
HMQC, DEPT, TOCY, NOESY, COSY, ROESY) with Delta NMR software for screening of bioactive fractions and
chemical structure elucidation
HPLC (including analytical, semi-prep, and prep), column chromatography, chiral separation by semi-synthetic
method, FTIR, NIR, optical polarimeter, tlc.
January, 1991 ~ January, 1998 (7 years and 1 month) Senior Research Scientist
E-Sung Chemicals, Ansung, Korea
• Analytical method development and validation for supporting R&D projects using HPLC
• Extraction, isolation, purification and structure elucidation of bioactive secondary metabolites by HPLC, NMR
spectroscopy (JEOL 60 MHz, Varian 60 MHz, Bruker 250 MHz, 360 MHz), GC-MS/MS, column chromatography, FT-IR,
pH meter, Thin layer Chromatography (tlc).
• Preparative scale (10L ~ 50L) isolation and purification chemistry and column chromatography (cationic & anionic
resin/normal phase/reversed phase), size exclusion chromatography, preparative thin film vacuum evaporation (up to 10
kg)
• New total synthetic method of dl-Lipoic acid, dl-Lipoic amide and purification optimization (up to 99.99%)
January, 1990 ~ January, 1991 (1 year and 1 month) Scientist
Korea Institute of Science and Technology, Seoul, Korea
• Organic syntheses of photoresist monomer and polymerization, characterization for excimer laser resists using DSC,
TGA, FT-NMR (60 MHz/100 MHz), HPLC, GC, GPC
• Preparative column chromatography including cationic, anionic, normal/reversed phase, size exclusion chromatography
(SEC)
SPECIALTIES
Multi Residues and Trace Levels (ppb and ppt) Analytical Method and Validation for Natural and Nutritional Ingredients,
Biocides, and Pesticides Analyses by LC-MS/MS; Single Quad (SIM mode) and Triple Quad (MRM mode)
Analytical Method Development and Validation using LC-MS/MS, HPLC, GC, and GC/MS
Chemical Structure Elucidation and Identification of Unknown Metabolites and Degradations using LC-MS/MS and 2D
NMR
Deformulation Chemistry (Reverse Engineering) using LC-MS/MS and 2 D NMR experiments
GMP and GLP studies for Regulatory Products Registration in Storage Stability, Product Characterization, Batch
Analysis, Chemical Certification
R&D Downstream Processing Optimization for Lyophilization, Extraction, Purification, Identification and Quantification of
Bioactive Secondary Metabolites in Plant Cells, Microbial Fermentations, Marine Organisms
Method Development for High Throughput Screening of Bioactive Secondary Metabolites in Plant Cell Suspensions,
Microbial Fermentations, Marine Organisms
EDUCATION HISTORY
2001 ~ 2004 Ph.D., Organic Chemistry/Natural Products Chemistry
Department of Chemistry, University of South Florida, Tampa, FL under the supervision of Bill J. Baker, Ph. D.
• Natural product chemistry for extraction/purification/identification/characterization of bioactive secondary metabolites
(antimicrobials, antifungals) in marine natural products
• Development of analytical data interpretation and chemical structure elucidation of unknown bioactive metabolites and
synthetic or natural impurities/byproducts using HPLC, LC/MS/MS and 1D NMR (1H and 13C) and 2D NMR
experiments
• Individual professional analytical and experimental skills:
NMR spectroscopy: 2D NMR experiments (HMBC, HMQC, DEPT, TOCY, NOESY, COSY, ROESY) using Varian 500
MHz and Bruker 250 MHz
HPLC (including analytical, semi-prep, and prep separation), column chromatography, analytical chiral separation by
semi-derivatization synthesis, Ion exchange resin chromatography, size exclusion chromatography (SEC), GC, GC-
MS/MS, FTIR, optical polarimeter, tlc.
1998 ~ 2001 Ph.D. Organic Chemistry/Natural Product Chemistry
Department of Chemistry, Florida Institute of Technology, Melbourne, FL, under the supervision of Bill J. Baker Ph.D.
(Transferred to USF)
• Isolation chemistry of bioactive secondary metabolites and chemical structure elucidation from Antarctic marine
organisms using HPLC, LC-MS/MS, and 2-d NMR experiments
• Individual professional analytical and experimental skills:
NMR spectroscopy: 2D NMR experiments (HMBC, HMQC, DEPT, TOCY, NOESY, COSY, ROESY) using Varian 500
MHz and Bruker 250 MHz
HPLC (including analytical, semi-prep, and prep separation), column chromatography, analytical chiral separation by
semi-derivatization synthesis, Ion exchange resin chromatography, size exclusion chromatography (SEC), GC, GC-
MS/MS, FTIR, optical polarimeter, tlc.
1987 ~ 1990 M.S. Organic Chemistry, Dankook University, Seoul, Korea
1983 ~ 1987 B.S. Chemistry, Dankook University, Korea
PROFESSIONAL SKILLS
1. Instrumental skills with full operation and maintain:
• LC-Mass Spectrometry (MS) :
i. Agilent 6120 Single Quadrupole ESI-LC/MS with Sing Ion Monitoring (SIM)
Agilent 6420 Triple Quadrupole ESI-LC-MS/MS with Multiple Reaction Monitoring (MRM) (5 years),
ii. Waters Quattro micro ESI-LC-MS/MS (SIM/MRM) (4 years),
iii. Thermo-Finnigan LTQ-ESI-LC-MS/MS, LCQ-ESI-LC-MS/MS (SIM/MRM) (4 years)
• Nuclear Magnetic Resonance (NMR) Spectroscopy : 1H,13C and 2D NMR experiments(HMBC, HMQC, DEPT,
TOCY, NOESY, COSY, ROESY) for Chemical Structure Elucidation (10 years)
i. JEOL 600 MHz (ECA600) (2 years)
ii. Bruker 250 MHz (4 years), 360 MHz (3 years), 500 MHz (3 years)
iii. Varian 500 MHz (1 year), 60 MHz (9 years)
• Analytical Data Acquisition, Process, and Reports : Empower 3 (Waters), MassHunter Workstation (Agilent),
ChemStation (Agilent), MassLynx(Waters), Xcalibur(Thermo-Finnigan), Empower 3 (Waters),
• HPLC (15 years), Preparative HPLC (5 years), GC, GC/MS, GPC, IR, NIR, DSC, TGA, UV Spectroscopy,
Optical Polarimeter, pH meter
2. Software skills for bioanalytical data interpretation and chemical structure elucidation :
MassHunter Workstation (Agilent), ChemStation (Agilent), MassLynx 4.01 (Waters), Xcalibur (Finnigan-LTQ, Thermo
Electron Corp.), Empower 3 (Waters), Delta NMR for chemical structure elucidation (JEOL, ECA 600,600 MHz), Acorn
NMR (interpretation of NMR data), MarinLit (the comprehensive marine natural products database from University of
Canterbury), Dictionary of Natural Products (Chapman & Hall/CRC), ChemOffice, ChemWindow, ISIS Chemdraw,
Spotfire for data analyses (TBICO).
TEACHING EXPERIENCE
• Teaching Assistant at Department of Chemistry, University of South Florida 2003~2004
o Organic Chemistry I/II
PUBLICATIONS
1. “Metabolites from the Marine-Derived Fungus Chromocleista sp. Isolated from a Deep-Water Sediment Sample Collected in
the Gulf of Mexico”, J. Nat. Prod. 2006, 69, 580-584.
2. “Chemical Investigation of Predator-Deterred Macroalgae from the Antarctic Peninsula”, J. Nat. Prod. 2004, 67, 1295-1302
3. “Structure and bioactivity of erebusinone, a pigment from the Antarctic sponge Isodictya erinacea”, Tetrahedron, 2000, 56,
9057-9062
4. “Photoinitiated free-radical ring-opening polymerization of 2-phenyl-4-methylene-1,3-dioxolane”, Makromol. Chem., Rapid
Commum.1991, 12, 141-144
5. “Syntheses and properties of polyphosphazene containing p-(tert-butyloxycarbonyl) aniline”, Polymer, 1990, 15, 552.
6. “Radical polymerization of 2-vinyl-3-(β-phenyl) vinyloxirane”, Polymer, 1990, 14, 298
7. “Synthesis and radical polymerization of 2-(p-substituted phenyl)-4-methylene-1,3-dioxolane derivatives”, Polymer, 1990, 1,
81
PATENTS
• “THREE COMPONENTS PHOTOSENSITIVE RESIN COMPOSITION”, Patent. No.199*-*******, Publication
No.101********** B1, Application No.101**********, Korea Patent, 1995
• “PRODUCTION AND EXTRACTION OF PROCYANIDINS FROM PLANT CELL CULTURES”, United States Patent
Application 201********, and World Intellectual Property Organization WO2012047817, 2012
TALKS AND POSTERS
1. “Metabolites of Fungi Isolated From Deep-Water Sponges And Sediment Samples Collected In The Gulf Of Mexico” Young
Chul Park, Sarath P. Gunasekera, Jose V. Lopez, Peter J. McCarthy, Amy E. Wright as a Poster session, The 47th Annual
Meeting of the American Society of Pharmacognosy), Arlington, Virginia, August 5- 9, 2006
2. “Synthesis of 13C-labeled Erebusinone and Erebusinonamine” Solomon T. Weldegirma, Young Chul Park, Charles D. Amsler,
James B. McClintock, Bill J. Baker as an Oral session, The 47th Annual Meeting of the American Society of
Pharmacognosy), Arlington, Virginia, August 5- 9, 2006
3. “New Metabolites from The Marine Derived Fungus Penicillium sp. Isolated from The Sponge Forcepia sp.” Young Chul Park,
Sarath P. Gunasekera, Jose V. Lopez, Peter J. McCarthy, Amy E. Wright as a Poster session, The 46th Annual Meeting of
the American Society of Pharmacognosy, Corvallis, OR, July 23- 28, 2005
4. “Tryptophan Catabolites Accumulation in two Antarctic Sponges” Young Chul Park, Charles D. Amsler, James B. McClintock,
Bill J. Baker as a Poster session, 2004, Gordon Research Conference) on Marine Natural Products, Ventura Beach Marriott,
Ventura, CA, February 22-27, 2004
5. Florida ACS Annual Meeting and Exposition 2004, Young Chul Park, Charles D. Amsler, James B. McClintock, Bill J. Baker,
American Chemical Society regional meeting as an Oral session, Orlando, FL, May 6-8, 2004
6. “Synthesis and bioactivity of the yellow pigment from the Antarctic sponge Isodictya Erinaca” Young Chul Park, Charles D.
Amsler, James B. McClintock, Bill J. Baker as an,Oral session I, O:6. The 44th Annual Meeting of the American Society of
Pharmacognosy, Chapel Hill, NC, July 12-16, 2003
7. Florida ACS Annual Meeting and Exposition 2003, Young Chul Park, Charles D. Amsler, James B. McClintock, Bill J. Baker,
American Chemical Society regional meeting as an Oral session, Orlando, FL, May 8-10, 2003
8. “Synthesis and Bioactivity of Erebusinone, a Pigment from the Antarctic Sponge Isodictya Erinacea” Young Chul Park, Bill J.
Baker as a Poster session, The 225th ACS National Meeting, New Orleans, LA, March 23-27, 2003
9. Florida ACS Annual Meeting and Exposition 2001, Young Chul Park, Charles D. Amsler, James B. McClintock, Bill J. Baker,
American Chemical Society regional meeting as an Oral session, Orlando, FL, May 11-12, 2001
10. Florida ACS Annual Meeting and Exposition 2000, Young Chul Park, Charles D. Amsler, James B. McClintock, Bill J. Baker,
American Chemical Society regional meeting as an Oral session, Orlando, FL, May 12-13, 2000
AWARDS AND FELLOWSHIPS
• University of South Florida (USF), Nicholas Alexiou award 2004
• USF, Graduate Admissions Committee Travel Grant 2003
• USF College of Arts and Sciences, Tharpe Endowed Award, summer 2002 and 2003
• National Science Foundation (NSF) USAP Research Fellowship 1999 ~ 2003
ASSOCIATIONS
• American Chemical Society (ACS) since 1998
• The American Society of Pharmacognosy (ASP) since 1999
PROFESSIONAL ACTIVITY
Younger Members Committee (07/2007 – Present) in American Society of Pharmacognosy (ASP)
REFERENCES
1. Sung Il Chang, Ph. D. Research Group Leader, Lonza Microbial Control, Lonza, 1200 Bluegrass Lakes Parkway,
Alpharetta, GA 30024, 678-***-****, ****.*****@*****.***
2. Denise Taylor, Ph. D. Research Leader, Consulting Scientist, Lonza Microbial Control, Lonza, 1200 Bluegrass Lakes
Parkway, Alpharetta, GA 30024, 678-***-****, ******.******@*****.***
3. Bill J. Baker, Ph.D. Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, CHE 205A, Tampa, FL
33620-5250, 813-***-****, *******@***.***.***
4. Amy E. Wright, Ph.D. Director, Center for Marine Biomedical and Biotechnology, Harbor Branch Oceanographic
Institution, Florida Atlantic University, 772-***-****, ********@****.***.***
5. Sarath Gunasekera Ph.D. Smithsonian Marine Station at Fort Pierce, 701 Seaway Drive, Fort Pierce, Florida 34949,
772-***-****, ***********@**.***
6. Peter McCarthy, Ph.D. Associate Director and Head of Microbiology, Center for Marine Biomedical and Biotechnology,
Harbor Branch Oceanographic Institution, Florida Atlantic University 772-***-****, ********@****.***.***
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